PANTHER Gene Information   
Gene Symbol(s): Mmp12
Organism: Rattus norvegicus
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Gene Name: Macrophage metalloelastase
Gene ID: 620195
Protein ID: Q63341
Persistent Id: PTN000024108
Alternate Ids:
NM_053963(refSeq) 3.4.24.65(EC)
X98517(EMBL) Q5I0P0(AltAccession)
Mmp12(Symbol) MMP12_RAT(UniProtKB-ID)
CHEMBL5506(ChEMBL) MME(Synonym)
117033(GeneID) 620195(RGD)
56972358(GI) CAA67142(EMBL-CDS)
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PANTHER Classification
PANTHER Family: MATRIX METALLOPROTEINASE (PTHR10201)
PANTHER Subfamily: MACROPHAGE METALLOELASTASE (PTHR10201:SF267)  
PANTHER GO-slim Molecular Function: metalloendopeptidase activity
PANTHER GO-slim Biological Process: extracellular matrix organization
catabolic process
PANTHER GO-slim Cellular Component:
PANTHER protein class: metalloprotease
Pathway Categories: Alzheimer disease-presenilin pathway
   Matrix metalloprotease

GO MF Complete: core promoter sequence-specific DNA binding, zinc ion binding, collagen binding, calcium ion binding, sequence-specific DNA binding, metalloendopeptidase activity
GO BP Complete: regulation of trophoblast cell migration, positive regulation of epithelial cell proliferation involved in wound healing, positive regulation of type I interferon-mediated signaling pathway, negative regulation of type I interferon-mediated signaling pathway, response to xenobiotic stimulus, response to organic cyclic compound, positive regulation of transcription by RNA polymerase II, bronchiole development, negative regulation of transcription by RNA polymerase II, cellular response to virus, positive regulation of interferon-alpha production, lung alveolus development, response to hypoxia, negative regulation of endothelial cell-matrix adhesion via fibronectin, elastin catabolic process, protein import into nucleus, positive regulation of gene expression, proteolysis, regulation of defense response to virus by host, extracellular matrix organization, collagen catabolic process, wound healing, spreading of epidermal cells, positive regulation of epithelial cell proliferation
GO CC Complete: nucleus, extracellular space, cytoplasm, extracellular matrix
Reactome Pathways: Degradation of the extracellular matrix, Collagen degradation, Extracellular matrix organization