PANTHER Gene Information

Gene Symbol(s):

MRGPRX2

Organism:

Homo sapiens

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Gene Name:

Mas-related G-protein coupled receptor member X2

Gene ID:

HGNC:17983

Protein ID:

Q96LB1

Enhancers:

View enhancers for HUMAN|HGNC=17983|UniProtKB=Q96LB1

Genetic Variant Annotation:

Annoq

Persistent Id:

PTN002477967

Alternate Ids:

ENSG00000183695(Ensembl)	AAW70045(EMBL-CDS)
HGNC:17983(HGNC)	58294230(GI)
Q4QXX2(AltAccession)	AY651157(EMBL)
NP_473371(refSeq)	117194(GeneID)
ENSP00000333800(Ensembl_PRO)	MRGX2_HUMAN(UniProtKB-ID)
CHEMBL5849(ChEMBL)	607228(MIM)
MRGX2(Synonym)	ENST00000329773(Ensembl_TRS)
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PANTHER Classification

PANTHER Family:	MAS-RELATED G-PROTEIN COUPLED RECEPTOR (PTHR11334)
PANTHER Subfamily:	MAS-RELATED G-PROTEIN COUPLED RECEPTOR MEMBER X2 (PTHR11334:SF29)
PANTHER GO-slim Molecular Function:
PANTHER GO-slim Biological Process:
PANTHER GO-slim Cellular Component:	plasma membrane
PANTHER protein class:	G-protein coupled receptor

Pathway Categories:

No pathway information available

GENE ONTOLOGY DATABASE ANNOTATIONS

Click to Expand...

GO MF Complete:	mast cell secretagogue receptor activity, G protein-coupled receptor activity, neuropeptide binding
GO BP Complete:	G protein-coupled receptor signaling pathway, sensory perception of pain, sleep, mast cell activation, mast cell degranulation, positive regulation of cytokinesis
GO CC Complete:	membrane, plasma membrane

REACTOME DATABASE ANNOTATIONS Click to Expand...

Reactome Pathways:

Orthologs

ID	Organism	Type
PANTR\|Gene=MRGPRX2\|UniProtKB=Q4QXX9	Pan troglodytes	O
PANTR\|Ensembl=ENSPTRG00000003432.3\|UniProtKB=A0A2K6H5F5	Pan troglodytes	LDO
GORGO\|Ensembl=ENSGGOG00000015832\|UniProtKB=Q4QXU0	Gorilla gorilla gorilla	LDO
MACMU\|Gene=MRGPRX2\|UniProtKB=Q4QXU5	Macaca mulatta	LDO
MOUSE\|MGI=MGI=3821888\|UniProtKB=A0A0R4J1Z0	Mus musculus	O
MOUSE\|MGI=MGI=3033107\|UniProtKB=Q91ZC6	Mus musculus	O
MOUSE\|MGI=MGI=2684085\|UniProtKB=Q91WW3	Mus musculus	O
MOUSE\|MGI=MGI=3033111\|UniProtKB=Q91ZC4	Mus musculus	O
MOUSE\|MGI=MGI=3033098\|UniProtKB=Q91WW4	Mus musculus	O
MOUSE\|MGI=MGI=3033109\|UniProtKB=Q91ZC5	Mus musculus	O
MOUSE\|MGI=MGI=3033100\|UniProtKB=Q91WW2	Mus musculus	O
MOUSE\|MGI=MGI=3033102\|UniProtKB=Q91ZC7	Mus musculus	O
MOUSE\|MGI=MGI=3033148\|UniProtKB=A0A140T8U8	Mus musculus	O
MOUSE\|MGI=MGI=3033095\|UniProtKB=Q91WW5	Mus musculus	O
RAT\|RGD=632282\|UniProtKB=A0A0H2UHL4	Rattus norvegicus	O
RAT\|RGD=738050\|UniProtKB=Q7TN49	Rattus norvegicus	O
MOUSE\|MGI=MGI=3033134\|UniProtKB=Q7TN51	Mus musculus	O
RAT\|RGD=2320559\|UniProtKB=M0RCQ2	Rattus norvegicus	O
RAT\|RGD=738051\|UniProtKB=Q7TN50	Rattus norvegicus	O
MOUSE\|MGI=MGI=3033121\|UniProtKB=Q91ZB9	Mus musculus	O
MOUSE\|MGI=MGI=3033119\|UniProtKB=Q91ZC0	Mus musculus	O
RAT\|RGD=738052\|UniProtKB=Q7TN44	Rattus norvegicus	O
RAT\|RGD=738043\|UniProtKB=Q7TN45	Rattus norvegicus	O
MOUSE\|MGI=MGI=3033117\|UniProtKB=Q91ZC1	Mus musculus	O
RAT\|RGD=1560730\|UniProtKB=D4AEH4	Rattus norvegicus	O
MOUSE\|MGI=MGI=2441674\|UniProtKB=Q3KNA1	Mus musculus	LDO
RAT\|RGD=1591915\|UniProtKB=E9PTZ2	Rattus norvegicus	LDO
MOUSE\|MGI=MGI=3033115\|UniProtKB=Q3UG61	Mus musculus	O
MOUSE\|MGI=MGI=3588270\|UniProtKB=Q3UG50	Mus musculus	O
RAT\|RGD=738053\|UniProtKB=E9PTZ8	Rattus norvegicus	O
RAT\|RGD=1587398\|UniProtKB=F1LLV4	Rattus norvegicus	O
BOVIN\|Ensembl=ENSBTAG00000002245.6\|UniProtKB=F1N4T7	Bos taurus	LDO
PIG\|Ensembl=ENSSSCG00000060771.1\|UniProtKB=A0A8W4FM26	Sus scrofa	LDO
HORSE\|Ensembl=ENSECAG00000039826.1\|UniProtKB=A0A3Q2HN46	Equus caballus	O
HORSE\|Ensembl=ENSECAG00000001949.3\|UniProtKB=F6U6Y2	Equus caballus	O
HORSE\|Ensembl=ENSECAG00000034393.2\|UniProtKB=A0A3Q2HIM0	Equus caballus	O
HORSE\|Ensembl=ENSECAG00000039541.2\|UniProtKB=A0A3Q2GYI0	Equus caballus	O
HORSE\|Ensembl=ENSECAG00000055468.1\|UniProtKB=A0A9L0TPG0	Equus caballus	O
HORSE\|Ensembl=ENSECAG00000031265.2\|UniProtKB=A0A3Q2HNQ5	Equus caballus	O
HORSE\|Ensembl=ENSECAG00000003099.4\|UniProtKB=F6XPH0	Equus caballus	LDO
FELCA\|Ensembl=ENSFCAG00000010700.5\|UniProtKB=M3XBY5	Felis catus	LDO
CANLF\|Ensembl=ENSCAFG00845018660.1\|UniProtKB=A0A8I3P4E8	Canis lupus familiaris	LDO
MONDO\|Ensembl=ENSMODG00000007359.3\|UniProtKB=F6TNL8	Monodelphis domestica	LDO
MONDO\|Ensembl=ENSMODG00000037521.1\|UniProtKB=F7B9H6	Monodelphis domestica	O
MONDO\|Ensembl=ENSMODG00000007340.3\|UniProtKB=F6TJX4	Monodelphis domestica	O
MONDO\|Ensembl=ENSMODG00000043375.1\|UniProtKB=F6ZKN1	Monodelphis domestica	O
MONDO\|Ensembl=ENSMODG00000044469.1\|UniProtKB=F7BLY8	Monodelphis domestica	O
MONDO\|Ensembl=ENSMODG00000003770.3\|UniProtKB=F7EG75	Monodelphis domestica	O
MONDO\|Ensembl=ENSMODG00000040037.1\|UniProtKB=A0A5F8G951	Monodelphis domestica	O
MONDO\|Ensembl=ENSMODG00000024123.2\|UniProtKB=F6QET3	Monodelphis domestica	O
MONDO\|Ensembl=ENSMODG00000046751.1\|UniProtKB=F7B023	Monodelphis domestica	O
MONDO\|Ensembl=ENSMODG00000051155.1\|UniProtKB=A0A5F8HDN2	Monodelphis domestica	O
MONDO\|Ensembl=ENSMODG00000007244.3\|UniProtKB=F6WBQ4	Monodelphis domestica	O
MONDO\|Ensembl=ENSMODG00000048854.1\|UniProtKB=A0A5F8H097	Monodelphis domestica	O
MONDO\|Ensembl=ENSMODG00000043017.1\|UniProtKB=A0A5F8G799	Monodelphis domestica	O
MONDO\|Ensembl=ENSMODG00000003289.3\|UniProtKB=F7EYU6	Monodelphis domestica	O
MONDO\|Ensembl=ENSMODG00000039204.1\|UniProtKB=F7EVQ1	Monodelphis domestica	O
MONDO\|Ensembl=ENSMODG00000048371.1\|UniProtKB=A0A5F8H9R5	Monodelphis domestica	O
MONDO\|Ensembl=ENSMODG00000022540.2\|UniProtKB=F7B9C2	Monodelphis domestica	O
MONDO\|Ensembl=ENSMODG00000003738.3\|UniProtKB=F7EDA0	Monodelphis domestica	O
MONDO\|Ensembl=ENSMODG00000050219.1\|UniProtKB=A0A5F8GMJ6	Monodelphis domestica	O
MONDO\|Ensembl=ENSMODG00000038513.1\|UniProtKB=F6TER6	Monodelphis domestica	O
MONDO\|Ensembl=ENSMODG00000047514.1\|UniProtKB=A0A5F8HB30	Monodelphis domestica	O
MONDO\|Ensembl=ENSMODG00000003699.4\|UniProtKB=F7FAE9	Monodelphis domestica	O
MONDO\|Ensembl=ENSMODG00000023750.2\|UniProtKB=F6TEL7	Monodelphis domestica	O
MONDO\|Ensembl=ENSMODG00000003797.3\|UniProtKB=F6ZKE7	Monodelphis domestica	O
MONDO\|Ensembl=ENSMODG00000011998.3\|UniProtKB=F7B919	Monodelphis domestica	O
MONDO\|Ensembl=ENSMODG00000037538.1\|UniProtKB=A0A5F8H8E5	Monodelphis domestica	O
MONDO\|Ensembl=ENSMODG00000007344.3\|UniProtKB=F7B0N6	Monodelphis domestica	O
MONDO\|Ensembl=ENSMODG00000007370.4\|UniProtKB=F6TNN2	Monodelphis domestica	O
ORNAN\|Ensembl=ENSOANG00000005851.3\|UniProtKB=F6XW62	Ornithorhynchus anatinus	O
ORNAN\|Ensembl=ENSOANG00000037515.1\|UniProtKB=A0A6I8N3W2	Ornithorhynchus anatinus	O
ORNAN\|Ensembl=ENSOANG00000015174.3\|UniProtKB=F6V4K4	Ornithorhynchus anatinus	LDO
CHICK\|Ensembl=ENSGALG00010022294.1\|UniProtKB=A0A3Q2UDQ6	Gallus gallus	O
ANOCA\|Ensembl=ENSACAG00000035785.1\|UniProtKB=A0A803TN51	Anolis carolinensis	O
ANOCA\|Ensembl=ENSACAG00000000133.3\|UniProtKB=G1K8B0	Anolis carolinensis	O
ANOCA\|Ensembl=ENSACAG00000042303.1\|UniProtKB=A0A803SSY9	Anolis carolinensis	O
ANOCA\|Ensembl=ENSACAG00000037284.1\|UniProtKB=A0A803TUT6	Anolis carolinensis	O
ANOCA\|Ensembl=ENSACAG00000021146.3\|UniProtKB=G1KUR9	Anolis carolinensis	O
ANOCA\|Ensembl=ENSACAG00000021137.3\|UniProtKB=G1KUS6	Anolis carolinensis	O
ANOCA\|Ensembl=ENSACAG00000035805.1\|UniProtKB=A0A803TXL8	Anolis carolinensis	O
ANOCA\|Ensembl=ENSACAG00000027706.2\|UniProtKB=G1KYP1	Anolis carolinensis	O
ANOCA\|Ensembl=ENSACAG00000020938.3\|UniProtKB=G1KUP4	Anolis carolinensis	O
ANOCA\|Ensembl=ENSACAG00000022451.2\|UniProtKB=L7N046	Anolis carolinensis	O
ANOCA\|Ensembl=ENSACAG00000035367.1\|UniProtKB=A0A803TSI6	Anolis carolinensis	O
ANOCA\|Ensembl=ENSACAG00000024154.3\|UniProtKB=G1K8B3	Anolis carolinensis	O
ANOCA\|Ensembl=ENSACAG00000044055.1\|UniProtKB=A0A803SN32	Anolis carolinensis	O
ANOCA\|Ensembl=ENSACAG00000045179.1\|UniProtKB=G1KUS9	Anolis carolinensis	O
ANOCA\|Ensembl=ENSACAG00000025714.3\|UniProtKB=G1KV93	Anolis carolinensis	O
CHICK\|Ensembl=ENSGALG00010022313.1\|UniProtKB=H9L2H9	Gallus gallus	O
CHICK\|Ensembl=ENSGALG00010022322.1\|UniProtKB=A0A8V0ZVB0	Gallus gallus	O
CHICK\|Ensembl=ENSGALG00010022270.1\|UniProtKB=A0A3Q3ALN6	Gallus gallus	O
ANOCA\|Ensembl=ENSACAG00000034943.1\|UniProtKB=A0A803TAS9	Anolis carolinensis	O
ANOCA\|Ensembl=ENSACAG00000021023.3\|UniProtKB=G1KUN4	Anolis carolinensis	O
ANOCA\|Ensembl=ENSACAG00000039869.1\|UniProtKB=A0A803TRH0	Anolis carolinensis	O
ANOCA\|Ensembl=ENSACAG00000000131.3\|UniProtKB=G1K8A9	Anolis carolinensis	O
ANOCA\|Ensembl=ENSACAG00000026564.2\|UniProtKB=G1KVL4	Anolis carolinensis	O
ANOCA\|Ensembl=ENSACAG00000025099.2\|UniProtKB=G1KYP2	Anolis carolinensis	O
ANOCA\|Ensembl=ENSACAG00000040192.1\|UniProtKB=A0A803SZK1	Anolis carolinensis	O
ANOCA\|Ensembl=ENSACAG00000042164.1\|UniProtKB=A0A803T3K7	Anolis carolinensis	O
ANOCA\|Ensembl=ENSACAG00000000135.3\|UniProtKB=G1K8B1	Anolis carolinensis	O
CHICK\|Ensembl=ENSGALG00010006448.1\|UniProtKB=E1BVU0	Gallus gallus	LDO
ANOCA\|Ensembl=ENSACAG00000045067.1\|UniProtKB=A0A803U0Y1	Anolis carolinensis	O
ANOCA\|Ensembl=ENSACAG00000004224.3\|UniProtKB=G1KYQ1	Anolis carolinensis	LDO
XENLA\|Gene=LOC108710288\|UniProtKB=A0A1L8H088	Xenopus laevis	O
XENLA\|Gene=LOC108712332\|UniProtKB=A0A1L8GT70	Xenopus laevis	O
XENTR\|Ensembl=ENSXETG00000044594\|UniProtKB=A0A803KCX8	Xenopus tropicalis	O
XENLA\|Gene=LOC108719117\|UniProtKB=A0A1L8FXU3	Xenopus laevis	O
XENLA\|Gene=LOC108718527\|UniProtKB=A0A8J0VI36	Xenopus laevis	O
XENLA\|Gene=LOC108718528\|UniProtKB=A0A8J0VJ93	Xenopus laevis	O
XENLA\|Gene=LOC108718525\|UniProtKB=A0A1L8FXU2	Xenopus laevis	O
XENLA\|Gene=LOC108720068\|UniProtKB=A0A1L8FSA0	Xenopus laevis	O
XENTR\|Ensembl=ENSXETG00000038879\|UniProtKB=A0A6I8SMY7	Xenopus tropicalis	O
XENTR\|Gene=LOC116411743\|UniProtKB=A0A8J1JRC2	Xenopus tropicalis	O
XENTR\|Ensembl=ENSXETG00000046693\|UniProtKB=A0A803JDB1	Xenopus tropicalis	O
XENLA\|Gene=LOC121401244\|UniProtKB=A0A8J1MIE8	Xenopus laevis	O
XENLA\|Gene=LOC108712474\|UniProtKB=A0A8J0UYM8	Xenopus laevis	LDO
XENTR\|Gene=LOC116411741\|UniProtKB=A0A8J1JTS6	Xenopus tropicalis	O
XENTR\|Gene=mas1\|UniProtKB=A0A8J0QP62	Xenopus tropicalis	LDO
LEPOC\|Ensembl=ENSLOCG00000010437.1\|UniProtKB=W5MWN1	lepisosteus oculatus	LDO