PANTHER Gene Information   
Gene Symbol(s): Dab2ip
Organism: Rattus norvegicus
View Gene in Tree
Tree Reduced Tree  
Tree Reduced Tree
Gene Name: Disabled homolog 2-interacting protein
Gene ID: 621686
Protein ID: Q6P730
Persistent Id: PTN000023120
Alternate Ids:
AAK93947(EMBL-CDS) AF236130(EMBL)
NP_619724(refSeq) 15277525(GI)
DAB2P_RAT(UniProtKB-ID) Q924M9(AltAccession)
621686(RGD) 192126(GeneID)
Dab2ip(Symbol) DAB2P(Synonym)
Show All

PANTHER Classification
PANTHER Family: RAS GTPASE-ACTIVATING PROTEINS (PTHR10194)
PANTHER Subfamily: DISABLED HOMOLOG 2-INTERACTING PROTEIN (PTHR10194:SF26)  
PANTHER GO-slim Molecular Function:
PANTHER GO-slim Biological Process:
PANTHER GO-slim Cellular Component:
PANTHER protein class: GTPase-activating protein
Pathway Categories: EGF receptor signaling pathway
   GTPase-Activating Protein
GENE ONTOLOGY DATABASE ANNOTATIONS      Click to Expand...
GO MF Complete: protein kinase binding, phosphatidylinositol 3-kinase binding, identical protein binding, phosphatidylinositol 3-kinase regulatory subunit binding, protein homodimerization activity, protein serine/threonine kinase activator activity, signaling adaptor activity, GTPase activator activity, death receptor binding, protein-containing complex binding, phosphatidylinositol-4-phosphate binding, protein binding, vascular endothelial growth factor receptor 2 binding, SH3 domain binding, phosphatidylinositol-3-phosphate binding, mitogen-activated protein kinase kinase kinase binding, kinase binding, protein phosphatase 2A binding, mitogen-activated protein kinase kinase binding, 14-3-3 protein binding
GO BP Complete: negative regulation of angiogenesis, negative regulation of protein catabolic process, extrinsic apoptotic signaling pathway via death domain receptors, negative regulation of epidermal growth factor receptor signaling pathway, negative regulation of Ras protein signal transduction, negative regulation of DNA-templated transcription, negative regulation of cell growth, negative regulation of vascular endothelial growth factor receptor signaling pathway, positive regulation of neuron projection development, regulation of cell cycle, vascular endothelial growth factor receptor-2 signaling pathway, positive regulation of epithelial cell proliferation, intracellular signal transduction, negative regulation of toll-like receptor 4 signaling pathway, positive regulation of protein catabolic process, regulation of p38MAPK cascade, negative regulation of epithelial cell proliferation, cellular response to epidermal growth factor stimulus, negative regulation of G0 to G1 transition, tube formation, negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction, layer formation in cerebral cortex, negative regulation of cell population proliferation, cell motility involved in cerebral cortex radial glia guided migration, positive regulation of canonical NF-kappaB signal transduction, neuron projection morphogenesis, regulation of canonical NF-kappaB signal transduction, negative regulation of canonical NF-kappaB signal transduction, positive regulation of transcription by RNA polymerase II, positive regulation of proteasomal protein catabolic process, response to unfolded protein, negative regulation of transcription by RNA polymerase II, negative regulation of vascular endothelial growth factor signaling pathway, negative regulation of epithelial to mesenchymal transition, angiogenesis, negative regulation of fibroblast proliferation, negative regulation of epithelial cell migration, cellular response to tumor necrosis factor, negative regulation of endothelial cell migration, positive regulation of protein-containing complex assembly, positive regulation of neuron migration, positive regulation of synapse maturation, protein catabolic process, regulation of protein-containing complex assembly, positive regulation of MAPK cascade, positive regulation of dendrite development, negative regulation of canonical Wnt signaling pathway, cellular response to lipopolysaccharide, positive regulation of JNK cascade, negative regulation of ERK1 and ERK2 cascade, positive regulation of apoptotic process, cellular response to interleukin-1, cellular response to vascular endothelial growth factor stimulus, intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress, positive regulation of apoptotic signaling pathway
GO CC Complete: endocytic vesicle, dendrite, AIP1-IRE1 complex, cytoplasm, cerebellar mossy fiber, neuronal cell body membrane, neuronal cell body, climbing fiber, plasma membrane, axon, parallel fiber
REACTOME DATABASE ANNOTATIONS   Click to Expand...
Reactome Pathways: MAPK1/MAPK3 signaling, MAPK family signaling cascades, Regulation of RAS by GAPs, Signal Transduction, RAF/MAP kinase cascade

Orthologs