PANTHER Gene Information

Gene Symbol(s):

ife-4

Organism:

Caenorhabditis elegans

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Gene Name:

Eukaryotic translation initiation factor 4E-4

Gene ID:

WBGene00002062

Protein ID:

Q22888

Persistent Id:

PTN000238738

Alternate Ids:

AF214651(EMBL)	2494316(GI)
IF4E4(Synonym)	AAF62414(EMBL-CDS)
C05D9(WormBase_TRS)	C05D9.5(Ensembl_PRO)
C05D9.5(Ensembl_TRS)	WBGene00002062(Ensembl)
WBGene00002062(WormBase)	180464(GeneID)
IF4E4_CAEEL(UniProtKB-ID)	CE07931(WormBase_PRO)
ife-4(Symbol)	NM_075809(refSeq)
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PANTHER Classification

PANTHER Family:	EUKARYOTIC TRANSLATION INITIATION FACTOR 4E RELATED (PTHR11960)
PANTHER Subfamily:	EUKARYOTIC TRANSLATION INITIATION FACTOR 4E HOMOLOGOUS PROTEIN, ISOFORM B (PTHR11960:SF18)
PANTHER GO-slim Molecular Function:	translation initiation factor activity RNA cap binding
PANTHER GO-slim Biological Process:	translational initiation
PANTHER GO-slim Cellular Component:	intracellular protein-containing complex cytoplasm
PANTHER protein class:	translation initiation factor

Pathway Categories:

No pathway information available

GENE ONTOLOGY DATABASE ANNOTATIONS

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GO MF Complete:	translation initiation factor activity, RNA 7-methylguanosine cap binding, RNA binding
GO BP Complete:	regulation of translation, translational initiation, translation
GO CC Complete:	eukaryotic translation initiation factor 4F complex

REACTOME DATABASE ANNOTATIONS Click to Expand...

Reactome Pathways:

Antiviral mechanism by IFN-stimulated genes, Cytokine Signaling in Immune system, Interferon Signaling, Immune System, ISG15 antiviral mechanism

Orthologs

ID	Organism	Type
XENLA\|Gene=LOC108711777\|UniProtKB=A0A8J1MPH3	Xenopus laevis	O
XENLA\|Gene=eif4e2.S\|UniProtKB=Q4V7K1	Xenopus laevis	O
XENLA\|Gene=eif4e2.L\|UniProtKB=A0A8J1MQI1	Xenopus laevis	O
XENTR\|Xenbase=XB-GENE-5823950\|UniProtKB=Q28F16	Xenopus tropicalis	O
DANRE\|ZFIN=ZDB-GENE-040426-1728\|UniProtKB=Q6PBU4	Danio rerio	O
PANTR\|Ensembl=ENSPTRG00000047830.1\|UniProtKB=A0A2I3SBC9	Pan troglodytes	O
GORGO\|Ensembl=ENSGGOG00000036742.1\|UniProtKB=A0A2I2YNS7	Gorilla gorilla gorilla	O
HUMAN\|HGNC=3293\|UniProtKB=O60573	Homo sapiens	LDO
GORGO\|Ensembl=ENSGGOG00000043810.1\|UniProtKB=G3SIC4	Gorilla gorilla gorilla	LDO
MACMU\|Ensembl=ENSMMUG00000046892.2\|UniProtKB=A0A5F8AC68	Macaca mulatta	O
MACMU\|Ensembl=ENSMMUG00000022151.4\|UniProtKB=F6TAR5	Macaca mulatta	LDO
MOUSE\|MGI=MGI=1914440\|UniProtKB=Q8BMB3	Mus musculus	LDO
BOVIN\|Ensembl=ENSBTAG00000010598.6\|UniProtKB=A0A3Q1LSC2	Bos taurus	LDO
BOVIN\|Ensembl=ENSBTAG00000054466.1\|UniProtKB=A0A3Q1MRS1	Bos taurus	LDO
PIG\|Ensembl=ENSSSCG00000038466.3\|UniProtKB=A0A287B357	Sus scrofa	LDO
HORSE\|Ensembl=ENSECAG00000031677.2\|UniProtKB=A0A3Q2LJH1	Equus caballus	O
HORSE\|Ensembl=ENSECAG00000020187.4\|UniProtKB=A0A9L0RKY6	Equus caballus	LDO
FELCA\|Ensembl=ENSFCAG00000024388.4\|UniProtKB=M3X834	Felis catus	O
FELCA\|Ensembl=ENSFCAG00000005684.6\|UniProtKB=A0A2I2U9W7	Felis catus	LDO
CANLF\|Ensembl=ENSCAFG00845010462.1\|UniProtKB=A0A8I3NDG3	Canis lupus familiaris	O
CANLF\|Ensembl=ENSCAFG00845016161.1\|UniProtKB=A0A8I3NWB2	Canis lupus familiaris	O
CANLF\|Ensembl=ENSCAFG00845001623.1\|UniProtKB=A0A8I3MGG6	Canis lupus familiaris	O
CANLF\|Ensembl=ENSCAFG00845025436.1\|UniProtKB=A0A8I3S9D5	Canis lupus familiaris	O
CANLF\|Ensembl=ENSCAFG00845021989.1\|UniProtKB=A0A8I3PEQ2	Canis lupus familiaris	O
CANLF\|Ensembl=ENSCAFG00845026782.1\|UniProtKB=A0A8I3PX40	Canis lupus familiaris	O
CANLF\|Ensembl=ENSCAFG00845026100.1\|UniProtKB=A0A8I3PNW0	Canis lupus familiaris	LDO
MONDO\|Ensembl=ENSMODG00000048748.1\|UniProtKB=A0A5F8GBZ4	Monodelphis domestica	O
MONDO\|Ensembl=ENSMODG00000002680.4\|UniProtKB=F7AZJ1	Monodelphis domestica	LDO
ORNAN\|Ensembl=ENSOANG00000048067.1\|UniProtKB=A0A6I8P286	Ornithorhynchus anatinus	LDO
CHICK\|Ensembl=ENSGALG00010017905.1\|UniProtKB=A0A8V0Z488	Gallus gallus	LDO
ANOCA\|Ensembl=ENSACAG00000010833.4\|UniProtKB=H9GGW9	Anolis carolinensis	LDO
XENLA\|Gene=mgc89871.S\|UniProtKB=A0A8J0VFP5	Xenopus laevis	O
XENLA\|Gene=mgc89871.L\|UniProtKB=Q4FZQ5	Xenopus laevis	LDO
XENTR\|Xenbase=XB-GENE-973579\|UniProtKB=Q6DER4	Xenopus tropicalis	LDO
ORYLA\|Ensembl=ENSORLG00000015731.2\|UniProtKB=A0A3B3IG38	Oryzias latipes	LDO
DANRE\|ZFIN=ZDB-GENE-050327-59\|UniProtKB=A1L200	Danio rerio	LDO
LEPOC\|Ensembl=ENSLOCG00000005798.1\|UniProtKB=W5MF44	lepisosteus oculatus	LDO
CIOIN\|Ensembl=ENSCING00000002342.3\|UniProtKB=F6PN13	Ciona intestinalis	LDO
BRAFL\|Gene_ORFName=BRAFLDRAFT_265613\|UniProtKB=C3YK25	Branchiostoma floridae	LDO
STRPU\|EnsemblGenome=GeneID_575773\|UniProtKB=A0A7M7SWV6	Strongylocentrotus purpuratus	LDO
CAEBR\|WormBase=WBGene00026866\|UniProtKB=A8WVM5	Caenorhabditis briggsae	LDO
PRIPA\|EnsemblGenome=WBGene00116828\|UniProtKB=A0A2A6C7C8	Pristionchus pacificus	LDO
DROME\|FlyBase=FBgn0053100\|UniProtKB=E1JIV5	Drosophila melanogaster	LDO
ANOGA\|EnsemblGenome=AGAP002948\|UniProtKB=Q7QD43	Anopheles gambiae	LDO
TRICA\|EnsemblGenome=TC012945\|UniProtKB=D6X3F1	Tribolium castaneum	LDO
DAPPU\|EnsemblGenome=DAPPUDRAFT_231617\|UniProtKB=E9HCX7	Daphnia pulex	LDO
IXOSC\|EnsemblGenome=ISCW006138\|UniProtKB=B7PMU0	Ixodes scapularis	LDO
HELRO\|EnsemblGenome=HelroG64314\|UniProtKB=T1FXS7	helobdella robusta	LDO
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g236749\|UniProtKB=A7RYG8	Nematostella vectensis	LDO
TRIAD\|EnsemblGenome=TriadG56506\|UniProtKB=B3RYC1	Trichoplax adhaerens	O
TRIAD\|EnsemblGenome=TriadG52187\|UniProtKB=B3RM04	Trichoplax adhaerens	LDO
MONBE\|EnsemblGenome=MONBRDRAFT_32697\|UniProtKB=A9V159	Monosiga brevicollis	LDO
CANAL\|CGD=CAL0000181390\|UniProtKB=A0A1D8PNX8	Candida albicans	LDO
YARLI\|EnsemblGenome=YALI0_F17864g\|UniProtKB=Q6C1A7	Yarrowia lipolytica	LDO
EMENI\|EnsemblGenome=ANIA_08191\|UniProtKB=Q5AU39	Emericella nidulans	LDO
ASPFU\|EnsemblGenome=AFUA_5G03180\|UniProtKB=Q4WEJ0	Neosartorya fumigata	LDO
NEUCR\|EnsemblGenome=NCU09546\|UniProtKB=Q7S2B5	Neurospora crassa	LDO
SCLS1\|Gene_ORFName=SS1G_07827\|UniProtKB=A7ER73	Sclerotinia sclerotiorum	LDO
PHANO\|EnsemblGenome=SNOG_11056\|UniProtKB=Q0UB08	Phaeosphaeria nodorum	LDO
CRYNJ\|EnsemblGenome=CNK02780\|UniProtKB=Q5K991	Cryptococcus neoformans	LDO
PUCGT\|EnsemblGenome=PGTG_08424\|UniProtKB=E3KDN2	Puccinia graminis	LDO
BATDJ\|Gene_ORFName=BATDEDRAFT_92181\|UniProtKB=F4PD21	Batrachochytrium dendrobatidis	LDO
DICDI\|dictyBase=DDB_G0281979\|UniProtKB=Q54T63	Dictyostelium discoideum	LDO
DICPU\|EnsemblGenome=DICPUDRAFT_25523\|UniProtKB=F0Z779	Dictyostelium purpureum	LDO
LEIMA\|EnsemblGenome=LMJF_30_0450\|UniProtKB=Q4Q7R3	Leishmania major	LDO
TRYB2\|Gene_ORFName=Tb927.6.1870\|UniProtKB=Q585M4	Trypanosoma brucei	LDO
GIAIC\|EnsemblGenome=GL50803_17261\|UniProtKB=A8BL39	Giardia intestinalis	LDO
TRIV3\|Gene_ORFName=TVAG_238140\|UniProtKB=A2DD14	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_343960\|UniProtKB=A2E7L7	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_089010\|UniProtKB=A2G3L7	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_476650\|UniProtKB=A2DA88	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_074020\|UniProtKB=A2G6I4	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_117150\|UniProtKB=A2E3Q5	Trichomonas vaginalis	LDO
TRIV3\|Gene_ORFName=TVAG_215090\|UniProtKB=A2F639	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_419550\|UniProtKB=A2EIS9	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_462790\|UniProtKB=A2DLZ0	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_450940\|UniProtKB=A2EYP7	Trichomonas vaginalis	O
PARTE\|EnsemblGenome=GSPATT00016718001\|UniProtKB=A0DFT8	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00023395001\|UniProtKB=A0E4K3	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00003164001\|UniProtKB=A0DYS9	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00030144001\|UniProtKB=A0BLU3	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00006942001\|UniProtKB=A0CD64	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00030713001\|UniProtKB=A0BNF8	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00021716001\|UniProtKB=A0DZT1	Paramecium tetraurelia	LDO
THAPS\|EnsemblGenome=THAPSDRAFT_36502\|UniProtKB=B8C956	Thalassiosira pseudonana	O
THAPS\|EnsemblGenome=THAPSDRAFT_35084\|UniProtKB=B8C4Q6	Thalassiosira pseudonana	LDO
PHYRM\|Gene=H3GYW7_PHYRM\|UniProtKB=H3GYW7	Phytophthora ramorum	LDO
AMBTC\|EnsemblGenome=AMTR_s00068p00082940\|UniProtKB=U5DCY6	Amborella trichopoda	LDO
ZOSMR\|Gene_ORFName=ZOSMA_38G00420\|UniProtKB=A0A0K9P4K3	Zostera marina	LDO
MUSAM\|EnsemblGenome=Ma03_g30810\|UniProtKB=A0A804II65	Musa acuminata subsp. malaccensis	O
MUSAM\|EnsemblGenome=Ma04_g11090\|UniProtKB=A0A804ING2	Musa acuminata subsp. malaccensis	LDO
SETIT\|EnsemblGenome=SETIT_037341mg\|UniProtKB=K4AEN4	Setaria italica	LDO
SORBI\|EnsemblGenome=SORBI_3001G429100\|UniProtKB=C5WQ71	Sorghum bicolor	LDO
MAIZE\|EnsemblGenome=Zm00001eb011490\|UniProtKB=B4FGA3	Zea mays	LDO
ORYSJ\|EnsemblGenome=Os03g0262400\|UniProtKB=Q10NQ9	Oryza sativa	LDO
BRADI\|EnsemblGenome=BRADI_1g67380v3\|UniProtKB=I1H778	Brachypodium distachyon	LDO
HORVV\|EnsemblGenome=HORVU.MOREX.r3.4HG0390230\|UniProtKB=F2CSX9	Hordeum vulgare subsp. vulgare	LDO
WHEAT\|EnsemblGenome=TraesCS4A02G087900\|UniProtKB=A0A3B6HPM4	Triticum aestivum	O
WHEAT\|EnsemblGenome=TraesCS4B02G216300\|UniProtKB=A0A3B6IR12	Triticum aestivum	O
WHEAT\|EnsemblGenome=TraesCAD_scaffold_029241_01G000100\|UniProtKB=A3RCV9	Triticum aestivum	LDO
NELNU\|Gene_ORFName=HUJ06_028643\|UniProtKB=A0A1U7ZYX8	Nelumbo nucifera	O
NELNU\|Gene=LOC104597662\|UniProtKB=A0A1U8A825	Nelumbo nucifera	LDO
SPIOL\|Gene=LOC110798428\|UniProtKB=A0A9R0J130	Spinacia oleracea	LDO
HELAN\|EnsemblGenome=HanXRQr2_Chr13g0581681\|UniProtKB=A0A251SQD2	Helianthus annuus	LDO
HELAN\|EnsemblGenome=HanXRQr2_Chr02g0080251\|UniProtKB=A0A251VI13	Helianthus annuus	LDO
LACSA\|Gene_ORFName=LSAT_V11C600313080\|UniProtKB=A0A9R1V6P4	Lactuca sativa	LDO
ERYGU\|Gene_ORFName=MIMGU_mgv1a013683mg\|UniProtKB=A0A022RJ40	Erythranthe guttata	LDO
CAPAN\|EnsemblGenome=T459_26441\|UniProtKB=A0A1U8EM87	Capsicum annuum	LDO
SOLTU\|EnsemblGenome=PGSC0003DMG400023664\|UniProtKB=M1C6I4	Solanum tuberosum	LDO
SOLLC\|EnsemblGenome=Solyc10g080660.2\|UniProtKB=A0A3Q7IKW2	Solanum lycopersicum	LDO
TOBAC\|Gene=LOC107763091\|UniProtKB=A0A1S3XAS0	Nicotiana tabacum	O
TOBAC\|Gene=LOC107814214\|UniProtKB=A0A075QLS4	Nicotiana tabacum	O
TOBAC\|Gene=LOC107826235\|UniProtKB=A0A075QRH1	Nicotiana tabacum	O
TOBAC\|Gene=LOC107808007\|UniProtKB=A0A075QVP3	Nicotiana tabacum	LDO
VITVI\|EnsemblGenome=Vitvi08g01803\|UniProtKB=D7TI73	Vitis vinifera	LDO
EUCGR\|EnsemblGenome=EUGRSUZ_A02106\|UniProtKB=A0A059DGK1	Eucalyptus grandis	LDO
BRANA\|Gene_ORFName=DARMORV10_A02P04740.1\|UniProtKB=A0A078ITC3	Brassica napus	LDO
BRANA\|Gene_ORFName=GSBRNA2T00082369001\|UniProtKB=A0A078I489	Brassica napus	LDO
BRACM\|EnsemblGenome=Bra023664\|UniProtKB=M4E4G1	Brassica campestris	LDO
BRANA\|Gene_ORFName=DARMORV10_A10P21390.1\|UniProtKB=A0A078HKU5	Brassica napus	LDO
BRACM\|EnsemblGenome=Bra002134\|UniProtKB=M4CD53	Brassica campestris	O
BRACM\|EnsemblGenome=Bra006439\|UniProtKB=M4CQF0	Brassica campestris	LDO
ARATH\|TAIR=locus=2172339\|UniProtKB=Q9FK59	Arabidopsis thaliana	LDO
GOSHI\|Gene=LOC107893766\|UniProtKB=A0A1U8I829	Gossypium hirsutum	O
GOSHI\|Gene=LOC107920746\|UniProtKB=A0A1U8KUE8	Gossypium hirsutum	LDO
THECC\|EnsemblGenome=TCM_025921\|UniProtKB=A0A061F1N9	Theobroma cacao	LDO
CITSI\|Gene_ORFName=CISIN_1g030198mg\|UniProtKB=A0A067EIJ2	Citrus sinensis	LDO
POPTR\|EnsemblGenome=POPTR_013G057000v3\|UniProtKB=B9I5X1	Populus trichocarpa	LDO
MANES\|EnsemblGenome=MANES_09G140300\|UniProtKB=A0A2C9VBX8	Manihot esculenta	O
MANES\|EnsemblGenome=MANES_08G145200\|UniProtKB=A0A2C9VGB0	Manihot esculenta	LDO
RICCO\|Gene_ORFName=RCOM_1120960\|UniProtKB=B9SHE9	Ricinus communis	LDO
SOYBN\|EnsemblGenome=GLYMA_16G153800\|UniProtKB=I1MNU7	Glycine max	LDO
SOYBN\|EnsemblGenome=GLYMA_02G072700\|UniProtKB=I1JD60	Glycine max	LDO
MEDTR\|EnsemblGenome=MTR_6g029230\|UniProtKB=G7KPL2	Medicago truncatula	LDO
JUGRE\|Gene=LOC108990544\|UniProtKB=A0A2I4EL09	Juglans regia	LDO
PRUPE\|EnsemblGenome=PRUPE_7G005900\|UniProtKB=M5WA91	Prunus persica	LDO
SELML\|EnsemblGenome=SELMODRAFT_419389\|UniProtKB=D8S8S9	Selaginella moellendorffii	LDO
SELML\|EnsemblGenome=SELMODRAFT_446282\|UniProtKB=D8SQ33	Selaginella moellendorffii	LDO
PHYPA\|EnsemblGenome=Pp3c4_24310\|UniProtKB=A0A2K1KPS1	Physcomitrella patens	O
PHYPA\|EnsemblGenome=Pp3c26_10900\|UniProtKB=A9RFE7	Physcomitrella patens	LDO
MARPO\|EnsemblGenome=MARPO_0034s0012\|UniProtKB=A0A2R6X5M2	Marchantia polymorpha	LDO
KLENI\|Gene_ORFName=KFL_001440220\|UniProtKB=A0A1Y1HXD9	Klebsormidium nitens	LDO