PANTHER Gene Information

Gene Symbol(s):

mtDNA-helicase

Organism:

Drosophila melanogaster

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Gene Name:

Mitochondrial DNA helicase

Gene ID:

FBgn0032154

Protein ID:

Q9VL76

Persistent Id:

PTN000305651

Alternate Ids:

AAF52820(EMBL-CDS)	Q8MZH0(AltAccession)
Twinkle mtDNA helicase {ECO:0000305}(Synonym)	24583154(GI)
PEO1_DROME(UniProtKB-ID)	FBgn0032154(Ensembl)
FBtr0079911(Ensembl_TRS)	mtDNA-helicase{ECO:0000312\|FlyBase:FBgn0032154}(Symbol)
34307(GeneID)	AE014134(EMBL)
FBpp0079501(Ensembl_PRO)	FBgn0032154(FlyBase)
NP_609318(refSeq)	3.6.4.12 {ECO:0000250\|UniProtKB:Q96RR1}(EC)
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PANTHER Classification

PANTHER Family:	T7-LIKE MITOCHONDRIAL DNA HELICASE (PTHR12873)
PANTHER Subfamily:	TWINKLE MTDNA HELICASE (PTHR12873:SF0)
PANTHER GO-slim Molecular Function:	DNA helicase activity single-stranded DNA binding
PANTHER GO-slim Biological Process:
PANTHER GO-slim Cellular Component:
PANTHER protein class:	DNA helicase

Pathway Categories:

No pathway information available

GENE ONTOLOGY DATABASE ANNOTATIONS

Click to Expand...

GO MF Complete:	ATP hydrolysis activity, ATP binding, DNA helicase activity, double-stranded DNA binding, lipid binding, iron-sulfur cluster binding, 2 iron, 2 sulfur cluster binding, single-stranded DNA binding, 5'-3' DNA helicase activity
GO BP Complete:	DNA replication, mitochondrial DNA replication, mitochondrial genome maintenance
GO CC Complete:	mitochondrial chromosome, mitochondrion, mitochondrial nucleoid

REACTOME DATABASE ANNOTATIONS Click to Expand...

Reactome Pathways:

Mitochondrial protein degradation, Metabolism of proteins

Orthologs

ID	Organism	Type
HUMAN\|HGNC=1160\|UniProtKB=Q96RR1	Homo sapiens	LDO
PANTR\|Ensembl=ENSPTRG00000029751.3\|UniProtKB=H2R7G8	Pan troglodytes	LDO
GORGO\|Ensembl=ENSGGOG00000015421.3\|UniProtKB=G3RHC9	Gorilla gorilla gorilla	LDO
MACMU\|Ensembl=ENSMMUG00000064033.1\|UniProtKB=H9Z0D9	Macaca mulatta	LDO
MOUSE\|MGI=MGI=2137410\|UniProtKB=Q8CIW5	Mus musculus	LDO
RAT\|RGD=1307884\|UniProtKB=D3ZA68	Rattus norvegicus	LDO
BOVIN\|Ensembl=ENSBTAG00000003296.6\|UniProtKB=A5D7A7	Bos taurus	LDO
PIG\|Ensembl=ENSSSCG00005008931.1\|UniProtKB=I3LNP8	Sus scrofa	LDO
HORSE\|Ensembl=ENSECAG00000017734.4\|UniProtKB=F6SPL7	Equus caballus	LDO
FELCA\|Ensembl=ENSFCAG00000015694.5\|UniProtKB=M3WN33	Felis catus	LDO
CANLF\|Ensembl=ENSCAFG00845019518.1\|UniProtKB=A0A8I3P5N0	Canis lupus familiaris	LDO
MONDO\|Ensembl=ENSMODG00000011966.3\|UniProtKB=F7CUW8	Monodelphis domestica	LDO
ORNAN\|Ensembl=ENSOANG00000042089.1\|UniProtKB=A0A6I8PBJ8	Ornithorhynchus anatinus	O
ORNAN\|Ensembl=ENSOANG00000007326.4\|UniProtKB=A0A6I8N448	Ornithorhynchus anatinus	O
ORNAN\|Ensembl=ENSOANG00000007325.3\|UniProtKB=F6WX75	Ornithorhynchus anatinus	LDO
CHICK\|Ensembl=ENSGALG00010018482.1\|UniProtKB=A0A8V0Z659	Gallus gallus	LDO
CHICK\|Gene_ORFName=RCJMB04_23c24\|UniProtKB=Q5ZIW1	Gallus gallus	LDO
ANOCA\|Ensembl=ENSACAG00000003783.4\|UniProtKB=G1KC80	Anolis carolinensis	LDO
XENLA\|Gene=twnk.L\|UniProtKB=Q6NU50	Xenopus laevis	LDO
XENTR\|Xenbase=XB-GENE-978896\|UniProtKB=F7A002	Xenopus tropicalis	LDO
ORYLA\|Ensembl=ENSORLG00000011537.2\|UniProtKB=H2M7J5	Oryzias latipes	LDO
DANRE\|ZFIN=ZDB-GENE-030131-5569\|UniProtKB=A0A0R4ICC1	Danio rerio	LDO
LEPOC\|Ensembl=ENSLOCG00000012623.1\|UniProtKB=W5N4I1	lepisosteus oculatus	LDO
BRAFL\|Gene=LOC118406640\|UniProtKB=A0A9J7HQX3	Branchiostoma floridae	LDO
STRPU\|EnsemblGenome=LOC581516\|UniProtKB=A0A7M7P3E4	Strongylocentrotus purpuratus	LDO
CAEEL\|WormBase=WBGene00018514\|UniProtKB=A0A3P6N6A0	Caenorhabditis elegans	LDO
CAEBR\|Gene_ORFName=CBG14751\|UniProtKB=A8XKL2	Caenorhabditis briggsae	LDO
PRIPA\|EnsemblGenome=WBGene00109675\|UniProtKB=A0A2A6B4J1	Pristionchus pacificus	LDO
ANOGA\|EnsemblGenome=AGAP010720\|UniProtKB=A0A1S4H4T0	Anopheles gambiae	LDO
TRICA\|EnsemblGenome=TC002994\|UniProtKB=D6WGI5	Tribolium castaneum	LDO
DAPPU\|EnsemblGenome=DAPPUDRAFT_314156\|UniProtKB=E9G4U0	Daphnia pulex	LDO
IXOSC\|EnsemblGenome=ISCW006569\|UniProtKB=B7PPS0	Ixodes scapularis	LDO
HELRO\|EnsemblGenome=HelroG189902\|UniProtKB=T1FRG7	helobdella robusta	LDO
DICDI\|dictyBase=DDB_G0288209\|UniProtKB=Q54J94	Dictyostelium discoideum	LDO
DICPU\|EnsemblGenome=DICPUDRAFT_97936\|UniProtKB=F0ZL70	Dictyostelium purpureum	LDO
PLAF7\|EnsemblGenome=PF3D7_1411400\|UniProtKB=Q8ILY1	Plasmodium falciparum	LDO
PARTE\|EnsemblGenome=GSPATT00011504001\|UniProtKB=A0CYN6	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00006831001\|UniProtKB=A0C9Q8	Paramecium tetraurelia	LDO
PARTE\|EnsemblGenome=GSPATT00002365001\|UniProtKB=A0DGR9	Paramecium tetraurelia	LDO
THAPS\|EnsemblGenome=THAPSDRAFT_bd1983\|UniProtKB=B8LE42	Thalassiosira pseudonana	LDO
THAPS\|EnsemblGenome=THAPSDRAFT_35968\|UniProtKB=B8C699	Thalassiosira pseudonana	O
PHYRM\|Gene=H3GG08_PHYRM\|UniProtKB=H3GG08	Phytophthora ramorum	LDO
PHYRM\|Gene=H3H6T1_PHYRM\|UniProtKB=H3H6T1	Phytophthora ramorum	LDO
CHLRE\|EnsemblGenome=CHLRE_12g503150v5\|UniProtKB=A0A2K3D357	Chlamydomonas reinhardtii	O
CHLRE\|EnsemblGenome=CHLRE_12g514950v5\|UniProtKB=A0A2K3D3N5	Chlamydomonas reinhardtii	LDO
AMBTC\|EnsemblGenome=AMTR_s00032p00034370\|UniProtKB=U5D333	Amborella trichopoda	LDO
ZOSMR\|Gene_ORFName=ZOSMA_228G00230\|UniProtKB=A0A0K9PIW0	Zostera marina	O
ZOSMR\|Gene_ORFName=ZOSMA_177G00020\|UniProtKB=A0A0K9PRV8	Zostera marina	LDO
MUSAM\|EnsemblGenome=Ma09_g31110\|UniProtKB=A0A804KQQ2	Musa acuminata subsp. malaccensis	O
MUSAM\|EnsemblGenome=Ma11_g12180\|UniProtKB=A0A804L712	Musa acuminata subsp. malaccensis	LDO
MUSAM\|EnsemblGenome=Ma09_g31120\|UniProtKB=A0A804KQQ3	Musa acuminata subsp. malaccensis	O
SETIT\|EnsemblGenome=SETIT_005915mg\|UniProtKB=K3XVF8	Setaria italica	LDO
SORBI\|EnsemblGenome=SORBI_3010G224700\|UniProtKB=C5Z7R8	Sorghum bicolor	LDO
MAIZE\|EnsemblGenome=Zm00001eb274090\|UniProtKB=A0A804PX23	Zea mays	LDO
BRADI\|EnsemblGenome=BRADI_1g32410v3\|UniProtKB=A0A0Q3JGY3	Brachypodium distachyon	LDO
HORVV\|EnsemblGenome=HORVU.MOREX.r3.7HG0736160\|UniProtKB=A0A8I6YIS7	Hordeum vulgare subsp. vulgare	LDO
WHEAT\|EnsemblGenome=TraesCS7D02G454700\|UniProtKB=A0A3B6TWU7	Triticum aestivum	O
WHEAT\|EnsemblGenome=TraesCS7A02G466900\|UniProtKB=A0A3B6RLL4	Triticum aestivum	LDO
WHEAT\|EnsemblGenome=TraesCS7B02G368200\|UniProtKB=A0A3B6SR37	Triticum aestivum	LDO
NELNU\|Gene_ORFName=HUJ06_001851\|UniProtKB=A0A1U7YWW4	Nelumbo nucifera	LDO
ERYGU\|Gene_ORFName=MIMGU_mgv1a008046mg\|UniProtKB=A0A022PRX7	Erythranthe guttata	O
CAPAN\|EnsemblGenome=T459_05150\|UniProtKB=A0A1U8FUN2	Capsicum annuum	O
SOLTU\|EnsemblGenome=PGSC0003DMG400021105\|UniProtKB=M1BW79	Solanum tuberosum	O
SOLLC\|EnsemblGenome=Solyc02g070230.2\|UniProtKB=A0A3Q7FNB2	Solanum lycopersicum	O
TOBAC\|Gene=LOC107823224\|UniProtKB=A0A1S4CW30	Nicotiana tabacum	O
VITVI\|EnsemblGenome=Vitvi10g01092\|UniProtKB=F6I3G4	Vitis vinifera	O
EUCGR\|EnsemblGenome=EUGRSUZ_D01012\|UniProtKB=A0A059CDT7	Eucalyptus grandis	O
THECC\|EnsemblGenome=TCM_027033\|UniProtKB=A0A061G7Y0	Theobroma cacao	O
CITSI\|Gene_ORFName=CISIN_1g042101mg\|UniProtKB=A0A067GG06	Citrus sinensis	O
POPTR\|EnsemblGenome=POPTR_001G461200v3\|UniProtKB=B9GGH6	Populus trichocarpa	O
RICCO\|Gene_ORFName=RCOM_1334340\|UniProtKB=B9SAY5	Ricinus communis	O
SOYBN\|EnsemblGenome=GLYMA_09G028800\|UniProtKB=I1L0J4	Glycine max	O
MEDTR\|EnsemblGenome=MTR_2g031740\|UniProtKB=A0A072VFZ5	Medicago truncatula	O
JUGRE\|EnsemblGenome=Jr03_17700\|UniProtKB=A0A6P9EBX2	Juglans regia	O
JUGRE\|EnsemblGenome=Jr03_17670\|UniProtKB=A0A2I4E2J0	Juglans regia	O
JUGRE\|EnsemblGenome=Jr03_17660\|UniProtKB=A0A2I4E2I1	Juglans regia	O
CUCSA\|EnsemblGenome=Csa_1G542430\|UniProtKB=A0A0A0LYN4	Cucumis sativus	O
PRUPE\|EnsemblGenome=PRUPE_4G099900\|UniProtKB=A0A251PIC0	Prunus persica	O
SPIOL\|Gene=LOC110804797\|UniProtKB=A0A9R0KC15	Spinacia oleracea	LDO
HELAN\|EnsemblGenome=HanXRQr2_Chr01g0023701\|UniProtKB=A0A251VPU7	Helianthus annuus	O
LACSA\|Gene_ORFName=LSAT_V11C100036990\|UniProtKB=A0A9R1XSS0	Lactuca sativa	O
HELAN\|EnsemblGenome=HanXRQr2_Chr01g0023731\|UniProtKB=A0A251VQG7	Helianthus annuus	LDO
HELAN\|EnsemblGenome=HanXRQr2_Chr11g0501671\|UniProtKB=A0A251TCA3	Helianthus annuus	O
ERYGU\|Gene_ORFName=MIMGU_mgv1a002055mg\|UniProtKB=A0A022PW97	Erythranthe guttata	LDO
SOLLC\|EnsemblGenome=Solyc02g022830.3\|UniProtKB=A0A3Q7EY06	Solanum lycopersicum	LDO
TOBAC\|Gene=LOC107819042\|UniProtKB=A0A1S4CHW6	Nicotiana tabacum	O
TOBAC\|Gene=LOC107826455\|UniProtKB=A0A1S4D6F3	Nicotiana tabacum	LDO
VITVI\|EnsemblGenome=Vitvi10g01037\|UniProtKB=D7TKP7	Vitis vinifera	LDO
EUCGR\|EnsemblGenome=EUGRSUZ_D01628\|UniProtKB=A0A059CGG0	Eucalyptus grandis	LDO
BRANA\|Gene_ORFName=DARMORV10_C05P29740.1\|UniProtKB=A0A078F557	Brassica napus	LDO
BRACM\|EnsemblGenome=Bra023117\|UniProtKB=M4E2W6	Brassica campestris	LDO
ARATH\|TAIR=locus=2204584\|UniProtKB=B5X582	Arabidopsis thaliana	LDO
GOSHI\|Gene=LOC107906337\|UniProtKB=A0A1U8JEX9	Gossypium hirsutum	O
GOSHI\|Gene=LOC107958509\|UniProtKB=A0A1U8PHX0	Gossypium hirsutum	LDO
THECC\|EnsemblGenome=TCM_027034\|UniProtKB=A0A061G759	Theobroma cacao	LDO
CITSI\|Gene_ORFName=CISIN_1g005204mg\|UniProtKB=A0A067GQJ2	Citrus sinensis	LDO
POPTR\|EnsemblGenome=POPTR_001G461300v3\|UniProtKB=A0A2K2CDZ9	Populus trichocarpa	LDO
MANES\|EnsemblGenome=MANES_14G125700\|UniProtKB=A0A2C9ULC1	Manihot esculenta	LDO
RICCO\|Gene_ORFName=RCOM_1334650\|UniProtKB=B9SAY6	Ricinus communis	LDO
SOYBN\|EnsemblGenome=GLYMA_09G028600\|UniProtKB=K7LBI0	Glycine max	O
SOYBN\|EnsemblGenome=GLYMA_15G134500\|UniProtKB=K7MB62	Glycine max	LDO
MEDTR\|EnsemblGenome=MTR_2g031620\|UniProtKB=A0A072VFY7	Medicago truncatula	LDO
JUGRE\|EnsemblGenome=Jr01_13300\|UniProtKB=A0A2I4F7U1	Juglans regia	O
JUGRE\|EnsemblGenome=Jr01_13290\|UniProtKB=A0A2I4F7T7	Juglans regia	LDO
CUCSA\|EnsemblGenome=Csa_1G541890\|UniProtKB=A0A0A0LYM8	Cucumis sativus	LDO
CUCSA\|EnsemblGenome=Csa_1G541910\|UniProtKB=A0A0A0LY49	Cucumis sativus	O
PRUPE\|EnsemblGenome=PRUPE_4G099700\|UniProtKB=A0A251PI91	Prunus persica	LDO
SELML\|EnsemblGenome=SELMODRAFT_171959\|UniProtKB=D8RJE0	Selaginella moellendorffii	LDO
SELML\|EnsemblGenome=SELMODRAFT_164801\|UniProtKB=D8QRG1	Selaginella moellendorffii	O
PHYPA\|EnsemblGenome=Pp3c12_26070\|UniProtKB=A0A2K1JS86	Physcomitrella patens	LDO
MARPO\|EnsemblGenome=MARPO_0003s0305\|UniProtKB=A0A2R6XTQ7	Marchantia polymorpha	LDO
KLENI\|Gene_ORFName=KFL_006140010\|UniProtKB=A0A1Y1IM31	Klebsormidium nitens	LDO