PANTHER Gene Information   
Gene Symbol(s): REST
Organism: Homo sapiens
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Gene Name: RE1-silencing transcription factor
Gene ID: HGNC:9966
Protein ID: Q13127
Enhancers: View enhancers for HUMAN|HGNC=9966|UniProtKB=Q13127
Genetic Variant Annotation: Annoq
Persistent Id: PTN002553473
Alternate Ids:
X2 box repressor(Synonym) AAC50115(EMBL-CDS)
REST_HUMAN(UniProtKB-ID) Q59ER1(AltAccession)
REST(Symbol) 124376608(GI)
XP_011532703(refSeq) U22680(EMBL)
616806(MIM) HGNC:9966(HGNC)
5978(GeneID) ENSG00000084093(Ensembl)
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PANTHER Classification
PANTHER Family: ZINC FINGER PROTEIN (PTHR24403)
PANTHER Subfamily: RE1-SILENCING TRANSCRIPTION FACTOR (PTHR24403:SF102)  
PANTHER GO-slim Molecular Function:
PANTHER GO-slim Biological Process: positive regulation of transcription by RNA polymerase II
PANTHER GO-slim Cellular Component: nucleus
PANTHER protein class: C2H2 zinc finger transcription factor
Pathway Categories: No pathway information available
GENE ONTOLOGY DATABASE ANNOTATIONS      Click to Expand...
GO MF Complete: DNA-binding transcription factor activity, protein binding, RNA polymerase II-specific DNA-binding transcription factor binding, metal ion binding, RNA polymerase II core promoter sequence-specific DNA binding, RNA polymerase II cis-regulatory region sequence-specific DNA binding, transcription cis-regulatory region binding, DNA-binding transcription repressor activity, RNA polymerase II-specific, chromatin binding
GO BP Complete: negative regulation by host of viral transcription, negative regulation of cortisol biosynthetic process, negative regulation of miRNA transcription, negative regulation of cell population proliferation, positive regulation of programmed cell death, negative regulation of neuron differentiation, positive regulation of neuron differentiation, negative regulation of insulin secretion, positive regulation of transcription by RNA polymerase II, neuronal stem cell population maintenance, hematopoietic progenitor cell differentiation, regulation of osteoblast differentiation, positive regulation of stem cell population maintenance, negative regulation of transcription by RNA polymerase II, chromatin remodeling, modification of synaptic structure, response to hypoxia, response to ischemia, negative regulation of DNA-templated transcription, regulation of alternative mRNA splicing, via spliceosome, positive regulation of DNA-templated transcription, somatic stem cell population maintenance, cellular response to electrical stimulus, negative regulation of amniotic stem cell differentiation, negative regulation of aldosterone biosynthetic process, nervous system process, regulation of DNA-templated transcription, negative regulation of calcium ion-dependent exocytosis, cardiac muscle cell myoblast differentiation, positive regulation of cysteine-type endopeptidase activity involved in apoptotic process, negative regulation of gene expression, negative regulation of dense core granule biogenesis, cellular response to glucocorticoid stimulus, positive regulation of apoptotic process, negative regulation of neurogenesis, cellular response to xenobiotic stimulus, negative regulation of mesenchymal stem cell differentiation
GO CC Complete: nucleus, cytoplasm, transcription repressor complex, cytosol, nucleoplasm
REACTOME DATABASE ANNOTATIONS   Click to Expand...
Reactome Pathways: Generic Transcription Pathway, Chromatin modifying enzymes, RNA Polymerase II Transcription, Disease, PTEN Regulation, Potential therapeutics for SARS, HDACs deacetylate histones, Infectious disease, Nuclear Events (kinase and transcription factor activation), NGF-stimulated transcription, Signal Transduction, Signaling by NTRKs, Regulation of NPAS4 gene expression, PIP3 activates AKT signaling, Gene expression (Transcription), Signaling by NTRK1 (TRKA), Transcriptional Regulation by NPAS4, Viral Infection Pathways, Regulation of PTEN gene transcription, Signaling by Receptor Tyrosine Kinases, Chromatin organization, SARS-CoV Infections, Regulation of NPAS4 gene transcription, Intracellular signaling by second messengers

Orthologs