PANTHER Gene Information   
Gene Symbol(s): Fgfr4
Organism: Rattus norvegicus
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Gene Name: Fibroblast growth factor receptor 4
Gene ID: 2612
Protein ID: Q498D6
Persistent Id: PTN000699338
Alternate Ids:
Fgfr4(Symbol) FGFR4(Synonym)
BC100260(EMBL) FGFR4_RAT(UniProtKB-ID)
71679849(GI) 25114(GeneID)
AAI00261(EMBL-CDS) 2612(RGD)
NM_001109904(refSeq) 2.7.10.1(EC)
CHEMBL4802008(ChEMBL)
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PANTHER Classification
PANTHER Family: TYROSINE-PROTEIN KINASE RECEPTOR (PTHR24416)
PANTHER Subfamily: FIBROBLAST GROWTH FACTOR RECEPTOR 4 (PTHR24416:SF343)  
PANTHER GO-slim Molecular Function: fibroblast growth factor binding
transmembrane receptor protein tyrosine kinase activity
PANTHER GO-slim Biological Process: positive regulation of kinase activity
transmembrane receptor protein tyrosine kinase signaling pathway
multicellular organism development
regulation of cellular biosynthetic process
positive regulation of ERK1 and ERK2 cascade
regulation of lipid biosynthetic process
PANTHER GO-slim Cellular Component: plasma membrane
receptor complex
PANTHER protein class: transmembrane signal receptor
Pathway Categories: FGF signaling pathway
   FGFR1-4
GENE ONTOLOGY DATABASE ANNOTATIONS      Click to Expand...
GO MF Complete: fibroblast growth factor receptor activity, ATP binding, heparin binding, fibroblast growth factor binding
GO BP Complete: multicellular organism development, positive regulation of cell population proliferation, fibroblast growth factor receptor signaling pathway, negative regulation of fibroblast growth factor production, positive regulation of proteolysis, cholesterol homeostasis, vitamin D3 metabolic process, regulation of extracellular matrix disassembly, positive regulation of parathyroid hormone secretion, positive regulation of kinase activity, cell migration, positive regulation of DNA biosynthetic process, lung development, alveolar secondary septum development, phosphate ion homeostasis, cell surface receptor protein tyrosine kinase signaling pathway, negative regulation of gene expression, regulation of phosphate transport, positive regulation of gene expression, regulation of phosphorus metabolic process, glucose homeostasis, positive regulation of ERK1 and ERK2 cascade, organ induction, regulation of lipid metabolic process, regulation of bile acid biosynthetic process
GO CC Complete: endosome, cell-cell junction, endoplasmic reticulum, Golgi apparatus, receptor complex, transport vesicle, plasma membrane
REACTOME DATABASE ANNOTATIONS   Click to Expand...
Reactome Pathways: IRS-mediated signalling, MAPK family signaling cascades, Signaling by Insulin receptor, Insulin receptor signalling cascade, FGFR4 ligand binding and activation, PIP3 activates AKT signaling, IRS-related events triggered by IGF1R, Signaling by Receptor Tyrosine Kinases, Phospholipase C-mediated cascade; FGFR4, PI-3K cascade:FGFR4, PI3K Cascade, Signaling by FGFR4, MAPK1/MAPK3 signaling, Signaling by FGFR, betaKlotho-mediated ligand binding, Signal Transduction, RAF/MAP kinase cascade, IGF1R signaling cascade, SHC-mediated cascade:FGFR4, PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling, Negative regulation of the PI3K/AKT network, Negative regulation of FGFR4 signaling, Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R), FRS-mediated FGFR4 signaling, Intracellular signaling by second messengers, Downstream signaling of activated FGFR4

Orthologs