PANTHER Gene Information

Gene Symbol(s):

Pde3a

Organism:

Rattus norvegicus

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Gene Name:

cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A

Gene ID:

61942

Protein ID:

Q62865

Persistent Id:

PTN000142492

Alternate Ids:

PDE3A_RAT(UniProtKB-ID)	NM_017337(refSeq)
3182952(GI)	ENSRNOG00000025042(Ensembl)
Cyclic GMP-inhibited phosphodiesterase A(Synonym)	61942(RGD)
Pde3a{ECO:0000312\|RGD:61942}(Symbol)	ENSRNOT00000032843(Ensembl_TRS)
AAA84964(EMBL-CDS)	U38179(EMBL)
ENSRNOP00000032282(Ensembl_PRO)	50678(GeneID)
3.1.4.17 {ECO:0000250\|UniProtKB:Q14432}(EC)
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PANTHER Classification

PANTHER Family:	CYCLIC NUCLEOTIDE PHOSPHODIESTERASE (PTHR11347)
PANTHER Subfamily:	PHOSPHODIESTERASE (PTHR11347:SF104)
PANTHER GO-slim Molecular Function:	cyclic-nucleotide phosphodiesterase activity
PANTHER GO-slim Biological Process:	cAMP-mediated signaling
PANTHER GO-slim Cellular Component:	cytosol
PANTHER protein class:	phosphodiesterase

Pathway Categories:

No pathway information available

GENE ONTOLOGY DATABASE ANNOTATIONS

Click to Expand...

GO MF Complete:	3',5'-cGMP-inhibited cyclic-nucleotide phosphodiesterase activity, 3',5'-cGMP-stimulated cyclic-nucleotide phosphodiesterase activity, metal ion binding, nuclear estrogen receptor activity, 3',5'-cyclic-GMP phosphodiesterase activity, cyclic-nucleotide phosphodiesterase activity, 3',5'-cyclic-AMP phosphodiesterase activity, estrogen binding, 3',5'-cyclic-nucleotide phosphodiesterase activity
GO BP Complete:	negative regulation of cAMP/PKA signal transduction, cGMP-mediated signaling, positive regulation of oocyte development, regulation of meiotic nuclear division, apoptotic signaling pathway, response to xenobiotic stimulus, negative regulation of vascular permeability, steroid hormone receptor signaling pathway, positive regulation of vascular permeability, regulation of ribonuclease activity, cellular response to transforming growth factor beta stimulus, oocyte maturation, oocyte development, cellular response to cGMP, negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway, negative regulation of apoptotic process, cAMP-mediated signaling
GO CC Complete:	membrane, cytosol

REACTOME DATABASE ANNOTATIONS Click to Expand...

Reactome Pathways:

Signaling by GPCR, GPCR downstream signalling, G alpha (s) signalling events, Signal Transduction

Orthologs

ID	Organism	Type
HUMAN\|HGNC=8778\|UniProtKB=Q14432	Homo sapiens	LDO
PANTR\|Ensembl=ENSPTRG00000004748.5\|UniProtKB=H2R265	Pan troglodytes	LDO
GORGO\|Ensembl=ENSGGOG00000013706.3\|UniProtKB=G3RCY0	Gorilla gorilla gorilla	LDO
MACMU\|Ensembl=ENSMMUG00000008269.4\|UniProtKB=F7HBP7	Macaca mulatta	LDO
MOUSE\|MGI=MGI=1860764\|UniProtKB=Q9Z0X4	Mus musculus	LDO
BOVIN\|Ensembl=ENSBTAG00000017260.7\|UniProtKB=A0A3Q1M1E8	Bos taurus	LDO
PIG\|Ensembl=ENSSSCG00000028662.4\|UniProtKB=I3L6S5	Sus scrofa	LDO
HORSE\|Ensembl=ENSECAG00000016360.4\|UniProtKB=A0A3Q2GSQ9	Equus caballus	LDO
FELCA\|Ensembl=ENSFCAG00000000972.6\|UniProtKB=M3VVR5	Felis catus	LDO
CANLF\|Ensembl=ENSCAFG00845015831.1\|UniProtKB=A0A8I3NYE0	Canis lupus familiaris	LDO
MONDO\|Ensembl=ENSMODG00000017859.5\|UniProtKB=F6YIK3	Monodelphis domestica	LDO
ORNAN\|Ensembl=ENSOANG00000032057.2\|UniProtKB=A0A6I8NMM6	Ornithorhynchus anatinus	LDO
CHICK\|Ensembl=ENSGALG00010011688.1\|UniProtKB=A0A8V0YC57	Gallus gallus	LDO
ANOCA\|Ensembl=ENSACAG00000017514.4\|UniProtKB=G1KU23	Anolis carolinensis	LDO
XENLA\|Gene=pde3a.L\|UniProtKB=A0A8J1MJX0	Xenopus laevis	O
XENLA\|Gene=LOC108712511\|UniProtKB=A0A8J1MPU3	Xenopus laevis	LDO
XENTR\|Gene=pde3a\|UniProtKB=A0A8J1J7W0	Xenopus tropicalis	LDO
ORYLA\|Ensembl=ENSORLG00000008246.2\|UniProtKB=H2LW64	Oryzias latipes	O
ORYLA\|Ensembl=ENSORLG00000004498.2\|UniProtKB=H2LI30	Oryzias latipes	LDO
DANRE\|Gene=pde3a\|UniProtKB=A0A8M3B8Q1	Danio rerio	LDO
LEPOC\|Ensembl=ENSLOCG00000015415.1\|UniProtKB=W5NEB5	lepisosteus oculatus	LDO
CIOIN\|Ensembl=ENSCING00000005633.3\|UniProtKB=F7A9J1	Ciona intestinalis	O
BRAFL\|Gene=LOC118406636\|UniProtKB=A0A9J7HND5	Branchiostoma floridae	O
STRPU\|EnsemblGenome=LOC589178\|UniProtKB=A0A7M7T005	Strongylocentrotus purpuratus	O
CAEEL\|WormBase=WBGene00008443\|UniProtKB=Q8I0P7	Caenorhabditis elegans	O
CAEBR\|Gene_ORFName=CBG20885\|UniProtKB=A8XYV6	Caenorhabditis briggsae	O
PRIPA\|EnsemblGenome=WBGene00111879\|UniProtKB=A0A2A6CX52	Pristionchus pacificus	O
IXOSC\|EnsemblGenome=ISCW006877\|UniProtKB=B7PL40	Ixodes scapularis	O
HELRO\|EnsemblGenome=HelroG114833\|UniProtKB=T1EG47	helobdella robusta	O
HELRO\|EnsemblGenome=HelroG191746\|UniProtKB=T1FT94	helobdella robusta	O
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g97137\|UniProtKB=A7RXZ4	Nematostella vectensis	O
TRIAD\|EnsemblGenome=TriadG22319\|UniProtKB=B3RSH4	Trichoplax adhaerens	O
MONBE\|EnsemblGenome=MONBRDRAFT_24275\|UniProtKB=A9UVX6	Monosiga brevicollis	O
MONBE\|EnsemblGenome=MONBRDRAFT_34427\|UniProtKB=A9VBQ1	Monosiga brevicollis	O
YEAST\|SGD=S000005887\|UniProtKB=P06776	Saccharomyces cerevisiae	O
EREGS\|EnsemblGenome=AGOS_ADR395C\|UniProtKB=Q758Y3	Eremothecium gossypii	O
CANAL\|CGD=CAL0000178266\|UniProtKB=A0A1D8PCV9	Candida albicans	O
YARLI\|EnsemblGenome=YALI0_A08041g\|UniProtKB=Q6CHK1	Yarrowia lipolytica	O
EMENI\|EnsemblGenome=ANIA_02740\|UniProtKB=Q5B9P0	Emericella nidulans	O
ASPFU\|EnsemblGenome=AFUA_1G05230\|UniProtKB=Q4WJP8	Neosartorya fumigata	O
NEUCR\|EnsemblGenome=NCU00478\|UniProtKB=U9W570	Neurospora crassa	O
SCLS1\|EnsemblGenome=SS1G_12594\|UniProtKB=A7F4R9	Sclerotinia sclerotiorum	O
PHANO\|EnsemblGenome=SNOG_00406\|UniProtKB=Q0V6F8	Phaeosphaeria nodorum	O
CRYNJ\|EnsemblGenome=CNB01170\|UniProtKB=Q5KMM5	Cryptococcus neoformans	O
PUCGT\|EnsemblGenome=PGTG_02535\|UniProtKB=E3JVL9	Puccinia graminis	O
BATDJ\|Gene_ORFName=BATDEDRAFT_86647\|UniProtKB=F4NWD5	Batrachochytrium dendrobatidis	O
BATDJ\|Gene_ORFName=BATDEDRAFT_2204\|UniProtKB=F4P9V8	Batrachochytrium dendrobatidis	O
BATDJ\|Gene_ORFName=BATDEDRAFT_35570\|UniProtKB=F4P6V0	Batrachochytrium dendrobatidis	O
BATDJ\|Gene_ORFName=BATDEDRAFT_12624\|UniProtKB=F4P784	Batrachochytrium dendrobatidis	O
DICDI\|dictyBase=DDB_G0268634\|UniProtKB=B0G0Y8	Dictyostelium discoideum	O
DICPU\|EnsemblGenome=DICPUDRAFT_168745\|UniProtKB=F0ZLZ6	Dictyostelium purpureum	O
DICDI\|dictyBase=DDB_G0289121\|UniProtKB=Q86H13	Dictyostelium discoideum	O
DICPU\|EnsemblGenome=DICPUDRAFT_150656\|UniProtKB=F0ZGW8	Dictyostelium purpureum	O
LEIMA\|EnsemblGenome=LMJF_29_2680\|UniProtKB=E9AED0	Leishmania major	O
TRYB2\|Gene_ORFName=Tb927.3.3070\|UniProtKB=Q57ZK5	Trypanosoma brucei	O
LEIMA\|EnsemblGenome=LMJF_15_1480\|UniProtKB=Q4QF31	Leishmania major	O
TRYB2\|Gene_ORFName=Tb09.160.3590\|UniProtKB=Q38F46	Trypanosoma brucei	O
TRYB2\|Gene_ORFName=Tb09.160.3630\|UniProtKB=Q38F42	Trypanosoma brucei	O
LEIMA\|EnsemblGenome=LMJF_29_2440\|UniProtKB=E9AEA6	Leishmania major	O
TRYB2\|Gene_ORFName=Tb927.3.3340\|UniProtKB=Q57V52	Trypanosoma brucei	O
GIAIC\|EnsemblGenome=GL50803_23389\|UniProtKB=A8BMZ9	Giardia intestinalis	O
GIAIC\|Gene_ORFName=GL50803_0014058\|UniProtKB=A0A644EZ75	Giardia intestinalis	O
TRIV3\|Gene_ORFName=TVAG_456690\|UniProtKB=A2DBZ3	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_139380\|UniProtKB=A2E4B2	Trichomonas vaginalis	O
PHYRM\|Gene=H3GMG8_PHYRM\|UniProtKB=H3GMG8	Phytophthora ramorum	O
CHLRE\|EnsemblGenome=CHLRE_02g080550v5\|UniProtKB=A0A2K3E0I9	Chlamydomonas reinhardtii	O
CHLRE\|EnsemblGenome=CHLRE_13g605100v5\|UniProtKB=A0A2K3D1E3	Chlamydomonas reinhardtii	O
PLAF7\|EnsemblGenome=PF3D7_1209500.1\|UniProtKB=Q8I5V4	Plasmodium falciparum	O
PLAF7\|EnsemblGenome=PF3D7_1321500.1\|UniProtKB=Q8I6Z7	Plasmodium falciparum	O
PLAF7\|EnsemblGenome=PF3D7_1470500\|UniProtKB=Q8IKD3	Plasmodium falciparum	O
PLAF7\|EnsemblGenome=PF3D7_1321600\|UniProtKB=B3FEM7	Plasmodium falciparum	O
PARTE\|EnsemblGenome=GSPATT00012165001\|UniProtKB=A0D0P6	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00026232001\|UniProtKB=A0EF18	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00024350001\|UniProtKB=A0E8K4	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00033829001\|UniProtKB=A0BZK9	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00005060001\|UniProtKB=A0BP44	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00028410001\|UniProtKB=A0BFQ8	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00007223001\|UniProtKB=A0CDZ4	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00019474001\|UniProtKB=A0DRT9	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00011705001\|UniProtKB=A0CZB5	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00021356001\|UniProtKB=A0DXF6	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00032825001\|UniProtKB=A0BWQ6	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00007186001\|UniProtKB=A0CDV7	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00016491001\|UniProtKB=A0DF61	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00022445001\|UniProtKB=A0E1V7	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00022614001\|UniProtKB=A0E2C5	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00017245001\|UniProtKB=A0DIM1	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00016009001\|UniProtKB=A0DDQ1	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00019716001\|UniProtKB=A0DSJ5	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00016916001\|UniProtKB=A0DHL2	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00025458001\|UniProtKB=A0EBQ7	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00026780001\|UniProtKB=A0EGL5	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00036148001\|UniProtKB=A0C8A0	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00036302001\|UniProtKB=A0C8Q0	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00026646001\|UniProtKB=A0EG81	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00013629001\|UniProtKB=A0D565	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00010500001\|UniProtKB=A0CU34	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00036826001\|UniProtKB=A0CB76	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00024359001\|UniProtKB=A0E8L3	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00027162001\|UniProtKB=A0EHP5	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00028038001\|UniProtKB=A0BEN8	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00016442001\|UniProtKB=A0DEZ9	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00038228001\|UniProtKB=A0CG66	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00006250001\|UniProtKB=A0C4N4	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00026769001\|UniProtKB=A0EGK4	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00031858001\|UniProtKB=A0BSV9	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00033366001\|UniProtKB=A0BY96	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00012334001\|UniProtKB=A0D193	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00039546001\|UniProtKB=A0DK29	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00011621001\|UniProtKB=A0CZ03	Paramecium tetraurelia	O
THAPS\|EnsemblGenome=THAPSDRAFT_268740\|UniProtKB=B8C004	Thalassiosira pseudonana	O
THAPS\|EnsemblGenome=THAPSDRAFT_261018\|UniProtKB=B8BRB2	Thalassiosira pseudonana	O
PHYRM\|Gene=H3GHE7_PHYRM\|UniProtKB=H3GHE7	Phytophthora ramorum	O
PHYRM\|Gene=H3GTZ2_PHYRM\|UniProtKB=H3GTZ2	Phytophthora ramorum	O
PHYRM\|Gene=H3GZZ5_PHYRM\|UniProtKB=H3GZZ5	Phytophthora ramorum	O
PHYRM\|Gene=H3GBS7_PHYRM\|UniProtKB=H3GBS7	Phytophthora ramorum	O
PHYRM\|Gene=H3GBT1_PHYRM\|UniProtKB=H3GBT1	Phytophthora ramorum	O
PHYRM\|Gene=H3GU47_PHYRM\|UniProtKB=H3GU47	Phytophthora ramorum	O
PHYRM\|Gene=H3HCP0_PHYRM\|UniProtKB=H3HCP0	Phytophthora ramorum	O
PHYRM\|Gene=H3HCQ7_PHYRM\|UniProtKB=H3HCQ7	Phytophthora ramorum	O
CHLRE\|EnsemblGenome=CHLRE_02g143500v5\|UniProtKB=A0A2K3E451	Chlamydomonas reinhardtii	O
CHLRE\|EnsemblGenome=CHLRE_09g389875v5\|UniProtKB=A0A2K3DE17	Chlamydomonas reinhardtii	O
CHLRE\|EnsemblGenome=CHLRE_02g143350v5\|UniProtKB=A0A2K3E413	Chlamydomonas reinhardtii	O
CHLRE\|EnsemblGenome=CHLRE_01g015200v5\|UniProtKB=A0A2K3E5T7	Chlamydomonas reinhardtii	O
CHLRE\|EnsemblGenome=CHLRE_11g468100v5\|UniProtKB=A0A2K3D839	Chlamydomonas reinhardtii	O
CHLRE\|EnsemblGenome=CHLRE_03g204689v5\|UniProtKB=A0A2K3DZP3	Chlamydomonas reinhardtii	O
CHLRE\|EnsemblGenome=CHLRE_13g564766v5\|UniProtKB=A0A2K3CZ72	Chlamydomonas reinhardtii	O
CHLRE\|EnsemblGenome=CHLRE_12g499250v5\|UniProtKB=A0A2K3D3E2	Chlamydomonas reinhardtii	O
CHLRE\|EnsemblGenome=CHLRE_14g617650v5\|UniProtKB=A0A2K3CXT4	Chlamydomonas reinhardtii	O
CHLRE\|EnsemblGenome=CHLRE_13g590600v5\|UniProtKB=A0A2K3D112	Chlamydomonas reinhardtii	O
CHLRE\|EnsemblGenome=CHLRE_11g467673v5\|UniProtKB=A0A2K3D7N5	Chlamydomonas reinhardtii	O
CHLRE\|EnsemblGenome=CHLRE_02g114100v5\|UniProtKB=A0A2K3E354	Chlamydomonas reinhardtii	O
CHLRE\|EnsemblGenome=CHLRE_16g664150v5\|UniProtKB=A0A2K3CTQ5	Chlamydomonas reinhardtii	O
CHLRE\|EnsemblGenome=CHLRE_12g559400v5\|UniProtKB=A0A2K3D5L0	Chlamydomonas reinhardtii	O
CHLRE\|EnsemblGenome=CHLRE_12g509550v5\|UniProtKB=A0A2K3D2M9	Chlamydomonas reinhardtii	O
CHLRE\|EnsemblGenome=CHLRE_14g617750v5\|UniProtKB=A0A2K3CXR2	Chlamydomonas reinhardtii	O
CHLRE\|EnsemblGenome=CHLRE_13g567400v5\|UniProtKB=A0A2K3CZD9	Chlamydomonas reinhardtii	O
CHLRE\|EnsemblGenome=CHLRE_13g603000v5\|UniProtKB=A0A2K3D180	Chlamydomonas reinhardtii	O
CHLRE\|EnsemblGenome=CHLRE_12g499300v5\|UniProtKB=A0A2K3D3C8	Chlamydomonas reinhardtii	O
CHLRE\|EnsemblGenome=CHLRE_14g617700v5\|UniProtKB=A0A2K3CXS8	Chlamydomonas reinhardtii	O
CHLRE\|EnsemblGenome=CHLRE_12g557500v5\|UniProtKB=A0A2K3D5P8	Chlamydomonas reinhardtii	O
CHLRE\|EnsemblGenome=CHLRE_02g141786v5\|UniProtKB=A0A2K3E4B4	Chlamydomonas reinhardtii	O
CHLRE\|EnsemblGenome=CHLRE_02g109100v5\|UniProtKB=A0A2K3E2U1	Chlamydomonas reinhardtii	O
CHLRE\|EnsemblGenome=CHLRE_10g454900v5\|UniProtKB=A0A2K3DBF7	Chlamydomonas reinhardtii	O
CHLRE\|EnsemblGenome=CHLRE_16g664200v5\|UniProtKB=A0A2K3CTS8	Chlamydomonas reinhardtii	O
CHLRE\|EnsemblGenome=CHLRE_02g143400v5\|UniProtKB=A0A2K3E402	Chlamydomonas reinhardtii	O
CHLRE\|EnsemblGenome=CHLRE_02g119850v5\|UniProtKB=A0A2K3E3K8	Chlamydomonas reinhardtii	O
CHLRE\|EnsemblGenome=CHLRE_07g342350v5\|UniProtKB=A0A2K3DKM3	Chlamydomonas reinhardtii	O
CHLRE\|EnsemblGenome=CHLRE_06g289400v5\|UniProtKB=A0A2K3DQ75	Chlamydomonas reinhardtii	O
KLENI\|Gene_ORFName=KFL_001960100\|UniProtKB=A0A1Y1I296	Klebsormidium nitens	O
KLENI\|Gene_ORFName=KFL_000010350\|UniProtKB=A0A0U9HHT7	Klebsormidium nitens	O
KLENI\|Gene_ORFName=KFL_002670040\|UniProtKB=A0A1Y1I6A5	Klebsormidium nitens	O