PANTHER Gene Information   
Gene Symbol(s): vps-34
Organism: Caenorhabditis elegans
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Gene Name: Phosphatidylinositol 3-kinase catalytic subunit type 3
Gene ID: WBGene00006932
Protein ID: Q9TXI7
Persistent Id: PTN000005989
Alternate Ids:
75024691(GI) NP_001020953(refSeq)
CAA73142(EMBL-CDS) WBGene00006932(Ensembl)
Q9TXI6(AltAccession) PK3C3_CAEEL(UniProtKB-ID)
B0025.1b(WormBase_TRS) 2.7.1.137 {ECO:0000255|PIRNR:PIRNR000587, ECO:0000269|PubMed:11927551}(EC)
172280(GeneID) Y12543(EMBL)
CE37691(WormBase_PRO) WBGene00006932(WormBase)
let-512{ECO:0000312|WormBase:B0025.1a}(Synonym) vps-34{ECO:0000312|WormBase:B0025.1a}(Symbol)
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PANTHER Classification
PANTHER Family: PHOSPHATIDYLINOSITOL KINASE (PTHR10048)
PANTHER Subfamily: PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3 (PTHR10048:SF7)  
PANTHER GO-slim Molecular Function: phosphotransferase activity, alcohol group as acceptor
lipid kinase activity
PANTHER GO-slim Biological Process: endocytosis
autophagosome assembly
intracellular signal transduction
phosphatidylinositol phosphate biosynthetic process
PANTHER GO-slim Cellular Component: peroxisome
phagophore assembly site
endosome
phosphatidylinositol 3-kinase complex, class III
PANTHER protein class: kinase
Pathway Categories: VEGF signaling pathway
   Phosphatidylinositol 3-kinase
T cell activation
   Phosphatidylinositol 3-kinase
Ras Pathway
   Phosphatidylinositol 3-kinase
Hypoxia response via HIF activation
   Phosphatidylinositol 3-kinase
Insulin/IGF pathway-protein kinase B signaling cascade
   Phosphatidylinositol 3-kinase
FGF signaling pathway
   Phosphatidylinositol 3-kinase
Angiogenesis
   Phosphatidylinositol 3-kinase
EGF receptor signaling pathway
   Phosphatidylinositol 3-kinase
Integrin signalling pathway
   Phosphatidylinositol 3-kinase
Endothelin signaling pathway
   Phosphatidylinositol 3-kinase
PDGF signaling pathway
   Phosphatidylinositol 3-kinase
p53 pathway feedback loops 2
   Phosphatidylinositol 3-kinase
p53 pathway
   Phosphatidylinositol 3-kinase
GENE ONTOLOGY DATABASE ANNOTATIONS      Click to Expand...
GO MF Complete: ATP binding, protein binding, kinase activity, 1-phosphatidylinositol-3-kinase activity
GO BP Complete: regulation of protein secretion, positive regulation of engulfment of apoptotic cell, determination of adult lifespan, phagosome maturation involved in apoptotic cell clearance, phosphatidylinositol-3-phosphate biosynthetic process, reproductive process, phosphatidylinositol phosphate biosynthetic process, pexophagy, endocytosis, autophagosome assembly, nuclear envelope organization, regulation of endosome size, nematode larval development, phosphatidylinositol-mediated signaling, lipid metabolic process, ecdysis, collagen and cuticulin-based cuticle, phagocytosis, regulation of endocytosis
GO CC Complete: nucleus, peroxisome, phosphatidylinositol 3-kinase complex, class III, type II, phosphatidylinositol 3-kinase complex, class III, type I, endosome, cytoplasm, phagophore assembly site, membrane, nuclear outer membrane, nucleolus, phagocytic cup, cell projection
REACTOME DATABASE ANNOTATIONS   Click to Expand...
Reactome Pathways: Phospholipid metabolism, Signal Transduction, Signaling by Rho GTPases, Macroautophagy, Autophagy, Metabolism of lipids, PI Metabolism, Metabolism, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, RHO GTPases Activate NADPH Oxidases, RHO GTPase Effectors, Synthesis of PIPs at the early endosome membrane, Synthesis of PIPs at the late endosome membrane, Synthesis of PIPs at the Golgi membrane

Orthologs