PANTHER Gene Information

Gene Symbol(s):

fgfr4

Organism:

Danio rerio

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Gene Name:

Fibroblast growth factor receptor 4

Gene ID:

ZDB-GENE-980526-488

Protein ID:

Q90413

Persistent Id:

PTN000699363

Alternate Ids:

FGFR4_DANRE(UniProtKB-ID)	NP_571505(refSeq)
U23839(EMBL)	18858679(GI)
fgfr4(Symbol)	AAA96816(EMBL-CDS)
2.7.10.1(EC)	FGFR4(Synonym)
ZDB-GENE-980526-488(ZFIN)	100000160(GeneID)
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PANTHER Classification

PANTHER Family:	TYROSINE-PROTEIN KINASE RECEPTOR (PTHR24416)
PANTHER Subfamily:	FIBROBLAST GROWTH FACTOR RECEPTOR 4 (PTHR24416:SF343)
PANTHER GO-slim Molecular Function:	fibroblast growth factor binding transmembrane receptor protein tyrosine kinase activity
PANTHER GO-slim Biological Process:	transmembrane receptor protein tyrosine kinase signaling pathway regulation of cellular biosynthetic process positive regulation of ERK1 and ERK2 cascade regulation of lipid biosynthetic process multicellular organism development positive regulation of kinase activity
PANTHER GO-slim Cellular Component:	plasma membrane receptor complex
PANTHER protein class:	transmembrane signal receptor

Pathway Categories:

FGF signaling pathway

FGFR1-4

GENE ONTOLOGY DATABASE ANNOTATIONS

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GO MF Complete:	nucleotide binding, fibroblast growth factor receptor activity, ATP binding, protein tyrosine kinase activity, protein binding, transmembrane receptor protein tyrosine kinase activity, protein kinase activity, fibroblast growth factor binding, transferase activity, kinase activity
GO BP Complete:	multicellular organism development, regulation of hematopoietic stem cell differentiation, positive regulation of ERK1 and ERK2 cascade, cell surface receptor protein tyrosine kinase signaling pathway, fibroblast growth factor receptor signaling pathway, positive regulation of kinase activity, regulation of bile acid biosynthetic process
GO CC Complete:	endosome, membrane, endoplasmic reticulum, receptor complex, plasma membrane

REACTOME DATABASE ANNOTATIONS Click to Expand...

Reactome Pathways:

FGFR4 ligand binding and activation, Signaling by FGFR4, MAPK1/MAPK3 signaling, Signaling by Receptor Tyrosine Kinases, Phospholipase C-mediated cascade; FGFR4, Signaling by FGFR, FRS-mediated FGFR4 signaling, Downstream signaling of activated FGFR4, Signal Transduction, MAPK family signaling cascades, RAF/MAP kinase cascade

Orthologs

ID	Organism	Type
HUMAN\|HGNC=3691\|UniProtKB=P22455	Homo sapiens	LDO
PANTR\|Ensembl=ENSPTRG00000017574.6\|UniProtKB=H2QS34	Pan troglodytes	LDO
GORGO\|Ensembl=ENSGGOG00000002917.3\|UniProtKB=G3RPD8	Gorilla gorilla gorilla	LDO
MOUSE\|MGI=MGI=95525\|UniProtKB=Q03142	Mus musculus	LDO
RAT\|RGD=2612\|UniProtKB=Q498D6	Rattus norvegicus	LDO
BOVIN\|Ensembl=ENSBTAG00000010543.6\|UniProtKB=F1MN51	Bos taurus	LDO
PIG\|Ensembl=ENSSSCG00000014047.6\|UniProtKB=F1S3B8	Sus scrofa	LDO
HORSE\|Ensembl=ENSECAG00000020869.4\|UniProtKB=A0A5F5PXI3	Equus caballus	LDO
FELCA\|Ensembl=ENSFCAG00000016224.6\|UniProtKB=M3WNB0	Felis catus	LDO
CANLF\|Ensembl=ENSCAFG00845010987.1\|UniProtKB=A0A8I3NHA2	Canis lupus familiaris	LDO
MONDO\|Ensembl=ENSMODG00000004899.4\|UniProtKB=F7C211	Monodelphis domestica	LDO
ORNAN\|Ensembl=ENSOANG00000007493.3\|UniProtKB=F6QKY2	Ornithorhynchus anatinus	LDO
CHICK\|Ensembl=ENSGALG00010011810.1\|UniProtKB=F1NCL8	Gallus gallus	LDO
ANOCA\|Ensembl=ENSACAG00000005410.4\|UniProtKB=G1KE82	Anolis carolinensis	LDO
XENLA\|Gene=fgfr4\|UniProtKB=Q91743	Xenopus laevis	O
XENLA\|Gene=fgfr4.S\|UniProtKB=Q9PSV8	Xenopus laevis	O
XENLA\|Gene=fgfr4.L\|UniProtKB=Q9PSV9	Xenopus laevis	LDO
XENTR\|Xenbase=XB-GENE-478699\|UniProtKB=Q28GC1	Xenopus tropicalis	LDO
ORYLA\|Ensembl=ENSORLG00000013964.2\|UniProtKB=H2MFY7	Oryzias latipes	LDO
LEPOC\|Ensembl=ENSLOCG00000012293.1\|UniProtKB=W5N3C2	lepisosteus oculatus	LDO
CIOIN\|Ensembl=ENSCING00000000875.3\|UniProtKB=F6QQF5	Ciona intestinalis	O
CIOIN\|Gene=FGFR\|UniProtKB=Q4H3K6	Ciona intestinalis	O
BRAFL\|Gene=LOC118414472\|UniProtKB=A0A9J7L2Z7	Branchiostoma floridae	O
BRAFL\|Gene=LOC118413855\|UniProtKB=A0A9J7L0C8	Branchiostoma floridae	O
STRPU\|EnsemblGenome=GeneID_373310\|UniProtKB=Q26614	Strongylocentrotus purpuratus	O
CAEEL\|WormBase=WBGene00001184\|UniProtKB=Q10656	Caenorhabditis elegans	O
CAEBR\|Gene_ORFName=CBG17516\|UniProtKB=A8XRD1	Caenorhabditis briggsae	O
PRIPA\|EnsemblGenome=WBGene00278198\|UniProtKB=A0A2A6B247	Pristionchus pacificus	O
DROME\|FlyBase=FBgn0010389\|UniProtKB=Q07407	Drosophila melanogaster	O
DROME\|FlyBase=FBgn0285896\|UniProtKB=Q09147	Drosophila melanogaster	O
ANOGA\|EnsemblGenome=AGAP003108\|UniProtKB=A0A1S4GGY3	Anopheles gambiae	O
TRICA\|EnsemblGenome=TC004713\|UniProtKB=D6W6I2	Tribolium castaneum	O
DAPPU\|EnsemblGenome=DAPPUDRAFT_300042\|UniProtKB=E9FS22	Daphnia pulex	O
IXOSC\|EnsemblGenome=ISCW018261\|UniProtKB=B7PFB4	Ixodes scapularis	O
HELRO\|EnsemblGenome=HelroG70474\|UniProtKB=T1G069	helobdella robusta	O
HELRO\|EnsemblGenome=HelroG81195\|UniProtKB=T1G4A9	helobdella robusta	O
HELRO\|EnsemblGenome=HelroG102694\|UniProtKB=T1EDB0	helobdella robusta	O
HELRO\|EnsemblGenome=HelroG132900\|UniProtKB=T1EHZ9	helobdella robusta	O
HELRO\|EnsemblGenome=HelroG79669\|UniProtKB=T1G3S0	helobdella robusta	O
HELRO\|EnsemblGenome=HelroG131255\|UniProtKB=T1EHV6	helobdella robusta	O
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g81258\|UniProtKB=A7RHA0	Nematostella vectensis	O
NEMVE\|Gene_ORFName=NEMVEDRAFT_v1g98570\|UniProtKB=A7RZ71	Nematostella vectensis	O
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g98616\|UniProtKB=A7RZ69	Nematostella vectensis	O
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g31143\|UniProtKB=A7RHA4	Nematostella vectensis	O
MONBE\|EnsemblGenome=MONBRDRAFT_37376\|UniProtKB=A9V1C1	Monosiga brevicollis	O
MONBE\|EnsemblGenome=MONBRDRAFT_20579\|UniProtKB=Q8WRF4	Monosiga brevicollis	O
MONBE\|EnsemblGenome=MONBRDRAFT_12702\|UniProtKB=A9VD25	Monosiga brevicollis	O
MONBE\|EnsemblGenome=MONBRDRAFT_39078\|UniProtKB=A9VC23	Monosiga brevicollis	O
MONBE\|EnsemblGenome=MONBRDRAFT_32678\|UniProtKB=A9V127	Monosiga brevicollis	O
MONBE\|EnsemblGenome=MONBRDRAFT_44364\|UniProtKB=A9V8G0	Monosiga brevicollis	O
MONBE\|EnsemblGenome=MONBRDRAFT_33202\|UniProtKB=A9V450	Monosiga brevicollis	O
MONBE\|EnsemblGenome=MONBRDRAFT_14040\|UniProtKB=A9UNI7	Monosiga brevicollis	O