PANTHER Gene Information

Gene Symbol(s):

sprA

Organism:

Dictyostelium discoideum

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Gene Name:

Sepiapterin reductase

Gene ID:

DDB_G0290009

Protein ID:

Q54GP3

Persistent Id:

PTN002387940

Alternate Ids:

EAL62410(EMBL-CDS)	SR {ECO:0000303\|PubMed:10987137, ECO:0000303\|PubMed:15896778}(Synonym)
AF253975(EMBL)	sprA(Symbol)
SPRE_DICDI(UniProtKB-ID)	74851993(GI)
EAL62410(Ensembl_TRS)	1.1.1.153 {ECO:0000269\|PubMed:10987137, ECO:0000269\|PubMed:15896778, ECO:0000269\|PubMed:16527408}(EC)
EAL62410(Ensembl_PRO)	Q9NGC5(AltAccession)
DDB_G0290009(dictyBase)	DDB_G0290009(Ensembl)
8627440(GeneID)	XM_630827(refSeq)
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PANTHER Classification

PANTHER Family:	SEPIAPTERIN REDUCTASE (PTHR44085)
PANTHER Subfamily:	SEPIAPTERIN REDUCTASE (PTHR44085:SF2)
PANTHER GO-slim Molecular Function:	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
PANTHER GO-slim Biological Process:	organonitrogen compound biosynthetic process heterocycle biosynthetic process cellular nitrogen compound biosynthetic process aromatic compound biosynthetic process organic cyclic compound biosynthetic process alcohol biosynthetic process
PANTHER GO-slim Cellular Component:
PANTHER protein class:	reductase

Pathway Categories:

No pathway information available

GENE ONTOLOGY DATABASE ANNOTATIONS

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GO MF Complete:	sepiapterin reductase (NADP+) activity, oxidoreductase activity
GO BP Complete:	response to oxidative stress, pteridine-containing compound biosynthetic process, response to Gram-negative bacterium, tetrahydrobiopterin biosynthetic process
GO CC Complete:	cytoplasm

REACTOME DATABASE ANNOTATIONS Click to Expand...

Reactome Pathways:

Metabolism, eNOS activation, Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation, Metabolism of cofactors, Metabolism of vitamins and cofactors, Metabolism of nitric oxide: NOS3 activation and regulation

Orthologs

ID	Organism	Type
HUMAN\|HGNC=11257\|UniProtKB=P35270	Homo sapiens	LDO
PANTR\|Ensembl=ENSPTRG00000050402.1\|UniProtKB=K7B3E1	Pan troglodytes	LDO
GORGO\|Ensembl=ENSGGOG00000005682.3\|UniProtKB=G3QSC9	Gorilla gorilla gorilla	LDO
MACMU\|Ensembl=ENSMMUG00000009485.4\|UniProtKB=F6YUE9	Macaca mulatta	LDO
MOUSE\|MGI=MGI=103078\|UniProtKB=Q64105	Mus musculus	LDO
RAT\|RGD=1560795\|UniProtKB=D3ZT59	Rattus norvegicus	O
RAT\|RGD=3753\|UniProtKB=P18297	Rattus norvegicus	LDO
BOVIN\|Ensembl=ENSBTAG00000021961.6\|UniProtKB=A0A3Q1N453	Bos taurus	O
BOVIN\|Gene=SPR\|UniProtKB=Q17QK8	Bos taurus	LDO
PIG\|Ensembl=ENSSSCG00000008309.5\|UniProtKB=A0A480ZCU6	Sus scrofa	LDO
HORSE\|Ensembl=ENSECAG00000018793.3\|UniProtKB=F7BPB8	Equus caballus	LDO
FELCA\|Ensembl=ENSFCAG00000037792.3\|UniProtKB=A0A2I2UR05	Felis catus	LDO
CANLF\|Ensembl=ENSCAFG00845018873.1\|UniProtKB=A0A8I3S3P1	Canis lupus familiaris	LDO
MONDO\|Ensembl=ENSMODG00000025779.2\|UniProtKB=F7FSW2	Monodelphis domestica	O
MONDO\|Ensembl=ENSMODG00000044059.1\|UniProtKB=A0A5F8GMM8	Monodelphis domestica	LDO
ORNAN\|Ensembl=ENSOANG00000038096.1\|UniProtKB=A0A6I8NTR7	Ornithorhynchus anatinus	LDO
CHICK\|Ensembl=ENSGALG00010018385.1\|UniProtKB=A0A8V0ZD26	Gallus gallus	LDO
XENLA\|Gene=spr.L\|UniProtKB=A0A1L8HSS2	Xenopus laevis	O
XENLA\|Gene=spr\|UniProtKB=Q7ZY31	Xenopus laevis	LDO
XENTR\|Ensembl=ENSXETG00000044997\|UniProtKB=A0A803K5T0	Xenopus tropicalis	O
XENTR\|Gene=spr\|UniProtKB=B0BML7	Xenopus tropicalis	LDO
ORYLA\|Ensembl=ENSORLG00000022199.1\|UniProtKB=A0A3B3IAZ2	Oryzias latipes	LDO
DANRE\|ZFIN=ZDB-GENE-050522-412\|UniProtKB=F1QWX4	Danio rerio	LDO
DANRE\|ZFIN=ZDB-GENE-070719-1\|UniProtKB=B3DJY2	Danio rerio	O
LEPOC\|Ensembl=ENSLOCG00000001239.1\|UniProtKB=W5LZ44	lepisosteus oculatus	LDO
CIOIN\|Ensembl=ENSCING00000011514.2\|UniProtKB=F6WU12	Ciona intestinalis	O
CIOIN\|Ensembl=ENSCING00000013810.2\|UniProtKB=F6QRU4	Ciona intestinalis	LDO
BRAFL\|Gene_ORFName=BRAFLDRAFT_77545\|UniProtKB=C3Z9Z6	Branchiostoma floridae	O
BRAFL\|Gene_ORFName=BRAFLDRAFT_208259\|UniProtKB=C3XQX1	Branchiostoma floridae	O
BRAFL\|Gene=LOC118414398\|UniProtKB=A0A9J7L2T4	Branchiostoma floridae	O
BRAFL\|Gene=LOC118427753\|UniProtKB=A0A9J7N6X0	Branchiostoma floridae	O
BRAFL\|Gene=LOC118412662\|UniProtKB=A0A9J7MLL4	Branchiostoma floridae	O
BRAFL\|Gene_ORFName=BRAFLDRAFT_85347\|UniProtKB=C3XPE4	Branchiostoma floridae	LDO
STRPU\|EnsemblGenome=LOC584912\|UniProtKB=A0A7M7RHJ4	Strongylocentrotus purpuratus	O
STRPU\|EnsemblGenome=LOC578162\|UniProtKB=A0A7M7RDY8	Strongylocentrotus purpuratus	O
STRPU\|EnsemblGenome=LOC577750\|UniProtKB=A0A7M7RA92	Strongylocentrotus purpuratus	LDO
DROME\|FlyBase=FBgn0030041\|UniProtKB=Q9W3F1	Drosophila melanogaster	O
DROME\|FlyBase=FBgn0014032\|UniProtKB=O76752	Drosophila melanogaster	LDO
ANOGA\|EnsemblGenome=AGAP008000\|UniProtKB=Q7PJ32	Anopheles gambiae	LDO
TRICA\|EnsemblGenome=TC006384\|UniProtKB=D6WWG1	Tribolium castaneum	LDO
DAPPU\|EnsemblGenome=DAPPUDRAFT_309138\|UniProtKB=E9HAJ7	Daphnia pulex	LDO
IXOSC\|EnsemblGenome=ISCW012651\|UniProtKB=B7QGH5	Ixodes scapularis	O
IXOSC\|EnsemblGenome=ISCW002953\|UniProtKB=B7PCL0	Ixodes scapularis	LDO
HELRO\|EnsemblGenome=HelroG90077\|UniProtKB=T1G7K9	helobdella robusta	LDO
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g161481\|UniProtKB=A7RQ68	Nematostella vectensis	LDO
TRIAD\|EnsemblGenome=TriadG58441\|UniProtKB=B3S2B2	Trichoplax adhaerens	LDO
PHANO\|EnsemblGenome=SNOG_08504\|UniProtKB=Q0UIB0	Phaeosphaeria nodorum	LDO
BATDJ\|Gene_ORFName=BATDEDRAFT_84986\|UniProtKB=F4NSN2	Batrachochytrium dendrobatidis	LDO
DICPU\|EnsemblGenome=DICPUDRAFT_157402\|UniProtKB=F0ZZ19	Dictyostelium purpureum	LDO
THAPS\|EnsemblGenome=THAPSDRAFT_40218\|UniProtKB=B8C1A6	Thalassiosira pseudonana	LDO
PHYRM\|Gene=H3H918_PHYRM\|UniProtKB=H3H918	Phytophthora ramorum	LDO
CHLRE\|EnsemblGenome=CHLRE_10g449600v5\|UniProtKB=A0A2K3DB28	Chlamydomonas reinhardtii	LDO