PANTHER Gene Information

Gene Symbol(s):

wkd

Organism:

Drosophila melanogaster

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Gene Name:

TBC1 domain family member whacked

Gene ID:

FBgn0037917

Protein ID:

Q9VGL8

Persistent Id:

PTN000538023

Alternate Ids:

41390(GeneID)	24645988(GI)
FBpp0081890(Ensembl_PRO)	FBgn0037917(FlyBase)
FBtr0082413(Ensembl_TRS)	wkd{ECO:0000303\|PubMed:22407366,ECO:0000312\|FlyBase:FBgn0037917}(Symbol)
BT010263(EMBL)	TBWKD(Synonym)
FBgn0037917(Ensembl)	AAQ23581(EMBL-CDS)
NP_650089(refSeq)	TBWKD_DROME(UniProtKB-ID)
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PANTHER Classification

PANTHER Family:	TBC1 DOMAIN FAMILY MEMBER GTPASE-ACTIVATING PROTEIN (PTHR22957)
PANTHER Subfamily:	TBC1 DOMAIN FAMILY MEMBER WHACKED (PTHR22957:SF352)
PANTHER GO-slim Molecular Function:	GTPase activator activity
PANTHER GO-slim Biological Process:	activation of GTPase activity
PANTHER GO-slim Cellular Component:
PANTHER protein class:	GTPase-activating protein

Pathway Categories:

No pathway information available

GENE ONTOLOGY DATABASE ANNOTATIONS

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GO MF Complete:	GTPase activator activity
GO BP Complete:	polarity specification of proximal/distal axis, retrograde transport, endosome to Golgi, lumen formation, open tracheal system
GO CC Complete:	cytoplasm, filopodium, cytoplasmic side of apical plasma membrane

REACTOME DATABASE ANNOTATIONS Click to Expand...

Reactome Pathways:

Rab regulation of trafficking, TBC/RABGAPs, Immune System, Membrane Trafficking, Innate Immune System, Vesicle-mediated transport, Neutrophil degranulation

Orthologs

ID	Organism	Type
HUMAN\|HGNC=23609\|UniProtKB=Q9BXI6	Homo sapiens	O
GORGO\|Ensembl=ENSGGOG00000007181.3\|UniProtKB=G3QW79	Gorilla gorilla gorilla	O
MACMU\|Ensembl=ENSMMUG00000005553.4\|UniProtKB=I0FHJ4	Macaca mulatta	O
MOUSE\|MGI=MGI=2144164\|UniProtKB=P58802	Mus musculus	O
RAT\|RGD=1311641\|UniProtKB=F7EVS3	Rattus norvegicus	O
BOVIN\|Ensembl=ENSBTAG00000018086.6\|UniProtKB=F1MB46	Bos taurus	O
PIG\|Ensembl=ENSSSCG00000009999.4\|UniProtKB=F1RFD6	Sus scrofa	O
HORSE\|Ensembl=ENSECAG00000018611.4\|UniProtKB=F7B6B3	Equus caballus	O
FELCA\|Ensembl=ENSFCAG00000011931.5\|UniProtKB=M3WG14	Felis catus	O
CANLF\|Ensembl=ENSCAFG00845019071.1\|UniProtKB=A0A8I3P840	Canis lupus familiaris	O
ORNAN\|Ensembl=ENSOANG00000049736.1\|UniProtKB=A0A6I8N2N2	Ornithorhynchus anatinus	O
ANOCA\|Ensembl=ENSACAG00000044495.1\|UniProtKB=A0A803TFM1	Anolis carolinensis	O
ORYLA\|Ensembl=ENSORLG00000028596.1\|UniProtKB=A0A3B3HBU0	Oryzias latipes	O
ORYLA\|Ensembl=ENSORLG00000013033.2\|UniProtKB=H2MCP2	Oryzias latipes	O
DANRE\|Gene=tbc1d10ab\|UniProtKB=A0A8N7TB33	Danio rerio	O
LEPOC\|Ensembl=ENSLOCG00000008261.1\|UniProtKB=W5MNS2	lepisosteus oculatus	O
HUMAN\|HGNC=24702\|UniProtKB=Q8IV04	Homo sapiens	O
PANTR\|Ensembl=ENSPTRG00000003954.5\|UniProtKB=H2Q485	Pan troglodytes	O
GORGO\|Ensembl=ENSGGOG00000009988.3\|UniProtKB=G3R3C7	Gorilla gorilla gorilla	O
MACMU\|Ensembl=ENSMMUG00000017280.4\|UniProtKB=F7GWK4	Macaca mulatta	O
MOUSE\|MGI=MGI=1922072\|UniProtKB=Q8C9V1	Mus musculus	O
RAT\|RGD=1311490\|UniProtKB=B1H212	Rattus norvegicus	O
BOVIN\|Ensembl=ENSBTAG00000013133.6\|UniProtKB=A0A3S5ZPJ1	Bos taurus	O
PIG\|Ensembl=ENSSSCG00000012912.5\|UniProtKB=A0A287BMF9	Sus scrofa	O
HORSE\|Ensembl=ENSECAG00000012029.4\|UniProtKB=F6QXP4	Equus caballus	O
CANLF\|Ensembl=ENSCAFG00845010400.1\|UniProtKB=A0A8I3NH98	Canis lupus familiaris	O
ANOCA\|Ensembl=ENSACAG00000008155.3\|UniProtKB=A0A803TQF0	Anolis carolinensis	O
ORYLA\|Ensembl=ENSORLG00000025085.1\|UniProtKB=A0A3B3I474	Oryzias latipes	O
DANRE\|ZFIN=ZDB-GENE-130125-1\|UniProtKB=E7F6L2	Danio rerio	O
LEPOC\|Ensembl=ENSLOCG00000008291.1\|UniProtKB=W5MNW0	lepisosteus oculatus	O
HUMAN\|HGNC=24510\|UniProtKB=Q4KMP7	Homo sapiens	LDO
PANTR\|Ensembl=ENSPTRG00000007996.6\|UniProtKB=H2R0A3	Pan troglodytes	LDO
GORGO\|Ensembl=ENSGGOG00000014283.3\|UniProtKB=G3REE8	Gorilla gorilla gorilla	LDO
MOUSE\|MGI=MGI=1915699\|UniProtKB=Q8BHL3	Mus musculus	LDO
RAT\|RGD=1309191\|UniProtKB=D3ZSY8	Rattus norvegicus	LDO
BOVIN\|Ensembl=ENSBTAG00000031852.4\|UniProtKB=F1MJZ7	Bos taurus	LDO
PIG\|Ensembl=ENSSSCG00000007798.4\|UniProtKB=F1RG61	Sus scrofa	LDO
HORSE\|Ensembl=ENSECAG00000022918.3\|UniProtKB=F6UMU0	Equus caballus	LDO
FELCA\|Ensembl=ENSFCAG00000030318.4\|UniProtKB=M3XE19	Felis catus	LDO
MONDO\|Ensembl=ENSMODG00000001468.4\|UniProtKB=F7APA5	Monodelphis domestica	LDO
ORNAN\|Ensembl=ENSOANG00000044271.1\|UniProtKB=A0A6I8P1E3	Ornithorhynchus anatinus	LDO
ORYLA\|Ensembl=ENSORLG00000002172.2\|UniProtKB=H2LA00	Oryzias latipes	LDO
LEPOC\|Ensembl=ENSLOCG00000003422.1\|UniProtKB=W5M6N9	lepisosteus oculatus	LDO
BRAFL\|Gene=LOC118426516\|UniProtKB=A0A9J7N6L1	Branchiostoma floridae	LDO
CAEEL\|WormBase=WBGene00019915\|UniProtKB=O44873	Caenorhabditis elegans	LDO
CAEBR\|Gene_ORFName=CBG15140\|UniProtKB=A8XLV0	Caenorhabditis briggsae	LDO
PRIPA\|EnsemblGenome=WBGene00092129\|UniProtKB=A0A2A6BQU5	Pristionchus pacificus	LDO
ANOGA\|EnsemblGenome=AGAP001953\|UniProtKB=Q7PYI3	Anopheles gambiae	LDO
TRICA\|EnsemblGenome=TC015650\|UniProtKB=D2A652	Tribolium castaneum	LDO
DAPPU\|EnsemblGenome=DAPPUDRAFT_47414\|UniProtKB=E9G8G2	Daphnia pulex	LDO
IXOSC\|EnsemblGenome=ISCW005174\|UniProtKB=B7PEM0	Ixodes scapularis	LDO
HELRO\|EnsemblGenome=HelroG188085\|UniProtKB=T1FPL9	helobdella robusta	LDO
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g168234\|UniProtKB=A7SA57	Nematostella vectensis	LDO
TRIAD\|EnsemblGenome=TriadG58493\|UniProtKB=B3S2V3	Trichoplax adhaerens	LDO
PARTE\|EnsemblGenome=GSPATT00020962001\|UniProtKB=A0DWA3	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00023316001\|UniProtKB=A0E4C5	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00021631001\|UniProtKB=A0DZJ7	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00023672001\|UniProtKB=A0E5C8	Paramecium tetraurelia	LDO