PANTHER Gene Information

Gene Symbol(s):

ISCA2

Organism:

Homo sapiens

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Gene Name:

Iron-sulfur cluster assembly 2 homolog, mitochondrial

Gene ID:

HGNC:19857

Protein ID:

Q86U28

Enhancers:

View enhancers for HUMAN|HGNC=19857|UniProtKB=Q86U28

Genetic Variant Annotation:

Annoq

Persistent Id:

PTN002534299

Alternate Ids:

23273089(GI)	615317(MIM)
ISCA2_HUMAN(UniProtKB-ID)	Q8IYZ0(AltAccession)
BX248252(EMBL)	AAH32893(EMBL-CDS)
HESB-like domain-containing protein 1(Synonym)	ISCA2(Symbol)
122961(GeneID)	HGNC:19857(HGNC)
ENSG00000165898(Ensembl)
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PANTHER Classification

PANTHER Family:	IRON-SULFUR CLUSTER ASSEMBLY 2 HOMOLOG, MITOCHONDRIAL (PTHR43011)
PANTHER Subfamily:	IRON-SULFUR CLUSTER ASSEMBLY 2 HOMOLOG, MITOCHONDRIAL (PTHR43011:SF1)
PANTHER GO-slim Molecular Function:	iron-sulfur cluster binding iron ion binding
PANTHER GO-slim Biological Process:	protein maturation iron-sulfur cluster assembly
PANTHER GO-slim Cellular Component:
PANTHER protein class:

Pathway Categories:

No pathway information available

GENE ONTOLOGY DATABASE ANNOTATIONS

Click to Expand...

GO MF Complete:	identical protein binding, protein binding, iron ion binding, 4 iron, 4 sulfur cluster binding, 2 iron, 2 sulfur cluster binding
GO BP Complete:	protein maturation by [4Fe-4S] cluster transfer, iron-sulfur cluster assembly
GO CC Complete:	mitochondrial [4Fe-4S] assembly complex, mitochondrial matrix, mitochondrion

REACTOME DATABASE ANNOTATIONS Click to Expand...

Reactome Pathways:

Metabolism, Mitochondrial iron-sulfur cluster biogenesis

Orthologs

ID	Organism	Type
PANTR\|Ensembl=ENSPTRG00000051248.1\|UniProtKB=A0A2I3RH40	Pan troglodytes	O
PANTR\|Ensembl=ENSPTRG00000006536.6\|UniProtKB=H2R991	Pan troglodytes	LDO
GORGO\|Ensembl=ENSGGOG00000012894.3\|UniProtKB=A0A2I2ZBS2	Gorilla gorilla gorilla	LDO
GORGO\|Ensembl=ENSGGOG00000027499.2\|UniProtKB=G3SGX5	Gorilla gorilla gorilla	LDO
MACMU\|Ensembl=ENSMMUG00000050430.1\|UniProtKB=H9EW17	Macaca mulatta	LDO
MOUSE\|MGI=MGI=1921566\|UniProtKB=Q9DCB8	Mus musculus	LDO
RAT\|RGD=1309506\|UniProtKB=A0A8I5ZSL2	Rattus norvegicus	O
RAT\|RGD=1563216\|UniProtKB=D4A4L5	Rattus norvegicus	LDO
BOVIN\|Ensembl=ENSBTAG00000021956\|UniProtKB=Q2TBG7	Bos taurus	LDO
PIG\|Ensembl=ENSSSCG00000002367.5\|UniProtKB=A0A5G2RC38	Sus scrofa	LDO
FELCA\|Ensembl=ENSFCAG00000040858.2\|UniProtKB=A0A2I2UPN0	Felis catus	LDO
CANLF\|Ensembl=ENSCAFG00845014307.1\|UniProtKB=A0A8I3NJ84	Canis lupus familiaris	LDO
MONDO\|Ensembl=ENSMODG00000006248.3\|UniProtKB=F7FEC7	Monodelphis domestica	LDO
ORNAN\|Ensembl=ENSOANG00000036503.1\|UniProtKB=A0A6I8N644	Ornithorhynchus anatinus	LDO
CHICK\|Ensembl=ENSGALG00010004380.1\|UniProtKB=A0A8V0XJP4	Gallus gallus	LDO
ANOCA\|Ensembl=ENSACAG00000016482.4\|UniProtKB=A0A803TNP6	Anolis carolinensis	LDO
XENLA\|Gene=isca2.L\|UniProtKB=A0A1L8F9A7	Xenopus laevis	LDO
XENTR\|Xenbase=XB-GENE-991849\|UniProtKB=A0A8J0QUS4	Xenopus tropicalis	LDO
ORYLA\|Ensembl=ENSORLG00000016363.2\|UniProtKB=H2MP29	Oryzias latipes	LDO
DANRE\|Gene=isca2\|UniProtKB=A0A8M1P3Z0	Danio rerio	LDO
LEPOC\|Ensembl=ENSLOCG00000010860.1\|UniProtKB=W5MY50	lepisosteus oculatus	LDO
CIOIN\|Ensembl=ENSCING00000021377.1\|UniProtKB=H2Y2X6	Ciona intestinalis	LDO
BRAFL\|Gene=LOC118413994\|UniProtKB=A0A9J7L0C5	Branchiostoma floridae	LDO
STRPU\|EnsemblGenome=LOC578588\|UniProtKB=A0A7M7GJG5	Strongylocentrotus purpuratus	LDO
CAEEL\|WormBase=WBGene00013218\|UniProtKB=Q9XVZ9	Caenorhabditis elegans	LDO
PRIPA\|EnsemblGenome=WBGene00304369\|UniProtKB=A0A8R1V5C3	Pristionchus pacificus	LDO
DROME\|FlyBase=FBgn0039205\|UniProtKB=Q9VC65	Drosophila melanogaster	LDO
ANOGA\|EnsemblGenome=AGAP010072\|UniProtKB=Q7Q0Y4	Anopheles gambiae	LDO
TRICA\|EnsemblGenome=TC033750\|UniProtKB=A0A139WEV1	Tribolium castaneum	LDO
IXOSC\|EnsemblGenome=ISCW023953\|UniProtKB=B7QNT8	Ixodes scapularis	LDO
HELRO\|EnsemblGenome=HelroG175503\|UniProtKB=T1F9C1	helobdella robusta	LDO
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g131080\|UniProtKB=A7STF6	Nematostella vectensis	LDO
TRIAD\|EnsemblGenome=TriadG29056\|UniProtKB=B3S590	Trichoplax adhaerens	LDO
MONBE\|EnsemblGenome=MONBRDRAFT_22682\|UniProtKB=A9URR8	Monosiga brevicollis	LDO
YEAST\|SGD=S000006271\|UniProtKB=Q12425	Saccharomyces cerevisiae	LDO
EREGS\|EnsemblGenome=AGOS_ADL334C\|UniProtKB=Q75BA0	Eremothecium gossypii	LDO
CANAL\|CGD=CAL0000191195\|UniProtKB=Q5ADN0	Candida albicans	LDO
YARLI\|EnsemblGenome=YALI0_E33077g\|UniProtKB=Q6C3Q0	Yarrowia lipolytica	LDO
EMENI\|EnsemblGenome=ANIA_05953\|UniProtKB=C8V3G5	Emericella nidulans	LDO
ASPFU\|EnsemblGenome=AFUA_2G10370\|UniProtKB=Q4X1D3	Neosartorya fumigata	LDO
NEUCR\|EnsemblGenome=NCU07828\|UniProtKB=Q7SBD6	Neurospora crassa	LDO
SCLS1\|EnsemblGenome=SS1G_00004\|UniProtKB=A7E3Y2	Sclerotinia sclerotiorum	LDO
PHANO\|EnsemblGenome=SNOG_08381\|UniProtKB=Q0UIN3	Phaeosphaeria nodorum	LDO
SCHPO\|PomBase=SPBC3B9.17\|UniProtKB=O43045	Schizosaccharomyces pombe	LDO
SCHJY\|EnsemblGenome=SJAG_04016\|UniProtKB=B6K5P0	Schizosaccharomyces japonicus	LDO
CRYNJ\|EnsemblGenome=CNA04710\|UniProtKB=Q5KP00	Cryptococcus neoformans	LDO
USTMA\|EnsemblGenome=UMAG_05471\|UniProtKB=A0A0D1BWZ6	Ustilago maydis	LDO
PUCGT\|EnsemblGenome=PGTG_00182\|UniProtKB=E3JQE7	Puccinia graminis	LDO
BATDJ\|Gene_ORFName=BATDEDRAFT_20293\|UniProtKB=F4P7M2	Batrachochytrium dendrobatidis	LDO
DICDI\|dictyBase=DDB_G0284809\|UniProtKB=Q54P40	Dictyostelium discoideum	LDO
DICPU\|EnsemblGenome=DICPUDRAFT_157381\|UniProtKB=F0ZYZ9	Dictyostelium purpureum	LDO
LEIMA\|EnsemblGenome=LMJF_35_1350\|UniProtKB=Q9GRP9	Leishmania major	LDO
TRYB2\|Gene_ORFName=Tb927.5.1030\|UniProtKB=Q57W48	Trypanosoma brucei	LDO
GIAIC\|EnsemblGenome=GL50803_14821\|UniProtKB=A8BCH8	Giardia intestinalis	LDO
TRIV3\|Gene_ORFName=TVAG_373690\|UniProtKB=A2FQR0	Trichomonas vaginalis	LDO
PLAF7\|EnsemblGenome=PF3D7_0207200\|UniProtKB=O96161	Plasmodium falciparum	LDO
PARTE\|EnsemblGenome=GSPATT00012458001\|UniProtKB=A0D1L7	Paramecium tetraurelia	LDO
THAPS\|EnsemblGenome=THAPSDRAFT_31510\|UniProtKB=B8BT66	Thalassiosira pseudonana	LDO
PHYRM\|Gene=H3GIW5_PHYRM\|UniProtKB=H3GIW5	Phytophthora ramorum	LDO
CHLRE\|EnsemblGenome=CHLRE_07g349600v5\|UniProtKB=A0A2K3DL73	Chlamydomonas reinhardtii	LDO
AMBTC\|EnsemblGenome=AMTR_s00153p00044690\|UniProtKB=W1PMQ3	Amborella trichopoda	LDO
ZOSMR\|Gene_ORFName=ZOSMA_81G00090\|UniProtKB=A0A0K9NMF9	Zostera marina	LDO
MUSAM\|EnsemblGenome=Ma11_g17400\|UniProtKB=A0A804L8W0	Musa acuminata subsp. malaccensis	O
MUSAM\|EnsemblGenome=Ma05_g00830\|UniProtKB=A0A804IZG5	Musa acuminata subsp. malaccensis	LDO
SETIT\|EnsemblGenome=SETIT_032444mg\|UniProtKB=K4A0Q4	Setaria italica	O
SETIT\|EnsemblGenome=SETIT_014571mg\|UniProtKB=K3YK02	Setaria italica	LDO
SORBI\|EnsemblGenome=SORBI_3007G105900\|UniProtKB=A0A1Z5R960	Sorghum bicolor	LDO
MAIZE\|EnsemblGenome=Zm00001eb170730\|UniProtKB=A0A804NM27	Zea mays	O
MAIZE\|EnsemblGenome=Zm00001eb042730\|UniProtKB=B6TY62	Zea mays	LDO
ORYSJ\|EnsemblGenome=Os08g0369700\|UniProtKB=A3BSI8	Oryza sativa	LDO
BRADI\|EnsemblGenome=BRADI_4g27970v3\|UniProtKB=A0A0Q3PKE2	Brachypodium distachyon	O
HORVV\|EnsemblGenome=HORVU.MOREX.r3.5HG0473180\|UniProtKB=A0A8I6Y8G5	Hordeum vulgare subsp. vulgare	O
WHEAT\|EnsemblGenome=TraesCS5D02G186800\|UniProtKB=A0A3B6MQL5	Triticum aestivum	O
WHEAT\|EnsemblGenome=TraesCS5B02G180400\|UniProtKB=A0A3B6LLG6	Triticum aestivum	O
WHEAT\|EnsemblGenome=TraesCS5A02G182400\|UniProtKB=A0A3B6KI74	Triticum aestivum	O
BRADI\|EnsemblGenome=BRADI_3g34680v3\|UniProtKB=I1I6L6	Brachypodium distachyon	LDO
NELNU\|Gene_ORFName=HUJ06_018482\|UniProtKB=A0A1U7YWS9	Nelumbo nucifera	LDO
SPIOL\|Gene=LOC110803121\|UniProtKB=A0A9R0JC54	Spinacia oleracea	LDO
HELAN\|Gene_ORFName=HanXRQr2_Chr17g0810931\|UniProtKB=A0A9K3DJB6	Helianthus annuus	LDO
HELAN\|EnsemblGenome=HanXRQr2_Chr15g0715801\|UniProtKB=A0A251SBD4	Helianthus annuus	LDO
LACSA\|Gene_ORFName=LSAT_V11C800419760\|UniProtKB=A0A9R1UMJ7	Lactuca sativa	LDO
ERYGU\|Gene_ORFName=MIMGU_mgv1a015468mg\|UniProtKB=A0A022RF47	Erythranthe guttata	LDO
CAPAN\|EnsemblGenome=T459_34586\|UniProtKB=A0A2G2XVL1	Capsicum annuum	LDO
SOLTU\|EnsemblGenome=PGSC0003DMG403002803\|UniProtKB=M0ZSR3	Solanum tuberosum	LDO
SOLLC\|EnsemblGenome=Solyc01g100410.3\|UniProtKB=A0A3Q7ENZ6	Solanum lycopersicum	LDO
TOBAC\|Gene=LOC107781148\|UniProtKB=A0A1S3YYT1	Nicotiana tabacum	O
TOBAC\|Gene=LOC107811611\|UniProtKB=A0A1S4BT55	Nicotiana tabacum	O
TOBAC\|Gene=LOC107821693\|UniProtKB=A0A1S4CR91	Nicotiana tabacum	LDO
VITVI\|EnsemblGenome=Vitvi08g01461\|UniProtKB=F6HKL0	Vitis vinifera	LDO
EUCGR\|EnsemblGenome=EUGRSUZ_C01891\|UniProtKB=A0A059CQ99	Eucalyptus grandis	LDO
EUCGR\|EnsemblGenome=EUGRSUZ_K02041\|UniProtKB=A0A059A4Q3	Eucalyptus grandis	O
BRANA\|Gene_ORFName=DARMORV10_C09P73010.1\|UniProtKB=A0A078HUL3	Brassica napus	O
BRACM\|EnsemblGenome=Bra009501\|UniProtKB=M4CZ54	Brassica campestris	O
BRANA\|Gene_ORFName=DARMORV10_C02P01610.1\|UniProtKB=A0A078FMK4	Brassica napus	LDO
BRACM\|EnsemblGenome=Bra028810\|UniProtKB=M4EJ45	Brassica campestris	LDO
ARATH\|TAIR=locus=505006581\|UniProtKB=Q8LCY2	Arabidopsis thaliana	LDO
GOSHI\|Gene=LOC107925510\|UniProtKB=A0A1U8LAT8	Gossypium hirsutum	O
GOSHI\|Gene=LOC107949457\|UniProtKB=A0A1U8NNG6	Gossypium hirsutum	O
GOSHI\|Gene=LOC107928167\|UniProtKB=A0A1U8LJT1	Gossypium hirsutum	O
GOSHI\|Gene=LOC107892589\|UniProtKB=A0A1U8I4N4	Gossypium hirsutum	LDO
THECC\|EnsemblGenome=TCM_022590\|UniProtKB=A0A061EV31	Theobroma cacao	LDO
CITSI\|Gene_ORFName=CISIN_1g031188mg\|UniProtKB=A0A067G4M7	Citrus sinensis	LDO
POPTR\|EnsemblGenome=POPTR_006G084300v3\|UniProtKB=B9HBK7	Populus trichocarpa	LDO
MANES\|EnsemblGenome=MANES_08G025200\|UniProtKB=A0A2C9VCV6	Manihot esculenta	LDO
RICCO\|Gene_ORFName=RCOM_0516990\|UniProtKB=B9SRX7	Ricinus communis	LDO
SOYBN\|EnsemblGenome=GLYMA_03G195800\|UniProtKB=A0A0R0KM26	Glycine max	O
SOYBN\|EnsemblGenome=GLYMA_10G072200\|UniProtKB=K7LHX1	Glycine max	O
SOYBN\|EnsemblGenome=GLYMA_13G153600\|UniProtKB=C6T5E6	Glycine max	LDO
MEDTR\|EnsemblGenome=MTR_7g104600\|UniProtKB=G7KQU7	Medicago truncatula	LDO
JUGRE\|EnsemblGenome=Jr03_01830\|UniProtKB=A0A2I4E2S2	Juglans regia	LDO
JUGRE\|EnsemblGenome=Jr03_01840\|UniProtKB=A0A2I4E2R7	Juglans regia	LDO
CUCSA\|EnsemblGenome=Csa_1G496290\|UniProtKB=A0A0A0LXX8	Cucumis sativus	LDO
CUCSA\|EnsemblGenome=Csa_1G108280\|UniProtKB=A0A0A0LSN2	Cucumis sativus	O
PRUPE\|EnsemblGenome=PRUPE_5G046500\|UniProtKB=M5WAY8	Prunus persica	LDO
SELML\|EnsemblGenome=SELMODRAFT_151749\|UniProtKB=D8S1K5	Selaginella moellendorffii	LDO
SELML\|EnsemblGenome=SELMODRAFT_134789\|UniProtKB=D8T945	Selaginella moellendorffii	LDO
PHYPA\|EnsemblGenome=Pp3c12_11160\|UniProtKB=A0A2K1JQC6	Physcomitrella patens	O
PHYPA\|EnsemblGenome=Pp3c3_34710\|UniProtKB=A0A2K1KX89	Physcomitrella patens	LDO
MARPO\|EnsemblGenome=MARPO_0089s0053\|UniProtKB=A0A2R6WHT9	Marchantia polymorpha	LDO
KLENI\|Gene_ORFName=KFL_000990150\|UniProtKB=A0A1Y1HZW6	Klebsormidium nitens	LDO
NITMS\|EnsemblGenome=Nmar_1303\|UniProtKB=A9A2G0	Nitrosopumilus maritimus	LDO
METAC\|EnsemblGenome=MA_0903\|UniProtKB=Q8TSA0	Methanosarcina acetivorans	LDO
STRCO\|Gene_OrderedLocusName=SCO2161\|UniProtKB=Q9X819	Streptomyces coelicolor	LDO
MYCTU\|Gene_OrderedLocusName=Rv2204c\|UniProtKB=P9WMN5	Mycobacterium tuberculosis	LDO
DEIRA\|EnsemblGenome=DR_0051\|UniProtKB=Q9RY99	Deinococcus radiodurans	LDO
NEIMB\|EnsemblGenome=NMB0557\|UniProtKB=Q7DDN1	Neisseria meningitidis serogroup b	LDO
BRADU\|Gene=Q89KY9_BRADU\|UniProtKB=Q89KY9	Bradyrhizobium diazoefficiens	LDO
COXBU\|EnsemblGenome=CBU_1878\|UniProtKB=Q83AK7	Coxiella burnetii	LDO
HAEIN\|EnsemblGenome=HI_1723\|UniProtKB=P45344	Haemophilus influenzae	LDO
SHEON\|Gene_OrderedLocusName=SO_1304\|UniProtKB=Q8EHC4	Shewanella oneidensis	LDO
VIBCH\|EnsemblGenome=VC_0627\|UniProtKB=Q9KU96	Vibrio cholerae	LDO
XANCP\|EnsemblGenome=XCC0488\|UniProtKB=Q8PD57	Xanthomonas campestris	LDO
PSEAE\|EnsemblGenome=PA0665\|UniProtKB=Q9I5Q6	Pseudomonas aeruginosa	LDO
SALTY\|EnsemblGenome=STM0204\|UniProtKB=Q7CR66	Salmonella typhimurium	LDO
YERPE\|EnsemblGenome=YP_0298\|UniProtKB=Q0WBQ9	Yersinia pestis	LDO
ECOLI\|EnsemblGenome=BAB96733\|UniProtKB=P0ACC3	Escherichia coli	LDO