PANTHER Gene Information

Gene Symbol(s):

Ptgs1

Organism:

Rattus norvegicus

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Gene Name:

Prostaglandin G_H synthase 1

Gene ID:

3439

Protein ID:

Q63921

Persistent Id:

PTN000224624

Alternate Ids:

S67721(EMBL)	PHS 1(Synonym)
Ptgs1{ECO:0000312\|RGD:3439}(Symbol)	603052(GI)
3439(RGD)	AAA03465(EMBL-CDS)
1.14.99.1 {ECO:0000250\|UniProtKB:P23219}(EC)	CHEMBL4042(ChEMBL)
PGH1_RAT(UniProtKB-ID)	Q63684(AltAccession)
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PANTHER Classification

PANTHER Family:	PROSTAGLANDIN G/H SYNTHASE (PTHR11903)
PANTHER Subfamily:	PROSTAGLANDIN G_H SYNTHASE 1 (PTHR11903:SF6)
PANTHER GO-slim Molecular Function:	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
PANTHER GO-slim Biological Process:	icosanoid biosynthetic process unsaturated fatty acid biosynthetic process prostaglandin metabolic process long-chain fatty acid metabolic process
PANTHER GO-slim Cellular Component:	neuron projection cytoplasm
PANTHER protein class:	oxygenase

Pathway Categories:

Inflammation mediated by chemokine and cytokine signaling pathway

Cyclooxygenase

GENE ONTOLOGY DATABASE ANNOTATIONS

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GO MF Complete:	peroxidase activity, dioxygenase activity, prostaglandin-endoperoxide synthase activity, oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen, metal ion binding, heme binding
GO BP Complete:	positive regulation of vasoconstriction, prostaglandin metabolic process, learning, memory, regulation of blood pressure, regulation of cell population proliferation, positive regulation of smooth muscle contraction, response to oxidative stress, response to corticosterone, cyclooxygenase pathway, prostaglandin biosynthetic process, cellular oxidant detoxification, response to fatty acid, negative regulation of norepinephrine secretion, negative regulation of epinephrine secretion, maintenance of blood-brain barrier
GO CC Complete:	nuclear envelope, endoplasmic reticulum membrane, cytoplasm, intracellular membrane-bounded organelle, Golgi apparatus, neuron projection, photoreceptor outer segment

REACTOME DATABASE ANNOTATIONS Click to Expand...

Reactome Pathways:

COX reactions, Metabolism, Arachidonic acid metabolism, Metabolism of lipids, Biological oxidations, Phase I - Functionalization of compounds, Fatty acid metabolism, Synthesis of Prostaglandins (PG) and Thromboxanes (TX)

Orthologs

ID	Organism	Type
HUMAN\|HGNC=9604\|UniProtKB=P23219	Homo sapiens	LDO
PANTR\|Ensembl=ENSPTRG00000021325.6\|UniProtKB=K7C9Z9	Pan troglodytes	LDO
GORGO\|Ensembl=ENSGGOG00000009372.3\|UniProtKB=G3R1S7	Gorilla gorilla gorilla	LDO
MACMU\|Ensembl=ENSMMUG00000012886.4\|UniProtKB=F6S984	Macaca mulatta	LDO
MOUSE\|MGI=MGI=97797\|UniProtKB=P22437	Mus musculus	LDO
BOVIN\|Gene=PTGS1\|UniProtKB=O62664	Bos taurus	LDO
BOVIN\|Ensembl=ENSBTAG00000006716.6\|UniProtKB=A0A452DI94	Bos taurus	LDO
PIG\|Ensembl=ENSSSCG00000005533.4\|UniProtKB=A0A287ANF9	Sus scrofa	LDO
HORSE\|Ensembl=ENSECAG00000009707.4\|UniProtKB=A0A9L0RE63	Equus caballus	LDO
FELCA\|Ensembl=ENSFCAG00000011194.6\|UniProtKB=M3WEM6	Felis catus	LDO
CANLF\|Ensembl=ENSCAFG00000020263\|UniProtKB=Q8HZR1	Canis lupus familiaris	LDO
MONDO\|Ensembl=ENSMODG00000025747.3\|UniProtKB=F6T1S9	Monodelphis domestica	LDO
ORNAN\|Ensembl=ENSOANG00000008197.4\|UniProtKB=F6ZRZ3	Ornithorhynchus anatinus	LDO
CHICK\|Ensembl=ENSGALG00010028372.1\|UniProtKB=A0A1D5PM03	Gallus gallus	LDO
ANOCA\|Ensembl=ENSACAG00000012242.4\|UniProtKB=A0A803SQ73	Anolis carolinensis	LDO
XENLA\|Gene=ptgs1.S\|UniProtKB=A0A9J3	Xenopus laevis	LDO
XENTR\|Xenbase=XB-GENE-995315\|UniProtKB=A0A6I8SVS9	Xenopus tropicalis	LDO
ORYLA\|Ensembl=ENSORLG00000000509.2\|UniProtKB=H2L4D4	Oryzias latipes	O
ORYLA\|Ensembl=ENSORLG00000005095.2\|UniProtKB=H2LK75	Oryzias latipes	LDO
DANRE\|ZFIN=ZDB-GENE-020530-1\|UniProtKB=Q8JH44	Danio rerio	LDO
LEPOC\|Ensembl=ENSLOCG00000003036.1\|UniProtKB=W5M5C7	lepisosteus oculatus	LDO
CIOIN\|Ensembl=ENSCING00000006498.3\|UniProtKB=F7AAV2	Ciona intestinalis	O
CIOIN\|Ensembl=ENSCING00000006154.3\|UniProtKB=F6SDP7	Ciona intestinalis	O
BRAFL\|Gene=LOC118427666\|UniProtKB=A0A9J7N6R7	Branchiostoma floridae	O
BRAFL\|Gene_ORFName=BRAFLDRAFT_129952\|UniProtKB=C3ZWS9	Branchiostoma floridae	O
DAPPU\|EnsemblGenome=DAPPUDRAFT_313427\|UniProtKB=E9G479	Daphnia pulex	O
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g240233\|UniProtKB=A7RRR3	Nematostella vectensis	O
NEUCR\|EnsemblGenome=NCU11286\|UniProtKB=A7UWH1	Neurospora crassa	O
PHANO\|EnsemblGenome=SNOG_05522\|UniProtKB=Q0URU2	Phaeosphaeria nodorum	O
AMBTC\|EnsemblGenome=AMTR_s00105p00011070\|UniProtKB=W1NSE1	Amborella trichopoda	O
NELNU\|Gene=LOC104587776\|UniProtKB=A0A1U7Z846	Nelumbo nucifera	O
HELAN\|EnsemblGenome=HanXRQr2_Chr08g0342271\|UniProtKB=A0A251VBE2	Helianthus annuus	O
LACSA\|Gene_ORFName=LSAT_V11C800388350\|UniProtKB=A0A9R1ULI7	Lactuca sativa	O
CAPAN\|EnsemblGenome=T459_10753\|UniProtKB=A0A2G3A338	Capsicum annuum	O
CAPAN\|EnsemblGenome=T459_10752\|UniProtKB=A0A2G3A350	Capsicum annuum	O
SOLTU\|EnsemblGenome=PGSC0003DMG400005738\|UniProtKB=M1A4R6	Solanum tuberosum	O
SOLLC\|EnsemblGenome=Solyc03g119060.3\|UniProtKB=Q5WM33	Solanum lycopersicum	O
TOBAC\|Gene=LOC107788258\|UniProtKB=A0A1S3ZLK4	Nicotiana tabacum	O
TOBAC\|Gene=LOC107788054\|UniProtKB=A0A1S3ZLL0	Nicotiana tabacum	O
TOBAC\|Gene=LOC107811991\|UniProtKB=A0A1S4BUD2	Nicotiana tabacum	O
VITVI\|EnsemblGenome=Vitvi17g00237\|UniProtKB=D7SJ80	Vitis vinifera	O
EUCGR\|EnsemblGenome=EUGRSUZ_K02262\|UniProtKB=A0A059A3A9	Eucalyptus grandis	O
BRANA\|Gene_ORFName=DARMORV10_A07P39540.1\|UniProtKB=A0A078J8K8	Brassica napus	O
BRACM\|EnsemblGenome=Bra015975\|UniProtKB=A0A3P6BI75	Brassica campestris	O
BRANA\|Gene_ORFName=GSBRNA2T00088021001\|UniProtKB=A0A078IEX1	Brassica napus	O
BRACM\|EnsemblGenome=Bra008107\|UniProtKB=M4CV61	Brassica campestris	O
BRANA\|Gene_ORFName=DARMORV10_C06P33900.1\|UniProtKB=A0A078FDM7	Brassica napus	O
BRACM\|EnsemblGenome=Bra003833\|UniProtKB=M4CI00	Brassica campestris	O
ARATH\|TAIR=locus=2027799\|UniProtKB=Q9C9U3	Arabidopsis thaliana	O
GOSHI\|Gene=LOC107899049\|UniProtKB=A0A1U8IW40	Gossypium hirsutum	O
CITSI\|Gene_ORFName=CISIN_1g0067401mg\|UniProtKB=A0A067FHE4	Citrus sinensis	O
POPTR\|EnsemblGenome=POPTR_012G049500v3\|UniProtKB=A0A2K1Y935	Populus trichocarpa	O
POPTR\|EnsemblGenome=POPTR_012G052800v3\|UniProtKB=A0A2K1Y979	Populus trichocarpa	O
MANES\|EnsemblGenome=MANES_14G168900\|UniProtKB=A0A2C9UND7	Manihot esculenta	O
RICCO\|Gene_ORFName=RCOM_0570940\|UniProtKB=B9SU86	Ricinus communis	O
SOYBN\|EnsemblGenome=GLYMA_08G051700\|UniProtKB=K7L518	Glycine max	O
MEDTR\|EnsemblGenome=MTR_8g106800\|UniProtKB=G7LD99	Medicago truncatula	O
JUGRE\|EnsemblGenome=Jr15_10330\|UniProtKB=A0A2I4FDG9	Juglans regia	O
JUGRE\|EnsemblGenome=Jr06_15190\|UniProtKB=A0A2I4HTA5	Juglans regia	O
CUCSA\|EnsemblGenome=Csa_1G024920\|UniProtKB=A0A0A0LPN7	Cucumis sativus	O
PRUPE\|EnsemblGenome=PRUPE_5G230200\|UniProtKB=M5WDX5	Prunus persica	O
AMBTC\|EnsemblGenome=AMTR_s00088p00083140\|UniProtKB=W1NXW2	Amborella trichopoda	O
MUSAM\|EnsemblGenome=Ma09_g16290\|UniProtKB=A0A804KK64	Musa acuminata subsp. malaccensis	O
MUSAM\|EnsemblGenome=Ma09_g18930\|UniProtKB=A0A804KL82	Musa acuminata subsp. malaccensis	O
MAIZE\|EnsemblGenome=Zm00001eb268320\|UniProtKB=H9BG22	Zea mays	O
ORYSJ\|EnsemblGenome=Os12g0448900\|UniProtKB=Q2QRV3	Oryza sativa	O
HORVV\|EnsemblGenome=HORVU.MOREX.r3.7HG0637280\|UniProtKB=A0A287VE25	Hordeum vulgare subsp. vulgare	O
HORVV\|EnsemblGenome=HORVU.MOREX.r3.7HG0637290\|UniProtKB=A0A8I6YZZ8	Hordeum vulgare subsp. vulgare	O
WHEAT\|EnsemblGenome=TraesCS4A02G090200\|UniProtKB=A0A3B6HT66	Triticum aestivum	O
WHEAT\|EnsemblGenome=TraesCS4A02G090300\|UniProtKB=A0A3B6HU14	Triticum aestivum	O
WHEAT\|EnsemblGenome=TraesCS3B02G549200\|UniProtKB=A0A3B6FXR6	Triticum aestivum	O
WHEAT\|EnsemblGenome=TraesCS3B02G549000\|UniProtKB=A0A077S030	Triticum aestivum	O
WHEAT\|EnsemblGenome=TraesCS5D02G183700\|UniProtKB=A0A3B6MPA3	Triticum aestivum	O
NELNU\|Gene_ORFName=HUJ06_005292\|UniProtKB=A0A1U8A0B8	Nelumbo nucifera	O
NELNU\|Gene_ORFName=HUJ06_005291\|UniProtKB=A0A1U7ZMH2	Nelumbo nucifera	O
HELAN\|EnsemblGenome=HanXRQr2_Chr07g0307781\|UniProtKB=A0A251T8Z4	Helianthus annuus	O
LACSA\|Gene_ORFName=LSAT_V11C200083440\|UniProtKB=A0A9R1WJ26	Lactuca sativa	O
LACSA\|Gene_ORFName=LSAT_V11C200083460\|UniProtKB=A0A9R1WAR4	Lactuca sativa	O
HELAN\|Gene_ORFName=HannXRQ_Chr14g0450081\|UniProtKB=A0A251SJY7	Helianthus annuus	O
HELAN\|Gene_ORFName=HannXRQ_Chr12g0385541\|UniProtKB=A0A251T6Y2	Helianthus annuus	O
HELAN\|EnsemblGenome=HanXRQr2_Chr14g0653861\|UniProtKB=A0A251SJN6	Helianthus annuus	O
HELAN\|EnsemblGenome=HanXRQr2_Chr14g0653921\|UniProtKB=A0A251SJ21	Helianthus annuus	O
HELAN\|Gene_ORFName=HanXRQr2_Chr14g0653791\|UniProtKB=A0A9K3ECF6	Helianthus annuus	O
HELAN\|Gene_ORFName=HanXRQr2_Chr07g0307821\|UniProtKB=A0A9K3IMI3	Helianthus annuus	O
HELAN\|EnsemblGenome=HanXRQr2_Chr14g0653821\|UniProtKB=A0A251SJS5	Helianthus annuus	O
LACSA\|Gene_ORFName=LSAT_V11C200083450\|UniProtKB=A0A9R1W6H2	Lactuca sativa	O
CAPAN\|EnsemblGenome=T459_06884\|UniProtKB=A0A1U8FRX6	Capsicum annuum	O
SOLTU\|EnsemblGenome=PGSC0003DMG400000505\|UniProtKB=M0ZIB2	Solanum tuberosum	O
SOLLC\|EnsemblGenome=Solyc02g087070.3\|UniProtKB=A0A3Q7FAG6	Solanum lycopersicum	O
TOBAC\|Gene=LOC107806116\|UniProtKB=A0A1S4B9X7	Nicotiana tabacum	O
CAPAN\|EnsemblGenome=T459_06887\|UniProtKB=A0A1U8FQJ9	Capsicum annuum	O
CAPAN\|EnsemblGenome=T459_06885\|UniProtKB=A0A2G3ABY4	Capsicum annuum	O
CAPAN\|EnsemblGenome=T459_06886\|UniProtKB=A0A2G3AC72	Capsicum annuum	O
SOLTU\|EnsemblGenome=PGSC0003DMG402000506\|UniProtKB=M0ZIB7	Solanum tuberosum	O
SOLLC\|EnsemblGenome=Solyc02g087110.3\|UniProtKB=A0A3Q7F8D0	Solanum lycopersicum	O
SOLTU\|EnsemblGenome=PGSC0003DMG401000506\|UniProtKB=M0ZIB4	Solanum tuberosum	O
SOLLC\|EnsemblGenome=Solyc02g087090.3\|UniProtKB=A0A3Q7FW38	Solanum lycopersicum	O
TOBAC\|Gene_ORFName=LOC107791409\|UniProtKB=A0A1S3ZX38	Nicotiana tabacum	O
TOBAC\|Gene=LOC107813858\|UniProtKB=A0A1S4C0Q1	Nicotiana tabacum	O
VITVI\|EnsemblGenome=Vitvi14g01808\|UniProtKB=D7TWT2	Vitis vinifera	O
VITVI\|EnsemblGenome=Vitvi14g01809\|UniProtKB=D7TWT5	Vitis vinifera	O
BRANA\|Gene_ORFName=DARMORV10_C09P75170.1\|UniProtKB=A0A078IGG8	Brassica napus	O
BRANA\|Gene_ORFName=DARMORV10_A05P44580.1\|UniProtKB=A0A078HL06	Brassica napus	O
BRACM\|EnsemblGenome=Bra039120\|UniProtKB=A0A397ZH06	Brassica campestris	O
ARATH\|TAIR=locus=2096697\|UniProtKB=Q9SGH6	Arabidopsis thaliana	O
GOSHI\|Gene=LOC107900136\|UniProtKB=A0A1U8IY92	Gossypium hirsutum	O
GOSHI\|Gene=LOC107938825\|UniProtKB=A0A1U8ML47	Gossypium hirsutum	O
GOSHI\|Gene=LOC107925999\|UniProtKB=A0A1U8LCC3	Gossypium hirsutum	O
THECC\|EnsemblGenome=TCM_016832\|UniProtKB=A0A061ED30	Theobroma cacao	O
THECC\|EnsemblGenome=TCM_016830\|UniProtKB=A0A061EJ51	Theobroma cacao	O
CITSI\|Gene_ORFName=CISIN_1g038600mg\|UniProtKB=A0A067FFX2	Citrus sinensis	O
POPTR\|EnsemblGenome=POPTR_008G106400v3\|UniProtKB=A0A2K1ZF68	Populus trichocarpa	O
MANES\|EnsemblGenome=MANES_17G124300\|UniProtKB=A0A2C9U8A1	Manihot esculenta	O
RICCO\|Gene_ORFName=RCOM_0852500\|UniProtKB=B9RUF7	Ricinus communis	O
RICCO\|Gene_ORFName=RCOM_0851850\|UniProtKB=B9RUD2	Ricinus communis	O
SOYBN\|EnsemblGenome=GLYMA_19G011800\|UniProtKB=A0A368UGC0	Glycine max	O
SOYBN\|EnsemblGenome=GLYMA_13G070900\|UniProtKB=I1LWD6	Glycine max	O
SOYBN\|EnsemblGenome=GLYMA_19G011700\|UniProtKB=I1N5V6	Glycine max	O
MEDTR\|EnsemblGenome=MTR_6g007770\|UniProtKB=A0A072U5H0	Medicago truncatula	O
MEDTR\|EnsemblGenome=MTR_6g007763\|UniProtKB=A0A072U6C1	Medicago truncatula	O
MEDTR\|EnsemblGenome=MTR_6g007767\|UniProtKB=A0A072U5G6	Medicago truncatula	O
JUGRE\|EnsemblGenome=Jr10_02970\|UniProtKB=A0A2I4FB51	Juglans regia	O
JUGRE\|EnsemblGenome=Jr10_02960\|UniProtKB=A0A2I4FB29	Juglans regia	O
CUCSA\|EnsemblGenome=Csa_3G829250\|UniProtKB=A0A0A0LC93	Cucumis sativus	O
CUCSA\|EnsemblGenome=Csa_3G829270\|UniProtKB=A0A0A0LG46	Cucumis sativus	O
CUCSA\|EnsemblGenome=Csa_3G829260\|UniProtKB=A0A0A0LHW3	Cucumis sativus	O
SELML\|EnsemblGenome=SELMODRAFT_229898\|UniProtKB=D8QQX3	Selaginella moellendorffii	O
PHYPA\|EnsemblGenome=Pp3c26_4220\|UniProtKB=A0A7I4CTJ7	Physcomitrella patens	O
MARPO\|EnsemblGenome=MARPO_0089s0042\|UniProtKB=A0A2R6WHU1	Marchantia polymorpha	O
MARPO\|EnsemblGenome=MARPO_0031s0055\|UniProtKB=A0A2R6X7J4	Marchantia polymorpha	O
KLENI\|Gene_ORFName=KFL_000460035\|UniProtKB=A0A1Y1HSW4	Klebsormidium nitens	O
KLENI\|Gene_ORFName=KFL_002730060\|UniProtKB=A0A1Y1IDI0	Klebsormidium nitens	O