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Gene Symbol(s):
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Shh
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| Organism: |
Mus musculus |
| View Gene in Tree |
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| Gene Name: |
Sonic hedgehog protein
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| Gene ID: |
MGI:98297
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| Protein ID: |
Q62226
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| Persistent Id: |
PTN000223635 |
| Alternate Ids: |
| ENSMUSP00000002708(Ensembl_PRO) |
20423(GeneID) |
| ShhN(Synonym) |
CHEMBL5387(ChEMBL) |
| ENSMUST00000002708(Ensembl_TRS) |
Shh{ECO:0000312|MGI:MGI:98297}(Symbol) |
| AAH63087(EMBL-CDS) |
AK077688(EMBL) |
| 242556220(GI) |
ENSMUSG00000002633(Ensembl) |
| NP_033196(refSeq) |
3.1.-.- {ECO:0000269|PubMed:8824192}(EC) |
| MGI:98297(MGI) |
SHH_MOUSE(UniProtKB-ID) |
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Show All
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| GO MF Complete: |
zinc ion binding, protein binding, glycosaminoglycan binding, calcium ion binding, peptidase activity, cholesterol-protein transferase activity, laminin-1 binding, patched binding
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| GO BP Complete: |
embryo development, lung-associated mesenchyme development, tongue morphogenesis, tongue development, thalamus development, skin development, epithelial cell proliferation, hair follicle development, kidney development, positive regulation of DNA-templated transcription, vasculature development, heart looping, cell fate specification, protein localization to nucleus, positive regulation of epithelial cell proliferation, positive regulation of kidney smooth muscle cell differentiation, negative regulation of kidney smooth muscle cell differentiation, male genitalia morphogenesis, alpha-tubulin acetylation, trunk neural crest cell migration, cell-cell signaling, pattern specification process, positive regulation of immature T cell proliferation in thymus, protein import into nucleus, mesenchymal cell proliferation involved in lung development, myotube differentiation, negative regulation of proteasomal ubiquitin-dependent protein catabolic process, negative regulation of T cell differentiation in thymus, negative regulation of alpha-beta T cell differentiation, positive regulation of T cell differentiation in thymus, Bergmann glial cell differentiation, roof of mouth development, negative regulation of neuron differentiation, positive regulation of neuron differentiation, apoptotic signaling pathway, blood coagulation, alpha-beta T cell differentiation, CD4-positive or CD8-positive, alpha-beta T cell lineage commitment, positive regulation of alpha-beta T cell differentiation, positive regulation of cell division, camera-type eye development, oligodendrocyte differentiation, astrocyte differentiation, T cell differentiation in thymus, regulation of glial cell proliferation, positive regulation of sprouting angiogenesis, spinal cord motor neuron differentiation, embryonic skeletal system development, determination of left/right symmetry, ventral spinal cord interneuron specification, androgen metabolic process, epithelial tube branching involved in lung morphogenesis, branching involved in prostate gland morphogenesis, epithelial-mesenchymal cell signaling, regulation of prostatic bud formation, embryonic digestive tract morphogenesis, response to axon injury, branching involved in salivary gland morphogenesis, bud outgrowth involved in lung branching, dorsal/ventral neural tube patterning, neuron differentiation, determination of left/right asymmetry in lateral mesoderm, positive regulation of neuroblast proliferation, trachea development, positive regulation of mesenchymal cell proliferation, embryonic organ development, trachea morphogenesis, positive thymic T cell selection, endocytosis, digestive tract mesoderm development, positive regulation of mesenchymal cell proliferation involved in ureter development, neural crest cell migration, striated muscle tissue development, regulation of gene expression, gene expression, negative regulation of Wnt signaling pathway, positive regulation of Wnt signaling pathway, mesenchymal cell proliferation, prostate gland development, negative thymic T cell selection, oligodendrocyte development, lung lobe morphogenesis, positive regulation of ureter smooth muscle cell differentiation, negative regulation of ureter smooth muscle cell differentiation, odontogenesis of dentin-containing tooth, ectoderm development, odontogenesis, mesenchymal cell apoptotic process, self proteolysis, neural tube formation, positive regulation of neurotrophin production, regulation of odontogenesis, metanephric collecting duct development, positive regulation of endothelial cell chemotaxis, pancreas development, intein-mediated protein splicing, signal transduction, regulation of proteolysis, left lung development, cell development, developmental growth, regulation of cell population proliferation, right lung development, negative regulation of canonical Wnt signaling pathway, embryonic morphogenesis, negative regulation of T cell proliferation, positive regulation of smoothened signaling pathway, protein autoprocessing, negative regulation of mesenchymal cell apoptotic process, somite development, anterior/posterior pattern specification, zona limitans intrathalamica formation, epithelial cell proliferation involved in prostate gland development, negative regulation of dopaminergic neuron differentiation, axon guidance, regulation of epithelial cell proliferation involved in prostate gland development, positive regulation of penile erection, positive regulation of epithelial cell proliferation involved in prostate gland development, branching morphogenesis of an epithelial tube, prostate epithelial cord elongation, dorsal/ventral pattern formation, polarity specification of anterior/posterior axis, neuroblast proliferation, positive regulation of skeletal muscle tissue development, positive regulation of skeletal muscle cell proliferation, skeletal muscle cell proliferation, positive regulation of oligodendrocyte progenitor proliferation, positive regulation of protein import into nucleus, positive regulation of cerebellar granule cell precursor proliferation, anatomical structure formation involved in morphogenesis, animal organ formation, primary prostatic bud elongation, central nervous system development, male genitalia development, hair follicle morphogenesis, cell population proliferation, regulation of mesenchymal cell proliferation involved in prostate gland development, salivary gland cavitation, mesenchymal smoothened signaling pathway involved in prostate gland development, fungiform papilla development, fungiform papilla morphogenesis, positive regulation of cell population proliferation, fungiform papilla formation, regulation of stem cell proliferation, cerebellar granule cell precursor proliferation, lung epithelium development, tracheoesophageal septum formation, positive regulation of transcription by RNA polymerase II, epithelial cell proliferation involved in salivary gland morphogenesis, thymus development, lung morphogenesis, heart development, striated muscle cell differentiation, angiogenesis, neuron fate commitment, stem cell proliferation, cell migration, commissural neuron axon guidance, positive regulation of sclerotome development, cell proliferation in external granule layer, digestive tract morphogenesis, establishment of epithelial cell polarity, osteoblast development, thyroid gland development, metanephros development, positive regulation of striated muscle cell differentiation, dopaminergic neuron differentiation, branching involved in ureteric bud morphogenesis, skeletal muscle tissue development, cell fate commitment, inner ear development, myoblast differentiation, positive regulation of photoreceptor cell differentiation, negative regulation of protein catabolic process, spinal cord dorsal/ventral patterning, positive regulation of astrocyte differentiation, artery development, lymphoid progenitor cell differentiation, forebrain regionalization, negative regulation of protein binding, negative regulation of cholesterol efflux, embryonic digit morphogenesis, positive regulation of oligodendrocyte differentiation, midbrain development, forebrain development, hindbrain development, embryonic forelimb morphogenesis, embryonic hindlimb morphogenesis, smoothened signaling pathway, negative regulation of gene expression, cellular response to lithium ion, metanephric mesenchymal cell proliferation involved in metanephros development, positive regulation of gene expression, negative regulation of cell migration, regulation of protein localization to nucleus, telencephalon regionalization, anatomical structure development, vasculogenesis, intermediate filament organization, embryonic foregut morphogenesis, formation of anatomical boundary, negative regulation of transcription by RNA polymerase II, embryonic limb morphogenesis, response to ethanol, branching involved in blood vessel morphogenesis, canonical Wnt signaling pathway, respiratory tube development, lung development, negative regulation of transcription elongation by RNA polymerase II, limb development, limb bud formation, regulation of DNA-templated transcription, smooth muscle tissue development, hindgut morphogenesis, stem cell development, vasculogenesis involved in coronary vascular morphogenesis, epithelial-mesenchymal signaling involved in prostate gland development, mesenchymal-epithelial cell signaling involved in prostate gland development, negative regulation of apoptotic process, T cell proliferation, skeletal muscle fiber differentiation
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| GO CC Complete: |
synaptic vesicle, Golgi membrane, endoplasmic reticulum, Golgi apparatus, neuronal cell body, extracellular region, plasma membrane, nucleoplasm, cell surface, endoplasmic reticulum membrane, endoplasmic reticulum lumen, dendrite, extracellular space, membrane, membrane raft, extracellular matrix, axon
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