PANTHER Gene Information

Gene Symbol(s):

LA_1247

Organism:

Leptospira interrogans

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Tree

Gene Name:

5-formyltetrahydrofolate cyclo-ligase

Gene ID:

LA_1247

Protein ID:

Q8F6Q4

Persistent Id:

PTN000601382

Alternate Ids:

LA_1247(Ensembl)	24194804(GI)
AE010300(EMBL)	AAN48446(EMBL-CDS)
61142335(GeneID)	Q8F6Q4(Synonym)
NP_711428(refSeq)	Q8F6Q4_LEPIN(UniProtKB-ID)
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PANTHER Classification

PANTHER Family:	ATPASE INHIBITOR/5-FORMYLTETRAHYDROFOLATE CYCLO-LIGASE (PTHR23407)
PANTHER Subfamily:	5-FORMYLTETRAHYDROFOLATE CYCLO-LIGASE (PTHR23407:SF1)
PANTHER GO-slim Molecular Function:	ligase activity
PANTHER GO-slim Biological Process:	heterocycle biosynthetic process aromatic compound biosynthetic process cellular nitrogen compound biosynthetic process folic acid-containing compound metabolic process organonitrogen compound biosynthetic process organic cyclic compound biosynthetic process small molecule metabolic process
PANTHER GO-slim Cellular Component:
PANTHER protein class:	ligase

Pathway Categories:

No pathway information available

GENE ONTOLOGY DATABASE ANNOTATIONS

Click to Expand...

GO MF Complete:	ATP binding, metal ion binding, 5-formyltetrahydrofolate cyclo-ligase activity
GO BP Complete:	folic acid-containing compound biosynthetic process, tetrahydrofolate interconversion
GO CC Complete:	-

REACTOME DATABASE ANNOTATIONS Click to Expand...

Reactome Pathways:

Orthologs

ID	Organism	Type
TRIAD\|EnsemblGenome=TriadG34978\|UniProtKB=B3SFC5	Trichoplax adhaerens	O
PARTE\|EnsemblGenome=GSPATT00009360001\|UniProtKB=A0CQE5	Paramecium tetraurelia	O
HUMAN\|HGNC=871\|UniProtKB=Q9UII2	Homo sapiens	O
PANTR\|Ensembl=ENSPTRG00000000428.7\|UniProtKB=H2PYG9	Pan troglodytes	O
GORGO\|Ensembl=ENSGGOG00000000822.3\|UniProtKB=G3QEV8	Gorilla gorilla gorilla	O
MACMU\|Ensembl=ENSMMUG00000018678.4\|UniProtKB=F6ZXX7	Macaca mulatta	O
MOUSE\|MGI=MGI=1196457\|UniProtKB=O35143	Mus musculus	O
RAT\|RGD=2181\|UniProtKB=Q03344	Rattus norvegicus	O
BOVIN\|Ensembl=ENSBTAG00000006342\|UniProtKB=P01096	Bos taurus	O
PIG\|Ensembl=ENSSSCG00000027072\|UniProtKB=Q29307	Sus scrofa	O
HORSE\|Ensembl=ENSECAG00000011826.4\|UniProtKB=F6ZXT0	Equus caballus	O
FELCA\|Ensembl=ENSFCAG00000013395.5\|UniProtKB=M3WIS8	Felis catus	O
MONDO\|Ensembl=ENSMODG00000010826.3\|UniProtKB=F7BE70	Monodelphis domestica	O
ORNAN\|Ensembl=ENSOANG00000049622.1\|UniProtKB=A0A6I8NDS4	Ornithorhynchus anatinus	O
ANOCA\|Ensembl=ENSACAG00000042388.1\|UniProtKB=A0A803SPR5	Anolis carolinensis	O
DANRE\|ZFIN=ZDB-GENE-050506-113\|UniProtKB=Q1LYB6	Danio rerio	O
DANRE\|ZFIN=ZDB-GENE-070410-36\|UniProtKB=A3KNL5	Danio rerio	O
CIOIN\|Ensembl=ENSCING00000021564.1\|UniProtKB=H2XLR3	Ciona intestinalis	O
IXOSC\|EnsemblGenome=ISCW001951\|UniProtKB=B7P7L5	Ixodes scapularis	O
HELRO\|EnsemblGenome=HelroG191850\|UniProtKB=T1FTC6	helobdella robusta	O
TRIAD\|EnsemblGenome=TriadG61171\|UniProtKB=B3SA83	Trichoplax adhaerens	O
HUMAN\|HGNC=7437\|UniProtKB=P49914	Homo sapiens	LDO
PANTR\|Ensembl=ENSPTRG00000007358.4\|UniProtKB=H2Q9X5	Pan troglodytes	LDO
GORGO\|Ensembl=ENSGGOG00000012188.3\|UniProtKB=G3R914	Gorilla gorilla gorilla	LDO
MACMU\|Ensembl=ENSMMUG00000015224.4\|UniProtKB=A0A1D5QRQ4	Macaca mulatta	LDO
MOUSE\|MGI=MGI=3780550\|UniProtKB=L7N466	Mus musculus	O
MOUSE\|MGI=MGI=1340032\|UniProtKB=Q9D110	Mus musculus	LDO
RAT\|RGD=1306876\|UniProtKB=Q5M9F6	Rattus norvegicus	LDO
BOVIN\|Ensembl=ENSBTAG00000017102.6\|UniProtKB=A0A3Q1MEJ8	Bos taurus	O
BOVIN\|Ensembl=ENSBTAG00000020023.4\|UniProtKB=Q1RMT3	Bos taurus	LDO
PIG\|Ensembl=ENSSSCG00000038708.3\|UniProtKB=A0A287BMU8	Sus scrofa	LDO
HORSE\|Ensembl=ENSECAG00000056595.1\|UniProtKB=F7C3A9	Equus caballus	LDO
FELCA\|Ensembl=ENSFCAG00000012202.5\|UniProtKB=A0A2I2UGT6	Felis catus	LDO
CANLF\|Ensembl=ENSCAFG00845005032.1\|UniProtKB=A0A8I3RSF7	Canis lupus familiaris	LDO
MONDO\|Ensembl=ENSMODG00000019430.4\|UniProtKB=F6SFK7	Monodelphis domestica	LDO
ORNAN\|Ensembl=ENSOANG00000009193.2\|UniProtKB=A0A6I8NZH7	Ornithorhynchus anatinus	LDO
CHICK\|Ensembl=ENSGALG00010019833.1\|UniProtKB=A0A8V0ZI79	Gallus gallus	LDO
ANOCA\|Ensembl=ENSACAG00000011900.4\|UniProtKB=H9GI82	Anolis carolinensis	LDO
XENLA\|Gene=mthfs.L\|UniProtKB=Q5FWN2	Xenopus laevis	LDO
XENTR\|Xenbase=XB-GENE-982611\|UniProtKB=B1H138	Xenopus tropicalis	LDO
DANRE\|ZFIN=ZDB-GENE-130103-5\|UniProtKB=A0A0G2L0J2	Danio rerio	LDO
LEPOC\|Ensembl=ENSLOCG00000012766.1\|UniProtKB=W5N4Z8	lepisosteus oculatus	LDO
CIOIN\|Ensembl=ENSCING00000015922.2\|UniProtKB=F6YZ79	Ciona intestinalis	LDO
BRAFL\|Gene=LOC118410015\|UniProtKB=A0A9J7KNP3	Branchiostoma floridae	LDO
STRPU\|EnsemblGenome=LOC753829\|UniProtKB=A0A7M7G3S7	Strongylocentrotus purpuratus	LDO
CAEEL\|WormBase=WBGene00013708\|UniProtKB=Q9XWE6	Caenorhabditis elegans	LDO
CAEBR\|Gene_ORFName=CBG12218\|UniProtKB=A8XEZ0	Caenorhabditis briggsae	LDO
DROME\|FlyBase=FBgn0085453\|UniProtKB=Q8MLS1	Drosophila melanogaster	LDO
ANOGA\|EnsemblGenome=AGAP006824\|UniProtKB=Q7QIG0	Anopheles gambiae	LDO
TRICA\|EnsemblGenome=TC008903\|UniProtKB=D6WQI7	Tribolium castaneum	LDO
DAPPU\|EnsemblGenome=DAPPUDRAFT_187016\|UniProtKB=E9FSQ6	Daphnia pulex	LDO
IXOSC\|EnsemblGenome=ISCW021606\|UniProtKB=B7Q8Q2	Ixodes scapularis	LDO
HELRO\|EnsemblGenome=HelroG69587\|UniProtKB=T1FZW8	helobdella robusta	LDO
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g169978\|UniProtKB=A7SFC3	Nematostella vectensis	LDO
TRIAD\|EnsemblGenome=TriadG54064\|UniProtKB=B3RR04	Trichoplax adhaerens	LDO
MONBE\|EnsemblGenome=MONBRDRAFT_13668\|UniProtKB=A9UPV0	Monosiga brevicollis	LDO
YEAST\|SGD=S000000985\|UniProtKB=P40099	Saccharomyces cerevisiae	LDO
EREGS\|EnsemblGenome=AGOS_ADL385C\|UniProtKB=Q75BE9	Eremothecium gossypii	LDO
CANAL\|CGD=CAL0000176281\|UniProtKB=Q59TA8	Candida albicans	LDO
YARLI\|EnsemblGenome=YALI0_D01309g\|UniProtKB=Q6CAN2	Yarrowia lipolytica	LDO
ASPFU\|EnsemblGenome=AFUA_7G05990\|UniProtKB=Q4WGR8	Neosartorya fumigata	LDO
NEUCR\|EnsemblGenome=NCU06353\|UniProtKB=Q7S9V3	Neurospora crassa	LDO
SCLS1\|Gene_ORFName=SS1G_09961\|UniProtKB=A7EXA0	Sclerotinia sclerotiorum	LDO
PHANO\|EnsemblGenome=SNOG_13666\|UniProtKB=Q0U3J8	Phaeosphaeria nodorum	LDO
SCHPO\|PomBase=SPBC1703.08c\|UniProtKB=Q9P7W2	Schizosaccharomyces pombe	LDO
SCHJY\|EnsemblGenome=SJAG_01616\|UniProtKB=B6JYF4	Schizosaccharomyces japonicus	LDO
CRYNJ\|EnsemblGenome=CNA05725\|UniProtKB=A0A0S2LHZ7	Cryptococcus neoformans	LDO
USTMA\|EnsemblGenome=UMAG_03307\|UniProtKB=A0A0D1DWY9	Ustilago maydis	LDO
PUCGT\|EnsemblGenome=PGTG_18175\|UniProtKB=E3L6B0	Puccinia graminis	LDO
PUCGT\|EnsemblGenome=PGTG_15714\|UniProtKB=E3KZ40	Puccinia graminis	O
PUCGT\|EnsemblGenome=PGTG_16449\|UniProtKB=E3L0U6	Puccinia graminis	O
BATDJ\|Gene_ORFName=BATDEDRAFT_84548\|UniProtKB=F4NSH5	Batrachochytrium dendrobatidis	LDO
LEIMA\|EnsemblGenome=LMJF_23_1045\|UniProtKB=Q4QB50	Leishmania major	LDO
TRYB2\|Gene_ORFName=Tb927.8.2990\|UniProtKB=Q57W74	Trypanosoma brucei	LDO
PLAF7\|EnsemblGenome=PF3D7_1245000\|UniProtKB=Q8I4Y1	Plasmodium falciparum	LDO
THAPS\|EnsemblGenome=THAPSDRAFT_5636\|UniProtKB=B8C3G7	Thalassiosira pseudonana	LDO
PHYRM\|Gene=H3HB68_PHYRM\|UniProtKB=H3HB68	Phytophthora ramorum	LDO
CHLRE\|EnsemblGenome=CHLRE_09g403293v5\|UniProtKB=A0A2K3DF64	Chlamydomonas reinhardtii	LDO
AMBTC\|EnsemblGenome=AMTR_s00002p00240930\|UniProtKB=W1P115	Amborella trichopoda	LDO
ZOSMR\|Gene_ORFName=ZOSMA_54G00390\|UniProtKB=A0A0K9NWV1	Zostera marina	LDO
MUSAM\|EnsemblGenome=Ma04_g28810\|UniProtKB=A0A804IV29	Musa acuminata subsp. malaccensis	LDO
MUSAM\|EnsemblGenome=Ma07_g01770\|UniProtKB=A0A804JR38	Musa acuminata subsp. malaccensis	O
SETIT\|EnsemblGenome=SETIT_030726mg\|UniProtKB=K3ZVU5	Setaria italica	LDO
SORBI\|EnsemblGenome=SORBI_3002G353000\|UniProtKB=C5XCF3	Sorghum bicolor	LDO
MAIZE\|EnsemblGenome=Zm00001eb107660\|UniProtKB=A0A804MS81	Zea mays	LDO
ORYSJ\|EnsemblGenome=Os07g0578600\|UniProtKB=Q0D564	Oryza sativa	LDO
BRADI\|EnsemblGenome=BRADI_1g23560v3\|UniProtKB=I1GT14	Brachypodium distachyon	LDO
HORVV\|EnsemblGenome=HORVU.MOREX.r3.2HG0131410\|UniProtKB=F2E2B4	Hordeum vulgare subsp. vulgare	LDO
WHEAT\|EnsemblGenome=TraesCS2D02G200100\|UniProtKB=A0A3B6D9S0	Triticum aestivum	O
WHEAT\|EnsemblGenome=TraesCS2A02G187700\|UniProtKB=A0A3B6AVY0	Triticum aestivum	LDO
NELNU\|Gene=LOC104608016\|UniProtKB=A0A1U8B7D5	Nelumbo nucifera	O
NELNU\|Gene=LOC104587781\|UniProtKB=A0A1U7Z9L3	Nelumbo nucifera	LDO
SPIOL\|Gene=LOC110789517\|UniProtKB=A0A9R0IKP1	Spinacia oleracea	O
TOBAC\|Gene=LOC107760549\|UniProtKB=A0A1S3X281	Nicotiana tabacum	O
TOBAC\|Gene=LOC107813911\|UniProtKB=A0A1S4C0Z3	Nicotiana tabacum	O
GOSHI\|Gene=LOC107945260\|UniProtKB=A0A1U8N9X6	Gossypium hirsutum	O
GOSHI\|Gene=LOC107927316\|UniProtKB=A0A1U8LL24	Gossypium hirsutum	O
THECC\|EnsemblGenome=TCM_010090\|UniProtKB=A0A061E5N0	Theobroma cacao	O
CITSI\|Gene_ORFName=CISIN_1g022563mg\|UniProtKB=A0A067GSL8	Citrus sinensis	O
JUGRE\|Gene=LOC108985000\|UniProtKB=A0A2I4DZU6	Juglans regia	O
PRUPE\|EnsemblGenome=PRUPE_1G263300\|UniProtKB=A0A251R3L7	Prunus persica	O
SPIOL\|Gene=LOC110794467\|UniProtKB=A0A9R0ITB7	Spinacia oleracea	LDO
HELAN\|EnsemblGenome=HanXRQr2_Chr02g0063091\|UniProtKB=A0A251VH08	Helianthus annuus	LDO
ERYGU\|Gene_ORFName=MIMGU_mgv1a011334mg\|UniProtKB=A0A022RR97	Erythranthe guttata	LDO
CAPAN\|EnsemblGenome=T459_10211\|UniProtKB=A0A2G3A1J4	Capsicum annuum	LDO
SOLTU\|EnsemblGenome=PGSC0003DMG400024570\|UniProtKB=M1CA66	Solanum tuberosum	LDO
SOLLC\|EnsemblGenome=Solyc03g113590.3\|UniProtKB=Q8LKF6	Solanum lycopersicum	LDO
TOBAC\|Gene=LOC107796143\|UniProtKB=A0A1S4ACU6	Nicotiana tabacum	O
TOBAC\|Gene=LOC107816621\|UniProtKB=A0A1S4CA55	Nicotiana tabacum	O
TOBAC\|Gene=LOC107818051\|UniProtKB=A0A1S4CE96	Nicotiana tabacum	O
TOBAC\|Gene=LOC107760804\|UniProtKB=A0A1S3X3C0	Nicotiana tabacum	LDO
VITVI\|EnsemblGenome=Vitvi17g00506\|UniProtKB=D7SIJ5	Vitis vinifera	LDO
EUCGR\|EnsemblGenome=EUGRSUZ_B00384\|UniProtKB=A0A059CYR4	Eucalyptus grandis	LDO
BRACM\|EnsemblGenome=Bra008861\|UniProtKB=M4CXB4	Brassica campestris	LDO
ARATH\|TAIR=locus=2179827\|UniProtKB=Q8L539	Arabidopsis thaliana	LDO
GOSHI\|Gene=LOC107895444\|UniProtKB=A0A1U8IDQ4	Gossypium hirsutum	O
GOSHI\|Gene=LOC107916295\|UniProtKB=A0A1U8KEY2	Gossypium hirsutum	LDO
THECC\|EnsemblGenome=TCM_045750\|UniProtKB=S1RW27	Theobroma cacao	LDO
CITSI\|Gene_ORFName=CISIN_1g025859mg\|UniProtKB=A0A067G2C4	Citrus sinensis	LDO
POPTR\|EnsemblGenome=POPTR_012G072800v3\|UniProtKB=A0A2K1YA93	Populus trichocarpa	LDO
MANES\|EnsemblGenome=MANES_06G098600\|UniProtKB=A0A2C9VPH7	Manihot esculenta	LDO
RICCO\|Gene_ORFName=RCOM_1512940\|UniProtKB=B9R910	Ricinus communis	LDO
SOYBN\|EnsemblGenome=GLYMA_04G177000\|UniProtKB=I1JX10	Glycine max	O
SOYBN\|EnsemblGenome=GLYMA_06G188000\|UniProtKB=I1KCM4	Glycine max	LDO
MEDTR\|EnsemblGenome=MTR_0168s0080\|UniProtKB=A0A072TSG6	Medicago truncatula	LDO
JUGRE\|Gene=LOC109000280\|UniProtKB=A0A2I4FLZ6	Juglans regia	LDO
JUGRE\|Gene=LOC109016972\|UniProtKB=A0A6P9DX82	Juglans regia	O
JUGRE\|EnsemblGenome=Jr09_02620\|UniProtKB=A0A2I4DU50	Juglans regia	O
JUGRE\|Gene=LOC109000253\|UniProtKB=A0A6P9F557	Juglans regia	O
JUGRE\|EnsemblGenome=Jr_Scaffold_92_00010\|UniProtKB=A0A2I4EJN2	Juglans regia	O
CUCSA\|EnsemblGenome=Csa_1G007880\|UniProtKB=A0A0A0LRK4	Cucumis sativus	LDO
PRUPE\|EnsemblGenome=PRUPE_5G182700\|UniProtKB=M5WV05	Prunus persica	LDO
SELML\|EnsemblGenome=SELMODRAFT_25619\|UniProtKB=D8SNI1	Selaginella moellendorffii	LDO
SELML\|EnsemblGenome=SELMODRAFT_25537\|UniProtKB=D8SRJ1	Selaginella moellendorffii	LDO
PHYPA\|EnsemblGenome=Pp3c12_22470\|UniProtKB=A0A2K1JRR3	Physcomitrella patens	O
PHYPA\|EnsemblGenome=Pp3c3_32060\|UniProtKB=A0A2K1KWU1	Physcomitrella patens	LDO
MARPO\|EnsemblGenome=MARPO_0019s0150\|UniProtKB=A0A2R6XF77	Marchantia polymorpha	LDO
NITMS\|EnsemblGenome=Nmar_1118\|UniProtKB=A9A4N6	Nitrosopumilus maritimus	LDO
CHLAA\|EnsemblGenome=Caur_2482\|UniProtKB=A9WHZ8	Chloroflexus aurantiacus	LDO
STRCO\|Gene_OrderedLocusName=SCO3183\|UniProtKB=Q9RKA5	Streptomyces coelicolor	LDO
MYCTU\|Gene_OrderedLocusName=Rv0992c\|UniProtKB=O05575	Mycobacterium tuberculosis	LDO
MYCGE\|EnsemblGenome=MG_245\|UniProtKB=P47487	mycoplasma genitalium	LDO
CLOBH\|Gene_OrderedLocusName=CBO2607\|UniProtKB=A5I538	Clostridium botulinum	LDO
STRR6\|EnsemblGenome=spr1905\|UniProtKB=Q8DN56	Streptococcus pneumoniae	LDO
STAA8\|EnsemblGenome=SAOUHSC_01650\|UniProtKB=Q2FY23	Staphylococcus aureus	LDO
LISMO\|Gene=Q8Y7E7_LISMO\|UniProtKB=Q8Y7E7	Listeria monocytogenes	LDO
BACSU\|EnsemblGenome=BSU_24890\|UniProtKB=P54491	Bacillus subtilis	LDO
BACCR\|EnsemblGenome=BC_4262\|UniProtKB=Q818J1	Bacillus cereus	LDO
DEIRA\|EnsemblGenome=DR_1815\|UniProtKB=Q9RTF0	Deinococcus radiodurans	LDO
GLOVI\|Gene=Q7NMK6_GLOVI\|UniProtKB=Q7NMK6	Gloeobacter violaceus	LDO
SYNY3\|Gene=P73038_SYNY3\|UniProtKB=P73038	Synechocystis	LDO
BACTN\|EnsemblGenome=BT_4258\|UniProtKB=Q89ZW3	Bacteroides thetaiotaomicron	LDO
CHLTR\|EnsemblGenome=CT_649\|UniProtKB=O84655	Chlamydia trachomatis	LDO
RHOBA\|EnsemblGenome=RB5405\|UniProtKB=Q7URX2	Rhodopirellula baltica	LDO
AQUAE\|EnsemblGenome=aq_1731\|UniProtKB=O67621	Aquifex aeolicus	LDO
THEYD\|EnsemblGenome=THEYE_A0672\|UniProtKB=B5YJU9	Thermodesulfovibrio yellowstonii	LDO
DICTD\|EnsemblGenome=Dtur_1222\|UniProtKB=B8E301	Dictyoglomus turgidum	LDO
FUSNN\|EnsemblGenome=FN0902\|UniProtKB=Q8RF22	Fusobacterium nucleatum	LDO
HELPY\|EnsemblGenome=HP_0761\|UniProtKB=O25456	Helicobacter pylori	LDO
NEIMB\|EnsemblGenome=NMB2099\|UniProtKB=Q9JXD4	Neisseria meningitidis serogroup b	LDO
GEOSL\|EnsemblGenome=GSU1136\|UniProtKB=Q74E28	Geobacter sulfurreducens	LDO
BRADU\|Gene=Q89U90_BRADU\|UniProtKB=Q89U90	Bradyrhizobium diazoefficiens	LDO
COXBU\|EnsemblGenome=CBU_0066\|UniProtKB=Q83F82	Coxiella burnetii	LDO
HAEIN\|EnsemblGenome=HI_0858\|UniProtKB=P44905	Haemophilus influenzae	LDO
SHEON\|Gene_OrderedLocusName=SO_0774\|UniProtKB=Q8EIR3	Shewanella oneidensis	LDO
VIBCH\|EnsemblGenome=VC_2479\|UniProtKB=Q9KP94	Vibrio cholerae	LDO
XANCP\|EnsemblGenome=XCC3263\|UniProtKB=Q8P5S3	Xanthomonas campestris	LDO
PSEAE\|EnsemblGenome=PA5228\|UniProtKB=Q9HTW2	Pseudomonas aeruginosa	LDO
SALTY\|EnsemblGenome=STM3061\|UniProtKB=Q8ZM70	Salmonella typhimurium	LDO
YERPE\|Gene_OrderedLocusName=YPO0913\|UniProtKB=A0A5P8YCV0	Yersinia pestis	LDO
ECOLI\|EnsemblGenome=BAE76976\|UniProtKB=P0AC28	Escherichia coli	LDO