PANTHER Gene Information

Gene Symbol(s):

sesn-1

Organism:

Caenorhabditis elegans

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Gene Name:

Sestrin homolog

Gene ID:

WBGene00022279

Protein ID:

Q9N4D6

Persistent Id:

PTN000280096

Alternate Ids:

WBGene00022279(Ensembl)	CCD68266(EMBL-CDS)
SESN1_CAEEL(UniProtKB-ID)	FO080986(EMBL)
13878768(GI)	NP_490664(refSeq)
WBGene00022279(WormBase)	171593(GeneID)
Y74C9A(WormBase_TRS)	CE40291(WormBase_PRO)
sesn-1{ECO:0000312\|WormBase:Y74C9A.5}(Symbol)	Y74C9A.5(Ensembl_PRO)
SESN1(Synonym)	Y74C9A.5(Ensembl_TRS)
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PANTHER Classification

PANTHER Family:	P53 REGULATED PA26 NUCLEAR PROTEIN SESTRIN (PTHR12474)
PANTHER Subfamily:	SESTRIN HOMOLOG (PTHR12474:SF0)
PANTHER GO-slim Molecular Function:	oxidoreductase activity, acting on peroxide as acceptor amino acid binding
PANTHER GO-slim Biological Process:	cellular response to oxygen-containing compound negative regulation of TORC1 signaling cellular response to amino acid starvation cellular response to organonitrogen compound positive regulation of macroautophagy
PANTHER GO-slim Cellular Component:
PANTHER protein class:	peroxidase

Pathway Categories:

No pathway information available

GENE ONTOLOGY DATABASE ANNOTATIONS

Click to Expand...

GO MF Complete:	L-leucine binding, oxidoreductase activity, acting on peroxide as acceptor
GO BP Complete:	positive regulation of macroautophagy, regulation of response to reactive oxygen species, negative regulation of TORC1 signaling, cellular response to L-leucine, cellular response to leucine starvation
GO CC Complete:	nucleus, cytoplasm

REACTOME DATABASE ANNOTATIONS Click to Expand...

Reactome Pathways:

Generic Transcription Pathway, Cellular responses to stress, Cellular response to chemical stress, KEAP1-NFE2L2 pathway, Gene expression (Transcription), RNA Polymerase II Transcription, TP53 Regulates Metabolic Genes, Transcriptional Regulation by TP53, Cellular responses to stimuli

Orthologs

ID	Organism	Type
HUMAN\|HGNC=20746\|UniProtKB=P58004	Homo sapiens	LDO
PANTR\|Ensembl=ENSPTRG00000000429.5\|UniProtKB=K7CUM5	Pan troglodytes	LDO
GORGO\|Ensembl=ENSGGOG00000014485.3\|UniProtKB=G3REY2	Gorilla gorilla gorilla	LDO
MACMU\|Ensembl=ENSMMUG00000019993.4\|UniProtKB=F7FNU6	Macaca mulatta	LDO
MOUSE\|MGI=MGI=2651874\|UniProtKB=P58043	Mus musculus	LDO
RAT\|RGD=1566319\|UniProtKB=B2GUV6	Rattus norvegicus	LDO
BOVIN\|Ensembl=ENSBTAG00000002363\|UniProtKB=Q58CN8	Bos taurus	LDO
PIG\|Ensembl=ENSSSCG00000029438.4\|UniProtKB=A0A4X1TPR3	Sus scrofa	LDO
HORSE\|Ensembl=ENSECAG00000001989.4\|UniProtKB=F6Z2X6	Equus caballus	LDO
FELCA\|Ensembl=ENSFCAG00000013396.5\|UniProtKB=A0A5F5XNP8	Felis catus	LDO
CANLF\|Ensembl=ENSCAFG00845010570.1\|UniProtKB=A0A8I3NDS6	Canis lupus familiaris	LDO
MONDO\|Ensembl=ENSMODG00000010846.4\|UniProtKB=F7ARK8	Monodelphis domestica	LDO
ORNAN\|Ensembl=ENSOANG00000000634.4\|UniProtKB=F7END0	Ornithorhynchus anatinus	LDO
CHICK\|Ensembl=ENSGALG00010016875.1\|UniProtKB=A0A8V0YY05	Gallus gallus	LDO
ANOCA\|Ensembl=ENSACAG00000010993.4\|UniProtKB=H9GH47	Anolis carolinensis	LDO
XENLA\|Gene=sesn2.S\|UniProtKB=A0A8J1ME70	Xenopus laevis	O
XENLA\|Gene=sesn2.L\|UniProtKB=Q6NU55	Xenopus laevis	LDO
XENTR\|Gene=sesn2\|UniProtKB=A0A8J1J4K5	Xenopus tropicalis	LDO
ORYLA\|Ensembl=ENSORLG00000011116.2\|UniProtKB=H2M654	Oryzias latipes	LDO
DANRE\|ZFIN=ZDB-GENE-070108-1\|UniProtKB=A0F081	Danio rerio	LDO
LEPOC\|Ensembl=ENSLOCG00000005106.1\|UniProtKB=W5MCN8	lepisosteus oculatus	LDO
HUMAN\|HGNC=23060\|UniProtKB=P58005	Homo sapiens	O
PANTR\|Ensembl=ENSPTRG00000004192.6\|UniProtKB=K7CXR4	Pan troglodytes	O
GORGO\|Ensembl=ENSGGOG00000004922.3\|UniProtKB=G3QQF9	Gorilla gorilla gorilla	O
MACMU\|Ensembl=ENSMMUG00000009394.4\|UniProtKB=F7HEU9	Macaca mulatta	O
MOUSE\|MGI=MGI=1922997\|UniProtKB=Q9CYP7	Mus musculus	O
RAT\|RGD=1309470\|UniProtKB=A0A8I6A0N4	Rattus norvegicus	O
BOVIN\|Ensembl=ENSBTAG00000004034.6\|UniProtKB=F1MFJ7	Bos taurus	O
PIG\|Ensembl=ENSSSCG00000037015.3\|UniProtKB=A0A287A0W1	Sus scrofa	O
HORSE\|Ensembl=ENSECAG00000017743.4\|UniProtKB=A0A9L0RJB0	Equus caballus	O
FELCA\|Ensembl=ENSFCAG00000005081.6\|UniProtKB=A0A337SQV6	Felis catus	O
CANLF\|Ensembl=ENSCAFG00845018942.1\|UniProtKB=A0A8I3NX72	Canis lupus familiaris	O
MONDO\|Ensembl=ENSMODG00000000163.4\|UniProtKB=F6XS87	Monodelphis domestica	O
ORNAN\|Ensembl=ENSOANG00000010503.4\|UniProtKB=A0A6I8MX44	Ornithorhynchus anatinus	O
CHICK\|Ensembl=ENSGALG00010008386.1\|UniProtKB=A0A8V0XTS4	Gallus gallus	O
ANOCA\|Ensembl=ENSACAG00000013850.3\|UniProtKB=G1KPC2	Anolis carolinensis	O
XENLA\|Gene=sesn3.L\|UniProtKB=Q6GQC2	Xenopus laevis	O
XENLA\|Gene=sesn3.S\|UniProtKB=A0A1L8HAZ1	Xenopus laevis	O
XENTR\|Xenbase=XB-GENE-494676\|UniProtKB=A0A6I8SKA8	Xenopus tropicalis	O
DANRE\|ZFIN=ZDB-GENE-040426-2924\|UniProtKB=F1R1P4	Danio rerio	O
LEPOC\|Ensembl=ENSLOCG00000007583.1\|UniProtKB=W5MLE5	lepisosteus oculatus	O
CHICK\|Ensembl=ENSGALG00010018422.1\|UniProtKB=A0A8V0YZQ5	Gallus gallus	O
ORYLA\|Ensembl=ENSORLG00000002176.2\|UniProtKB=A0A3B3HNY1	Oryzias latipes	O
DANRE\|ZFIN=ZDB-GENE-160114-34\|UniProtKB=E7F0F7	Danio rerio	O
LEPOC\|Ensembl=ENSLOCG00000014911.1\|UniProtKB=W5NCK4	lepisosteus oculatus	O
HUMAN\|HGNC=21595\|UniProtKB=Q9Y6P5	Homo sapiens	O
PANTR\|Ensembl=ENSPTRG00000018479.5\|UniProtKB=K7B8T7	Pan troglodytes	O
GORGO\|Ensembl=ENSGGOG00000008196.3\|UniProtKB=G3RU39	Gorilla gorilla gorilla	O
MACMU\|Ensembl=ENSMMUG00000018232.4\|UniProtKB=F7D7D8	Macaca mulatta	O
MOUSE\|MGI=MGI=2155278\|UniProtKB=P58006	Mus musculus	O
RAT\|RGD=1307517\|UniProtKB=A0A8I6AEX8	Rattus norvegicus	O
BOVIN\|Ensembl=ENSBTAG00000003015.6\|UniProtKB=A6QQS4	Bos taurus	O
PIG\|Ensembl=ENSSSCG00000004390.5\|UniProtKB=F1RT20	Sus scrofa	O
HORSE\|Ensembl=ENSECAG00000001101.4\|UniProtKB=F6TVU6	Equus caballus	O
FELCA\|Ensembl=ENSFCAG00000031995.4\|UniProtKB=M3X2C6	Felis catus	O
CANLF\|Ensembl=ENSCAFG00845009981.1\|UniProtKB=A0A8I3RXG2	Canis lupus familiaris	O
MONDO\|Ensembl=ENSMODG00000017990.4\|UniProtKB=F7B8G7	Monodelphis domestica	O
ORNAN\|Ensembl=ENSOANG00000015028.4\|UniProtKB=F6W2I5	Ornithorhynchus anatinus	O
CHICK\|Ensembl=ENSGALG00010014244.1\|UniProtKB=A0A8V0YH04	Gallus gallus	O
ANOCA\|Ensembl=ENSACAG00000006083.4\|UniProtKB=G1KF20	Anolis carolinensis	O
XENLA\|Gene=sesn1.L\|UniProtKB=A0A8J1KL11	Xenopus laevis	O
XENLA\|Gene=sesn1\|UniProtKB=P58003	Xenopus laevis	O
XENLA\|Gene=sesn1.S\|UniProtKB=A0A1L8G2X6	Xenopus laevis	O
XENTR\|Xenbase=XB-GENE-491636\|UniProtKB=B3DLB2	Xenopus tropicalis	O
ORYLA\|Ensembl=ENSORLG00000013484.2\|UniProtKB=A0A3B3I4R8	Oryzias latipes	O
DANRE\|Gene=sesn1\|UniProtKB=A0A8M2B7J7	Danio rerio	O
LEPOC\|Ensembl=ENSLOCG00000016607.1\|UniProtKB=W5NIQ5	lepisosteus oculatus	O
CIOIN\|Ensembl=ENSCING00000007668.3\|UniProtKB=F6T7E5	Ciona intestinalis	LDO
BRAFL\|Gene=LOC118423082\|UniProtKB=A0A9J7LQS3	Branchiostoma floridae	LDO
STRPU\|EnsemblGenome=LOC584902\|UniProtKB=A0A7M7PFI8	Strongylocentrotus purpuratus	LDO
CAEBR\|Gene_ORFName=CBG03915\|UniProtKB=A8WVR0	Caenorhabditis briggsae	LDO
PRIPA\|EnsemblGenome=WBGene00117377\|UniProtKB=A0A2A6BL70	Pristionchus pacificus	LDO
DROME\|FlyBase=FBgn0034897\|UniProtKB=Q9W1K5	Drosophila melanogaster	LDO
ANOGA\|EnsemblGenome=AGAP007169\|UniProtKB=Q7PTB1	Anopheles gambiae	LDO
TRICA\|EnsemblGenome=TC003553\|UniProtKB=D6WHQ5	Tribolium castaneum	LDO
DAPPU\|EnsemblGenome=DAPPUDRAFT_200622\|UniProtKB=E9H5P4	Daphnia pulex	LDO
IXOSC\|EnsemblGenome=ISCW002773\|UniProtKB=B7P7V9	Ixodes scapularis	LDO
HELRO\|EnsemblGenome=HelroG117076\|UniProtKB=T1EGK0	helobdella robusta	O
HELRO\|EnsemblGenome=HelroG185938\|UniProtKB=T1FNG7	helobdella robusta	LDO
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g188161\|UniProtKB=A7SCG7	Nematostella vectensis	LDO
TRIAD\|EnsemblGenome=TriadG25289\|UniProtKB=B3RYA9	Trichoplax adhaerens	LDO
MONBE\|EnsemblGenome=MONBRDRAFT_1017\|UniProtKB=A9UW02	Monosiga brevicollis	LDO
DICDI\|dictyBase=DDB_G0279427\|UniProtKB=Q54WU6	Dictyostelium discoideum	LDO
DICPU\|EnsemblGenome=DICPUDRAFT_98918\|UniProtKB=F0ZUS8	Dictyostelium purpureum	LDO
LEIMA\|EnsemblGenome=LMJF_18_0650\|UniProtKB=Q4QDX6	Leishmania major	LDO
TRYB2\|Gene_ORFName=Tb10.05.0190\|UniProtKB=Q388Q1	Trypanosoma brucei	LDO
PARTE\|EnsemblGenome=GSPATT00006213001\|UniProtKB=A0C4J8	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00023191001\|UniProtKB=A0E401	Paramecium tetraurelia	LDO
PARTE\|EnsemblGenome=GSPATT00009541001\|UniProtKB=A0CR11	Paramecium tetraurelia	O
PHYRM\|Gene=H3GGE2_PHYRM\|UniProtKB=H3GGE2	Phytophthora ramorum	LDO