PANTHER Gene Information

Gene Symbol(s):

D2hgdh

Organism:

Mus musculus

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Gene Name:

D-2-hydroxyglutarate dehydrogenase, mitochondrial

Gene ID:

MGI:2138209

Protein ID:

Q8CIM3

Persistent Id:

PTN000202320

Alternate Ids:

ENSMUST00000097633(Ensembl_TRS)	ENSMUSP00000095235(Ensembl_PRO)
BC023277(EMBL)	D2HDH(Synonym)
ENSMUSG00000073609(Ensembl)	BAC40205(EMBL-CDS)
1.1.99.39 {ECO:0000250\|UniProtKB:Q8N465}(EC)	408360294(GI)
NP_849213(refSeq)	Q3TDF5(AltAccession)
MGI:2138209(MGI)	D2HDH_MOUSE(UniProtKB-ID)
D2hgdh(Symbol)	98314(GeneID)
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PANTHER Classification

PANTHER Family:	D-2-HYDROXYGLUTARATE DEHYDROGENASE, MITOCHONDRIAL (PTHR43716)
PANTHER Subfamily:	D-2-HYDROXYGLUTARATE DEHYDROGENASE, MITOCHONDRIAL (PTHR43716:SF1)
PANTHER GO-slim Molecular Function:
PANTHER GO-slim Biological Process:
PANTHER GO-slim Cellular Component:
PANTHER protein class:	dehydrogenase

Pathway Categories:

No pathway information available

GENE ONTOLOGY DATABASE ANNOTATIONS

Click to Expand...

GO MF Complete:	FAD binding, zinc ion binding, (R)-2-hydroxyglutarate dehydrogenase activity
GO BP Complete:	response to manganese ion, protein metabolic process, malate metabolic process, response to zinc ion, response to cobalt ion
GO CC Complete:	mitochondrion

REACTOME DATABASE ANNOTATIONS Click to Expand...

Reactome Pathways:

Interconversion of 2-oxoglutarate and 2-hydroxyglutarate, The citric acid (TCA) cycle and respiratory electron transport, Metabolism, Pyruvate metabolism and Citric Acid (TCA) cycle

Orthologs

ID	Organism	Type
HUMAN\|HGNC=28358\|UniProtKB=Q8N465	Homo sapiens	LDO
PANTR\|Ensembl=ENSPTRG00000013131.6\|UniProtKB=K6Z916	Pan troglodytes	LDO
GORGO\|Ensembl=ENSGGOG00000014288.3\|UniProtKB=G3REF1	Gorilla gorilla gorilla	LDO
MACMU\|Ensembl=ENSMMUG00000018548.4\|UniProtKB=A0A5F7Z7B0	Macaca mulatta	LDO
RAT\|RGD=1307976\|UniProtKB=P84850	Rattus norvegicus	LDO
BOVIN\|Ensembl=ENSBTAG00000002847\|UniProtKB=Q1JPD3	Bos taurus	LDO
PIG\|Ensembl=ENSSSCG00000034101.3\|UniProtKB=A0A5G2R4W1	Sus scrofa	LDO
HORSE\|Ensembl=ENSECAG00000018063.4\|UniProtKB=A0A3Q2HMV1	Equus caballus	LDO
FELCA\|Ensembl=ENSFCAG00000014284.5\|UniProtKB=M3WKF3	Felis catus	LDO
CANLF\|Ensembl=ENSCAFG00845024104.1\|UniProtKB=A0A8I3PQI0	Canis lupus familiaris	LDO
MONDO\|Ensembl=ENSMODG00000008616.4\|UniProtKB=F6PH88	Monodelphis domestica	LDO
ORNAN\|Ensembl=ENSOANG00000000857.2\|UniProtKB=F6YIX9	Ornithorhynchus anatinus	LDO
CHICK\|Ensembl=ENSGALG00010024879.1\|UniProtKB=A0A8V1A0H3	Gallus gallus	LDO
ANOCA\|Ensembl=ENSACAG00000000533.4\|UniProtKB=G1K8L8	Anolis carolinensis	LDO
XENLA\|Gene=d2hgdh.S\|UniProtKB=A0A1L8G4P4	Xenopus laevis	LDO
XENTR\|Xenbase=XB-GENE-988655\|UniProtKB=A0A6I8SE28	Xenopus tropicalis	LDO
ORYLA\|Ensembl=ENSORLG00000013844.2\|UniProtKB=H2MFI3	Oryzias latipes	LDO
DANRE\|ZFIN=ZDB-GENE-070112-482\|UniProtKB=A1L258	Danio rerio	LDO
LEPOC\|Ensembl=ENSLOCG00000006684.1\|UniProtKB=W5MI62	lepisosteus oculatus	LDO
CIOIN\|Ensembl=ENSCING00000012479.2\|UniProtKB=F6W0L1	Ciona intestinalis	LDO
BRAFL\|Gene_ORFName=BRAFLDRAFT_94338\|UniProtKB=C3YN21	Branchiostoma floridae	O
BRAFL\|Gene=LOC118423164\|UniProtKB=A0A9J7LRW0	Branchiostoma floridae	LDO
STRPU\|EnsemblGenome=LOC578006\|UniProtKB=A0A7M7NWW2	Strongylocentrotus purpuratus	LDO
CAEEL\|WormBase=WBGene00010055\|UniProtKB=G5EE46	Caenorhabditis elegans	LDO
CAEBR\|WormBase=WBGene00025835\|UniProtKB=A8WTC3	Caenorhabditis briggsae	LDO
PRIPA\|EnsemblGenome=WBGene00304340\|UniProtKB=A0A8R1ZBP4	Pristionchus pacificus	LDO
DROME\|FlyBase=FBgn0023507\|UniProtKB=Q7K511	Drosophila melanogaster	LDO
ANOGA\|EnsemblGenome=AGAP004189\|UniProtKB=A0NDE2	Anopheles gambiae	O
ANOGA\|EnsemblGenome=AGAP004195\|UniProtKB=Q7QB44	Anopheles gambiae	LDO
TRICA\|EnsemblGenome=TC030784\|UniProtKB=D6WE92	Tribolium castaneum	O
TRICA\|EnsemblGenome=TC002688\|UniProtKB=D6WE94	Tribolium castaneum	LDO
DAPPU\|EnsemblGenome=DAPPUDRAFT_307847\|UniProtKB=E9G1Q8	Daphnia pulex	LDO
IXOSC\|EnsemblGenome=ISCW005219\|UniProtKB=B7PE50	Ixodes scapularis	LDO
HELRO\|EnsemblGenome=HelroG64272\|UniProtKB=T1FXS1	helobdella robusta	LDO
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g112243\|UniProtKB=A7SBJ2	Nematostella vectensis	LDO
TRIAD\|EnsemblGenome=TriadG31230\|UniProtKB=B3S946	Trichoplax adhaerens	O
TRIAD\|EnsemblGenome=TriadG60696\|UniProtKB=B3S947	Trichoplax adhaerens	LDO
MONBE\|EnsemblGenome=MONBRDRAFT_25135\|UniProtKB=A9UYI4	Monosiga brevicollis	LDO
YEAST\|SGD=S000000797\|UniProtKB=P39976	Saccharomyces cerevisiae	O
YEAST\|SGD=S000002337\|UniProtKB=P46681	Saccharomyces cerevisiae	LDO
EREGS\|EnsemblGenome=AGOS_ACL021C\|UniProtKB=Q75CD0	Eremothecium gossypii	LDO
CANAL\|CGD=CAL0000192859\|UniProtKB=A0A1D8PJK5	Candida albicans	LDO
YARLI\|EnsemblGenome=YALI0_C06446g\|UniProtKB=Q6CCU5	Yarrowia lipolytica	LDO
EMENI\|EnsemblGenome=ANIA_02696\|UniProtKB=Q5B9T4	Emericella nidulans	O
EMENI\|EnsemblGenome=ANIA_11045\|UniProtKB=C8V5Z6	Emericella nidulans	LDO
ASPFU\|EnsemblGenome=AFUA_5G02230\|UniProtKB=Q4WE96	Neosartorya fumigata	LDO
NEUCR\|EnsemblGenome=NCU06441\|UniProtKB=Q7RYX6	Neurospora crassa	LDO
SCLS1\|Gene_ORFName=SS1G_07702\|UniProtKB=A7EQU9	Sclerotinia sclerotiorum	LDO
PHANO\|EnsemblGenome=SNOG_11128\|UniProtKB=Q0UAT6	Phaeosphaeria nodorum	LDO
SCHPO\|PomBase=SPBC713.03\|UniProtKB=Q9C1X2	Schizosaccharomyces pombe	LDO
CRYNJ\|EnsemblGenome=CNB01750\|UniProtKB=Q5KMG8	Cryptococcus neoformans	O
CRYNJ\|EnsemblGenome=CNK01540\|UniProtKB=Q5K9L7	Cryptococcus neoformans	LDO
USTMA\|EnsemblGenome=UMAG_01314\|UniProtKB=A0A0D1E799	Ustilago maydis	LDO
PUCGT\|EnsemblGenome=PGTG_05096\|UniProtKB=E3K6E0	Puccinia graminis	LDO
BATDJ\|Gene_ORFName=BATDEDRAFT_92357\|UniProtKB=F4PDJ8	Batrachochytrium dendrobatidis	LDO
DICDI\|dictyBase=DDB_G0270500\|UniProtKB=Q55E52	Dictyostelium discoideum	LDO
DICPU\|EnsemblGenome=DICPUDRAFT_158305\|UniProtKB=F1A1A1	Dictyostelium purpureum	LDO
LEIMA\|EnsemblGenome=LMJF_23_0810\|UniProtKB=Q4QB82	Leishmania major	LDO
PARTE\|EnsemblGenome=GSPATT00036992001\|UniProtKB=A0CBP2	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00036991001\|UniProtKB=A0CBP1	Paramecium tetraurelia	LDO
THAPS\|EnsemblGenome=THAPSDRAFT_42965\|UniProtKB=B8CEV7	Thalassiosira pseudonana	LDO
PHYRM\|Gene=H3G764_PHYRM\|UniProtKB=H3G764	Phytophthora ramorum	O
PHYRM\|Gene=H3G9R8_PHYRM\|UniProtKB=H3G9R8	Phytophthora ramorum	LDO
CHLRE\|EnsemblGenome=CHLRE_08g370550v5\|UniProtKB=A0A2K3DH85	Chlamydomonas reinhardtii	LDO
AMBTC\|EnsemblGenome=AMTR_s00002p00236270\|UniProtKB=W1NUB4	Amborella trichopoda	LDO
ZOSMR\|Gene_ORFName=ZOSMA_91G00080\|UniProtKB=A0A0K9NJF1	Zostera marina	LDO
MUSAM\|EnsemblGenome=Ma04_g18280\|UniProtKB=A0A804IR25	Musa acuminata subsp. malaccensis	LDO
SETIT\|EnsemblGenome=SETIT_029387mg\|UniProtKB=K3ZS07	Setaria italica	LDO
SORBI\|EnsemblGenome=SORBI_3002G058500\|UniProtKB=A0A1B6Q9G5	Sorghum bicolor	LDO
MAIZE\|EnsemblGenome=Zm00001eb302200\|UniProtKB=B4FWJ7	Zea mays	LDO
ORYSJ\|Gene_OrderedLocusName=LOC_Os07g08950\|UniProtKB=Q7XI14	Oryza sativa	LDO
BRADI\|EnsemblGenome=BRADI_1g55030v3\|UniProtKB=I1H2Y6	Brachypodium distachyon	LDO
HORVV\|EnsemblGenome=HORVU.MOREX.r3.2HG0195930\|UniProtKB=A0A8I6WI16	Hordeum vulgare subsp. vulgare	LDO
WHEAT\|EnsemblGenome=TraesCS2B02G480200\|UniProtKB=A0A3B6CCW5	Triticum aestivum	O
WHEAT\|EnsemblGenome=TraesCS2A02G457900\|UniProtKB=A0A3B6B5I6	Triticum aestivum	LDO
WHEAT\|EnsemblGenome=TraesCS2D02G458500\|UniProtKB=W5BSG8	Triticum aestivum	LDO
NELNU\|Gene=LOC104610558\|UniProtKB=A0A1U8B7I0	Nelumbo nucifera	LDO
SPIOL\|Gene=LOC110798890\|UniProtKB=A0A9R0K606	Spinacia oleracea	LDO
HELAN\|Gene_ORFName=HanXRQr2_Chr07g0295171\|UniProtKB=A0A9K3IKR1	Helianthus annuus	LDO
LACSA\|Gene_ORFName=LSAT_V11C200078190\|UniProtKB=A0A9R1WIK0	Lactuca sativa	LDO
ERYGU\|Gene_ORFName=MIMGU_mgv1a003621mg\|UniProtKB=A0A022QR13	Erythranthe guttata	LDO
CAPAN\|EnsemblGenome=T459_04160\|UniProtKB=A0A1U8FJ61	Capsicum annuum	LDO
SOLLC\|EnsemblGenome=Solyc02g062430.3\|UniProtKB=A0A3Q7EYP2	Solanum lycopersicum	LDO
TOBAC\|Gene=LOC107820135\|UniProtKB=A0A1S4CKR9	Nicotiana tabacum	O
TOBAC\|Gene=LOC107819913\|UniProtKB=A0A1S4CKN4	Nicotiana tabacum	LDO
VITVI\|EnsemblGenome=Vitvi04g01383\|UniProtKB=F6GWS1	Vitis vinifera	LDO
EUCGR\|EnsemblGenome=EUGRSUZ_I02389\|UniProtKB=A0A059ATC4	Eucalyptus grandis	LDO
EUCGR\|EnsemblGenome=EUGRSUZ_I02388\|UniProtKB=A0A059AS61	Eucalyptus grandis	O
BRANA\|Gene_ORFName=GSBRNA2T00027605001\|UniProtKB=A0A078J8H8	Brassica napus	O
BRANA\|Gene_ORFName=GSBRNA2T00043865001\|UniProtKB=A0A078JBG1	Brassica napus	LDO
BRACM\|EnsemblGenome=Bra017758\|UniProtKB=M4DMM3	Brassica campestris	LDO
ARATH\|TAIR=locus=2115230\|UniProtKB=O23240	Arabidopsis thaliana	LDO
GOSHI\|Gene=LOC107897617\|UniProtKB=A0A1U8IKI5	Gossypium hirsutum	O
GOSHI\|Gene=LOC107914279\|UniProtKB=A0A1U8K809	Gossypium hirsutum	LDO
THECC\|EnsemblGenome=TCM_000289\|UniProtKB=A0A061DFW5	Theobroma cacao	LDO
POPTR\|EnsemblGenome=POPTR_007G018600v3\|UniProtKB=A0A2K1ZMT2	Populus trichocarpa	LDO
MANES\|EnsemblGenome=MANES_01G140700\|UniProtKB=A0A2C9WNB0	Manihot esculenta	LDO
RICCO\|Gene_ORFName=RCOM_0533320\|UniProtKB=B9S687	Ricinus communis	LDO
SOYBN\|EnsemblGenome=GLYMA_01G169800\|UniProtKB=K7K4A7	Glycine max	LDO
MEDTR\|EnsemblGenome=MTR_5g021240\|UniProtKB=G7KGB4	Medicago truncatula	LDO
JUGRE\|EnsemblGenome=Jr11_07300\|UniProtKB=A0A2I4ERJ9	Juglans regia	O
JUGRE\|EnsemblGenome=Jr11_07290\|UniProtKB=A0A2I4ERJ6	Juglans regia	LDO
CUCSA\|EnsemblGenome=Csa_4G044990\|UniProtKB=A0A0A0KWM4	Cucumis sativus	LDO
PRUPE\|EnsemblGenome=PRUPE_7G162700\|UniProtKB=A0A251NEB0	Prunus persica	LDO
SELML\|EnsemblGenome=SELMODRAFT_83489\|UniProtKB=D8R1P4	Selaginella moellendorffii	LDO
SELML\|EnsemblGenome=SELMODRAFT_76083\|UniProtKB=D8QSH8	Selaginella moellendorffii	LDO
PHYPA\|EnsemblGenome=Pp3c26_11820\|UniProtKB=A0A2K1ICP8	Physcomitrella patens	LDO
MARPO\|EnsemblGenome=MARPO_0113s0062\|UniProtKB=A0A2R6WBX2	Marchantia polymorpha	LDO
KLENI\|Gene_ORFName=KFL_004560090\|UniProtKB=A0A1Y1IKY2	Klebsormidium nitens	LDO
MYCTU\|Gene_OrderedLocusName=Rv0161\|UniProtKB=O07406	Mycobacterium tuberculosis	LDO
LEPIN\|EnsemblGenome=LA_3461\|UniProtKB=Q8F0N1	Leptospira interrogans	LDO
NEIMB\|EnsemblGenome=NMB1524\|UniProtKB=Q9JYL6	Neisseria meningitidis serogroup b	O
BRADU\|Gene=Q89GX1_BRADU\|UniProtKB=Q89GX1	Bradyrhizobium diazoefficiens	O
BRADU\|Gene=Q89NF5_BRADU\|UniProtKB=Q89NF5	Bradyrhizobium diazoefficiens	O
BRADU\|Gene=Q89S36_BRADU\|UniProtKB=Q89S36	Bradyrhizobium diazoefficiens	O
NEIMB\|EnsemblGenome=NMB0997\|UniProtKB=Q9JZL7	Neisseria meningitidis serogroup b	LDO
BRADU\|Gene=Q89C28_BRADU\|UniProtKB=Q89C28	Bradyrhizobium diazoefficiens	LDO
HAEIN\|EnsemblGenome=HI_1649\|UniProtKB=P45295	Haemophilus influenzae	LDO
XANCP\|EnsemblGenome=XCC1826\|UniProtKB=Q8P9M7	Xanthomonas campestris	LDO
PSEAE\|EnsemblGenome=PA4140\|UniProtKB=Q9HWP1	Pseudomonas aeruginosa	O
PSEAE\|EnsemblGenome=PA1416\|UniProtKB=Q9I3S8	Pseudomonas aeruginosa	O
PSEAE\|EnsemblGenome=PA0317\|UniProtKB=Q9I6H4	Pseudomonas aeruginosa	LDO
SALTY\|EnsemblGenome=STM2167\|UniProtKB=Q8ZNM7	Salmonella typhimurium	LDO
YERPE\|Gene_OrderedLocusName=YPO1177\|UniProtKB=Q7CH75	Yersinia pestis	LDO
ECOLI\|EnsemblGenome=BAE76610\|UniProtKB=P06149	Escherichia coli	LDO