PANTHER Gene Information

Gene Symbol(s):

vav-1

Organism:

Caenorhabditis elegans

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Gene Name:

Protein vav-1

Gene ID:

WBGene00006887

Protein ID:

Q45FX5

Persistent Id:

PTN000518585

Alternate Ids:

181153(GeneID)	BX284606(EMBL)
CE38040(WormBase_PRO)	WBGene00006887(WormBase)
vav-1{ECO:0000312\|WormBase:C35B8.2a}(Symbol)	C35B8.2b(WormBase_TRS)
AAZ66767(EMBL-CDS)	VAV(Synonym)
115305910(GI)	WBGene00006887(Ensembl)
Q18479(AltAccession)	NM_001047758(refSeq)
VAV_CAEEL(UniProtKB-ID)
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PANTHER Classification

PANTHER Family:	PROTEIN VAV (PTHR45818)
PANTHER Subfamily:	PROTEIN VAV (PTHR45818:SF3)
PANTHER GO-slim Molecular Function:	guanyl-nucleotide exchange factor activity
PANTHER GO-slim Biological Process:	regulation of GTPase activity
PANTHER GO-slim Cellular Component:	cytoplasm
PANTHER protein class:

Pathway Categories:

PDGF signaling pathway

Guanine nucleotide exchange factor VAV

GENE ONTOLOGY DATABASE ANNOTATIONS

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GO MF Complete:	metal ion binding, guanyl-nucleotide exchange factor activity
GO BP Complete:	regulation of response to stimulus, small GTPase-mediated signal transduction, positive regulation of nematode male tail tip morphogenesis, negative regulation of Notch signaling pathway, cell migration, positive regulation of locomotion, regulation of vulval development
GO CC Complete:	cytoplasm

REACTOME DATABASE ANNOTATIONS Click to Expand...

Reactome Pathways:

p75 NTR receptor-mediated signalling, NRAGE signals death through JNK, Signal Transduction, Signaling by Rho GTPases, Signaling by VEGF, Nervous system development, RHOB GTPase cycle, Developmental Biology, RAC3 GTPase cycle, CDC42 GTPase cycle, RAC1 GTPase cycle, G alpha (12/13) signalling events, EPH-ephrin mediated repulsion of cells, Interleukin-3, Interleukin-5 and GM-CSF signaling, VEGFR2 mediated vascular permeability, RHOA GTPase cycle, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, Axon guidance, GPCR downstream signalling, Signaling by Receptor Tyrosine Kinases, Immune System, L1CAM interactions, Platelet activation, signaling and aggregation, Hemostasis, Drug ADME, Signaling by GPCR, Signaling by SCF-KIT, Azathioprine ADME, Cell death signalling via NRAGE, NRIF and NADE, VEGFA-VEGFR2 Pathway, EPH-Ephrin signaling, RHOG GTPase cycle, Signal transduction by L1, Cytokine Signaling in Immune system, Signaling by Interleukins, RAC2 GTPase cycle, RHO GTPase cycle, Death Receptor Signaling, GPVI-mediated activation cascade, Regulation of signaling by CBL

Orthologs

ID	Organism	Type
HUMAN\|HGNC=12657\|UniProtKB=P15498	Homo sapiens	LDO
PANTR\|Ensembl=ENSPTRG00000010378.4\|UniProtKB=H2QF58	Pan troglodytes	LDO
GORGO\|Ensembl=ENSGGOG00000012257.3\|UniProtKB=G3R994	Gorilla gorilla gorilla	LDO
MACMU\|Ensembl=ENSMMUG00000019314.4\|UniProtKB=A0A1D5RF06	Macaca mulatta	LDO
MOUSE\|MGI=MGI=98923\|UniProtKB=P27870	Mus musculus	LDO
RAT\|RGD=3951\|UniProtKB=P54100	Rattus norvegicus	LDO
BOVIN\|Ensembl=ENSBTAG00000039160\|UniProtKB=Q08DN7	Bos taurus	LDO
PIG\|Ensembl=ENSSSCG00000013553.4\|UniProtKB=A0A286ZQX2	Sus scrofa	LDO
HORSE\|Ensembl=ENSECAG00000014896.3\|UniProtKB=F6VK33	Equus caballus	LDO
FELCA\|Ensembl=ENSFCAG00000005052.6\|UniProtKB=M3W3D5	Felis catus	LDO
CANLF\|Ensembl=ENSCAFG00845008896.1\|UniProtKB=A0A8I3NA65	Canis lupus familiaris	LDO
MONDO\|Ensembl=ENSMODG00000002314.5\|UniProtKB=F7A3L2	Monodelphis domestica	LDO
ORNAN\|Ensembl=ENSOANG00000014870.3\|UniProtKB=F6XXJ5	Ornithorhynchus anatinus	LDO
CHICK\|Ensembl=ENSGALG00010003064.1\|UniProtKB=A0A8V0XJF3	Gallus gallus	LDO
XENLA\|Gene=LOC108705008\|UniProtKB=A0A8J1ME72	Xenopus laevis	O
XENLA\|Gene=vav1.L\|UniProtKB=Q6DCX0	Xenopus laevis	LDO
XENTR\|Xenbase=XB-GENE-6074281\|UniProtKB=A0A6I8SUJ4	Xenopus tropicalis	LDO
ORYLA\|Ensembl=ENSORLG00000009385.2\|UniProtKB=A0A3B3HII6	Oryzias latipes	LDO
LEPOC\|Ensembl=ENSLOCG00000007259.1\|UniProtKB=W5MK78	lepisosteus oculatus	LDO
HUMAN\|HGNC=12659\|UniProtKB=Q9UKW4	Homo sapiens	O
PANTR\|Ensembl=ENSPTRG00000001024.7\|UniProtKB=H2PZI8	Pan troglodytes	O
GORGO\|Ensembl=ENSGGOG00000001895.3\|UniProtKB=G3RM52	Gorilla gorilla gorilla	O
MACMU\|Ensembl=ENSMMUG00000019714.4\|UniProtKB=A0A5F8A629	Macaca mulatta	O
MOUSE\|MGI=MGI=1888518\|UniProtKB=Q9R0C8	Mus musculus	O
RAT\|RGD=1565941\|UniProtKB=A0A8I5ZPB5	Rattus norvegicus	O
BOVIN\|Ensembl=ENSBTAG00000031575.4\|UniProtKB=E1BBD2	Bos taurus	O
HORSE\|Ensembl=ENSECAG00000011099.4\|UniProtKB=A0A3Q2I4K3	Equus caballus	O
FELCA\|Ensembl=ENSFCAG00000001191.6\|UniProtKB=M3VW63	Felis catus	O
CANLF\|Ensembl=ENSCAFG00845009278.1\|UniProtKB=A0A8I3NC73	Canis lupus familiaris	O
MONDO\|Ensembl=ENSMODG00000002796.4\|UniProtKB=F7EJL2	Monodelphis domestica	O
ORNAN\|Ensembl=ENSOANG00000048060.1\|UniProtKB=A0A6I8NA57	Ornithorhynchus anatinus	O
CHICK\|Ensembl=ENSGALG00010011932.1\|UniProtKB=A0A8V0Y6W5	Gallus gallus	O
ANOCA\|Ensembl=ENSACAG00000000782.4\|UniProtKB=A0A803SKV0	Anolis carolinensis	O
XENLA\|Gene=vav3.L\|UniProtKB=A0A8J1MZ10	Xenopus laevis	O
XENLA\|Gene=vav3.S\|UniProtKB=A0A8J1KJL0	Xenopus laevis	O
XENTR\|Xenbase=XB-GENE-6075609\|UniProtKB=F6USI5	Xenopus tropicalis	O
ORYLA\|Ensembl=ENSORLG00000023424.1\|UniProtKB=A0A3B3IIY9	Oryzias latipes	O
DANRE\|Gene=vav3b\|UniProtKB=A0A8M2BAQ7	Danio rerio	O
ORYLA\|Ensembl=ENSORLG00000005788.2\|UniProtKB=A0A3B3I2I2	Oryzias latipes	O
DANRE\|Gene=vav3\|UniProtKB=A0A8M9PGG6	Danio rerio	O
LEPOC\|Ensembl=ENSLOCG00000007934.1\|UniProtKB=W5MMP0	lepisosteus oculatus	O
HUMAN\|HGNC=12658\|UniProtKB=P52735	Homo sapiens	O
PANTR\|Ensembl=ENSPTRG00000021525.7\|UniProtKB=A0A2I3TV44	Pan troglodytes	O
GORGO\|Ensembl=ENSGGOG00000007911.3\|UniProtKB=G3S5N5	Gorilla gorilla gorilla	O
MACMU\|Ensembl=ENSMMUG00000017214.4\|UniProtKB=I2CU78	Macaca mulatta	O
MOUSE\|MGI=MGI=102718\|UniProtKB=Q60992	Mus musculus	O
RAT\|RGD=1306285\|UniProtKB=D3ZYG0	Rattus norvegicus	O
BOVIN\|Ensembl=ENSBTAG00000004511.6\|UniProtKB=A0A3Q1MQP9	Bos taurus	O
PIG\|Ensembl=ENSSSCG00000005743.5\|UniProtKB=A0A287B8N4	Sus scrofa	O
HORSE\|Ensembl=ENSECAG00000015126.4\|UniProtKB=A0A5F5Q0A3	Equus caballus	O
FELCA\|Ensembl=ENSFCAG00000011529.6\|UniProtKB=M3WF96	Felis catus	O
CANLF\|Ensembl=ENSCAFG00845011337.1\|UniProtKB=A0A8I3NEZ8	Canis lupus familiaris	O
MONDO\|Ensembl=ENSMODG00000001674.3\|UniProtKB=F6SQP5	Monodelphis domestica	O
MONDO\|Ensembl=ENSMODG00000013038.4\|UniProtKB=A0A5F8GRN7	Monodelphis domestica	O
ORNAN\|Ensembl=ENSOANG00000002845.4\|UniProtKB=F6U979	Ornithorhynchus anatinus	O
CHICK\|Ensembl=ENSGALG00010028884.1\|UniProtKB=A0A8V1AAH7	Gallus gallus	O
ANOCA\|Ensembl=ENSACAG00000014720.4\|UniProtKB=H9GLK6	Anolis carolinensis	O
XENLA\|Gene=vav2.L\|UniProtKB=A0A8J1LHZ8	Xenopus laevis	O
XENLA\|Gene=vav2.S\|UniProtKB=A0A8J1LL69	Xenopus laevis	O
XENTR\|Gene=vav2\|UniProtKB=A0A8J1IPD9	Xenopus tropicalis	O
ORYLA\|Ensembl=ENSORLG00000012202.2\|UniProtKB=A0A3B3HN02	Oryzias latipes	O
DANRE\|Gene=vav2\|UniProtKB=A0A8M9PUI9	Danio rerio	O
LEPOC\|Ensembl=ENSLOCG00000004506.1\|UniProtKB=W5MAI5	lepisosteus oculatus	O
CIOIN\|Ensembl=ENSCING00000008711.3\|UniProtKB=F6WCA3	Ciona intestinalis	LDO
BRAFL\|Gene=LOC118422080\|UniProtKB=A0A9J7LM76	Branchiostoma floridae	LDO
STRPU\|EnsemblGenome=LOC582602\|UniProtKB=A0A7M7NQJ6	Strongylocentrotus purpuratus	O
STRPU\|EnsemblGenome=LOC582411\|UniProtKB=A0A7M7PMI4	Strongylocentrotus purpuratus	LDO
CAEBR\|Gene_ORFName=CBG16186\|UniProtKB=A8XNX6	Caenorhabditis briggsae	LDO
PRIPA\|EnsemblGenome=WBGene00090011\|UniProtKB=A0A2A6BGJ4	Pristionchus pacificus	LDO
DROME\|FlyBase=FBgn0040068\|UniProtKB=Q9NHV9	Drosophila melanogaster	LDO
ANOGA\|EnsemblGenome=AGAP010292\|UniProtKB=A0A1S4H3M1	Anopheles gambiae	LDO
TRICA\|EnsemblGenome=TC004356\|UniProtKB=A0A139WAM6	Tribolium castaneum	LDO
DAPPU\|EnsemblGenome=DAPPUDRAFT_221220\|UniProtKB=E9FX29	Daphnia pulex	O
DAPPU\|EnsemblGenome=DAPPUDRAFT_323685\|UniProtKB=E9GZG4	Daphnia pulex	LDO
IXOSC\|EnsemblGenome=ISCW014238\|UniProtKB=B7QJT0	Ixodes scapularis	LDO
HELRO\|EnsemblGenome=HelroG193493\|UniProtKB=T1FV18	helobdella robusta	O
HELRO\|EnsemblGenome=HelroG168451\|UniProtKB=T1F0L8	helobdella robusta	O
HELRO\|EnsemblGenome=HelroG163684\|UniProtKB=T1EUC8	helobdella robusta	O
HELRO\|EnsemblGenome=HelroG183126\|UniProtKB=T1FJ61	helobdella robusta	LDO
HELRO\|EnsemblGenome=HelroG181812\|UniProtKB=T1FHD1	helobdella robusta	O
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g248472\|UniProtKB=A7T185	Nematostella vectensis	LDO
TRIAD\|EnsemblGenome=TriadG53249\|UniProtKB=B3RNQ4	Trichoplax adhaerens	LDO
MONBE\|EnsemblGenome=MONBRDRAFT_22586\|UniProtKB=A9UR12	Monosiga brevicollis	O
MONBE\|EnsemblGenome=MONBRDRAFT_31066\|UniProtKB=A9UNJ0	Monosiga brevicollis	O
MONBE\|EnsemblGenome=MONBRDRAFT_33960\|UniProtKB=A9V8S2	Monosiga brevicollis	O
MONBE\|EnsemblGenome=MONBRDRAFT_31054\|UniProtKB=A9UR08	Monosiga brevicollis	LDO
PHANO\|EnsemblGenome=SNOG_14232\|UniProtKB=Q0U265	Phaeosphaeria nodorum	LDO
CRYNJ\|EnsemblGenome=CNA05310\|UniProtKB=Q5KNU3	Cryptococcus neoformans	LDO