PANTHER Gene Information

Gene Symbol(s):

MMACHC

Organism:

Gallus gallus

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Gene Name:

Cyanocobalamin reductase _ alkylcobalamin dealkylase

Gene ID:

RCJMB04_8d5

Protein ID:

Q5ZL21

Persistent Id:

PTN000779094

Alternate Ids:

MMAC_CHICK(UniProtKB-ID)	1.16.1.6 {ECO:0000250\|UniProtKB:Q9Y4U1}(EC)
82082380(GI)	NM_001031281(refSeq)
AJ719913(EMBL)	CAG31572(EMBL-CDS)
Alkylcobalamin:glutathione S-alkyltransferase(Synonym)	MMACHC(Symbol)
424597(GeneID)
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PANTHER Classification

PANTHER Family:	METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE C PROTEIN (PTHR31457)
PANTHER Subfamily:	CYANOCOBALAMIN REDUCTASE _ ALKYLCOBALAMIN DEALKYLASE (PTHR31457:SF2)
PANTHER GO-slim Molecular Function:	demethylase activity flavin adenine dinucleotide binding oxidoreductase activity, acting on metal ions
PANTHER GO-slim Biological Process:	small molecule metabolic process tetrapyrrole metabolic process
PANTHER GO-slim Cellular Component:	cytoplasm
PANTHER protein class:

Pathway Categories:

No pathway information available

GENE ONTOLOGY DATABASE ANNOTATIONS

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GO MF Complete:	FAD binding, glutathione binding, oxidoreductase activity, demethylase activity, cobalamin binding, transferase activity, cyanocobalamin reductase (cyanide-eliminating) (NADP+) activity
GO BP Complete:	glutathione metabolic process, cobalamin metabolic process, demethylation
GO CC Complete:	cytoplasm, cytosol

REACTOME DATABASE ANNOTATIONS Click to Expand...

Reactome Pathways:

Orthologs

ID	Organism	Type
HUMAN\|HGNC=24525\|UniProtKB=Q9Y4U1	Homo sapiens	LDO
PANTR\|Ensembl=ENSPTRG00000052080.1\|UniProtKB=H2PYX3	Pan troglodytes	LDO
GORGO\|Ensembl=ENSGGOG00000005407.3\|UniProtKB=G3QRN2	Gorilla gorilla gorilla	LDO
MACMU\|Ensembl=ENSMMUG00000015950.4\|UniProtKB=H9EX34	Macaca mulatta	LDO
MOUSE\|MGI=MGI=1914346\|UniProtKB=Q9CZD0	Mus musculus	LDO
RAT\|RGD=1310806\|UniProtKB=D4A729	Rattus norvegicus	LDO
BOVIN\|Ensembl=ENSBTAG00000017027\|UniProtKB=Q5E9C8	Bos taurus	LDO
PIG\|Ensembl=ENSSSCG00000037354.3\|UniProtKB=A0A287A359	Sus scrofa	LDO
HORSE\|Ensembl=ENSECAG00000015728.4\|UniProtKB=F6U012	Equus caballus	LDO
FELCA\|Ensembl=ENSFCAG00000000204.6\|UniProtKB=M3VUA3	Felis catus	LDO
CANLF\|Ensembl=ENSCAFG00845022783.1\|UniProtKB=A0A8I3S3A9	Canis lupus familiaris	LDO
MONDO\|Ensembl=ENSMODG00000002391.3\|UniProtKB=A0A5F8GF05	Monodelphis domestica	LDO
ORNAN\|Ensembl=ENSOANG00000021591.3\|UniProtKB=F6Y8E9	Ornithorhynchus anatinus	LDO
ANOCA\|Ensembl=ENSACAG00000015193.4\|UniProtKB=G1KQS9	Anolis carolinensis	LDO
XENLA\|Gene=mmachc.L\|UniProtKB=A0A1L8GM62	Xenopus laevis	LDO
XENTR\|Xenbase=XB-GENE-963487\|UniProtKB=A0A6I8Q1G4	Xenopus tropicalis	LDO
ORYLA\|Ensembl=ENSORLG00000014689.2\|UniProtKB=H2MID2	Oryzias latipes	LDO
DANRE\|ZFIN=ZDB-GENE-030131-3167\|UniProtKB=Q5RFU5	Danio rerio	LDO
LEPOC\|Ensembl=ENSLOCG00000010596.1\|UniProtKB=W5MX68	lepisosteus oculatus	LDO
CIOIN\|Ensembl=ENSCING00000022447.1\|UniProtKB=H2XLX9	Ciona intestinalis	LDO
BRAFL\|Gene=LOC118431891\|UniProtKB=A0A9J7MDE2	Branchiostoma floridae	LDO
STRPU\|EnsemblGenome=LOC575015\|UniProtKB=A0A7M7RCN0	Strongylocentrotus purpuratus	LDO
CAEEL\|WormBase=WBGene00022766\|UniProtKB=Q7Z144	Caenorhabditis elegans	LDO
CAEBR\|WormBase=WBGene00194763\|UniProtKB=C9QPK7	Caenorhabditis briggsae	LDO
DAPPU\|EnsemblGenome=DAPPUDRAFT_309806\|UniProtKB=E9FQV4	Daphnia pulex	LDO
IXOSC\|EnsemblGenome=ISCW000540\|UniProtKB=B7P3Q7	Ixodes scapularis	LDO
HELRO\|EnsemblGenome=HelroG62766\|UniProtKB=T1FX49	helobdella robusta	LDO
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g110826\|UniProtKB=A7SAA7	Nematostella vectensis	LDO
TRIAD\|EnsemblGenome=TriadG29163\|UniProtKB=B3S4S5	Trichoplax adhaerens	LDO
DICDI\|dictyBase=DDB_G0274205\|UniProtKB=Q86KB5	Dictyostelium discoideum	LDO
DICPU\|EnsemblGenome=DICPUDRAFT_92412\|UniProtKB=F0ZRG5	Dictyostelium purpureum	LDO