PANTHER Gene Information

Gene Symbol(s):

Egln3

Organism:

Rattus norvegicus

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Gene Name:

Prolyl hydroxylase EGLN3

Gene ID:

71019

Protein ID:

Q62630

Persistent Id:

PTN000308039

Alternate Ids:

469478(GI)	1.14.11.- {ECO:0000250\|UniProtKB:Q9H6Z9}(EC)
HIF-PH3(Synonym)	71019(RGD)
EGLN3_RAT(UniProtKB-ID)	U06713(EMBL)
AAA19321(EMBL-CDS)	NP_062244(refSeq)
54702(GeneID)	Egln3(Symbol)
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PANTHER Classification

PANTHER Family:	EGL NINE HOMOLOG-RELATED (PTHR12907)
PANTHER Subfamily:	PROLYL HYDROXYLASE EGLN3 (PTHR12907:SF28)
PANTHER GO-slim Molecular Function:	catalytic activity, acting on a protein 2-oxoglutarate-dependent dioxygenase activity ferrous iron binding
PANTHER GO-slim Biological Process:	protein hydroxylation response to hypoxia cellular response to chemical stimulus organic cyclic compound metabolic process cellular response to stress L-amino acid metabolic process cellular modified amino acid metabolic process heterocycle metabolic process peptidyl-amino acid modification
PANTHER GO-slim Cellular Component:	nucleus cytoplasm
PANTHER protein class:

Pathway Categories:

Hypoxia response via HIF activation

HIF-1 alpha prolyl hydroxylase 2

GENE ONTOLOGY DATABASE ANNOTATIONS

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GO MF Complete:	L-ascorbic acid binding, protein binding, iron ion binding, ferrous iron binding, hypoxia-inducible factor-proline dioxygenase activity, 2-oxoglutarate-dependent dioxygenase activity, peptidyl-proline 4-dioxygenase activity, peptidyl-proline dioxygenase activity
GO BP Complete:	response to hypoxia, cellular response to leukemia inhibitory factor, apoptotic process, cellular response to hypoxia, DNA damage response, regulation of neuron apoptotic process, positive regulation of cysteine-type endopeptidase activity, protein hydroxylation, regulation of cell population proliferation
GO CC Complete:	nucleus, cytoplasm, cytosol

REACTOME DATABASE ANNOTATIONS Click to Expand...

Reactome Pathways:

Cellular responses to stress, Cellular response to hypoxia, Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha, Cellular responses to stimuli

Orthologs

ID	Organism	Type
HUMAN\|HGNC=14661\|UniProtKB=Q9H6Z9	Homo sapiens	LDO
PANTR\|Ensembl=ENSPTRG00000006250.3\|UniProtKB=H2Q856	Pan troglodytes	LDO
GORGO\|Ensembl=ENSGGOG00000014900.3\|UniProtKB=G3RG06	Gorilla gorilla gorilla	LDO
MACMU\|Ensembl=ENSMMUG00000000040.4\|UniProtKB=F7HPH6	Macaca mulatta	LDO
MOUSE\|MGI=MGI=1932288\|UniProtKB=Q91UZ4	Mus musculus	LDO
BOVIN\|Ensembl=ENSBTAG00000008172.6\|UniProtKB=A7MBA0	Bos taurus	LDO
PIG\|Ensembl=ENSSSCG00000001963.5\|UniProtKB=A0A8D1FKB1	Sus scrofa	LDO
HORSE\|Ensembl=ENSECAG00000005086.3\|UniProtKB=F7CIB5	Equus caballus	LDO
FELCA\|Ensembl=ENSFCAG00000040826.2\|UniProtKB=A0A2I2UN10	Felis catus	LDO
CANLF\|Ensembl=ENSCAFG00845012583.1\|UniProtKB=A0A8I3ND68	Canis lupus familiaris	LDO
MONDO\|Ensembl=ENSMODG00000017625.4\|UniProtKB=F6ZT25	Monodelphis domestica	LDO
ORNAN\|Ensembl=ENSOANG00000037294.1\|UniProtKB=A0A6I8MZI4	Ornithorhynchus anatinus	LDO
CHICK\|Ensembl=ENSGALG00010005871.1\|UniProtKB=E1C8C0	Gallus gallus	LDO
ANOCA\|Ensembl=ENSACAG00000040138.1\|UniProtKB=A0A803T309	Anolis carolinensis	LDO
XENLA\|Gene=egln3.L\|UniProtKB=A9JS11	Xenopus laevis	O
XENLA\|Gene=egln3.S\|UniProtKB=A1L2K9	Xenopus laevis	LDO
XENTR\|Xenbase=XB-GENE-964334\|UniProtKB=B1H3D4	Xenopus tropicalis	LDO
ORYLA\|Ensembl=ENSORLG00000018068.2\|UniProtKB=H2MV09	Oryzias latipes	LDO
DANRE\|Gene=egln3\|UniProtKB=A0A8M2BH64	Danio rerio	LDO
LEPOC\|Ensembl=ENSLOCG00000009500.1\|UniProtKB=W5MT95	lepisosteus oculatus	LDO
CIOIN\|Ensembl=ENSCING00000001903.3\|UniProtKB=F7A2P1	Ciona intestinalis	LDO
BRAFL\|Gene=LOC118410958\|UniProtKB=A0A9J7MIP7	Branchiostoma floridae	O
BRAFL\|Gene=LOC118414714\|UniProtKB=A0A9J7L460	Branchiostoma floridae	LDO
STRPU\|EnsemblGenome=LOC587363\|UniProtKB=W4ZE79	Strongylocentrotus purpuratus	O
STRPU\|EnsemblGenome=LOC578715\|UniProtKB=A0A7M7RAT7	Strongylocentrotus purpuratus	LDO
CAEEL\|WormBase=WBGene00001178\|UniProtKB=G5EBV0	Caenorhabditis elegans	LDO
CAEBR\|WormBase=WBGene00031163\|UniProtKB=A8X8P5	Caenorhabditis briggsae	LDO
PRIPA\|EnsemblGenome=WBGene00273003\|UniProtKB=A0A2A6C5D2	Pristionchus pacificus	LDO
DROME\|FlyBase=FBgn0264785\|UniProtKB=Q8SX21	Drosophila melanogaster	LDO
ANOGA\|EnsemblGenome=AGAP003523\|UniProtKB=Q7QAV2	Anopheles gambiae	LDO
TRICA\|EnsemblGenome=TC033631\|UniProtKB=A0A139WFL6	Tribolium castaneum	LDO
DAPPU\|EnsemblGenome=DAPPUDRAFT_64722\|UniProtKB=E9HPC2	Daphnia pulex	O
DAPPU\|EnsemblGenome=DAPPUDRAFT_347569\|UniProtKB=E9HPB4	Daphnia pulex	O
DAPPU\|EnsemblGenome=DAPPUDRAFT_347567\|UniProtKB=E9H863	Daphnia pulex	LDO
IXOSC\|EnsemblGenome=ISCW000901\|UniProtKB=B7P5Z6	Ixodes scapularis	LDO
HELRO\|EnsemblGenome=HelroG72205\|UniProtKB=T1G0X1	helobdella robusta	LDO
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g110999\|UniProtKB=A7SAI3	Nematostella vectensis	O
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g53555\|UniProtKB=A7SKM8	Nematostella vectensis	O
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g88939\|UniProtKB=A7RPG5	Nematostella vectensis	LDO
TRIAD\|EnsemblGenome=TriadG50295\|UniProtKB=B3RXW9	Trichoplax adhaerens	LDO
MONBE\|EnsemblGenome=MONBRDRAFT_27914\|UniProtKB=A9V6U4	Monosiga brevicollis	LDO
DICDI\|dictyBase=DDB_G0277759\|UniProtKB=Q86KR9	Dictyostelium discoideum	LDO
DICPU\|EnsemblGenome=DICPUDRAFT_81472\|UniProtKB=F0ZTL0	Dictyostelium purpureum	LDO
THAPS\|EnsemblGenome=THAPSDRAFT_4454\|UniProtKB=B8BZB7	Thalassiosira pseudonana	O
THAPS\|EnsemblGenome=THAPSDRAFT_1091\|UniProtKB=B8BPY4	Thalassiosira pseudonana	O
THAPS\|EnsemblGenome=THAPSDRAFT_3663\|UniProtKB=B8BYE9	Thalassiosira pseudonana	LDO
CHLRE\|EnsemblGenome=CHLRE_13g576800v5\|UniProtKB=A0A2K3D024	Chlamydomonas reinhardtii	LDO