PANTHER Gene Information

Gene Symbol(s):

S2P

Organism:

Drosophila melanogaster

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Gene Name:

Membrane-bound transcription factor site-2 protease

Gene ID:

FBgn0033656

Protein ID:

Q7JZ56

Persistent Id:

PTN000330432

Alternate Ids:

NM_136861(refSeq)	19922044(GI)
AAL49151(EMBL-CDS)	FBgn0033656(Ensembl)
Q7JZ56_DROME(UniProtKB-ID)	AF441757(EMBL)
FBtr0088063(Ensembl_TRS)	Q7JZ56(Synonym)
FBgn0033656(FlyBase)	FBpp0087169(Ensembl_PRO)
36262(GeneID)
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PANTHER Classification

PANTHER Family:	PROTEASE M50 MEMBRANE-BOUND TRANSCRIPTION FACTOR SITE 2 PROTEASE (PTHR13325)
PANTHER Subfamily:	MEMBRANE-BOUND TRANSCRIPTION FACTOR SITE-2 PROTEASE (PTHR13325:SF3)
PANTHER GO-slim Molecular Function:	metalloendopeptidase activity
PANTHER GO-slim Biological Process:	membrane protein proteolysis
PANTHER GO-slim Cellular Component:	cytoplasm
PANTHER protein class:	metalloprotease

Pathway Categories:

No pathway information available

GENE ONTOLOGY DATABASE ANNOTATIONS

Click to Expand...

GO MF Complete:	metalloendopeptidase activity
GO BP Complete:	regulation of response to endoplasmic reticulum stress, membrane protein intracellular domain proteolysis, proteolysis
GO CC Complete:	cytoplasm, membrane

REACTOME DATABASE ANNOTATIONS Click to Expand...

Reactome Pathways:

Metabolism of steroids, Metabolism, ATF6B (ATF6-beta) activates chaperones, Regulation of cholesterol biosynthesis by SREBP (SREBF), Cellular responses to stress, Unfolded Protein Response (UPR), Cellular responses to stimuli, Metabolism of lipids, ATF6 (ATF6-alpha) activates chaperones

Orthologs

ID	Organism	Type
HUMAN\|HGNC=15455\|UniProtKB=O43462	Homo sapiens	LDO
PANTR\|Ensembl=ENSPTRG00000021735.5\|UniProtKB=K7DAA0	Pan troglodytes	LDO
GORGO\|Ensembl=ENSGGOG00000012064.3\|UniProtKB=G3R8Q6	Gorilla gorilla gorilla	LDO
MOUSE\|MGI=MGI=2444506\|UniProtKB=Q8CHX6	Mus musculus	LDO
BOVIN\|Ensembl=ENSBTAG00000008183\|UniProtKB=Q0III2	Bos taurus	LDO
PIG\|Ensembl=ENSSSCG00000012165.6\|UniProtKB=A0A5G2QWX7	Sus scrofa	LDO
FELCA\|Ensembl=ENSFCAG00000029861.4\|UniProtKB=A0A2I2USK0	Felis catus	LDO
CANLF\|Ensembl=ENSCAFG00845029854.1\|UniProtKB=A0A8I3Q4F4	Canis lupus familiaris	LDO
MONDO\|Ensembl=ENSMODG00000007926.4\|UniProtKB=A0A5F8GF19	Monodelphis domestica	LDO
ORNAN\|Ensembl=ENSOANG00000044594.1\|UniProtKB=A0A6I8NWP5	Ornithorhynchus anatinus	LDO
CHICK\|Ensembl=ENSGALG00010003275.1\|UniProtKB=A0A3Q2TYD2	Gallus gallus	LDO
ANOCA\|Ensembl=ENSACAG00000016735.4\|UniProtKB=G1KT01	Anolis carolinensis	LDO
XENLA\|Gene=mbtps2.L\|UniProtKB=A0A1L8HDN7	Xenopus laevis	LDO
XENTR\|Xenbase=XB-GENE-953524\|UniProtKB=F6QLY7	Xenopus tropicalis	LDO
ORYLA\|Ensembl=ENSORLG00000014065.2\|UniProtKB=A0A3B3I1E2	Oryzias latipes	LDO
DANRE\|ZFIN=ZDB-GENE-030131-6598\|UniProtKB=Q4V9P5	Danio rerio	LDO
LEPOC\|Ensembl=ENSLOCG00000003747.1\|UniProtKB=W5M7V7	lepisosteus oculatus	LDO
CIOIN\|Ensembl=ENSCING00000007631.3\|UniProtKB=F6XNG1	Ciona intestinalis	LDO
BRAFL\|Gene=LOC118422803\|UniProtKB=A0A9J7LP07	Branchiostoma floridae	LDO
STRPU\|EnsemblGenome=LOC582844\|UniProtKB=A0A7M7PI39	Strongylocentrotus purpuratus	LDO
CAEEL\|WormBase=WBGene00013225\|UniProtKB=Q9U227	Caenorhabditis elegans	LDO
CAEBR\|WormBase=WBGene00034082\|UniProtKB=A8XHI8	Caenorhabditis briggsae	LDO
PRIPA\|EnsemblGenome=WBGene00281614\|UniProtKB=A0A2A6CDX9	Pristionchus pacificus	LDO
ANOGA\|EnsemblGenome=AGAP011819\|UniProtKB=Q7PZA9	Anopheles gambiae	LDO
TRICA\|EnsemblGenome=TC000469\|UniProtKB=D6WA43	Tribolium castaneum	LDO
DAPPU\|EnsemblGenome=DAPPUDRAFT_326128\|UniProtKB=E9H6T5	Daphnia pulex	LDO
IXOSC\|EnsemblGenome=ISCW019725\|UniProtKB=B7PTD0	Ixodes scapularis	LDO
HELRO\|EnsemblGenome=HelroG107238\|UniProtKB=T1EE89	helobdella robusta	LDO
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g185856\|UniProtKB=A7S5C2	Nematostella vectensis	LDO
TRIAD\|EnsemblGenome=TriadG24878\|UniProtKB=B3RYA0	Trichoplax adhaerens	LDO
CRYNJ\|EnsemblGenome=CNF02350\|UniProtKB=Q5KFB2	Cryptococcus neoformans	LDO
PUCGT\|EnsemblGenome=PGTG_02405\|UniProtKB=E3JY19	Puccinia graminis	LDO
DICDI\|dictyBase=DDB_G0275939\|UniProtKB=Q552N4	Dictyostelium discoideum	LDO
DICPU\|EnsemblGenome=DICPUDRAFT_91002\|UniProtKB=F1A6C9	Dictyostelium purpureum	LDO
AMBTC\|EnsemblGenome=AMTR_s00068p00204430\|UniProtKB=U5D4P1	Amborella trichopoda	LDO
MUSAM\|EnsemblGenome=Ma05_g09160\|UniProtKB=A0A804J2J9	Musa acuminata subsp. malaccensis	LDO
SORBI\|EnsemblGenome=SORBI_3003G241100\|UniProtKB=A0A1B6Q549	Sorghum bicolor	LDO
MAIZE\|EnsemblGenome=Zm00001eb158090\|UniProtKB=A0A1D6NH37	Zea mays	LDO
BRADI\|EnsemblGenome=BRADI_2g45400v3\|UniProtKB=A0A2K2DE27	Brachypodium distachyon	LDO
HORVV\|EnsemblGenome=HORVU.MOREX.r3.3HG0276510\|UniProtKB=A0A8I6X229	Hordeum vulgare subsp. vulgare	LDO
WHEAT\|EnsemblGenome=TraesCS3D02G237200\|UniProtKB=A0A3B6GU91	Triticum aestivum	O
WHEAT\|EnsemblGenome=TraesCS3A02G236800\|UniProtKB=A0A3B6EIR6	Triticum aestivum	O
WHEAT\|EnsemblGenome=TraesCS3B02G263000\|UniProtKB=A0A3B6FR51	Triticum aestivum	LDO
NELNU\|Gene=LOC104599827\|UniProtKB=A0A1U8AFX3	Nelumbo nucifera	LDO
SPIOL\|Gene=LOC110782937\|UniProtKB=A0A9R0I586	Spinacia oleracea	LDO
HELAN\|EnsemblGenome=HanXRQr2_Chr14g0640621\|UniProtKB=A0A251SGD7	Helianthus annuus	LDO
LACSA\|Gene_ORFName=LSAT_V11C200071860\|UniProtKB=A0A9R1WEH4	Lactuca sativa	LDO
ERYGU\|Gene_ORFName=MIMGU_mgv1a005741mg\|UniProtKB=A0A022RXB7	Erythranthe guttata	O
ERYGU\|Gene_ORFName=MIMGU_mgv1a026360mg\|UniProtKB=A0A022RD60	Erythranthe guttata	LDO
CAPAN\|EnsemblGenome=T459_02188\|UniProtKB=A0A2G3AJ79	Capsicum annuum	LDO
SOLTU\|EnsemblGenome=PGSC0003DMG402016926\|UniProtKB=M1BEW9	Solanum tuberosum	LDO
SOLLC\|EnsemblGenome=Solyc01g020525.1\|UniProtKB=A0A3Q7ECZ4	Solanum lycopersicum	O
SOLLC\|EnsemblGenome=Solyc01g049910.3\|UniProtKB=A0A3Q7EDM3	Solanum lycopersicum	LDO
TOBAC\|Gene=LOC107823653\|UniProtKB=A0A1S4CXS5	Nicotiana tabacum	LDO
EUCGR\|EnsemblGenome=EUGRSUZ_E04333\|UniProtKB=A0A059CBH5	Eucalyptus grandis	LDO
BRANA\|EnsemblGenome=GSBRNA2T00065203001\|UniProtKB=A0A078JMF2	Brassica napus	LDO
BRACM\|EnsemblGenome=Bra013454\|UniProtKB=M4DAE4	Brassica campestris	LDO
ARATH\|TAIR=locus=2120352\|UniProtKB=F4JUU5	Arabidopsis thaliana	LDO
GOSHI\|Gene=LOC107893637\|UniProtKB=A0A1U8I7E8	Gossypium hirsutum	LDO
GOSHI\|Gene=LOC107918360\|UniProtKB=A0A1U8KLQ3	Gossypium hirsutum	O
THECC\|EnsemblGenome=TCM_026662\|UniProtKB=A0A061F386	Theobroma cacao	LDO
POPTR\|EnsemblGenome=POPTR_003G157800v3\|UniProtKB=A0A2K2B7T3	Populus trichocarpa	LDO
MANES\|EnsemblGenome=MANES_18G124500\|UniProtKB=A0A251ISR2	Manihot esculenta	LDO
RICCO\|Gene_ORFName=RCOM_0096190\|UniProtKB=B9T384	Ricinus communis	LDO
SOYBN\|EnsemblGenome=GLYMA_16G096000\|UniProtKB=A0A368UGX6	Glycine max	LDO
MEDTR\|EnsemblGenome=MTR_8g070630\|UniProtKB=G7L723	Medicago truncatula	LDO
JUGRE\|EnsemblGenome=Jr03_16930\|UniProtKB=A0A2I4EEA9	Juglans regia	LDO
CUCSA\|EnsemblGenome=Csa_5G139060\|UniProtKB=A0A0A0KQ25	Cucumis sativus	LDO
PRUPE\|EnsemblGenome=PRUPE_4G123400\|UniProtKB=A0A251PKZ1	Prunus persica	LDO
NITMS\|EnsemblGenome=Nmar_0107\|UniProtKB=A9A146	Nitrosopumilus maritimus	LDO
KORCO\|EnsemblGenome=Kcr_1459\|UniProtKB=B1L6X6	Korarchaeum cryptofilum	LDO
SACS2\|EnsemblGenome=SSO0087\|UniProtKB=Q7LXZ3	Sulfolobus solfataricus	LDO
PYRAE\|EnsemblGenome=PAE1702\|UniProtKB=Q8ZWN5	Pyrobaculum aerophilum	LDO
METAC\|EnsemblGenome=MA_2449\|UniProtKB=Q8TN44	Methanosarcina acetivorans	LDO
METJA\|EnsemblGenome=MJ_0971\|UniProtKB=Q58381	Methanocaldococcus jannaschii	LDO
HALSA\|EnsemblGenome=VNG_2019C\|UniProtKB=Q9HNN6	Halobacterium salinarum	LDO
THEKO\|EnsemblGenome=TK1820\|UniProtKB=Q5JDV9	Thermococcus kodakaraensis	LDO