PANTHER Gene Information

Gene Symbol(s):

Lars1

Organism:

Rattus norvegicus

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Gene Name:

leucine--tRNA ligase

Gene ID:

1304962

Protein ID:

Q5PPJ6

Persistent Id:

PTN000236243

Alternate Ids:

ENSRNOG00000018304(Ensembl)	ENSRNOP00000025284(Ensembl_PRO)
BC087655(EMBL)	AAH87655(EMBL-CDS)
ENSRNOT00000025284(Ensembl_TRS)	Q5PPJ6(Synonym)
56388592(GI)	1304962(RGD)
Q5PPJ6_RAT(UniProtKB-ID)	291624(GeneID)
NM_001009637(refSeq)
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PANTHER Classification

PANTHER Family:	LEUCYL-TRNA SYNTHETASE (PTHR45794)
PANTHER Subfamily:	LEUCINE--TRNA LIGASE, CYTOPLASMIC (PTHR45794:SF1)
PANTHER GO-slim Molecular Function:	catalytic activity, acting on RNA ligase activity
PANTHER GO-slim Biological Process:	tRNA metabolic process amino acid metabolic process translation
PANTHER GO-slim Cellular Component:
PANTHER protein class:	aminoacyl-tRNA synthetase

Pathway Categories:

No pathway information available

GENE ONTOLOGY DATABASE ANNOTATIONS

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GO MF Complete:	ATP binding, leucine-tRNA ligase activity, protein binding, GTPase activator activity, aminoacyl-tRNA editing activity, glutamine-tRNA ligase activity
GO BP Complete:	leucyl-tRNA aminoacylation, cellular response to amino acid stimulus, positive regulation of TORC1 signaling, aminoacyl-tRNA metabolism involved in translational fidelity, cellular response to L-leucine, cellular response to amino acid starvation, regulation of cell size, glutaminyl-tRNA aminoacylation, positive regulation of TOR signaling, cellular response to leucine starvation
GO CC Complete:	nuclear body, cytoplasm, cytosol, endomembrane system, endoplasmic reticulum, aminoacyl-tRNA synthetase multienzyme complex, lysosome

REACTOME DATABASE ANNOTATIONS Click to Expand...

Reactome Pathways:

Orthologs

ID	Organism	Type
HUMAN\|HGNC=6512\|UniProtKB=Q9P2J5	Homo sapiens	LDO
PANTR\|Ensembl=ENSPTRG00000017372.6\|UniProtKB=A0A2I3SYT4	Pan troglodytes	LDO
GORGO\|Ensembl=ENSGGOG00000004103.3\|UniProtKB=G3QNC6	Gorilla gorilla gorilla	LDO
MACMU\|Ensembl=ENSMMUG00000029787.3\|UniProtKB=F6VKE8	Macaca mulatta	LDO
MOUSE\|MGI=MGI=1913808\|UniProtKB=Q8BMJ2	Mus musculus	LDO
BOVIN\|Ensembl=ENSBTAG00000006765.6\|UniProtKB=A0A3S5ZPT9	Bos taurus	LDO
PIG\|Ensembl=ENSSSCG00000014411.5\|UniProtKB=A0A5G2R6F2	Sus scrofa	LDO
HORSE\|Ensembl=ENSECAG00000008963.4\|UniProtKB=F6YTK4	Equus caballus	LDO
FELCA\|Ensembl=ENSFCAG00000008715.6\|UniProtKB=M3WA40	Felis catus	LDO
CANLF\|Ensembl=ENSCAFG00845020164.1\|UniProtKB=A0A8I3PH02	Canis lupus familiaris	LDO
MONDO\|Ensembl=ENSMODG00000010231.4\|UniProtKB=F6WRZ1	Monodelphis domestica	LDO
ORNAN\|Ensembl=ENSOANG00000005755.4\|UniProtKB=F6VA17	Ornithorhynchus anatinus	LDO
CHICK\|Ensembl=ENSGALG00010016629.1\|UniProtKB=A0A8V0Z3U7	Gallus gallus	LDO
ANOCA\|Ensembl=ENSACAG00000013916.4\|UniProtKB=A0A803U0A8	Anolis carolinensis	LDO
XENLA\|Gene=lars1.L\|UniProtKB=Q6AX83	Xenopus laevis	LDO
XENTR\|Xenbase=XB-GENE-972511\|UniProtKB=Q5EB29	Xenopus tropicalis	LDO
ORYLA\|Ensembl=ENSORLG00000001622.2\|UniProtKB=A0A3B3HJH0	Oryzias latipes	LDO
DANRE\|Gene=larsb\|UniProtKB=A0A8N7T837	Danio rerio	LDO
LEPOC\|Ensembl=ENSLOCG00000010442.1\|UniProtKB=W5MWP8	lepisosteus oculatus	LDO
CIOIN\|Ensembl=ENSCING00000008535.3\|UniProtKB=A0A1W3JM58	Ciona intestinalis	LDO
BRAFL\|Gene=LOC118419192\|UniProtKB=A0A9J7MWH3	Branchiostoma floridae	LDO
STRPU\|EnsemblGenome=LOC100890123\|UniProtKB=A0A7M7NIF0	Strongylocentrotus purpuratus	LDO
CAEEL\|WormBase=WBGene00003073\|UniProtKB=Q09996	Caenorhabditis elegans	LDO
CAEBR\|WormBase=WBGene00039214\|UniProtKB=A8XXA4	Caenorhabditis briggsae	LDO
PRIPA\|EnsemblGenome=WBGene00272260\|UniProtKB=A0A2A6CIL5	Pristionchus pacificus	LDO
DROME\|FlyBase=FBgn0284253\|UniProtKB=Q9VQR8	Drosophila melanogaster	LDO
ANOGA\|EnsemblGenome=AGAP008297\|UniProtKB=A0A1S4GYI9	Anopheles gambiae	LDO
TRICA\|EnsemblGenome=TC008372\|UniProtKB=D2A1C9	Tribolium castaneum	LDO
DAPPU\|EnsemblGenome=DAPPUDRAFT_300874\|UniProtKB=E9HF12	Daphnia pulex	LDO
IXOSC\|EnsemblGenome=ISCW017581\|UniProtKB=B7PFM8	Ixodes scapularis	LDO
HELRO\|EnsemblGenome=HelroG157396\|UniProtKB=T1EMA9	helobdella robusta	LDO
TRIAD\|EnsemblGenome=TriadG61696\|UniProtKB=B3SBQ2	Trichoplax adhaerens	LDO
MONBE\|EnsemblGenome=MONBRDRAFT_20503\|UniProtKB=A9UW56	Monosiga brevicollis	LDO
YEAST\|SGD=S000006081\|UniProtKB=P26637	Saccharomyces cerevisiae	LDO
EREGS\|EnsemblGenome=AGOS_AAL088W\|UniProtKB=Q75F16	Eremothecium gossypii	LDO
CANAL\|CGD=CAL0000201312\|UniProtKB=A0A1D8PS12	Candida albicans	LDO
YARLI\|EnsemblGenome=YALI0_E24607g\|UniProtKB=Q6C4Q2	Yarrowia lipolytica	LDO
EMENI\|EnsemblGenome=ANIA_03702\|UniProtKB=Q5B6X8	Emericella nidulans	LDO
ASPFU\|EnsemblGenome=AFUA_6G12630\|UniProtKB=Q4WLR1	Neosartorya fumigata	LDO
NEUCR\|EnsemblGenome=NCU09463\|UniProtKB=P10857	Neurospora crassa	LDO
SCLS1\|Gene_ORFName=SS1G_10729\|UniProtKB=A7EZG2	Sclerotinia sclerotiorum	LDO
PHANO\|EnsemblGenome=SNOG_07648\|UniProtKB=Q0UKR6	Phaeosphaeria nodorum	LDO
SCHPO\|PomBase=SPAC26F1.13c\|UniProtKB=Q10490	Schizosaccharomyces pombe	LDO
SCHJY\|EnsemblGenome=SJAG_02015\|UniProtKB=B6JZH5	Schizosaccharomyces japonicus	LDO
CRYNJ\|EnsemblGenome=CNM01290\|UniProtKB=Q5K7U0	Cryptococcus neoformans	LDO
USTMA\|EnsemblGenome=UMAG_05108\|UniProtKB=A0A0D1E1S2	Ustilago maydis	LDO
PUCGT\|EnsemblGenome=PGTG_05585\|UniProtKB=E3K4U9	Puccinia graminis	LDO
BATDJ\|Gene_ORFName=BATDEDRAFT_15609\|UniProtKB=F4NSP1	Batrachochytrium dendrobatidis	LDO
ENTH1\|EnsemblGenome=CL6EHI_161970\|UniProtKB=C4M6P0	Entamoeba histolytica	LDO
DICDI\|dictyBase=DDB_G0285451\|UniProtKB=Q54N83	Dictyostelium discoideum	LDO
DICPU\|EnsemblGenome=DICPUDRAFT_78187\|UniProtKB=F0ZIT8	Dictyostelium purpureum	O
DICPU\|EnsemblGenome=DICPUDRAFT_81646\|UniProtKB=F0ZU55	Dictyostelium purpureum	LDO
LEIMA\|EnsemblGenome=LMJF_13_1100\|UniProtKB=Q4QG44	Leishmania major	LDO
TRYB2\|Gene_ORFName=Tb11.02.1210\|UniProtKB=Q386D9	Trypanosoma brucei	LDO
GIAIC\|EnsemblGenome=GL50803_8621\|UniProtKB=A8BY54	Giardia intestinalis	LDO
TRIV3\|Gene_ORFName=TVAG_334040\|UniProtKB=A2EIB0	Trichomonas vaginalis	LDO
TRIV3\|Gene_ORFName=TVAG_217760\|UniProtKB=A2F0M3	Trichomonas vaginalis	O
PLAF7\|EnsemblGenome=PF3D7_0622800\|UniProtKB=C6KT64	Plasmodium falciparum	LDO
PARTE\|EnsemblGenome=GSPATT00004878001\|UniProtKB=A0BIY8	Paramecium tetraurelia	LDO
THAPS\|EnsemblGenome=THAPSDRAFT_39979\|UniProtKB=B8BYD7	Thalassiosira pseudonana	LDO
PHYRM\|Gene=H3G7T4_PHYRM\|UniProtKB=H3G7T4	Phytophthora ramorum	LDO
AMBTC\|EnsemblGenome=AMTR_s00078p00168060\|UniProtKB=W1P8E3	Amborella trichopoda	LDO
ZOSMR\|Gene_ORFName=ZOSMA_2G00660\|UniProtKB=A0A0K9PAQ9	Zostera marina	LDO
MUSAM\|EnsemblGenome=Ma07_g25030\|UniProtKB=A0A804JZK8	Musa acuminata subsp. malaccensis	LDO
SETIT\|EnsemblGenome=SETIT_024905mg\|UniProtKB=K3ZEB2	Setaria italica	O
SORBI\|EnsemblGenome=SORBI_3006G256300\|UniProtKB=C5Y9Z7	Sorghum bicolor	O
SORBI\|EnsemblGenome=SORBI_3001G407700\|UniProtKB=C5WNJ7	Sorghum bicolor	O
MAIZE\|EnsemblGenome=Zm00001eb067180\|UniProtKB=A0A804M8Q1	Zea mays	O
MAIZE\|EnsemblGenome=Zm00001eb097790\|UniProtKB=A0A1D6ENT5	Zea mays	O
SETIT\|EnsemblGenome=SETIT_021014mg\|UniProtKB=K3Z396	Setaria italica	LDO
ORYSJ\|EnsemblGenome=Os09g0378300\|UniProtKB=Q6H4P7	Oryza sativa	O
ORYSJ\|EnsemblGenome=Os09g0503400\|UniProtKB=Q0J0N6	Oryza sativa	LDO
BRADI\|EnsemblGenome=BRADI_3g33360v3\|UniProtKB=A0A0Q3FDV8	Brachypodium distachyon	O
BRADI\|EnsemblGenome=BRADI_2g08390v3\|UniProtKB=I1HDS0	Brachypodium distachyon	LDO
HORVV\|EnsemblGenome=HORVU.MOREX.r3.3HG0250640\|UniProtKB=A0A287KP21	Hordeum vulgare subsp. vulgare	LDO
WHEAT\|EnsemblGenome=TraesCS3B02G194400\|UniProtKB=A0A3B6FL03	Triticum aestivum	LDO
WHEAT\|EnsemblGenome=TraesCS3A02G163300\|UniProtKB=A0A3B6EDZ8	Triticum aestivum	O
WHEAT\|EnsemblGenome=TraesCS3D02G169600\|UniProtKB=A0A3B6GUF5	Triticum aestivum	LDO
HORVV\|EnsemblGenome=HORVU.MOREX.r3.2HG0120760\|UniProtKB=A0A8I6WY90	Hordeum vulgare subsp. vulgare	LDO
WHEAT\|EnsemblGenome=TraesCS1D02G221400\|UniProtKB=A0A3B5ZWC5	Triticum aestivum	O
WHEAT\|EnsemblGenome=TraesCS5D02G048600\|UniProtKB=A0A3B6MKI4	Triticum aestivum	O
WHEAT\|EnsemblGenome=TraesCS1A02G219900\|UniProtKB=A0A3B5Y0B1	Triticum aestivum	O
WHEAT\|EnsemblGenome=TraesCS2B02G174100\|UniProtKB=A0A3B6C250	Triticum aestivum	O
WHEAT\|EnsemblGenome=TraesCS1B02G233200\|UniProtKB=A0A3B5YXP2	Triticum aestivum	O
WHEAT\|EnsemblGenome=TraesCS5B02G042800\|UniProtKB=A0A3B6LG71	Triticum aestivum	O
WHEAT\|EnsemblGenome=TraesCS2A02G149200\|UniProtKB=A0A3B6AUM2	Triticum aestivum	O
WHEAT\|EnsemblGenome=TraesCS2D02G154000\|UniProtKB=A0A3B6D889	Triticum aestivum	LDO
NELNU\|Gene=LOC104593634\|UniProtKB=A0A1U7ZSR4	Nelumbo nucifera	O
NELNU\|Gene=LOC104602749\|UniProtKB=A0A1U8AD57	Nelumbo nucifera	LDO
SPIOL\|Gene=LOC110789865\|UniProtKB=A0A9R0JXK0	Spinacia oleracea	O
SPIOL\|Gene=LOC110787285\|UniProtKB=A0A9R0IE89	Spinacia oleracea	LDO
HELAN\|EnsemblGenome=HanXRQr2_Chr11g0493981\|UniProtKB=A0A251TAQ9	Helianthus annuus	O
HELAN\|EnsemblGenome=HanXRQr2_Chr12g0557421\|UniProtKB=A0A251T3Z0	Helianthus annuus	LDO
LACSA\|Gene_ORFName=LSAT_V11C500242320\|UniProtKB=A0A9R1X9S6	Lactuca sativa	LDO
ERYGU\|Gene_ORFName=MIMGU_mgv11b016468mg\|UniProtKB=A0A022RIR9	Erythranthe guttata	O
ERYGU\|Gene_ORFName=MIMGU_mgv1a000538mg\|UniProtKB=A0A022QUR3	Erythranthe guttata	LDO
CAPAN\|EnsemblGenome=T459_04622\|UniProtKB=A0A1U8FI50	Capsicum annuum	O
SOLTU\|EnsemblGenome=PGSC0003DMG400013102\|UniProtKB=M1B054	Solanum tuberosum	O
SOLLC\|EnsemblGenome=Solyc02g065300.1\|UniProtKB=A0A3Q7EZK3	Solanum lycopersicum	O
CAPAN\|EnsemblGenome=T459_33489\|UniProtKB=A0A2G2XZ91	Capsicum annuum	LDO
SOLTU\|EnsemblGenome=PGSC0003DMG400010338\|UniProtKB=M1ANP7	Solanum tuberosum	LDO
SOLLC\|EnsemblGenome=Solyc02g069140.2\|UniProtKB=A0A3Q7F179	Solanum lycopersicum	LDO
TOBAC\|Gene=LOC107805395\|UniProtKB=A0A1S4B7I8	Nicotiana tabacum	O
TOBAC\|Gene=LOC107788946\|UniProtKB=A0A1S3ZPJ9	Nicotiana tabacum	O
TOBAC\|Gene=LOC107794429\|UniProtKB=A0A1S4A755	Nicotiana tabacum	O
TOBAC\|Gene=LOC107802103\|UniProtKB=A0A1S4AWN0	Nicotiana tabacum	LDO
VITVI\|EnsemblGenome=Vitvi18g02185\|UniProtKB=F6HN51	Vitis vinifera	O
VITVI\|EnsemblGenome=Vitvi12g02058\|UniProtKB=F6HK37	Vitis vinifera	LDO
EUCGR\|EnsemblGenome=EUGRSUZ_H01506\|UniProtKB=A0A059AZM3	Eucalyptus grandis	LDO
BRANA\|Gene_ORFName=GSBRNA2T00019299001\|UniProtKB=A0A078G839	Brassica napus	O
BRACM\|EnsemblGenome=Bra031675\|UniProtKB=M4ES97	Brassica campestris	O
BRANA\|Gene_ORFName=GSBRNA2T00097723001\|UniProtKB=A0A078IIL3	Brassica napus	LDO
BRACM\|EnsemblGenome=Bra020007\|UniProtKB=M4DU14	Brassica campestris	LDO
ARATH\|TAIR=locus=2012240\|UniProtKB=F4I116	Arabidopsis thaliana	LDO
GOSHI\|Gene=LOC107941996\|UniProtKB=A0A1U8MZX1	Gossypium hirsutum	O
GOSHI\|Gene=LOC107961863\|UniProtKB=A0A1U8PTB1	Gossypium hirsutum	LDO
THECC\|EnsemblGenome=TCM_025952\|UniProtKB=A0A061F816	Theobroma cacao	LDO
CITSI\|Gene_ORFName=CISIN_1g039882mg\|UniProtKB=A0A067DHH7	Citrus sinensis	LDO
POPTR\|EnsemblGenome=POPTR_003G003900v3\|UniProtKB=A0A2K2AZI7	Populus trichocarpa	O
POPTR\|EnsemblGenome=POPTR_004G226700v3\|UniProtKB=A0A2K2AYS8	Populus trichocarpa	LDO
MANES\|EnsemblGenome=MANES_10G115700\|UniProtKB=A0A2C9V5D7	Manihot esculenta	O
MANES\|EnsemblGenome=MANES_07G026300\|UniProtKB=A0A2C9VHY7	Manihot esculenta	LDO
RICCO\|Gene_ORFName=RCOM_0757640\|UniProtKB=B9SKB0	Ricinus communis	O
RICCO\|Gene_ORFName=RCOM_0982370\|UniProtKB=B9SZE7	Ricinus communis	LDO
SOYBN\|EnsemblGenome=GLYMA_01G208100\|UniProtKB=I1J9U5	Glycine max	LDO
SOYBN\|EnsemblGenome=GLYMA_11G034100\|UniProtKB=I1LGR6	Glycine max	O
MEDTR\|EnsemblGenome=MTR_7g006450\|UniProtKB=A2Q4Y9	Medicago truncatula	LDO
JUGRE\|EnsemblGenome=Jr13_00320\|UniProtKB=A0A2I4EEI5	Juglans regia	LDO
CUCSA\|EnsemblGenome=Csa_1G084310\|UniProtKB=A0A0A0LV91	Cucumis sativus	LDO
PRUPE\|EnsemblGenome=PRUPE_2G015100\|UniProtKB=A0A251Q9B8	Prunus persica	O
PRUPE\|EnsemblGenome=PRUPE_1G582000\|UniProtKB=M5Y947	Prunus persica	LDO
SELML\|EnsemblGenome=SELMODRAFT_410808\|UniProtKB=D8RFX9	Selaginella moellendorffii	O
SELML\|EnsemblGenome=SELMODRAFT_131311\|UniProtKB=D8T3V3	Selaginella moellendorffii	O
SELML\|EnsemblGenome=SELMODRAFT_77212\|UniProtKB=D8QTN5	Selaginella moellendorffii	O
SELML\|EnsemblGenome=SELMODRAFT_157130\|UniProtKB=D8SPD3	Selaginella moellendorffii	LDO
PHYPA\|EnsemblGenome=Pp3c1_8463\|UniProtKB=A0A7I4BX43	Physcomitrella patens	LDO
MARPO\|EnsemblGenome=MARPO_0153s0002\|UniProtKB=A0A2R6W4N8	Marchantia polymorpha	LDO
KLENI\|Gene_ORFName=KFL_001870180\|UniProtKB=A0A1Y1I6P3	Klebsormidium nitens	LDO
NITMS\|EnsemblGenome=Nmar_0367\|UniProtKB=A9A564	Nitrosopumilus maritimus	LDO
KORCO\|EnsemblGenome=Kcr_0231\|UniProtKB=B1L3G2	Korarchaeum cryptofilum	LDO
SACS2\|EnsemblGenome=SSO0504\|UniProtKB=P58176	Sulfolobus solfataricus	O
SACS2\|EnsemblGenome=SSO0589\|UniProtKB=O33768	Sulfolobus solfataricus	LDO
PYRAE\|EnsemblGenome=PAE1107\|UniProtKB=Q8ZXT6	Pyrobaculum aerophilum	LDO
METAC\|EnsemblGenome=MA_1611\|UniProtKB=Q8TQD3	Methanosarcina acetivorans	LDO
METJA\|EnsemblGenome=MJ_0633\|UniProtKB=Q58050	Methanocaldococcus jannaschii	LDO
THEKO\|EnsemblGenome=TK1461\|UniProtKB=Q8NKR7	Thermococcus kodakaraensis	LDO