PANTHER Gene Information

Gene Symbol(s):

CELE_D1054.1

Organism:

Caenorhabditis elegans

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Gene Name:

PNPLA domain-containing protein

Gene ID:

WBGene00008370

Protein ID:

Q18948

Persistent Id:

PTN000274542

Alternate Ids:

BX284605(EMBL)	Q18948(Synonym)
CAA98440(EMBL-CDS)	Q18948_CAEEL(UniProtKB-ID)
179492(GeneID)	WBGene00008370(Ensembl)
CE35445(WormBase_PRO)	WBGene00008370(WormBase)
D1054(WormBase_TRS)	NP_505749(refSeq)
34555848(GI)
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PANTHER Classification

PANTHER Family:	CALCIUM-INDEPENDENT PHOSPHOLIPASE A2 IPLA2 -RELATED (PTHR12406)
PANTHER Subfamily:	PNPLA DOMAIN-CONTAINING PROTEIN (PTHR12406:SF38)
PANTHER GO-slim Molecular Function:	triglyceride lipase activity
PANTHER GO-slim Biological Process:	lipid homeostasis triglyceride catabolic process
PANTHER GO-slim Cellular Component:	lipid droplet membrane cytoplasm
PANTHER protein class:	phospholipase

Pathway Categories:

No pathway information available

GENE ONTOLOGY DATABASE ANNOTATIONS

Click to Expand...

GO MF Complete:	triacylglycerol lipase activity, hydrolase activity
GO BP Complete:	lipid homeostasis, lipid metabolic process, lipid catabolic process, retinol metabolic process, triglyceride catabolic process
GO CC Complete:	lipid droplet, cytoplasm, membrane

REACTOME DATABASE ANNOTATIONS Click to Expand...

Reactome Pathways:

Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs), Acyl chain remodeling of DAG and TAG, Phospholipid metabolism, Glycerophospholipid biosynthesis, Triglyceride metabolism, Triglyceride catabolism, Metabolism of lipids, Post-translational protein phosphorylation, Post-translational protein modification, Metabolism of proteins, Metabolism

Orthologs

ID	Organism	Type
HUMAN\|HGNC=30802\|UniProtKB=Q96AD5	Homo sapiens	O
PANTR\|Ensembl=ENSPTRG00000003138.6\|UniProtKB=H2Q2V9	Pan troglodytes	O
GORGO\|Ensembl=ENSGGOG00000010797.3\|UniProtKB=G3R5F3	Gorilla gorilla gorilla	O
MACMU\|Ensembl=ENSMMUG00000056078.1\|UniProtKB=A0A5F7ZPL2	Macaca mulatta	O
MOUSE\|MGI=MGI=1914103\|UniProtKB=Q8BJ56	Mus musculus	O
RAT\|RGD=1309044\|UniProtKB=P0C548	Rattus norvegicus	O
BOVIN\|Ensembl=ENSBTAG00000005144.4\|UniProtKB=G5E5T0	Bos taurus	O
BOVIN\|Gene=PNPLA2\|UniProtKB=Q2KI18	Bos taurus	O
PIG\|Ensembl=ENSSSCG00000012841.5\|UniProtKB=A5JT15	Sus scrofa	O
HORSE\|Ensembl=ENSECAG00000012411.4\|UniProtKB=F6QQ01	Equus caballus	O
FELCA\|Ensembl=ENSFCAG00000026020.4\|UniProtKB=M3X6E2	Felis catus	O
CANLF\|Ensembl=ENSCAFG00845006576.1\|UniProtKB=A0A8I3MZB7	Canis lupus familiaris	O
MONDO\|Ensembl=ENSMODG00000014995.4\|UniProtKB=H9H6Q9	Monodelphis domestica	O
ORNAN\|Ensembl=ENSOANG00000036833.1\|UniProtKB=A0A6I8NFI4	Ornithorhynchus anatinus	O
CHICK\|Ensembl=ENSGALG00010026898.1\|UniProtKB=A0A8V1A948	Gallus gallus	O
ANOCA\|Ensembl=ENSACAG00000015353.4\|UniProtKB=G1KR24	Anolis carolinensis	O
XENLA\|Gene=pnpla2.S\|UniProtKB=A0A1L8GDE5	Xenopus laevis	O
XENLA\|Gene=pnpla2.L\|UniProtKB=A0A1L8GJE1	Xenopus laevis	O
XENTR\|Xenbase=XB-GENE-953517\|UniProtKB=F6VCJ4	Xenopus tropicalis	O
ORYLA\|Ensembl=ENSORLG00000006274.2\|UniProtKB=H2LPA1	Oryzias latipes	O
DANRE\|ZFIN=ZDB-GENE-120913-3\|UniProtKB=E7FGN6	Danio rerio	O
LEPOC\|Ensembl=ENSLOCG00000000228.1\|UniProtKB=W5LVU6	lepisosteus oculatus	O
HUMAN\|HGNC=21246\|UniProtKB=Q8N8W4	Homo sapiens	O
PANTR\|Ensembl=ENSPTRG00000018100.6\|UniProtKB=H2RCP9	Pan troglodytes	O
GORGO\|Ensembl=ENSGGOG00000007014.3\|UniProtKB=G3QVT1	Gorilla gorilla gorilla	O
MACMU\|Ensembl=ENSMMUG00000000685.4\|UniProtKB=F6Z087	Macaca mulatta	O
MOUSE\|MGI=MGI=3617850\|UniProtKB=Q3V1D5	Mus musculus	O
RAT\|RGD=1306685\|UniProtKB=D4A3G9	Rattus norvegicus	O
BOVIN\|Ensembl=ENSBTAG00000015118.6\|UniProtKB=A0A3Q1M7Z1	Bos taurus	O
PIG\|Ensembl=ENSSSCG00000001559.5\|UniProtKB=A0A8W4FCJ7	Sus scrofa	O
HORSE\|Ensembl=ENSECAG00000012343.4\|UniProtKB=A0A9L0RWF3	Equus caballus	O
FELCA\|Ensembl=ENSFCAG00000001750.6\|UniProtKB=M3VX77	Felis catus	O
CANLF\|Ensembl=ENSCAFG00845008874.1\|UniProtKB=A0A8I3N9T0	Canis lupus familiaris	O
MONDO\|Ensembl=ENSMODG00000013586.4\|UniProtKB=F7AVV1	Monodelphis domestica	O
CHICK\|Ensembl=ENSGALG00010024584.1\|UniProtKB=A0A8V1A0K2	Gallus gallus	O
CHICK\|Ensembl=ENSGALG00010024603.1\|UniProtKB=A0A8V1A0Q9	Gallus gallus	O
ANOCA\|Ensembl=ENSACAG00000009492.4\|UniProtKB=G1KVH5	Anolis carolinensis	O
ANOCA\|Ensembl=ENSACAG00000009453.4\|UniProtKB=G1KIY1	Anolis carolinensis	O
XENLA\|Gene=pnpla1.S\|UniProtKB=A0A1L8H690	Xenopus laevis	O
XENLA\|Gene=pnpla1.L\|UniProtKB=A0A1L8HE03	Xenopus laevis	O
XENTR\|Xenbase=XB-GENE-6464189\|UniProtKB=A0A8J1J451	Xenopus tropicalis	O
HUMAN\|HGNC=24888\|UniProtKB=Q7Z6Z6	Homo sapiens	O
PANTR\|Ensembl=ENSPTRG00000014478.6\|UniProtKB=H2QLV2	Pan troglodytes	O
GORGO\|Ensembl=ENSGGOG00000024230.2\|UniProtKB=G3SGJ2	Gorilla gorilla gorilla	O
MACMU\|Ensembl=ENSMMUG00000002020.4\|UniProtKB=F6TML9	Macaca mulatta	O
MOUSE\|MGI=MGI=1923022\|UniProtKB=Q32LZ8	Mus musculus	O
RAT\|RGD=1307495\|UniProtKB=D3ZXU1	Rattus norvegicus	O
HORSE\|Ensembl=ENSECAG00000013596.4\|UniProtKB=A0A9L0T7F0	Equus caballus	O
FELCA\|Ensembl=ENSFCAG00000007341.6\|UniProtKB=M3W7J8	Felis catus	O
CANLF\|Ensembl=ENSCAFG00845012877.1\|UniProtKB=A0A8I3NK02	Canis lupus familiaris	O
ORNAN\|Ensembl=ENSOANG00000030717.2\|UniProtKB=K7ED98	Ornithorhynchus anatinus	O
HUMAN\|HGNC=18590\|UniProtKB=Q9NST1	Homo sapiens	O
PANTR\|Ensembl=ENSPTRG00000014481.5\|UniProtKB=H2R6Y4	Pan troglodytes	O
GORGO\|Ensembl=ENSGGOG00000005225.3\|UniProtKB=G3SH79	Gorilla gorilla gorilla	O
MACMU\|Ensembl=ENSMMUG00000016698.4\|UniProtKB=F6VKY9	Macaca mulatta	O
MOUSE\|MGI=MGI=2151796\|UniProtKB=Q91WW7	Mus musculus	O
RAT\|RGD=1595843\|UniProtKB=D3Z9J9	Rattus norvegicus	O
BOVIN\|Ensembl=ENSBTAG00000045746.2\|UniProtKB=G3N1H9	Bos taurus	O
BOVIN\|Ensembl=ENSBTAG00000003367.6\|UniProtKB=G5E554	Bos taurus	O
PIG\|Ensembl=ENSSSCG00000027266.3\|UniProtKB=I3LTE6	Sus scrofa	O
HORSE\|Ensembl=ENSECAG00000014604.4\|UniProtKB=F7DJT2	Equus caballus	O
CANLF\|Ensembl=ENSCAFG00845012819.1\|UniProtKB=A0A8I3NNR8	Canis lupus familiaris	O
MONDO\|Ensembl=ENSMODG00000006216.4\|UniProtKB=F7FSA6	Monodelphis domestica	O
CHICK\|Ensembl=ENSGALG00010013267.1\|UniProtKB=A0A8V0YLD7	Gallus gallus	O
ANOCA\|Ensembl=ENSACAG00000015959.4\|UniProtKB=G1KRW9	Anolis carolinensis	O
XENLA\|Gene=LOC108712532\|UniProtKB=A0A1L8GQH8	Xenopus laevis	O
XENLA\|Gene=pnpla3.L\|UniProtKB=Q68FI5	Xenopus laevis	O
XENTR\|Xenbase=XB-GENE-5855123\|UniProtKB=Q5FWR9	Xenopus tropicalis	O
ORYLA\|Ensembl=ENSORLG00000008473.2\|UniProtKB=H2LWZ0	Oryzias latipes	O
LEPOC\|Ensembl=ENSLOCG00000010576.1\|UniProtKB=W5MX48	lepisosteus oculatus	O
ORYLA\|Ensembl=ENSORLG00000029635.1\|UniProtKB=A0A3B3H6R4	Oryzias latipes	O
ORYLA\|Ensembl=ENSORLG00000024238.1\|UniProtKB=A0A3B3HAV5	Oryzias latipes	O
ORYLA\|Ensembl=ENSORLG00000012922.2\|UniProtKB=H2MCB0	Oryzias latipes	O
DANRE\|ZFIN=ZDB-GENE-040718-27\|UniProtKB=Q6DHN9	Danio rerio	O
LEPOC\|Ensembl=ENSLOCG00000015085.1\|UniProtKB=W5ND55	lepisosteus oculatus	O
CIOIN\|Ensembl=ENSCING00000022268.1\|UniProtKB=H2XSB5	Ciona intestinalis	O
BRAFL\|Gene=LOC118413925\|UniProtKB=A0A9J7MN79	Branchiostoma floridae	O
STRPU\|EnsemblGenome=LOC582648\|UniProtKB=A0A7M7P3R3	Strongylocentrotus purpuratus	O
CAEBR\|Gene_ORFName=CBG09699\|UniProtKB=A8X8G8	Caenorhabditis briggsae	LDO
PRIPA\|EnsemblGenome=WBGene00106235\|UniProtKB=A0A2A6BXD2	Pristionchus pacificus	O
PRIPA\|EnsemblGenome=WBGene00275453\|UniProtKB=A0A2A6BGP7	Pristionchus pacificus	LDO
DROME\|FlyBase=FBgn0030607\|UniProtKB=Q9VXY8	Drosophila melanogaster	O
DROME\|FlyBase=FBgn0036449\|UniProtKB=E1JI03	Drosophila melanogaster	O
ANOGA\|EnsemblGenome=AGAP011925\|UniProtKB=A0A1S4H7U8	Anopheles gambiae	O
TRICA\|EnsemblGenome=TC007628\|UniProtKB=D2A2L1	Tribolium castaneum	O
DAPPU\|EnsemblGenome=DAPPUDRAFT_40590\|UniProtKB=E9FT48	Daphnia pulex	O
DAPPU\|EnsemblGenome=DAPPUDRAFT_199604\|UniProtKB=E9GZM5	Daphnia pulex	O
IXOSC\|EnsemblGenome=ISCW017608\|UniProtKB=B7PFS6	Ixodes scapularis	O
HELRO\|EnsemblGenome=HelroG76015\|UniProtKB=T1G2E0	helobdella robusta	O
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g107650\|UniProtKB=A7S7I7	Nematostella vectensis	O
TRIAD\|EnsemblGenome=TriadG18195\|UniProtKB=B3RJ99	Trichoplax adhaerens	O
TRIAD\|EnsemblGenome=TriadG51458\|UniProtKB=B3RJ97	Trichoplax adhaerens	O
TRIAD\|EnsemblGenome=TriadG18188\|UniProtKB=B3RJ95	Trichoplax adhaerens	O
MONBE\|EnsemblGenome=MONBRDRAFT_23560\|UniProtKB=A9UTT0	Monosiga brevicollis	O
BATDJ\|Gene_ORFName=BATDEDRAFT_22555\|UniProtKB=F4NV55	Batrachochytrium dendrobatidis	O
LEIMA\|EnsemblGenome=LMJF_34_2910\|UniProtKB=Q4Q2Q3	Leishmania major	O
TRYB2\|Gene_ORFName=Tb927.4.1780\|UniProtKB=Q581Q3	Trypanosoma brucei	O
PHYRM\|Gene=H3GIV2_PHYRM\|UniProtKB=H3GIV2	Phytophthora ramorum	O
PHYRM\|Gene=H3H3W6_PHYRM\|UniProtKB=H3H3W6	Phytophthora ramorum	O
PHYRM\|Gene=H3H459_PHYRM\|UniProtKB=H3H459	Phytophthora ramorum	O
PHYRM\|Gene=H3H460_PHYRM\|UniProtKB=H3H460	Phytophthora ramorum	O
LEIMA\|EnsemblGenome=LMJF_13_1150\|UniProtKB=Q4QG39	Leishmania major	O
TRYB2\|Gene_ORFName=Tb11.02.1440\|UniProtKB=Q386C0	Trypanosoma brucei	O
PLAF7\|EnsemblGenome=PF3D7_0218600\|UniProtKB=O96266	Plasmodium falciparum	O
THAPS\|EnsemblGenome=THAPSDRAFT_9458\|UniProtKB=B8CBD8	Thalassiosira pseudonana	O
THAPS\|EnsemblGenome=THAPSDRAFT_2521\|UniProtKB=B8BUL3	Thalassiosira pseudonana	O
PHYRM\|Gene=H3H4J5_PHYRM\|UniProtKB=H3H4J5	Phytophthora ramorum	O
PHYRM\|Gene=H3H3B2_PHYRM\|UniProtKB=H3H3B2	Phytophthora ramorum	O
CHLRE\|EnsemblGenome=CHLRE_04g214700v5\|UniProtKB=A0A2K3DTR7	Chlamydomonas reinhardtii	O
CHLRE\|EnsemblGenome=CHLRE_10g462000v5\|UniProtKB=A0A2K3DBZ3	Chlamydomonas reinhardtii	O
CHLRE\|EnsemblGenome=CHLRE_26g756847v5\|UniProtKB=A0A2K3CN09	Chlamydomonas reinhardtii	O
CHLRE\|EnsemblGenome=CHLRE_10g431350v5\|UniProtKB=A8IBA6	Chlamydomonas reinhardtii	O
KLENI\|Gene_ORFName=KFL_003100140\|UniProtKB=A0A1Y1IDI1	Klebsormidium nitens	O
CHLRE\|EnsemblGenome=CHLRE_03g195500v5\|UniProtKB=A0A2K3DYL8	Chlamydomonas reinhardtii	O
CHLRE\|EnsemblGenome=CHLRE_03g175100v5\|UniProtKB=A0A2K3DXB5	Chlamydomonas reinhardtii	O
CHLRE\|EnsemblGenome=CHLRE_09g400219v5\|UniProtKB=A0A2K3DEX6	Chlamydomonas reinhardtii	O
CHLRE\|EnsemblGenome=CHLRE_12g530950v5\|UniProtKB=A0A2K3D4U4	Chlamydomonas reinhardtii	O
AMBTC\|EnsemblGenome=AMTR_s00008p00125700\|UniProtKB=W1NHN9	Amborella trichopoda	O
MUSAM\|EnsemblGenome=Ma03_g01710\|UniProtKB=A0A804I7D4	Musa acuminata subsp. malaccensis	O
SETIT\|EnsemblGenome=SETIT_026450mg\|UniProtKB=K3ZIP8	Setaria italica	O
SORBI\|EnsemblGenome=SORBI_3005G144300\|UniProtKB=C5Y3W6	Sorghum bicolor	O
MAIZE\|EnsemblGenome=Zm00001eb113740\|UniProtKB=B4F8G3	Zea mays	O
ORYSJ\|EnsemblGenome=Os11g0546300\|UniProtKB=Q0IS87	Oryza sativa	O
HORVV\|EnsemblGenome=HORVU.MOREX.r3.2HG0182880\|UniProtKB=A0A8I6WG23	Hordeum vulgare subsp. vulgare	O
WHEAT\|EnsemblGenome=TraesCS2A02G377000\|UniProtKB=A0A3B6B1H0	Triticum aestivum	O
WHEAT\|EnsemblGenome=TraesCS2D02G373600\|UniProtKB=A0A1D5UIX7	Triticum aestivum	O
WHEAT\|EnsemblGenome=TraesCS2B02G394200\|UniProtKB=A0A3B6C9U7	Triticum aestivum	O
SPIOL\|Gene=LOC110783510\|UniProtKB=A0A9R0JR43	Spinacia oleracea	O
HELAN\|Gene_ORFName=HannXRQ_Chr02g0058791\|UniProtKB=A0A251VIZ4	Helianthus annuus	O
HELAN\|Gene_ORFName=HanXRQr2_Chr06g0270561\|UniProtKB=A0A9K3IUU6	Helianthus annuus	O
HELAN\|EnsemblGenome=HanXRQr2_Chr11g0486811\|UniProtKB=A0A251TCP3	Helianthus annuus	O
LACSA\|Gene_ORFName=LSAT_V11C700372630\|UniProtKB=A0A9R1V3R5	Lactuca sativa	O
CAPAN\|EnsemblGenome=T459_34251\|UniProtKB=A0A2G2XWI8	Capsicum annuum	O
SOLTU\|EnsemblGenome=PGSC0003DMG400023754\|UniProtKB=M1C6Z3	Solanum tuberosum	O
SOLLC\|EnsemblGenome=Solyc01g104310.3\|UniProtKB=A0A3Q7ERW0	Solanum lycopersicum	O
TOBAC\|Gene=LOC107829125\|UniProtKB=A0A1S4DFD8	Nicotiana tabacum	O
TOBAC\|Gene=LOC107780405\|UniProtKB=A0A1S3YX46	Nicotiana tabacum	O
VITVI\|EnsemblGenome=Vitvi12g01816\|UniProtKB=D7T034	Vitis vinifera	O
EUCGR\|EnsemblGenome=EUGRSUZ_G00613\|UniProtKB=A0A059BAH5	Eucalyptus grandis	O
BRANA\|Gene_ORFName=DARMORV10_C06P12670.1\|UniProtKB=A0A078J0B5	Brassica napus	O
BRACM\|EnsemblGenome=Bra041092\|UniProtKB=A0A397XX23	Brassica campestris	O
BRANA\|Gene_ORFName=GSBRNA2T00021574001\|UniProtKB=A0A078G9J4	Brassica napus	O
BRANA\|Gene_ORFName=GSBRNA2T00081127001\|UniProtKB=A0A078I505	Brassica napus	O
BRACM\|EnsemblGenome=Bra036734\|UniProtKB=M4F6M4	Brassica campestris	O
ARATH\|TAIR=locus=2196685\|UniProtKB=Q6NPP7	Arabidopsis thaliana	O
GOSHI\|Gene=LOC107938399\|UniProtKB=A0A1U8MJR7	Gossypium hirsutum	O
GOSHI\|Gene=LOC107936982\|UniProtKB=A0A1U8MEJ5	Gossypium hirsutum	O
GOSHI\|Gene=LOC107932420\|UniProtKB=A0A1U8M2X1	Gossypium hirsutum	O
GOSHI\|Gene=LOC107928966\|UniProtKB=A0A1U8LRD8	Gossypium hirsutum	O
GOSHI\|Gene=LOC107939224\|UniProtKB=A0A1U8MR58	Gossypium hirsutum	O
THECC\|EnsemblGenome=TCM_006407\|UniProtKB=A0A061DZ51	Theobroma cacao	O
CITSI\|Gene_ORFName=CISIN_1g015942mg\|UniProtKB=A0A067EJ17	Citrus sinensis	O
POPTR\|EnsemblGenome=POPTR_003G020800v3\|UniProtKB=A0A2K2B094	Populus trichocarpa	O
POPTR\|EnsemblGenome=POPTR_001G209500v3\|UniProtKB=A9PFI5	Populus trichocarpa	O
MANES\|EnsemblGenome=MANES_07G014400\|UniProtKB=A0A2C9VJ48	Manihot esculenta	O
RICCO\|Gene_ORFName=RCOM_1411270\|UniProtKB=B9SRI9	Ricinus communis	O
SOYBN\|EnsemblGenome=GLYMA_08G184900\|UniProtKB=K7L7H6	Glycine max	O
SOYBN\|EnsemblGenome=GLYMA_15G047800\|UniProtKB=I1MDQ4	Glycine max	O
MEDTR\|EnsemblGenome=MTR_2g007650\|UniProtKB=A2Q497	Medicago truncatula	O
JUGRE\|EnsemblGenome=Jr16_19530\|UniProtKB=A0A2I4FV16	Juglans regia	O
CUCSA\|EnsemblGenome=Csa_3G214570\|UniProtKB=A0A0A0L746	Cucumis sativus	O
PRUPE\|EnsemblGenome=PRUPE_1G566300\|UniProtKB=A0A251RJ53	Prunus persica	O
SELML\|EnsemblGenome=SELMODRAFT_103868\|UniProtKB=D8RXH3	Selaginella moellendorffii	O
SELML\|EnsemblGenome=SELMODRAFT_99699\|UniProtKB=D8RRL1	Selaginella moellendorffii	O
SELML\|EnsemblGenome=SELMODRAFT_103449\|UniProtKB=D8RXG7	Selaginella moellendorffii	O
PHYPA\|EnsemblGenome=Pp3c11_20720\|UniProtKB=A0A2K1JVH4	Physcomitrella patens	O
MARPO\|EnsemblGenome=MARPO_0101s0012\|UniProtKB=A0A2R6WEC8	Marchantia polymorpha	O
KLENI\|Gene_ORFName=KFL_000290010\|UniProtKB=A0A1Y1HNP0	Klebsormidium nitens	O