PANTHER Gene Information

Gene Symbol(s):

cue

Organism:

Drosophila melanogaster

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Gene Name:

Protein cueball

Gene ID:

FBgn0011204

Protein ID:

Q95RU0

Persistent Id:

PTN000056332

Alternate Ids:

CUE(Synonym)	AY061139(EMBL)
FBgn0011204(Ensembl)	AAF47503(EMBL-CDS)
NP_612113(refSeq)	16768936(GI)
CUE_DROME(UniProtKB-ID)	Q9W0E5(AltAccession)
FBtr0072706(Ensembl_TRS)	FBgn0011204(FlyBase)
38174(GeneID)	cue{ECO:0000312\|FlyBase:FBgn0011204}(Symbol)
FBpp0072590(Ensembl_PRO)
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PANTHER Classification

PANTHER Family:	VITELLOGENIN RECEPTOR-LIKE PROTEIN-RELATED-RELATED (PTHR46513)
PANTHER Subfamily:	PROTEIN CUEBALL (PTHR46513:SF42)
PANTHER GO-slim Molecular Function:	transmembrane signaling receptor activity Wnt-protein binding
PANTHER GO-slim Biological Process:	canonical Wnt signaling pathway
PANTHER GO-slim Cellular Component:	plasma membrane
PANTHER protein class:	transmembrane signal receptor

Pathway Categories:

No pathway information available

GENE ONTOLOGY DATABASE ANNOTATIONS

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GO MF Complete:	calcium ion binding
GO BP Complete:	positive regulation of circadian sleep/wake cycle, sleep, triglyceride homeostasis
GO CC Complete:	-

REACTOME DATABASE ANNOTATIONS Click to Expand...

Reactome Pathways:

Response to elevated platelet cytosolic Ca2+, Signaling by WNT, ERBB2 Regulates Cell Motility, Signaling by ERBB4, MAPK family signaling cascades, Downregulation of ERBB2 signaling, Signal Transduction, Signaling by Receptor Tyrosine Kinases, GRB2 events in EGFR signaling, GAB1 signalosome, Platelet activation, signaling and aggregation, Cargo recognition for clathrin-mediated endocytosis, Disassembly of the destruction complex and recruitment of AXIN to the membrane, EGFR downregulation, Clathrin-mediated endocytosis, SHC1 events in ERBB2 signaling, Platelet degranulation , Hemostasis, RAF/MAP kinase cascade, PIP3 activates AKT signaling, SHC1 events in EGFR signaling, MAPK1/MAPK3 signaling, Negative regulation of the PI3K/AKT network, EGFR interacts with phospholipase C-gamma, TCF dependent signaling in response to WNT, Signaling by EGFR, Signaling by ERBB2, Intracellular signaling by second messengers, Vesicle-mediated transport, PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling, PI3K events in ERBB2 signaling, Membrane Trafficking

Orthologs

ID	Organism	Type
GORGO\|Ensembl=ENSGGOG00000040868.1\|UniProtKB=A0A2I2Z2U5	Gorilla gorilla gorilla	O
BOVIN\|Ensembl=ENSBTAG00000024632.6\|UniProtKB=A0A3Q1MEB6	Bos taurus	O
PIG\|Ensembl=ENSSSCG00000023746.4\|UniProtKB=I3LC88	Sus scrofa	O
HORSE\|Ensembl=ENSECAG00000012212.4\|UniProtKB=A0A3Q2HLW4	Equus caballus	O
ORYLA\|Ensembl=ENSORLG00000018260.2\|UniProtKB=H2MVM6	Oryzias latipes	O
HUMAN\|HGNC=3229\|UniProtKB=P01133	Homo sapiens	O
PANTR\|Ensembl=ENSPTRG00000016367.5\|UniProtKB=H2QQ13	Pan troglodytes	O
GORGO\|Ensembl=ENSGGOG00000005808.3\|UniProtKB=G3QSQ3	Gorilla gorilla gorilla	O
MACMU\|Ensembl=ENSMMUG00000010043.4\|UniProtKB=F6TFM0	Macaca mulatta	O
MOUSE\|MGI=MGI=95290\|UniProtKB=P01132	Mus musculus	O
RAT\|RGD=2542\|UniProtKB=P07522	Rattus norvegicus	O
PIG\|Ensembl=ENSSSCG00000009134.5\|UniProtKB=A0A287A231	Sus scrofa	O
PIG\|Gene=EGF\|UniProtKB=Q00968	Sus scrofa	O
HORSE\|Ensembl=ENSECAG00000010741.4\|UniProtKB=F7B762	Equus caballus	O
FELCA\|Ensembl=ENSFCAG00000000506.6\|UniProtKB=A0A5F5Y0J7	Felis catus	O
FELCA\|Gene=EGF\|UniProtKB=Q95ND4	Felis catus	O
CANLF\|Ensembl=ENSCAFG00845030111.1\|UniProtKB=A0A8I3Q5L9	Canis lupus familiaris	O
CANLF\|Gene=EGF\|UniProtKB=Q9BEA0	Canis lupus familiaris	O
MONDO\|Ensembl=ENSMODG00000005870.4\|UniProtKB=F6R392	Monodelphis domestica	O
ORNAN\|Ensembl=ENSOANG00000003668.4\|UniProtKB=A0A6I8MYA0	Ornithorhynchus anatinus	O
CHICK\|Ensembl=ENSGALG00010003806.1\|UniProtKB=A0A8V0XLN7	Gallus gallus	O
ANOCA\|Ensembl=ENSACAG00000010153.4\|UniProtKB=A0A803SU34	Anolis carolinensis	O
XENLA\|Gene=egf.L\|UniProtKB=A0A8J1MX61	Xenopus laevis	O
XENTR\|Xenbase=XB-GENE-951823\|UniProtKB=A8KBG4	Xenopus tropicalis	O
ORYLA\|Ensembl=ENSORLG00000020598.2\|UniProtKB=A0A3B3HR79	Oryzias latipes	O
DANRE\|Gene=egf\|UniProtKB=A0A8M2B432	Danio rerio	O
LEPOC\|Ensembl=ENSLOCG00000011771.1\|UniProtKB=W5N1G8	lepisosteus oculatus	O
HUMAN\|HGNC=7821\|UniProtKB=P14543	Homo sapiens	O
PANTR\|Ensembl=ENSPTRG00000002135.7\|UniProtKB=H2Q1E0	Pan troglodytes	O
GORGO\|Ensembl=ENSGGOG00000000381.3\|UniProtKB=G3SAI9	Gorilla gorilla gorilla	O
MACMU\|Ensembl=ENSMMUG00000012716.4\|UniProtKB=F7DF16	Macaca mulatta	O
MOUSE\|MGI=MGI=97342\|UniProtKB=P10493	Mus musculus	O
BOVIN\|Ensembl=ENSBTAG00000007244.6\|UniProtKB=A6QNS6	Bos taurus	O
PIG\|Ensembl=ENSSSCG00000026819.4\|UniProtKB=A0A287BMX9	Sus scrofa	O
HORSE\|Ensembl=ENSECAG00000016615.4\|UniProtKB=F6XH19	Equus caballus	O
FELCA\|Ensembl=ENSFCAG00000011029.5\|UniProtKB=M3WED3	Felis catus	O
CANLF\|Ensembl=ENSCAFG00845003062.1\|UniProtKB=A0A8I3MUT8	Canis lupus familiaris	O
MONDO\|Ensembl=ENSMODG00000008119.4\|UniProtKB=F7FV41	Monodelphis domestica	O
ORNAN\|Ensembl=ENSOANG00000001218.3\|UniProtKB=F6Z6E0	Ornithorhynchus anatinus	O
CHICK\|Ensembl=ENSGALG00010009327.1\|UniProtKB=A0A8V0Y357	Gallus gallus	O
ANOCA\|Ensembl=ENSACAG00000002089.4\|UniProtKB=A0A803SLH8	Anolis carolinensis	O
XENLA\|Gene=nid1.L\|UniProtKB=A0A1L8G884	Xenopus laevis	O
XENLA\|Gene=nid1.S\|UniProtKB=A0A1L8G2K1	Xenopus laevis	O
ORYLA\|Ensembl=ENSORLG00000001273.2\|UniProtKB=H2L6V9	Oryzias latipes	O
ORYLA\|Ensembl=ENSORLG00000012649.2\|UniProtKB=H2MBD4	Oryzias latipes	O
DANRE\|Gene=nid2b\|UniProtKB=A0A8M9PT02	Danio rerio	O
DANRE\|ZFIN=ZDB-GENE-050302-58\|UniProtKB=F1RAG3	Danio rerio	O
LEPOC\|Ensembl=ENSLOCG00000015814.1\|UniProtKB=W5NFR3	lepisosteus oculatus	O
PIG\|Ensembl=ENSSSCG00005027591.1\|UniProtKB=A0A4X1W843	Sus scrofa	O
ORYLA\|Ensembl=ENSORLG00000007784.2\|UniProtKB=H2LUH7	Oryzias latipes	O
GORGO\|Ensembl=ENSGGOG00000016592.3\|UniProtKB=G3RKG1	Gorilla gorilla gorilla	O
PIG\|Ensembl=ENSSSCG00000040746.3\|UniProtKB=A0A287AZ36	Sus scrofa	O
PIG\|Gene=LRP2\|UniProtKB=C0HL13	Sus scrofa	O
CHICK\|Ensembl=ENSGALG00010024034.1\|UniProtKB=A0A8V0ZQA7	Gallus gallus	O
XENLA\|Gene=lrp2.L\|UniProtKB=A0A8J0TMK5	Xenopus laevis	O
XENTR\|Xenbase=XB-GENE-486052\|UniProtKB=A0A6I8RWX3	Xenopus tropicalis	O
ORYLA\|Ensembl=ENSORLG00000005381.2\|UniProtKB=H2LL78	Oryzias latipes	O
GORGO\|Ensembl=ENSGGOG00000041779.1\|UniProtKB=A0A2I2ZH12	Gorilla gorilla gorilla	O
BOVIN\|Ensembl=ENSBTAG00000021945.6\|UniProtKB=F1MF97	Bos taurus	O
FELCA\|Ensembl=ENSFCAG00000042061.2\|UniProtKB=A0A337SMW2	Felis catus	O
CANLF\|Ensembl=ENSCAFG00845003626.1\|UniProtKB=A0A8I3MQB2	Canis lupus familiaris	O
XENLA\|Gene=nid2.S\|UniProtKB=A0A1L8F057	Xenopus laevis	O
XENLA\|Gene=nid2.L\|UniProtKB=A0A8J0TF48	Xenopus laevis	O
XENTR\|Gene=nid2\|UniProtKB=A0A8J0SV11	Xenopus tropicalis	O
GORGO\|Ensembl=ENSGGOG00000010171.3\|UniProtKB=G3R3Z1	Gorilla gorilla gorilla	O
CHICK\|Ensembl=ENSGALG00010025368.1\|UniProtKB=A0A8V1AA50	Gallus gallus	O
CHICK\|Gene=LRP1\|UniProtKB=P98157	Gallus gallus	O
ORYLA\|Ensembl=ENSORLG00000029487.1\|UniProtKB=A0A3B3IEL5	Oryzias latipes	O
ORYLA\|Ensembl=ENSORLG00000025636.1\|UniProtKB=A0A3B3I0H7	Oryzias latipes	O
ORYLA\|Ensembl=ENSORLG00000023990.1\|UniProtKB=A0A3B3HXJ5	Oryzias latipes	O
ORYLA\|Ensembl=ENSORLG00000030474.1\|UniProtKB=A0A3B3I0G6	Oryzias latipes	O
LEPOC\|Ensembl=ENSLOCG00000006089.1\|UniProtKB=W5MG75	lepisosteus oculatus	O
CIOIN\|Ensembl=ENSCING00000017654.2\|UniProtKB=F6WZ22	Ciona intestinalis	O
CIOIN\|Ensembl=ENSCING00000022078.1\|UniProtKB=H2XLM3	Ciona intestinalis	O
BRAFL\|Gene=LOC118427149\|UniProtKB=A0A9J7M3Y3	Branchiostoma floridae	O
BRAFL\|Gene=LOC118427146\|UniProtKB=A0A9J7M151	Branchiostoma floridae	O
BRAFL\|Gene=LOC118409884\|UniProtKB=A0A9J7KNA2	Branchiostoma floridae	O
BRAFL\|Gene=LOC118427150\|UniProtKB=A0A9J7M0V8	Branchiostoma floridae	O
BRAFL\|Gene=LOC118418087\|UniProtKB=A0A9J7LDW4	Branchiostoma floridae	O
BRAFL\|Gene=LOC118418084\|UniProtKB=A0A9J7MUW8	Branchiostoma floridae	O
BRAFL\|Gene=LOC118427152\|UniProtKB=A0A9J7M0S3	Branchiostoma floridae	O
BRAFL\|Gene=LOC118417668\|UniProtKB=A0A9J7MUH3	Branchiostoma floridae	O
BRAFL\|Gene=LOC118405902\|UniProtKB=A0A9J7KGA4	Branchiostoma floridae	O
STRPU\|EnsemblGenome=LOC581905\|UniProtKB=A0A7M7P5D6	Strongylocentrotus purpuratus	O
STRPU\|EnsemblGenome=LOC105438789\|UniProtKB=A0A7M7PMS8	Strongylocentrotus purpuratus	O
STRPU\|EnsemblGenome=LOC115923116\|UniProtKB=A0A7M7NNP7	Strongylocentrotus purpuratus	O
STRPU\|EnsemblGenome=LOC100888447\|UniProtKB=A0A7M7NE90	Strongylocentrotus purpuratus	O
STRPU\|EnsemblGenome=LOC105446596\|UniProtKB=A0A7M7NG87	Strongylocentrotus purpuratus	O
STRPU\|EnsemblGenome=LOC115929295\|UniProtKB=A0A7M7T4T3	Strongylocentrotus purpuratus	O
STRPU\|EnsemblGenome=LOC586685\|UniProtKB=A0A7M7RDE0	Strongylocentrotus purpuratus	O
STRPU\|EnsemblGenome=LOC594262\|UniProtKB=A0A7M7PLJ1	Strongylocentrotus purpuratus	O
STRPU\|EnsemblGenome=LOC115925099\|UniProtKB=A0A7M7NZZ2	Strongylocentrotus purpuratus	O
STRPU\|EnsemblGenome=LOC105446106\|UniProtKB=A0A7M7PI37	Strongylocentrotus purpuratus	O
STRPU\|EnsemblGenome=LOC105443672\|UniProtKB=A0A7M7HKG7	Strongylocentrotus purpuratus	O
STRPU\|EnsemblGenome=LOC115924457\|UniProtKB=A0A7M7NVQ1	Strongylocentrotus purpuratus	O
STRPU\|EnsemblGenome=LOC591940\|UniProtKB=A0A7M7NLH8	Strongylocentrotus purpuratus	O
STRPU\|EnsemblGenome=LOC754161\|UniProtKB=A0A7M7SXU5	Strongylocentrotus purpuratus	O
STRPU\|EnsemblGenome=LOC105446184\|UniProtKB=A0A7M7PJR2	Strongylocentrotus purpuratus	O
STRPU\|EnsemblGenome=LOC757083\|UniProtKB=A0A7M7PKJ0	Strongylocentrotus purpuratus	O
STRPU\|EnsemblGenome=LOC105442855\|UniProtKB=A0A7M7NNI7	Strongylocentrotus purpuratus	O
STRPU\|EnsemblGenome=LOC115924993\|UniProtKB=A0A7M7NZA2	Strongylocentrotus purpuratus	O
STRPU\|EnsemblGenome=LOC115923115\|UniProtKB=A0A7M7NND0	Strongylocentrotus purpuratus	O
STRPU\|EnsemblGenome=LOC105442169\|UniProtKB=A0A7M7NRG6	Strongylocentrotus purpuratus	O
STRPU\|EnsemblGenome=LOC115923430\|UniProtKB=A0A7M7NQ26	Strongylocentrotus purpuratus	O
STRPU\|EnsemblGenome=LOC115926091\|UniProtKB=A0A7M7P7Q5	Strongylocentrotus purpuratus	O
STRPU\|EnsemblGenome=LOC587773\|UniProtKB=A0A7M7NGF7	Strongylocentrotus purpuratus	O
CAEEL\|WormBase=WBGene00004374\|UniProtKB=O44191	Caenorhabditis elegans	O
CAEBR\|Gene_ORFName=CBG03794\|UniProtKB=A8WWR1	Caenorhabditis briggsae	O
PRIPA\|EnsemblGenome=WBGene00109458\|UniProtKB=A0A2A6BAV3	Pristionchus pacificus	O
CAEEL\|WormBase=WBGene00008779\|UniProtKB=G5EFK8	Caenorhabditis elegans	O
CAEBR\|Gene_ORFName=CBG09505\|UniProtKB=A8X8Y5	Caenorhabditis briggsae	O
CAEBR\|WormBase=WBGene00038687\|UniProtKB=A8XVN1	Caenorhabditis briggsae	O
PRIPA\|EnsemblGenome=WBGene00100282\|UniProtKB=A0A2A6BMJ2	Pristionchus pacificus	O
ANOGA\|EnsemblGenome=AGAP007023\|UniProtKB=Q7QIQ6	Anopheles gambiae	LDO
TRICA\|EnsemblGenome=TC002911\|UniProtKB=D6WHF9	Tribolium castaneum	LDO
DAPPU\|EnsemblGenome=DAPPUDRAFT_237349\|UniProtKB=E9G3P6	Daphnia pulex	O
DAPPU\|EnsemblGenome=DAPPUDRAFT_314322\|UniProtKB=E9G6S4	Daphnia pulex	O
DAPPU\|EnsemblGenome=DAPPUDRAFT_248813\|UniProtKB=E9GVA3	Daphnia pulex	O
DAPPU\|EnsemblGenome=DAPPUDRAFT_303927\|UniProtKB=E9GIG6	Daphnia pulex	O
DAPPU\|EnsemblGenome=DAPPUDRAFT_313913\|UniProtKB=E9G5N7	Daphnia pulex	O
DAPPU\|EnsemblGenome=DAPPUDRAFT_303856\|UniProtKB=E9GIF7	Daphnia pulex	O
DAPPU\|EnsemblGenome=DAPPUDRAFT_303858\|UniProtKB=E9GIF9	Daphnia pulex	O
DAPPU\|EnsemblGenome=DAPPUDRAFT_318319\|UniProtKB=E9GIG3	Daphnia pulex	O
DAPPU\|EnsemblGenome=DAPPUDRAFT_263601\|UniProtKB=E9HQ28	Daphnia pulex	O
DAPPU\|EnsemblGenome=DAPPUDRAFT_318320\|UniProtKB=E9GIG4	Daphnia pulex	O
DAPPU\|EnsemblGenome=DAPPUDRAFT_303924\|UniProtKB=E9GIG2	Daphnia pulex	O
DAPPU\|EnsemblGenome=DAPPUDRAFT_68539\|UniProtKB=E9I293	Daphnia pulex	O
HELRO\|EnsemblGenome=HelroG180677\|UniProtKB=T1FG57	helobdella robusta	O
HELRO\|EnsemblGenome=HelroG178815\|UniProtKB=T1FDS3	helobdella robusta	O
HELRO\|EnsemblGenome=HelroG188530\|UniProtKB=T1FQ35	helobdella robusta	O
HELRO\|EnsemblGenome=HelroG170722\|UniProtKB=T1F3D0	helobdella robusta	O
HELRO\|EnsemblGenome=HelroG175287\|UniProtKB=T1F941	helobdella robusta	O
HELRO\|EnsemblGenome=HelroG164869\|UniProtKB=T1EVW5	helobdella robusta	O
HELRO\|EnsemblGenome=HelroG185306\|UniProtKB=T1FMN1	helobdella robusta	O
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g118240\|UniProtKB=A7SH94	Nematostella vectensis	O
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g177505\|UniProtKB=A7RGB1	Nematostella vectensis	O
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g83852\|UniProtKB=A7RJD6	Nematostella vectensis	O
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g212268\|UniProtKB=A7SH97	Nematostella vectensis	O
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g245263\|UniProtKB=A7SH96	Nematostella vectensis	O
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g61732\|UniProtKB=A7RIK9	Nematostella vectensis	O