PANTHER Gene Information

Gene Symbol(s):

Setd6

Organism:

Mus musculus

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Gene Name:

N-lysine methyltransferase SETD6

Gene ID:

MGI:1913333

Protein ID:

Q9CWY3

Persistent Id:

PTN000328077

Alternate Ids:

ENSMUSP00000034096(Ensembl_PRO)	74198625(GI)
EDL11181(EMBL-CDS)	BC139199(EMBL)
SETD6_MOUSE(UniProtKB-ID)	MGI:1913333(MGI)
Setd6(Symbol)	ENSMUST00000034096(Ensembl_TRS)
2.1.1.- {ECO:0000250\|UniProtKB:Q8TBK2}(EC)	SET domain-containing protein 6(Synonym)
66083(GeneID)	NM_001035123(refSeq)
ENSMUSG00000031671(Ensembl)	B2RTA7(AltAccession)
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PANTHER Classification

PANTHER Family:	UNCHARACTERIZED PUTATIVE METHYLTRANSFERASE (PTHR13271)
PANTHER Subfamily:	N-LYSINE METHYLTRANSFERASE SETD6 (PTHR13271:SF34)
PANTHER GO-slim Molecular Function:	protein-lysine N-methyltransferase activity
PANTHER GO-slim Biological Process:	macromolecule methylation peptidyl-amino acid modification
PANTHER GO-slim Cellular Component:	nucleus
PANTHER protein class:	methyltransferase

Pathway Categories:

No pathway information available

GENE ONTOLOGY DATABASE ANNOTATIONS

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GO MF Complete:	NF-kappaB binding, protein binding, S-adenosyl-L-methionine binding, methyltransferase activity, transferase activity, protein-lysine N-methyltransferase activity
GO BP Complete:	stem cell population maintenance, stem cell differentiation, negative regulation of NF-kappaB transcription factor activity, peptidyl-lysine methylation, regulation of inflammatory response, peptidyl-lysine monomethylation, methylation
GO CC Complete:	nucleus, cytosol, nucleoplasm

REACTOME DATABASE ANNOTATIONS Click to Expand...

Reactome Pathways:

Chromatin organization, PKMTs methylate histone lysines, Chromatin modifying enzymes

Orthologs

ID	Organism	Type
HUMAN\|HGNC=26116\|UniProtKB=Q8TBK2	Homo sapiens	LDO
PANTR\|Ensembl=ENSPTRG00000008182.6\|UniProtKB=A0A2I3RJ48	Pan troglodytes	LDO
GORGO\|Ensembl=ENSGGOG00000009544.3\|UniProtKB=G3R280	Gorilla gorilla gorilla	LDO
MACMU\|Ensembl=ENSMMUG00000014621.4\|UniProtKB=A0A5F7ZXE4	Macaca mulatta	LDO
RAT\|RGD=1560538\|UniProtKB=D3ZSK5	Rattus norvegicus	LDO
BOVIN\|Ensembl=ENSBTAG00000020781.5\|UniProtKB=A0A3Q1MJ82	Bos taurus	O
BOVIN\|Gene=SETD6\|UniProtKB=E1BI64	Bos taurus	LDO
PIG\|Ensembl=ENSSSCG00000026505.3\|UniProtKB=A0A5G2Q8J7	Sus scrofa	LDO
HORSE\|Ensembl=ENSECAG00000008587.4\|UniProtKB=F6UJG8	Equus caballus	LDO
FELCA\|Ensembl=ENSFCAG00000006604.5\|UniProtKB=M3W666	Felis catus	LDO
CANLF\|Ensembl=ENSCAFG00845001902.1\|UniProtKB=A0A8I3MEM3	Canis lupus familiaris	LDO
MONDO\|Ensembl=ENSMODG00000014173.3\|UniProtKB=F6U7C1	Monodelphis domestica	LDO
ORNAN\|Ensembl=ENSOANG00000012110.2\|UniProtKB=F7F9Z2	Ornithorhynchus anatinus	LDO
CHICK\|Gene_ORFName=RCJMB04_13m6\|UniProtKB=Q5ZK17	Gallus gallus	LDO
XENLA\|Gene=setd6\|UniProtKB=Q6INM2	Xenopus laevis	LDO
XENTR\|Xenbase=XB-GENE-998235\|UniProtKB=A4QNG5	Xenopus tropicalis	LDO
ORYLA\|Ensembl=ENSORLG00000014911.2\|UniProtKB=H2MJ57	Oryzias latipes	LDO
DANRE\|ZFIN=ZDB-GENE-030131-1067\|UniProtKB=Q803K4	Danio rerio	LDO
LEPOC\|Ensembl=ENSLOCG00000006305.1\|UniProtKB=W5MGV5	lepisosteus oculatus	LDO
CIOIN\|Ensembl=ENSCING00000010066.3\|UniProtKB=F6QD73	Ciona intestinalis	LDO
BRAFL\|Gene=LOC118415051\|UniProtKB=A0A9J7L505	Branchiostoma floridae	LDO
STRPU\|EnsemblGenome=LOC582478\|UniProtKB=A0A7M7RER8	Strongylocentrotus purpuratus	LDO
HELRO\|EnsemblGenome=HelroG193766\|UniProtKB=T1FVC2	helobdella robusta	LDO
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g115756\|UniProtKB=A7SES5	Nematostella vectensis	LDO
MONBE\|EnsemblGenome=MONBRDRAFT_37907\|UniProtKB=A9V4I8	Monosiga brevicollis	LDO
YEAST\|SGD=S000001031\|UniProtKB=P38732	Saccharomyces cerevisiae	O
EREGS\|EnsemblGenome=AGOS_ADR237C\|UniProtKB=Q759N8	Eremothecium gossypii	O
YEAST\|SGD=S000006129\|UniProtKB=Q08961	Saccharomyces cerevisiae	O
CANAL\|CGD=CAL0000179997\|UniProtKB=A0A1D8PTX3	Candida albicans	O
SCHPO\|PomBase=SPBC1709.13c\|UniProtKB=O74738	Schizosaccharomyces pombe	O
SCHJY\|EnsemblGenome=SJAG_03228\|UniProtKB=B6K3N8	Schizosaccharomyces japonicus	O
CRYNJ\|EnsemblGenome=CNC04000\|UniProtKB=Q5KK75	Cryptococcus neoformans	O
USTMA\|EnsemblGenome=UMAG_00990\|UniProtKB=A0A0D1E549	Ustilago maydis	O
EMENI\|EnsemblGenome=ANIA_00690\|UniProtKB=Q5BFJ0	Emericella nidulans	O
ASPFU\|EnsemblGenome=AFUA_1G13520\|UniProtKB=Q4WS98	Neosartorya fumigata	O
NEUCR\|EnsemblGenome=NCU06658\|UniProtKB=Q1K6M4	Neurospora crassa	O
SCLS1\|EnsemblGenome=SS1G_10341\|UniProtKB=A7EYC6	Sclerotinia sclerotiorum	O
PHANO\|EnsemblGenome=SNOG_10770\|UniProtKB=Q0UBU4	Phaeosphaeria nodorum	O
SCHPO\|PomBase=SPAC3C7.09\|UniProtKB=O14135	Schizosaccharomyces pombe	O
SCHJY\|EnsemblGenome=SJAG_02692\|UniProtKB=B6K0X4	Schizosaccharomyces japonicus	O
YEAST\|SGD=S000000234\|UniProtKB=P38222	Saccharomyces cerevisiae	O
EREGS\|EnsemblGenome=AGOS_AAR193C\|UniProtKB=Q75E87	Eremothecium gossypii	O
YEAST\|SGD=S000002665\|UniProtKB=Q12504	Saccharomyces cerevisiae	LDO
EREGS\|EnsemblGenome=AGOS_AFL100W\|UniProtKB=Q755C3	Eremothecium gossypii	O
EREGS\|EnsemblGenome=AGOS_AEL225C\|UniProtKB=Q758I7	Eremothecium gossypii	LDO
CANAL\|CGD=CAL0000185918\|UniProtKB=A0A1D8PFW1	Candida albicans	O
CANAL\|CGD=CAL0000193221\|UniProtKB=A0A1D8PNN9	Candida albicans	LDO
YARLI\|EnsemblGenome=YALI0_B08624g\|UniProtKB=Q6CFB4	Yarrowia lipolytica	O
YARLI\|EnsemblGenome=YALI0_E34397g\|UniProtKB=Q6C3J1	Yarrowia lipolytica	O
YARLI\|EnsemblGenome=YALI0_F28061g\|UniProtKB=Q6C037	Yarrowia lipolytica	LDO
EMENI\|EnsemblGenome=ANIA_06568\|UniProtKB=Q5AYR2	Emericella nidulans	LDO
ASPFU\|EnsemblGenome=AFUA_6G04520\|UniProtKB=Q4WDF0	Neosartorya fumigata	LDO
NEUCR\|EnsemblGenome=NCU09581\|UniProtKB=Q7S4L9	Neurospora crassa	O
SCLS1\|EnsemblGenome=SS1G_05991\|UniProtKB=A7EKZ4	Sclerotinia sclerotiorum	O
NEUCR\|EnsemblGenome=NCU08733\|UniProtKB=Q1K8U9	Neurospora crassa	O
NEUCR\|EnsemblGenome=NCU09827\|UniProtKB=Q7S1R5	Neurospora crassa	LDO
SCLS1\|EnsemblGenome=SS1G_00212\|UniProtKB=A7E4J0	Sclerotinia sclerotiorum	LDO
PHANO\|EnsemblGenome=SNOG_16462\|UniProtKB=Q0TVK2	Phaeosphaeria nodorum	LDO
SCHPO\|PomBase=SPBC16C6.01c\|UniProtKB=O42925	Schizosaccharomyces pombe	LDO
SCHJY\|EnsemblGenome=SJAG_01482\|UniProtKB=B6JY24	Schizosaccharomyces japonicus	LDO
SCHPO\|PomBase=SPAC688.14\|UniProtKB=Q9P6L2	Schizosaccharomyces pombe	O
SCHJY\|EnsemblGenome=SJAG_03869\|UniProtKB=B6K5A0	Schizosaccharomyces japonicus	O
CRYNJ\|EnsemblGenome=CNL04230\|UniProtKB=Q5K8W8	Cryptococcus neoformans	LDO
USTMA\|EnsemblGenome=UMAG_10015\|UniProtKB=A0A0D1E6V2	Ustilago maydis	LDO
PUCGT\|EnsemblGenome=PGTG_12431\|UniProtKB=E3KQA0	Puccinia graminis	O
PUCGT\|EnsemblGenome=PGTG_01556\|UniProtKB=E3JSJ0	Puccinia graminis	O
PUCGT\|EnsemblGenome=PGTG_00642\|UniProtKB=E3JQN7	Puccinia graminis	LDO
BATDJ\|Gene_ORFName=BATDEDRAFT_87914\|UniProtKB=F4P0T6	Batrachochytrium dendrobatidis	LDO
DICDI\|dictyBase=DDB_G0275621\|UniProtKB=Q86A13	Dictyostelium discoideum	LDO
DICPU\|EnsemblGenome=DICPUDRAFT_152307\|UniProtKB=F0ZL09	Dictyostelium purpureum	LDO
LEIMA\|EnsemblGenome=LMJF_30_2320\|UniProtKB=Q4Q761	Leishmania major	O
TRYB2\|Gene_ORFName=Tb927.6.3610\|UniProtKB=Q585V9	Trypanosoma brucei	O
LEIMA\|EnsemblGenome=LMJF_31_1060\|UniProtKB=Q4Q6F7	Leishmania major	O
TRYB2\|Gene_ORFName=Tb927.4.4300\|UniProtKB=Q57Y34	Trypanosoma brucei	O
CHLRE\|EnsemblGenome=CHLRE_16g661350v5\|UniProtKB=A0A2K3CTJ0	Chlamydomonas reinhardtii	O
LEIMA\|EnsemblGenome=LMJF_34_3800\|UniProtKB=Q4Q2G3	Leishmania major	LDO
TRYB2\|Gene_ORFName=Tb927.4.950\|UniProtKB=Q580C3	Trypanosoma brucei	LDO
PARTE\|EnsemblGenome=GSPATT00018482001\|UniProtKB=A0DMJ7	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00013745001\|UniProtKB=A0D5J8	Paramecium tetraurelia	O
THAPS\|EnsemblGenome=THAPS_25436\|UniProtKB=B5YM88	Thalassiosira pseudonana	O
PARTE\|EnsemblGenome=GSPATT00026565001\|UniProtKB=A0EG01	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00010386001\|UniProtKB=A0CTN5	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00015390001\|UniProtKB=A0DBU6	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00032844001\|UniProtKB=A0BWS5	Paramecium tetraurelia	LDO
PARTE\|EnsemblGenome=GSPATT00037632001\|UniProtKB=A0CEH7	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00035192001\|UniProtKB=A0C4J5	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00010387001\|UniProtKB=A0CTN6	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00024003001\|UniProtKB=A0E7K8	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00037631001\|UniProtKB=A0CEH6	Paramecium tetraurelia	O
THAPS\|EnsemblGenome=THAPSDRAFT_3163\|UniProtKB=B8BX00	Thalassiosira pseudonana	O
THAPS\|EnsemblGenome=THAPSDRAFT_9884\|UniProtKB=B8CCJ8	Thalassiosira pseudonana	LDO
AMBTC\|EnsemblGenome=AMTR_s00071p00159140\|UniProtKB=U5DEY2	Amborella trichopoda	LDO
ZOSMR\|Gene_ORFName=ZOSMA_3G00600\|UniProtKB=A0A0K9P5W7	Zostera marina	LDO
MUSAM\|EnsemblGenome=Ma08_g32980\|UniProtKB=A0A804KDH7	Musa acuminata subsp. malaccensis	LDO
SETIT\|EnsemblGenome=SETIT_001278mg\|UniProtKB=K3XHA7	Setaria italica	LDO
SORBI\|EnsemblGenome=SORBI_3003G376500\|UniProtKB=A0A1W0W0R4	Sorghum bicolor	LDO
MAIZE\|EnsemblGenome=Zm00001eb366280\|UniProtKB=B4FRT5	Zea mays	LDO
ORYSJ\|EnsemblGenome=Os01g0879500\|UniProtKB=Q8L4K4	Oryza sativa	LDO
BRADI\|EnsemblGenome=BRADI_2g56792v3\|UniProtKB=A0A0Q3RCG0	Brachypodium distachyon	LDO
HORVV\|EnsemblGenome=HORVU.MOREX.r3.3HG0307630\|UniProtKB=A0A8I6Y4Y6	Hordeum vulgare subsp. vulgare	LDO
WHEAT\|EnsemblGenome=TraesCS3A02G409800\|UniProtKB=A0A3B6EN34	Triticum aestivum	LDO
WHEAT\|EnsemblGenome=TraesCS3B02G442900\|UniProtKB=A0A3B6FUD7	Triticum aestivum	LDO
NELNU\|Gene=LOC104589235\|UniProtKB=A0A1U7ZEB8	Nelumbo nucifera	LDO
SPIOL\|Gene=LOC110775827\|UniProtKB=A0A9R0HSH4	Spinacia oleracea	LDO
HELAN\|EnsemblGenome=HanXRQr2_Chr14g0632901\|UniProtKB=A0A251TGM3	Helianthus annuus	LDO
LACSA\|Gene_ORFName=LSAT_V11C200064280\|UniProtKB=A0A9R1WB02	Lactuca sativa	LDO
ERYGU\|Gene_ORFName=MIMGU_mgv1a005032mg\|UniProtKB=A0A022PY36	Erythranthe guttata	LDO
CAPAN\|EnsemblGenome=T459_14459\|UniProtKB=A0A2G2ZHM6	Capsicum annuum	LDO
TOBAC\|Gene=LOC107829813\|UniProtKB=A0A1S4DHB9	Nicotiana tabacum	O
TOBAC\|Gene=LOC107769942\|UniProtKB=A0A1S3XXL1	Nicotiana tabacum	LDO
VITVI\|Gene_OrderedLocusName=VIT_07s0130g00260\|UniProtKB=D7TB34	Vitis vinifera	LDO
BRANA\|Gene_ORFName=GSBRNA2T00037077001\|UniProtKB=A0A078GKW2	Brassica napus	O
BRANA\|Gene_ORFName=GSBRNA2T00037078001\|UniProtKB=A0A078GPE1	Brassica napus	LDO
BRACM\|EnsemblGenome=Bra007252\|UniProtKB=M4CSR0	Brassica campestris	LDO
ARATH\|TAIR=locus=2102549\|UniProtKB=A0A1I9LQY7	Arabidopsis thaliana	LDO
GOSHI\|Gene=LOC107937654\|UniProtKB=A0A1U8MGU8	Gossypium hirsutum	LDO
THECC\|EnsemblGenome=TCM_001657\|UniProtKB=A0A061DJD8	Theobroma cacao	LDO
CITSI\|Gene_ORFName=CISIN_1g0417271mg\|UniProtKB=A0A067EUE1	Citrus sinensis	LDO
POPTR\|EnsemblGenome=POPTR_004G135700v3\|UniProtKB=A0A2K2AU91	Populus trichocarpa	LDO
MANES\|EnsemblGenome=MANES_13G154300\|UniProtKB=A0A251K0R9	Manihot esculenta	LDO
RICCO\|Gene_ORFName=RCOM_1176880\|UniProtKB=B9RWA1	Ricinus communis	LDO
SOYBN\|EnsemblGenome=GLYMA_20G214500\|UniProtKB=I1NIE2	Glycine max	LDO
SOYBN\|EnsemblGenome=GLYMA_10G176100\|UniProtKB=K7LK18	Glycine max	LDO
MEDTR\|EnsemblGenome=MTR_1g077040\|UniProtKB=A0A072VLJ5	Medicago truncatula	LDO
JUGRE\|EnsemblGenome=Jr06_20750\|UniProtKB=A0A2I4DQ27	Juglans regia	LDO
PRUPE\|EnsemblGenome=PRUPE_4G288100\|UniProtKB=A0A251PSQ2	Prunus persica	LDO
SELML\|EnsemblGenome=SELMODRAFT_235145\|UniProtKB=D8SUE8	Selaginella moellendorffii	O
SELML\|EnsemblGenome=SELMODRAFT_107696\|UniProtKB=D8S3K9	Selaginella moellendorffii	LDO
PHYPA\|EnsemblGenome=Pp3c8_4410\|UniProtKB=A0A7I4FV74	Physcomitrella patens	LDO
MARPO\|EnsemblGenome=MARPO_0036s0143\|UniProtKB=A0A2R6X4Z2	Marchantia polymorpha	O
MARPO\|EnsemblGenome=MARPO_0010s0148\|UniProtKB=A0A2R6XKY0	Marchantia polymorpha	LDO
KLENI\|Gene_ORFName=KFL_007340050\|UniProtKB=A0A1Y1IJW0	Klebsormidium nitens	LDO