PANTHER Gene Information   
Gene Symbol(s): CREB1
Organism: Gallus gallus
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Gene Name: cAMP response element-binding protein
Gene ID: ENSGALG00010025351.1
Protein ID: Q7SX83
Persistent Id: PTN000536874
Alternate Ids:
Q7SX83_CHICK(UniProtKB-ID) 45383261(GI)
XP_015144857(refSeq) Q7SX83(Synonym)
AF516339(EMBL) ENSGALT00010061903(Ensembl_TRS)
ENSGALP00010038218(Ensembl_PRO) ENSGALG00010025351(Ensembl)
AAP47151(EMBL-CDS) 395099(GeneID)
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PANTHER Classification
PANTHER Family: CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN B (PTHR45879)
PANTHER Subfamily: CYCLIC AMP-RESPONSIVE ELEMENT-BINDING PROTEIN 1 (PTHR45879:SF1)  
PANTHER GO-slim Molecular Function: DNA-binding transcription factor activity, RNA polymerase II-specific
RNA polymerase II cis-regulatory region sequence-specific DNA binding
PANTHER GO-slim Biological Process: regulation of transcription by RNA polymerase II
PANTHER GO-slim Cellular Component: RNA polymerase II transcription regulator complex
PANTHER protein class: basic leucine zipper transcription factor
Pathway Categories: Transcription regulation by bZIP transcription factor
   cAMP response element binding protein
Enkephalin release
   cAMP response element binding protein
Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
   CREB binding protein
Gonadotropin-releasing hormone receptor pathway
   CREB
p38 MAPK pathway
   cAMP response element binding protein
CCKR signaling map
   CREB1
Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
   cAMP response element binding protein
Apoptosis signaling pathway
   Activating transcription factor

GO MF Complete: cAMP response element binding, identical protein binding, RNA polymerase II-specific DNA-binding transcription factor binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, RNA polymerase II-specific, enzyme binding
GO BP Complete: secretory granule organization, regulation of cell size, positive regulation of fat cell differentiation, lung epithelium development, response to xenobiotic stimulus, positive regulation of transcription by RNA polymerase II, hormone secretion, memory, positive regulation of multicellular organism growth, cellular response to zinc ion, positive regulation of osteoclast differentiation, axonogenesis, positive regulation of cardiac muscle tissue development, mRNA transcription by RNA polymerase II, cellular response to forskolin, response to purine-containing compound, positive regulation of hormone secretion, circadian rhythm, regulation of transcription by RNA polymerase II, pituitary gland development, positive regulation of lipid biosynthetic process, osteoclast differentiation, cellular response to leukemia inhibitory factor, negative regulation of transcription by competitive promoter binding, cellular response to retinoic acid, cellular response to hepatocyte growth factor stimulus, negative regulation of apoptotic process, response to glucagon, protein stabilization, cAMP/PKA signal transduction, regulation of testosterone biosynthetic process
GO CC Complete: euchromatin, ATF4-CREB1 transcription factor complex, nucleoplasm
Reactome Pathways: MyD88:MAL(TIRAP) cascade initiated on plasma membrane, Nuclear Events (kinase and transcription factor activation), CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling, Toll Like Receptor 4 (TLR4) Cascade, Intracellular signaling by second messengers, Nervous system development, Signaling by NTRK1 (TRKA), MAPK targets/ Nuclear events mediated by MAP kinases, ESR-mediated signaling, TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation, Extra-nuclear estrogen signaling, Gastrin-CREB signalling pathway via PKC and MAPK, Innate Immune System, Activation of NMDA receptors and postsynaptic events, Signaling by Interleukins, Signaling by Receptor Tyrosine Kinases, PIP3 activates AKT signaling, Toll Like Receptor 3 (TLR3) Cascade, Signal Transduction, Signaling by Nuclear Receptors, MAP kinase activation, NCAM signaling for neurite out-growth, CREB phosphorylation, Post NMDA receptor activation events, G alpha (q) signalling events, Toll-like Receptor Cascades, Toll Like Receptor 9 (TLR9) Cascade, NGF-stimulated transcription, Axon guidance, GPCR downstream signalling, Toll Like Receptor 5 (TLR5) Cascade, Interleukin-17 signaling, Toll Like Receptor TLR1:TLR2 Cascade, Immune System, Toll Like Receptor 2 (TLR2) Cascade, Toll Like Receptor 7/8 (TLR7/8) Cascade, MyD88 dependent cascade initiated on endosome, Developmental Biology, MyD88 cascade initiated on plasma membrane, Signaling by NTRKs, Toll Like Receptor 10 (TLR10) Cascade, Toll Like Receptor TLR6:TLR2 Cascade, MyD88-independent TLR4 cascade , TRIF(TICAM1)-mediated TLR4 signaling , Neuronal System, Transmission across Chemical Synapses, Neurotransmitter receptors and postsynaptic signal transmission, AKT phosphorylates targets in the nucleus, Cytokine Signaling in Immune system, Estrogen-dependent nuclear events downstream of ESR-membrane signaling, Signaling by GPCR