PANTHER Gene Information

Gene Symbol(s):

alien

Organism:

Drosophila melanogaster

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Gene Name:

COP9 signalosome complex subunit 2

Gene ID:

FBgn0013746

Protein ID:

Q94899

Persistent Id:

PTN000073714

Alternate Ids:

FBgn0013746(Ensembl)	AAB49932(EMBL-CDS)
Q9V3Z0(AltAccession)	17647149(GI)
FBtr0079780(Ensembl_TRS)	NP_001285771(refSeq)
alien{ECO:0000312\|FlyBase:FBgn0013746}(Symbol)	AE014134(EMBL)
34225(GeneID)	CSN2_DROME(UniProtKB-ID)
FBpp0089195(Ensembl_PRO)	FBgn0013746(FlyBase)
Signalosome subunit 2(Synonym)
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PANTHER Classification

PANTHER Family:	26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 11/COP9 SIGNALOSOME COMPLEX SUBUNIT 2 (PTHR10678)
PANTHER Subfamily:	COP9 SIGNALOSOME COMPLEX SUBUNIT 2 (PTHR10678:SF3)
PANTHER GO-slim Molecular Function:
PANTHER GO-slim Biological Process:	protein modification by small protein removal
PANTHER GO-slim Cellular Component:	COP9 signalosome
PANTHER protein class:

Pathway Categories:

No pathway information available

GENE ONTOLOGY DATABASE ANNOTATIONS

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GO MF Complete:	nuclear receptor binding, protein binding, transcription corepressor activity
GO BP Complete:	germ cell development, germarium-derived cystoblast division, negative regulation of DNA-templated transcription, female germ-line stem cell population maintenance, protein deneddylation, eclosion, male germ-line cyst encapsulation, protein stabilization
GO CC Complete:	cytoplasm, repressor ecdysone receptor complex, COP9 signalosome

REACTOME DATABASE ANNOTATIONS Click to Expand...

Reactome Pathways:

DNA Repair, Signaling by Rho GTPases, Signal Transduction, RHOBTB GTPase Cycle, Metabolism of proteins, RHOBTB1 GTPase cycle, Vesicle-mediated transport, Cargo recognition for clathrin-mediated endocytosis, Post-translational protein modification, RHO GTPase cycle, Transcription-Coupled Nucleotide Excision Repair (TC-NER), Clathrin-mediated endocytosis, Global Genome Nucleotide Excision Repair (GG-NER), Nucleotide Excision Repair, Formation of TC-NER Pre-Incision Complex, Neddylation, Membrane Trafficking, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, DNA Damage Recognition in GG-NER

Orthologs

ID	Organism	Type
HUMAN\|HGNC=30747\|UniProtKB=P61201	Homo sapiens	LDO
PANTR\|Ensembl=ENSPTRG00000007051.5\|UniProtKB=H2Q9E2	Pan troglodytes	LDO
GORGO\|Ensembl=ENSGGOG00000002827.3\|UniProtKB=A0A2I2Z3U7	Gorilla gorilla gorilla	LDO
MACMU\|Ensembl=ENSMMUG00000042620.2\|UniProtKB=A0A5F7ZD84	Macaca mulatta	O
MACMU\|Ensembl=ENSMMUG00000009838.4\|UniProtKB=H9G1W2	Macaca mulatta	LDO
MOUSE\|MGI=MGI=1330276\|UniProtKB=P61202	Mus musculus	LDO
RAT\|RGD=628791\|UniProtKB=P61203	Rattus norvegicus	LDO
BOVIN\|Ensembl=ENSBTAG00000019284.5\|UniProtKB=G3X736	Bos taurus	LDO
PIG\|Ensembl=ENSSSCG00000004652.5\|UniProtKB=A0A5K1ULP5	Sus scrofa	LDO
PIG\|Ensembl=ENSSSCG00000004652.5\|UniProtKB=A0A5K1ULP5	Sus scrofa	LDO
HORSE\|Ensembl=ENSECAG00000024709.4\|UniProtKB=A0A3Q2IB89	Equus caballus	LDO
FELCA\|Ensembl=ENSFCAG00000023002.4\|UniProtKB=A0A5F5XJ43	Felis catus	LDO
CANLF\|Ensembl=ENSCAFG00845021829.1\|UniProtKB=A0A8I3PCP2	Canis lupus familiaris	LDO
MONDO\|Ensembl=ENSMODG00000002466.3\|UniProtKB=F7DDQ2	Monodelphis domestica	LDO
ORNAN\|Ensembl=ENSOANG00000010593.3\|UniProtKB=F6SE02	Ornithorhynchus anatinus	LDO
CHICK\|Ensembl=ENSGALG00010016027.1\|UniProtKB=E1C3U6	Gallus gallus	LDO
ANOCA\|Ensembl=ENSACAG00000015992.4\|UniProtKB=H9GMT9	Anolis carolinensis	LDO
XENLA\|Gene=cops2.L\|UniProtKB=A0A1L8H0N4	Xenopus laevis	O
XENLA\|Gene=csn2\|UniProtKB=Q6IR75	Xenopus laevis	LDO
XENLA\|Gene=cops2.S\|UniProtKB=A0A1L8GSU3	Xenopus laevis	LDO
XENTR\|Xenbase=XB-GENE-954196\|UniProtKB=Q5EB36	Xenopus tropicalis	LDO
ORYLA\|Ensembl=ENSORLG00000002351.2\|UniProtKB=H2LAL0	Oryzias latipes	LDO
DANRE\|ZFIN=ZDB-GENE-040625-15\|UniProtKB=Q6IQT4	Danio rerio	LDO
LEPOC\|Ensembl=ENSLOCG00000013176.1\|UniProtKB=W5N6H0	lepisosteus oculatus	LDO
CIOIN\|Ensembl=ENSCING00000008702.3\|UniProtKB=F6WYI9	Ciona intestinalis	LDO
BRAFL\|Gene=LOC118405270\|UniProtKB=A0A9J7K843	Branchiostoma floridae	LDO
STRPU\|EnsemblGenome=LOC576418\|UniProtKB=A0A7M7RBN9	Strongylocentrotus purpuratus	LDO
CAEEL\|WormBase=WBGene00000814\|UniProtKB=O01422	Caenorhabditis elegans	LDO
PRIPA\|EnsemblGenome=WBGene00096090\|UniProtKB=A0A8R1Y8M1	Pristionchus pacificus	LDO
ANOGA\|EnsemblGenome=AGAP008598\|UniProtKB=Q7PPL9	Anopheles gambiae	LDO
TRICA\|EnsemblGenome=TC004854\|UniProtKB=D6WBJ5	Tribolium castaneum	O
TRICA\|EnsemblGenome=TC004662\|UniProtKB=D6W6G1	Tribolium castaneum	LDO
DAPPU\|EnsemblGenome=DAPPUDRAFT_307388\|UniProtKB=E9H1V3	Daphnia pulex	LDO
IXOSC\|EnsemblGenome=ISCW021720\|UniProtKB=B7Q657	Ixodes scapularis	LDO
HELRO\|EnsemblGenome=HelroG184988\|UniProtKB=T1FM84	helobdella robusta	LDO
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g160233\|UniProtKB=A7RLS7	Nematostella vectensis	LDO
TRIAD\|EnsemblGenome=TriadG30777\|UniProtKB=B3S818	Trichoplax adhaerens	LDO
MONBE\|EnsemblGenome=MONBRDRAFT_16111\|UniProtKB=A9UWC1	Monosiga brevicollis	LDO
EREGS\|EnsemblGenome=AGOS_ADL153W\|UniProtKB=Q75AS3	Eremothecium gossypii	LDO
CANAL\|CGD=CAL0000176740\|UniProtKB=A0A1D8PIE9	Candida albicans	LDO
YARLI\|EnsemblGenome=YALI0_F16874g\|UniProtKB=Q6C1F1	Yarrowia lipolytica	LDO
EMENI\|EnsemblGenome=ANIA_04783\|UniProtKB=Q5B3U7	Emericella nidulans	LDO
ASPFU\|EnsemblGenome=AFUA_3G06700\|UniProtKB=Q4WWQ5	Neosartorya fumigata	LDO
NEUCR\|EnsemblGenome=NCU00593\|UniProtKB=Q7SI58	Neurospora crassa	LDO
SCLS1\|EnsemblGenome=SS1G_02767\|UniProtKB=A7EBT1	Sclerotinia sclerotiorum	LDO
PHANO\|EnsemblGenome=SNOG_00976\|UniProtKB=Q0V4T8	Phaeosphaeria nodorum	LDO
SCHPO\|PomBase=SPAPB17E12.04c\|UniProtKB=Q9HFR0	Schizosaccharomyces pombe	LDO
SCHJY\|EnsemblGenome=SJAG_03325\|UniProtKB=B6K3X9	Schizosaccharomyces japonicus	LDO
CRYNJ\|EnsemblGenome=CND01880\|UniProtKB=Q5KIS9	Cryptococcus neoformans	LDO
USTMA\|EnsemblGenome=UMAG_00817\|UniProtKB=A0A0D1D204	Ustilago maydis	LDO
PUCGT\|EnsemblGenome=PGTG_13056\|UniProtKB=E3KQU9	Puccinia graminis	LDO
BATDJ\|Gene_ORFName=BATDEDRAFT_90405\|UniProtKB=F4P7Z0	Batrachochytrium dendrobatidis	LDO
ENTH1\|EnsemblGenome=CL6EHI_174890\|UniProtKB=C4LZL4	Entamoeba histolytica	LDO
DICDI\|dictyBase=DDB_G0289361\|UniProtKB=Q54HL6	Dictyostelium discoideum	LDO
DICPU\|EnsemblGenome=DICPUDRAFT_148196\|UniProtKB=F0ZAI1	Dictyostelium purpureum	LDO
LEIMA\|EnsemblGenome=LMJF_25_2210\|UniProtKB=Q4Q9L6	Leishmania major	LDO
TRYB2\|Gene_ORFName=Tb927.3.2320\|UniProtKB=Q582U5	Trypanosoma brucei	LDO
TRIV3\|Gene_ORFName=TVAG_151040\|UniProtKB=A2FM16	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_279420\|UniProtKB=A2G5Q0	Trichomonas vaginalis	LDO
PARTE\|EnsemblGenome=GSPATT00030613001\|UniProtKB=A0BN58	Paramecium tetraurelia	LDO
THAPS\|EnsemblGenome=THAPSDRAFT_35771\|UniProtKB=B8C6S9	Thalassiosira pseudonana	LDO
PHYRM\|Gene=H3G736_PHYRM\|UniProtKB=H3G736	Phytophthora ramorum	O
PHYRM\|Gene=H3GHW8_PHYRM\|UniProtKB=H3GHW8	Phytophthora ramorum	LDO
CHLRE\|EnsemblGenome=CHLRE_01g030800v5\|UniProtKB=A0A2K3E6P1	Chlamydomonas reinhardtii	LDO
AMBTC\|EnsemblGenome=AMTR_s00095p00125060\|UniProtKB=W1NQW9	Amborella trichopoda	LDO
ZOSMR\|Gene_ORFName=ZOSMA_6G00140\|UniProtKB=A0A0K9NQQ0	Zostera marina	LDO
MUSAM\|EnsemblGenome=Ma06_g24970\|UniProtKB=A0A804JK42	Musa acuminata subsp. malaccensis	LDO
SETIT\|EnsemblGenome=SETIT_001486mg\|UniProtKB=K3XHW4	Setaria italica	LDO
SORBI\|EnsemblGenome=SORBI_3003G132000\|UniProtKB=C5XHA8	Sorghum bicolor	LDO
MAIZE\|EnsemblGenome=Zm00001eb332660\|UniProtKB=A0A804QK19	Zea mays	O
MAIZE\|EnsemblGenome=Zm00001eb128990\|UniProtKB=C0HFZ9	Zea mays	LDO
ORYSJ\|EnsemblGenome=Os01g0279200\|UniProtKB=A0A0P0V105	Oryza sativa	LDO
BRADI\|EnsemblGenome=BRADI_2g10780v3\|UniProtKB=I1HEK2	Brachypodium distachyon	LDO
HORVV\|EnsemblGenome=HORVU.MOREX.r3.3HG0257890\|UniProtKB=F2D6A6	Hordeum vulgare subsp. vulgare	LDO
WHEAT\|EnsemblGenome=TraesCS3B02G219800\|UniProtKB=A0A3B6FLV0	Triticum aestivum	LDO
WHEAT\|EnsemblGenome=TraesCS3A02G191800\|UniProtKB=A0A1D6RQA5	Triticum aestivum	LDO
NELNU\|Gene_ORFName=HUJ06_001346\|UniProtKB=A0A1U7ZTR1	Nelumbo nucifera	LDO
SPIOL\|Gene=LOC110796473\|UniProtKB=A0A9R0K4A7	Spinacia oleracea	LDO
HELAN\|EnsemblGenome=HanXRQr2_Chr06g0259701\|UniProtKB=A0A251UI73	Helianthus annuus	LDO
HELAN\|EnsemblGenome=HanXRQr2_Chr04g0188681\|UniProtKB=A0A251V357	Helianthus annuus	LDO
LACSA\|Gene_ORFName=LSAT_V11C800422900\|UniProtKB=A0A9R1UNA4	Lactuca sativa	LDO
ERYGU\|Gene_ORFName=MIMGU_mgv1a006546mg\|UniProtKB=A0A022R6W0	Erythranthe guttata	LDO
CAPAN\|EnsemblGenome=T459_27970\|UniProtKB=A0A2G2YFE8	Capsicum annuum	LDO
SOLTU\|EnsemblGenome=PGSC0003DMG400032509\|UniProtKB=M1D5U4	Solanum tuberosum	LDO
SOLLC\|EnsemblGenome=Solyc11g062430.2\|UniProtKB=A0A3Q7JN65	Solanum lycopersicum	LDO
TOBAC\|Gene=LOC107784887\|UniProtKB=A0A1S3ZAW7	Nicotiana tabacum	O
TOBAC\|Gene=LOC107803597\|UniProtKB=A0A1S4B1X2	Nicotiana tabacum	LDO
CAPAN\|EnsemblGenome=T459_26396\|UniProtKB=A0A2G2YNH5	Capsicum annuum	O
SOLTU\|EnsemblGenome=PGSC0003DMG400028109\|UniProtKB=M1CPW6	Solanum tuberosum	O
CAPAN\|EnsemblGenome=T459_33789\|UniProtKB=A0A2G2XXY6	Capsicum annuum	O
SOLTU\|EnsemblGenome=PGSC0003DMG400022712\|UniProtKB=M1C2R1	Solanum tuberosum	O
SOLLC\|EnsemblGenome=Solyc01g008840.3\|UniProtKB=A0A3Q7EA30	Solanum lycopersicum	O
TOBAC\|Gene=LOC107767670\|UniProtKB=A0A1S3XQS6	Nicotiana tabacum	O
TOBAC\|Gene=LOC107807237\|UniProtKB=A0A1S4BDY7	Nicotiana tabacum	O
VITVI\|EnsemblGenome=Vitvi08g02106\|UniProtKB=D7TQ50	Vitis vinifera	LDO
EUCGR\|EnsemblGenome=EUGRSUZ_B03772\|UniProtKB=A0A059D9K4	Eucalyptus grandis	LDO
BRANA\|Gene_ORFName=GSBRNA2T00066196001\|UniProtKB=A0A078HP40	Brassica napus	LDO
BRACM\|EnsemblGenome=Bra012038\|UniProtKB=M4D6C9	Brassica campestris	O
BRACM\|EnsemblGenome=Bra000529\|UniProtKB=M4C8K1	Brassica campestris	LDO
ARATH\|TAIR=locus=2059289\|UniProtKB=Q8W207	Arabidopsis thaliana	LDO
GOSHI\|Gene=LOC107891480\|UniProtKB=A0A1U8I7T2	Gossypium hirsutum	O
GOSHI\|Gene=LOC107953235\|UniProtKB=A0A1U8P177	Gossypium hirsutum	O
GOSHI\|Gene=LOC107889261\|UniProtKB=A0A1U8HYT5	Gossypium hirsutum	LDO
THECC\|EnsemblGenome=TCM_041031\|UniProtKB=A0A061GU38	Theobroma cacao	LDO
CITSI\|Gene_ORFName=CISIN_1g014143mg\|UniProtKB=A0A067FJM7	Citrus sinensis	LDO
POPTR\|EnsemblGenome=POPTR_009G020900v3\|UniProtKB=A0A2K1Z1F5	Populus trichocarpa	LDO
POPTR\|EnsemblGenome=POPTR_001G222700v3\|UniProtKB=B9N6U1	Populus trichocarpa	LDO
MANES\|EnsemblGenome=MANES_02G133500\|UniProtKB=A0A2C9WDX5	Manihot esculenta	O
MANES\|EnsemblGenome=MANES_01G175000\|UniProtKB=A0A2C9WLR7	Manihot esculenta	LDO
RICCO\|Gene_ORFName=RCOM_1394390\|UniProtKB=B9T2W1	Ricinus communis	LDO
SOYBN\|EnsemblGenome=GLYMA_19G121500\|UniProtKB=A0A0R0EWR2	Glycine max	O
SOYBN\|EnsemblGenome=GLYMA_19G072400\|UniProtKB=I1N780	Glycine max	O
SOYBN\|EnsemblGenome=GLYMA_05G079400\|UniProtKB=I1K1W8	Glycine max	O
SOYBN\|EnsemblGenome=GLYMA_03G004400\|UniProtKB=I1JK31	Glycine max	LDO
MEDTR\|EnsemblGenome=MTR_7g087530\|UniProtKB=G7L2Q4	Medicago truncatula	LDO
JUGRE\|EnsemblGenome=Jr03_19780\|UniProtKB=A0A2I4FJD2	Juglans regia	LDO
PRUPE\|EnsemblGenome=PRUPE_6G156800\|UniProtKB=M5VYA1	Prunus persica	LDO
SELML\|EnsemblGenome=SELMODRAFT_147370\|UniProtKB=D8REP6	Selaginella moellendorffii	LDO
PHYPA\|EnsemblGenome=Pp3c15_2200\|UniProtKB=A0A7I4AZ21	Physcomitrella patens	O
PHYPA\|EnsemblGenome=Pp3c17_10150\|UniProtKB=A0A2K1J3D1	Physcomitrella patens	O
PHYPA\|EnsemblGenome=Pp3c9_2060\|UniProtKB=A9SLD4	Physcomitrella patens	LDO
MARPO\|EnsemblGenome=MARPO_0063s0071\|UniProtKB=A0A2R6WRT7	Marchantia polymorpha	LDO
KLENI\|Gene_ORFName=KFL_002380030\|UniProtKB=A0A1Y1I3H9	Klebsormidium nitens	LDO