PANTHER Gene Information

Gene Symbol(s):

DENND4A

Organism:

Homo sapiens

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Gene Name:

C-myc promoter-binding protein

Gene ID:

HGNC:24321

Protein ID:

Q7Z401

Enhancers:

View enhancers for HUMAN|HGNC=24321|UniProtKB=Q7Z401

Genetic Variant Annotation:

Annoq

Persistent Id:

PTN002487262

Alternate Ids:

88909230(GI)	XM_005254121(refSeq)
DENN domain-containing protein 4A(Synonym)	ENSG00000174485(Ensembl)
AL832602(EMBL)	DENND4A(Symbol)
10260(GeneID)	BAC03648(EMBL-CDS)
600382(MIM)	HGNC:24321(HGNC)
Q8IVX2(AltAccession)	MYCPP_HUMAN(UniProtKB-ID)
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PANTHER Classification

PANTHER Family:	DENN DOMAIN-CONTAINING PROTEIN 4 (PTHR12296)
PANTHER Subfamily:	C-MYC PROMOTER-BINDING PROTEIN (PTHR12296:SF16)
PANTHER GO-slim Molecular Function:
PANTHER GO-slim Biological Process:	regulation of small GTPase mediated signal transduction
PANTHER GO-slim Cellular Component:	cytoplasmic vesicle
PANTHER protein class:	guanyl-nucleotide exchange factor

Pathway Categories:

No pathway information available

GENE ONTOLOGY DATABASE ANNOTATIONS

Click to Expand...

GO MF Complete:	DNA binding, protein binding, guanyl-nucleotide exchange factor activity
GO BP Complete:	regulation of Rab protein signal transduction, regulation of DNA-templated transcription
GO CC Complete:	nucleus, cytosol, cytoplasmic vesicle

REACTOME DATABASE ANNOTATIONS Click to Expand...

Reactome Pathways:

Membrane Trafficking, Rab regulation of trafficking, RAB GEFs exchange GTP for GDP on RABs, Vesicle-mediated transport

Orthologs

ID	Organism	Type
PANTR\|Ensembl=ENSPTRG00000007186.6\|UniProtKB=A0A2I3RVZ3	Pan troglodytes	LDO
GORGO\|Ensembl=ENSGGOG00000014870.3\|UniProtKB=G3RFY4	Gorilla gorilla gorilla	LDO
MACMU\|Ensembl=ENSMMUG00000022056.4\|UniProtKB=A0A5F8ATF6	Macaca mulatta	LDO
MOUSE\|MGI=MGI=2142979\|UniProtKB=E9Q8V6	Mus musculus	LDO
RAT\|RGD=1562639\|UniProtKB=D4A518	Rattus norvegicus	LDO
BOVIN\|Ensembl=ENSBTAG00000017095.6\|UniProtKB=E1BJE1	Bos taurus	LDO
PIG\|Ensembl=ENSSSCG00000004938.5\|UniProtKB=A0A286ZRP0	Sus scrofa	LDO
HORSE\|Ensembl=ENSECAG00000024306.4\|UniProtKB=A0A3Q2LLS9	Equus caballus	LDO
FELCA\|Ensembl=ENSFCAG00000008694.6\|UniProtKB=A0A2I2UZ40	Felis catus	LDO
CANLF\|Ensembl=ENSCAFG00845026536.1\|UniProtKB=A0A8I3QAK9	Canis lupus familiaris	LDO
MONDO\|Ensembl=ENSMODG00000009838.4\|UniProtKB=F6WAR3	Monodelphis domestica	LDO
ORNAN\|Ensembl=ENSOANG00000044994.1\|UniProtKB=A0A6I8NUX8	Ornithorhynchus anatinus	LDO
CHICK\|Ensembl=ENSGALG00010017830.1\|UniProtKB=A0A8V0Z3U9	Gallus gallus	LDO
ANOCA\|Ensembl=ENSACAG00000004531.4\|UniProtKB=A0A803T726	Anolis carolinensis	LDO
XENLA\|Gene=dennd4a.L\|UniProtKB=A0A8J1MM72	Xenopus laevis	LDO
XENTR\|Xenbase=XB-GENE-991418\|UniProtKB=F6U1V2	Xenopus tropicalis	LDO
ORYLA\|Ensembl=ENSORLG00000012092.2\|UniProtKB=A0A3B3HLF9	Oryzias latipes	O
ORYLA\|Ensembl=ENSORLG00000007022.2\|UniProtKB=A0A3B3HLS6	Oryzias latipes	LDO
ORYLA\|Ensembl=ENSORLG00000025274.1\|UniProtKB=A0A3B3I1D8	Oryzias latipes	O
DANRE\|ZFIN=ZDB-GENE-060503-285\|UniProtKB=A0A286Y972	Danio rerio	LDO
LEPOC\|Ensembl=ENSLOCG00000013827.1\|UniProtKB=W5N8U4	lepisosteus oculatus	LDO
BRAFL\|Gene=LOC118408866\|UniProtKB=A0A9J7HTK0	Branchiostoma floridae	O
BRAFL\|Gene=LOC118406390\|UniProtKB=A0A9J7HPZ8	Branchiostoma floridae	LDO
STRPU\|EnsemblGenome=LOC590671\|UniProtKB=A0A7M7N8E0	Strongylocentrotus purpuratus	LDO
CAEEL\|WormBase=WBGene00018681\|UniProtKB=U4PBM1	Caenorhabditis elegans	LDO
CAEBR\|Gene_ORFName=CBG10547\|UniProtKB=A8XBD9	Caenorhabditis briggsae	LDO
PRIPA\|EnsemblGenome=WBGene00101119\|UniProtKB=A0A8R1YEJ5	Pristionchus pacificus	LDO
DROME\|FlyBase=FBgn0025864\|UniProtKB=Q9W3D3	Drosophila melanogaster	LDO
ANOGA\|EnsemblGenome=AGAP001102\|UniProtKB=Q7PWX7	Anopheles gambiae	LDO
TRICA\|EnsemblGenome=TC000538\|UniProtKB=D6W9R2	Tribolium castaneum	LDO
DAPPU\|EnsemblGenome=DAPPUDRAFT_224383\|UniProtKB=E9GHR1	Daphnia pulex	LDO
HELRO\|EnsemblGenome=HelroG77102\|UniProtKB=T1G2T2	helobdella robusta	O
HELRO\|EnsemblGenome=HelroG68059\|UniProtKB=T1FZ97	helobdella robusta	LDO
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g90622\|UniProtKB=A7RR72	Nematostella vectensis	LDO
TRIAD\|EnsemblGenome=TriadG22465\|UniProtKB=B3RSP5	Trichoplax adhaerens	LDO
MONBE\|EnsemblGenome=MONBRDRAFT_25114\|UniProtKB=A9UYG4	Monosiga brevicollis	O
EMENI\|EnsemblGenome=ANIA_00575\|UniProtKB=Q5BFV5	Emericella nidulans	O
ASPFU\|EnsemblGenome=AFUA_6G11200\|UniProtKB=E9QR82	Neosartorya fumigata	O
NEUCR\|EnsemblGenome=NCU03364\|UniProtKB=V5IPS0	Neurospora crassa	O
SCLS1\|EnsemblGenome=SS1G_02490\|UniProtKB=A7EB04	Sclerotinia sclerotiorum	O
PHANO\|EnsemblGenome=SNOG_07124\|UniProtKB=Q0UM90	Phaeosphaeria nodorum	O
CRYNJ\|EnsemblGenome=CNJ01890\|UniProtKB=Q5KAF5	Cryptococcus neoformans	O
PUCGT\|EnsemblGenome=PGTG_14794\|UniProtKB=E3KWB4	Puccinia graminis	O
EMENI\|EnsemblGenome=ANIA_04349\|UniProtKB=Q5B531	Emericella nidulans	O
ASPFU\|EnsemblGenome=AFUA_4G06480\|UniProtKB=Q4WNP4	Neosartorya fumigata	O
NEUCR\|EnsemblGenome=NCU01659\|UniProtKB=V5IPI7	Neurospora crassa	O
SCLS1\|EnsemblGenome=SS1G_03951\|UniProtKB=A7EF60	Sclerotinia sclerotiorum	O
PHANO\|EnsemblGenome=SNOG_05394\|UniProtKB=Q0US70	Phaeosphaeria nodorum	O
SCHPO\|PomBase=SPCC297.05\|UniProtKB=Q9Y7Q7	Schizosaccharomyces pombe	O
SCHJY\|EnsemblGenome=SJAG_04329\|UniProtKB=B6K6J6	Schizosaccharomyces japonicus	O
SCHJY\|EnsemblGenome=SJAG_03488\|UniProtKB=B6K4D2	Schizosaccharomyces japonicus	O
ENTH1\|EnsemblGenome=EHI_183170\|UniProtKB=C4LV90	Entamoeba histolytica	O
ENTH1\|EnsemblGenome=CL6EHI_187130\|UniProtKB=C4LVT0	Entamoeba histolytica	O
ENTH1\|EnsemblGenome=EHI_065230\|UniProtKB=B1N400	Entamoeba histolytica	O
ENTH1\|EnsemblGenome=CL6EHI_174930\|UniProtKB=C4LZL8	Entamoeba histolytica	O
ENTH1\|EnsemblGenome=CL6EHI_009660\|UniProtKB=C4LZ40	Entamoeba histolytica	O
DICDI\|dictyBase=DDB_G0280221\|UniProtKB=Q54VP0	Dictyostelium discoideum	O
DICPU\|EnsemblGenome=DICPUDRAFT_97633\|UniProtKB=F0ZIE8	Dictyostelium purpureum	O
DICPU\|EnsemblGenome=DICPUDRAFT_155132\|UniProtKB=F0ZT55	Dictyostelium purpureum	O
THAPS\|EnsemblGenome=THAPSDRAFT_24000\|UniProtKB=B8C8A1	Thalassiosira pseudonana	O
PHYRM\|Gene=H3GBT2_PHYRM\|UniProtKB=H3GBT2	Phytophthora ramorum	O
AMBTC\|EnsemblGenome=AMTR_s00104p00054580\|UniProtKB=W1NT14	Amborella trichopoda	O
ZOSMR\|Gene_ORFName=ZOSMA_40G00310\|UniProtKB=A0A0K9P585	Zostera marina	O
ZOSMR\|Gene_ORFName=ZOSMA_40G00290\|UniProtKB=A0A0K9P2X7	Zostera marina	O
MUSAM\|EnsemblGenome=Ma04_g24970\|UniProtKB=A0A804ITL0	Musa acuminata subsp. malaccensis	O
SETIT\|EnsemblGenome=SETIT_000088mg\|UniProtKB=K3XDX1	Setaria italica	O
SORBI\|EnsemblGenome=SORBI_3003G195900\|UniProtKB=A0A1B6Q4F6	Sorghum bicolor	O
MAIZE\|EnsemblGenome=Zm00001eb160220\|UniProtKB=A0A804NH50	Zea mays	O
ORYSJ\|EnsemblGenome=Os01g0575500\|UniProtKB=A0A0P0V4C5	Oryza sativa	O
BRADI\|EnsemblGenome=BRADI_2g41690v3\|UniProtKB=I1HNT3	Brachypodium distachyon	O
HORVV\|EnsemblGenome=HORVU.MOREX.r3.3HG0267340\|UniProtKB=A0A8I6XE27	Hordeum vulgare subsp. vulgare	O
WHEAT\|EnsemblGenome=TraesCS3A02G204600\|UniProtKB=A0A3B6EFK9	Triticum aestivum	O
WHEAT\|EnsemblGenome=TraesCS3B02G236700\|UniProtKB=A0A077RXK6	Triticum aestivum	O
WHEAT\|EnsemblGenome=TraesCS3D02G210700\|UniProtKB=A0A3B6GSK3	Triticum aestivum	O
NELNU\|Gene_ORFName=HUJ06_010593\|UniProtKB=A0A1U8AHD4	Nelumbo nucifera	O
SPIOL\|Gene=LOC110796437\|UniProtKB=A0A9R0IX66	Spinacia oleracea	O
SPIOL\|Gene=LOC110796439\|UniProtKB=A0A9R0IYC1	Spinacia oleracea	O
HELAN\|Gene_ORFName=HanXRQr2_Chr17g0811791\|UniProtKB=A0A9K3DJ09	Helianthus annuus	O
HELAN\|Gene_ORFName=HannXRQ_Chr17g0558431\|UniProtKB=A0A251RRL2	Helianthus annuus	O
LACSA\|Gene_ORFName=LSAT_V11C800447600\|UniProtKB=A0A9R1UTG5	Lactuca sativa	O
ERYGU\|Gene_ORFName=MIMGU_mgv1a000375mg\|UniProtKB=A0A022QWJ1	Erythranthe guttata	O
CAPAN\|EnsemblGenome=T459_10814\|UniProtKB=A0A2G3A399	Capsicum annuum	O
SOLLC\|EnsemblGenome=Solyc03g119650.3\|UniProtKB=A0A3Q7FV33	Solanum lycopersicum	O
TOBAC\|Gene=LOC107811481\|UniProtKB=A0A1S4BSM9	Nicotiana tabacum	O
TOBAC\|Gene=LOC107772888\|UniProtKB=A0A1S3Y782	Nicotiana tabacum	O
VITVI\|EnsemblGenome=Vitvi17g00344\|UniProtKB=F6GTJ4	Vitis vinifera	O
EUCGR\|EnsemblGenome=EUGRSUZ_B00711\|UniProtKB=A0A059CZD1	Eucalyptus grandis	O
BRANA\|Gene_ORFName=DARMORV10_C06P03880.1\|UniProtKB=A0A078IGS7	Brassica napus	O
BRACM\|EnsemblGenome=Bra018775\|UniProtKB=M4DQI2	Brassica campestris	O
ARATH\|TAIR=locus=2028481\|UniProtKB=Q8RXA7	Arabidopsis thaliana	O
GOSHI\|Gene=LOC107892477\|UniProtKB=A0A1U8I9V7	Gossypium hirsutum	O
GOSHI\|Gene=LOC107930245\|UniProtKB=A0A1U8LRX5	Gossypium hirsutum	O
THECC\|EnsemblGenome=TCM_012299\|UniProtKB=A0A061FV61	Theobroma cacao	O
POPTR\|EnsemblGenome=POPTR_015G049500v3\|UniProtKB=A0A2K1XI56	Populus trichocarpa	O
POPTR\|EnsemblGenome=POPTR_012G060800v3\|UniProtKB=A0A2K1Y9P1	Populus trichocarpa	O
MANES\|EnsemblGenome=MANES_01G013600\|UniProtKB=A0A2C9WH63	Manihot esculenta	O
RICCO\|Gene_ORFName=RCOM_1617450\|UniProtKB=B9RE28	Ricinus communis	O
SOYBN\|EnsemblGenome=GLYMA_08G040500\|UniProtKB=I1KQ47	Glycine max	O
MEDTR\|EnsemblGenome=MTR_8g104010\|UniProtKB=A0A072TV61	Medicago truncatula	O
JUGRE\|Gene=LOC109016591\|UniProtKB=A0A6P9E3G2	Juglans regia	O
JUGRE\|EnsemblGenome=Jr06_14020\|UniProtKB=A0A6P9EHR2	Juglans regia	O
CUCSA\|EnsemblGenome=Csa_1G042240\|UniProtKB=A0A0A0LTM5	Cucumis sativus	O
PRUPE\|EnsemblGenome=PRUPE_5G219600\|UniProtKB=A0A251PC09	Prunus persica	O
SELML\|EnsemblGenome=SELMODRAFT_129087\|UniProtKB=D8T0G6	Selaginella moellendorffii	O
SELML\|EnsemblGenome=SELMODRAFT_118822\|UniProtKB=D8SKF3	Selaginella moellendorffii	O
PHYPA\|EnsemblGenome=Pp3c26_9700\|UniProtKB=A0A2K1ICE7	Physcomitrella patens	O
MARPO\|EnsemblGenome=MARPO_0058s0028\|UniProtKB=A0A2R6WTP1	Marchantia polymorpha	O
KLENI\|Gene_ORFName=KFL_001290220\|UniProtKB=A0A1Y1I177	Klebsormidium nitens	O