PANTHER Gene Information

Gene Symbol(s):

Cttn

Organism:

Rattus norvegicus

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Gene Name:

Src substrate cortactin

Gene ID:

619839

Protein ID:

Q66HL2

Persistent Id:

PTN000089232

Alternate Ids:

60465(GeneID)	619839(RGD)
SRC8(Synonym)	Cttn{ECO:0000312\|RGD:619839}(Symbol)
AAH81802(EMBL-CDS)	BC081802(EMBL)
XM_017590270(refSeq)	76563930(GI)
SRC8_RAT(UniProtKB-ID)	D3ZRB0(AltAccession)
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PANTHER Classification

PANTHER Family:	CORTACTIN AND DREBRIN (PTHR10829)
PANTHER Subfamily:	SRC SUBSTRATE CORTACTIN (PTHR10829:SF15)
PANTHER GO-slim Molecular Function:	actin filament binding
PANTHER GO-slim Biological Process:	regulation of actin filament polymerization cell migration
PANTHER GO-slim Cellular Component:	site of polarized growth lamellipodium plasma membrane actin filament cortical actin cytoskeleton
PANTHER protein class:	non-motor actin binding protein

Pathway Categories:

No pathway information available

GENE ONTOLOGY DATABASE ANNOTATIONS

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GO MF Complete:	actin filament binding, proline-rich region binding, protein binding, profilin binding, Arp2/3 complex binding
GO BP Complete:	regulation of cell projection assembly, neuron projection morphogenesis, extrinsic apoptotic signaling pathway, intracellular protein transport, substrate-dependent cell migration, cell extension, receptor-mediated endocytosis, dendritic spine maintenance, regulation of mitophagy, positive regulation of smooth muscle contraction, lamellipodium organization, modification of postsynaptic structure, regulation of actin filament polymerization, cell motility, regulation of axon extension, modification of postsynaptic actin cytoskeleton, positive regulation of actin filament polymerization, negative regulation of extrinsic apoptotic signaling pathway, focal adhesion assembly, cell migration, actin cytoskeleton organization, positive regulation of chemotaxis
GO CC Complete:	voltage-gated potassium channel complex, endoplasmic reticulum, Golgi apparatus, actin filament, plasma membrane, podosome, growth cone, mitotic spindle midzone, site of polarized growth, postsynapse, postsynaptic actin cytoskeleton, focal adhesion, cytoplasm, clathrin-coated pit, cell cortex, intracellular membrane-bounded organelle, dendritic spine, ruffle, cytosol, cell junction, glutamatergic synapse, cortical actin cytoskeleton, lamellipodium, cortical cytoskeleton

REACTOME DATABASE ANNOTATIONS Click to Expand...

Reactome Pathways:

Orthologs

ID	Organism	Type
PANTR\|Ensembl=ENSPTRG00000049553.1\|UniProtKB=K7BUV0	Pan troglodytes	LDO
GORGO\|Ensembl=ENSGGOG00000003011.3\|UniProtKB=A0A2I2Y2E1	Gorilla gorilla gorilla	LDO
MACMU\|Ensembl=ENSMMUG00000013267.4\|UniProtKB=H9FR13	Macaca mulatta	LDO
MOUSE\|MGI=MGI=99695\|UniProtKB=Q60598	Mus musculus	LDO
BOVIN\|Ensembl=ENSBTAG00000006071.5\|UniProtKB=Q1RMR3	Bos taurus	LDO
PIG\|Ensembl=ENSSSCG00000031769.3\|UniProtKB=A0A5G2QWJ7	Sus scrofa	LDO
HORSE\|Ensembl=ENSECAG00000021450.4\|UniProtKB=F6WKM3	Equus caballus	LDO
FELCA\|Ensembl=ENSFCAG00000004767.5\|UniProtKB=M3W2T5	Felis catus	LDO
CANLF\|Ensembl=ENSCAFG00845013798.1\|UniProtKB=A0A8I3NGK5	Canis lupus familiaris	LDO
MONDO\|Ensembl=ENSMODG00000045767.1\|UniProtKB=A0A5F8G3J7	Monodelphis domestica	LDO
ORNAN\|Ensembl=ENSOANG00000007408.4\|UniProtKB=F7CIG5	Ornithorhynchus anatinus	LDO
CHICK\|Ensembl=ENSGALG00010024767.1\|UniProtKB=A0A8V1A211	Gallus gallus	LDO
CHICK\|Gene=CTTN1\|UniProtKB=Q01406	Gallus gallus	LDO
ANOCA\|Ensembl=ENSACAG00000003923.4\|UniProtKB=H9G8E2	Anolis carolinensis	LDO
XENLA\|Gene=cttn.S\|UniProtKB=B7ZQN6	Xenopus laevis	O
XENLA\|Gene=cttn.L\|UniProtKB=Q6GNQ0	Xenopus laevis	LDO
XENTR\|Gene=cttn\|UniProtKB=A0A8J1JCG8	Xenopus tropicalis	LDO
ORYLA\|Ensembl=ENSORLG00000000034.2\|UniProtKB=H2L2U4	Oryzias latipes	LDO
LEPOC\|Ensembl=ENSLOCG00000005239.1\|UniProtKB=W5MD49	lepisosteus oculatus	LDO
CIOIN\|Ensembl=ENSCING00000008480.3\|UniProtKB=F6T3V6	Ciona intestinalis	O
BRAFL\|Gene=LOC118406421\|UniProtKB=A0A9J7HMX7	Branchiostoma floridae	O
STRPU\|EnsemblGenome=GeneID_373471\|UniProtKB=A0A7M7P583	Strongylocentrotus purpuratus	O
PRIPA\|EnsemblGenome=WBGene00107989\|UniProtKB=A0A2A6CZF5	Pristionchus pacificus	O
DROME\|FlyBase=FBgn0025865\|UniProtKB=Q9VDF4	Drosophila melanogaster	O
ANOGA\|EnsemblGenome=AGAP004625\|UniProtKB=Q5TRW2	Anopheles gambiae	O
DAPPU\|EnsemblGenome=DAPPUDRAFT_305633\|UniProtKB=E9FWW1	Daphnia pulex	O
IXOSC\|EnsemblGenome=ISCW000141\|UniProtKB=B7P0V4	Ixodes scapularis	O
HELRO\|EnsemblGenome=HelroG111918\|UniProtKB=T1EFF8	helobdella robusta	O
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g79346\|UniProtKB=A7RF47	Nematostella vectensis	O
TRIAD\|EnsemblGenome=TriadG21918\|UniProtKB=B3RT04	Trichoplax adhaerens	O
MONBE\|EnsemblGenome=MONBRDRAFT_33251\|UniProtKB=A9V4D3	Monosiga brevicollis	O
CANAL\|CGD=CAL0000185371\|UniProtKB=Q5AQ36	Candida albicans	O
YARLI\|EnsemblGenome=YALI0_D04048g\|UniProtKB=Q6CAC5	Yarrowia lipolytica	O
YEAST\|SGD=S000000684\|UniProtKB=P15891	Saccharomyces cerevisiae	O
EREGS\|EnsemblGenome=AGOS_AGL237C\|UniProtKB=Q751E3	Eremothecium gossypii	O
CANAL\|CGD=CAL0000190151\|UniProtKB=Q5AFA8	Candida albicans	O
YARLI\|EnsemblGenome=YALI0_B14102g\|UniProtKB=Q6CEP4	Yarrowia lipolytica	O
EMENI\|EnsemblGenome=ANIA_11139\|UniProtKB=C8VLV0	Emericella nidulans	O
ASPFU\|EnsemblGenome=AFUA_8G02850\|UniProtKB=Q4WBM8	Neosartorya fumigata	O
NEUCR\|EnsemblGenome=NCU10073\|UniProtKB=Q7S016	Neurospora crassa	O
SCLS1\|Gene_ORFName=SS1G_07643\|UniProtKB=A7EQP0	Sclerotinia sclerotiorum	O
PHANO\|EnsemblGenome=SNOG_04101\|UniProtKB=Q0UVW3	Phaeosphaeria nodorum	O
SCHPO\|PomBase=SPAPJ760.02c\|UniProtKB=Q9P7E8	Schizosaccharomyces pombe	O
SCHJY\|EnsemblGenome=SJAG_02566\|UniProtKB=B6K0L0	Schizosaccharomyces japonicus	O
CRYNJ\|EnsemblGenome=CND04880\|UniProtKB=Q5KHY4	Cryptococcus neoformans	O
USTMA\|EnsemblGenome=UMAG_05340\|UniProtKB=A0A0D1DPG9	Ustilago maydis	O
PUCGT\|EnsemblGenome=PGTG_19395\|UniProtKB=E3LAA8	Puccinia graminis	O
PUCGT\|EnsemblGenome=PGTG_20551\|UniProtKB=E3NYE6	Puccinia graminis	O
BATDJ\|Gene_ORFName=BATDEDRAFT_92572\|UniProtKB=F4PDW4	Batrachochytrium dendrobatidis	O
ENTH1\|EnsemblGenome=CL6EHI_164480\|UniProtKB=C4M1S9	Entamoeba histolytica	O
ENTH1\|EnsemblGenome=CL6EHI_035630\|UniProtKB=C4LXZ3	Entamoeba histolytica	O
ENTH1\|EnsemblGenome=CL6EHI_092320\|UniProtKB=C4LUZ6	Entamoeba histolytica	O
ENTH1\|EnsemblGenome=CL6EHI_118750\|UniProtKB=C4LYM3	Entamoeba histolytica	O
DICDI\|dictyBase=DDB_G0283837\|UniProtKB=Q54QG8	Dictyostelium discoideum	O
DICPU\|EnsemblGenome=DICPUDRAFT_84356\|UniProtKB=F1A2E6	Dictyostelium purpureum	O
DICDI\|dictyBase=DDB_G0290593\|UniProtKB=Q54FU0	Dictyostelium discoideum	O
DICPU\|EnsemblGenome=DICPUDRAFT_9196\|UniProtKB=F0ZZB7	Dictyostelium purpureum	O
DICPU\|EnsemblGenome=DICPUDRAFT_57957\|UniProtKB=F0ZYD7	Dictyostelium purpureum	O
DICPU\|EnsemblGenome=DICPUDRAFT_48521\|UniProtKB=F0ZPH2	Dictyostelium purpureum	O
DICDI\|dictyBase=DDB_G0270134\|UniProtKB=Q55CB2	Dictyostelium discoideum	O
DICDI\|dictyBase=DDB_G0270132\|UniProtKB=Q55CB3	Dictyostelium discoideum	O
DICPU\|EnsemblGenome=DICPUDRAFT_148253\|UniProtKB=F0ZAN0	Dictyostelium purpureum	O
ENTH1\|EnsemblGenome=CL6EHI_054800\|UniProtKB=C4M2J9	Entamoeba histolytica	O
ENTH1\|EnsemblGenome=CL6EHI_180030\|UniProtKB=C4M654	Entamoeba histolytica	O
ENTH1\|EnsemblGenome=CL6EHI_186840\|UniProtKB=C4LVQ1	Entamoeba histolytica	O
ENTH1\|EnsemblGenome=CL6EHI_168340\|UniProtKB=C4M4P4	Entamoeba histolytica	O
DICDI\|dictyBase=DDB_G0273447\|UniProtKB=Q557J6	Dictyostelium discoideum	O
DICPU\|EnsemblGenome=DICPUDRAFT_84230\|UniProtKB=F1A1Z7	Dictyostelium purpureum	O
DICDI\|dictyBase=DDB_G0277615\|UniProtKB=Q75JY8	Dictyostelium discoideum	O
DICPU\|EnsemblGenome=DICPUDRAFT_91304\|UniProtKB=F0ZAH0	Dictyostelium purpureum	O
DICDI\|dictyBase=DDB_G0295683\|UniProtKB=B0G198	Dictyostelium discoideum	O
DICDI\|dictyBase=DDB_G0293898\|UniProtKB=P34121	Dictyostelium discoideum	O
DICPU\|EnsemblGenome=DICPUDRAFT_88560\|UniProtKB=F0ZQ44	Dictyostelium purpureum	O
DICPU\|EnsemblGenome=DICPUDRAFT_45162\|UniProtKB=F0Z975	Dictyostelium purpureum	O
LEIMA\|EnsemblGenome=LMJF_30_2570\|UniProtKB=Q4Q738	Leishmania major	O
TRYB2\|Gene_ORFName=Tb927.6.3830\|UniProtKB=Q585Y1	Trypanosoma brucei	O
TRIV3\|Gene_ORFName=TVAG_203740\|UniProtKB=A2ETF0	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_402260\|UniProtKB=A2DHY3	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_382030\|UniProtKB=A2F2A6	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_150940\|UniProtKB=A2FM06	Trichomonas vaginalis	O
KLENI\|Gene_ORFName=KFL_000950230\|UniProtKB=A0A1Y1HZJ1	Klebsormidium nitens	O