PANTHER Gene Information

Gene Symbol(s):

hey2

Organism:

Danio rerio

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Gene Name:

Hairy_enhancer-of-split related with YRPW motif protein 2

Gene ID:

ZDB-GENE-000526-1

Protein ID:

Q9I9L0

Persistent Id:

PTN000105753

Alternate Ids:

NM_131622(refSeq)	HEY2_DANRE(UniProtKB-ID)
AAI14264(EMBL-CDS)	90112091(GI)
hey2(Symbol)	BC114263(EMBL)
ZDB-GENE-000526-1(ZFIN)	grl(Synonym)
Q24JW1(AltAccession)	58146(GeneID)
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PANTHER Classification

PANTHER Family:	BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTOR, HES-RELATED (PTHR10985)
PANTHER Subfamily:	HAIRY_ENHANCER-OF-SPLIT RELATED WITH YRPW MOTIF PROTEIN 2 (PTHR10985:SF88)
PANTHER GO-slim Molecular Function:	DNA-binding transcription factor activity, RNA polymerase II-specific RNA polymerase II cis-regulatory region sequence-specific DNA binding
PANTHER GO-slim Biological Process:	anterior/posterior pattern specification regulation of transcription by RNA polymerase II Notch signaling pathway circulatory system development regulation of neurogenesis
PANTHER GO-slim Cellular Component:	nucleus
PANTHER protein class:	basic helix-loop-helix transcription factor

Pathway Categories:

Notch signaling pathway

Enhancer of Split complex genes

GENE ONTOLOGY DATABASE ANNOTATIONS

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GO MF Complete:	DNA binding, protein binding, RNA polymerase II cis-regulatory region sequence-specific DNA binding, protein dimerization activity, DNA-binding transcription factor activity, RNA polymerase II-specific
GO BP Complete:	cardiac muscle tissue regeneration, anterior/posterior pattern specification, regulation of DNA-templated transcription, blood vessel morphogenesis, artery morphogenesis, vasculogenesis, artery development, cardiac muscle cell proliferation, Notch signaling pathway involved in arterial endothelial cell fate commitment, regulation of transcription by RNA polymerase II, heart development, Notch signaling pathway, blood vessel development, negative regulation of DNA-templated transcription, circulatory system development, dorsal aorta morphogenesis, regulation of neurogenesis
GO CC Complete:	nucleus

REACTOME DATABASE ANNOTATIONS Click to Expand...

Reactome Pathways:

Orthologs

ID	Organism	Type
HUMAN\|HGNC=4881\|UniProtKB=Q9UBP5	Homo sapiens	LDO
PANTR\|Ensembl=ENSPTRG00000018574.3\|UniProtKB=H2QTP5	Pan troglodytes	LDO
GORGO\|Ensembl=ENSGGOG00000002589.3\|UniProtKB=G3QJF6	Gorilla gorilla gorilla	LDO
MACMU\|Ensembl=ENSMMUG00000053773.1\|UniProtKB=H9EU40	Macaca mulatta	LDO
MOUSE\|MGI=MGI=1341884\|UniProtKB=Q9QUS4	Mus musculus	LDO
RAT\|RGD=621405\|UniProtKB=G3V7S6	Rattus norvegicus	LDO
BOVIN\|Ensembl=ENSBTAG00000000919.4\|UniProtKB=E1BEV8	Bos taurus	LDO
PIG\|Ensembl=ENSSSCG00000004223.4\|UniProtKB=F1S2V4	Sus scrofa	LDO
HORSE\|Ensembl=ENSECAG00000038178.3\|UniProtKB=A0A3Q2GS59	Equus caballus	LDO
FELCA\|Ensembl=ENSFCAG00000026914.4\|UniProtKB=A0A2I2V181	Felis catus	LDO
CANLF\|Ensembl=ENSCAFG00845000089.1\|UniProtKB=A0A8I3M9U4	Canis lupus familiaris	LDO
MONDO\|Ensembl=ENSMODG00000017701.5\|UniProtKB=F7FUU4	Monodelphis domestica	LDO
ORNAN\|Ensembl=ENSOANG00000044829.1\|UniProtKB=A0A6I8N096	Ornithorhynchus anatinus	LDO
CHICK\|Ensembl=ENSGALG00010004892.1\|UniProtKB=A0A8V0XNN7	Gallus gallus	LDO
ANOCA\|Ensembl=ENSACAG00000001813.3\|UniProtKB=A0A803SUY2	Anolis carolinensis	LDO
XENLA\|Gene=hey2.L\|UniProtKB=A0A1L8G8T5	Xenopus laevis	LDO
XENTR\|Xenbase=XB-GENE-485923\|UniProtKB=A0A803JFG0	Xenopus tropicalis	LDO
ORYLA\|Ensembl=ENSORLG00000025170.1\|UniProtKB=A0A3B3HGN6	Oryzias latipes	LDO
LEPOC\|Ensembl=ENSLOCG00000017268.1\|UniProtKB=W5NL51	lepisosteus oculatus	LDO
CIOIN\|Ensembl=ENSCING00000006427.3\|UniProtKB=F6QRK3	Ciona intestinalis	O
BRAFL\|Gene=LOC118404227\|UniProtKB=A0A9J7HGE8	Branchiostoma floridae	O
STRPU\|EnsemblGenome=LOC593175\|UniProtKB=A0A7M7RFY8	Strongylocentrotus purpuratus	O
STRPU\|EnsemblGenome=LOC578414\|UniProtKB=A0A7M7TGB2	Strongylocentrotus purpuratus	O
DROME\|FlyBase=FBgn0259938\|UniProtKB=Q9VGZ5	Drosophila melanogaster	O
ANOGA\|EnsemblGenome=AGAP003844\|UniProtKB=A0A1S4GJA7	Anopheles gambiae	O
TRICA\|EnsemblGenome=TC012119\|UniProtKB=D6X1U3	Tribolium castaneum	O
DAPPU\|EnsemblGenome=DAPPUDRAFT_317068\|UniProtKB=E9GEU4	Daphnia pulex	O
IXOSC\|EnsemblGenome=ISCW004855\|UniProtKB=B7PGM4	Ixodes scapularis	O
DROME\|FlyBase=FBgn0027788\|UniProtKB=Q7KM13	Drosophila melanogaster	O
ANOGA\|EnsemblGenome=AGAP007450\|UniProtKB=Q5TWX7	Anopheles gambiae	O
TRICA\|EnsemblGenome=TC001593\|UniProtKB=D7GY39	Tribolium castaneum	O
DAPPU\|EnsemblGenome=DAPPUDRAFT_347250\|UniProtKB=E9H2B3	Daphnia pulex	O
IXOSC\|EnsemblGenome=ISCW011251\|UniProtKB=B7Q8B1	Ixodes scapularis	O
HELRO\|EnsemblGenome=HelroG98385\|UniProtKB=T1G9M2	helobdella robusta	O
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g246249\|UniProtKB=A7SMU2	Nematostella vectensis	O
TRIAD\|EnsemblGenome=TriadG61134\|UniProtKB=B3SA50	Trichoplax adhaerens	O
EREGS\|EnsemblGenome=AGOS_ADL123C\|UniProtKB=Q75AP3	Eremothecium gossypii	O
EMENI\|EnsemblGenome=ANIA_08271\|UniProtKB=C8V3P3	Emericella nidulans	O
ASPFU\|EnsemblGenome=AFUA_5G04190\|UniProtKB=Q4WEU1	Neosartorya fumigata	O
EMENI\|EnsemblGenome=ANIA_02811\|UniProtKB=Q5B9G9	Emericella nidulans	O
CHLRE\|EnsemblGenome=CHLRE_14g609700v5\|UniProtKB=A0A2K3CX93	Chlamydomonas reinhardtii	O
CHLRE\|EnsemblGenome=CHLRE_09g401400v5\|UniProtKB=A0A2K3DCS8	Chlamydomonas reinhardtii	O