PANTHER Gene Information

Gene Symbol(s):

Usp5

Organism:

Drosophila melanogaster

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Gene Name:

Ubiquitin carboxyl-terminal hydrolase

Gene ID:

FBgn0035402

Protein ID:

Q9VZU7

Persistent Id:

PTN002364007

Alternate Ids:

1111668517(GI)	NP_001334708(refSeq)
FBgn0035402(Ensembl)	FBpp0401600(Ensembl_PRO)
38375(GeneID)	FBgn0035402(FlyBase)
Q9VZU7(Synonym)	FBtr0445725(Ensembl_TRS)
AAF47720(EMBL-CDS)	AY121697(EMBL)
Q9VZU7_DROME(UniProtKB-ID)
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PANTHER Classification

PANTHER Family:	UBIQUITIN CARBOXYL-TERMINAL HYDROLASE (PTHR24006)
PANTHER Subfamily:	UBIQUITIN CARBOXYL-TERMINAL HYDROLASE (PTHR24006:SF664)
PANTHER GO-slim Molecular Function:	cysteine-type deubiquitinase activity
PANTHER GO-slim Biological Process:	protein deubiquitination
PANTHER GO-slim Cellular Component:	nucleus cytosol
PANTHER protein class:	cysteine protease

Pathway Categories:

No pathway information available

GENE ONTOLOGY DATABASE ANNOTATIONS

Click to Expand...

GO MF Complete:	cysteine-type deubiquitinase activity, zinc ion binding, deubiquitinase activity, K48-linked deubiquitinase activity
GO BP Complete:	compound eye photoreceptor cell differentiation, protein deubiquitination, proteasome-mediated ubiquitin-dependent protein catabolic process, regulation of protein stability, negative regulation of apoptotic process, regulation of proteasome assembly, free ubiquitin chain depolymerization, ubiquitin recycling, positive regulation of proteasomal ubiquitin-dependent protein catabolic process, negative regulation of JNK cascade, positive regulation of double-strand break repair
GO CC Complete:	nucleus, cytoplasm, cytosol

REACTOME DATABASE ANNOTATIONS Click to Expand...

Reactome Pathways:

Protein ubiquitination, Regulation of PTEN stability and activity, Deubiquitination, Signal Transduction, Synthesis of active ubiquitin: roles of E1 and E2 enzymes, Metabolism of proteins, PTEN Regulation, Intracellular signaling by second messengers, PIP3 activates AKT signaling, Ub-specific processing proteases, Post-translational protein modification

Orthologs

ID	Organism	Type
HUMAN\|HGNC=12611\|UniProtKB=Q92995	Homo sapiens	O
PANTR\|Ensembl=ENSPTRG00000015650.2\|UniProtKB=A0A2I3TG67	Pan troglodytes	O
GORGO\|Ensembl=ENSGGOG00000034809.2\|UniProtKB=A0A2I2Y8U6	Gorilla gorilla gorilla	O
MACMU\|Ensembl=ENSMMUG00000003594.4\|UniProtKB=F7EMP5	Macaca mulatta	O
MOUSE\|MGI=MGI=1919857\|UniProtKB=Q5BKP2	Mus musculus	O
RAT\|RGD=1306044\|UniProtKB=D3ZDI9	Rattus norvegicus	O
BOVIN\|Ensembl=ENSBTAG00000005946\|UniProtKB=E1BMF7	Bos taurus	O
PIG\|Ensembl=ENSSSCG00000011765.5\|UniProtKB=F1SGC5	Sus scrofa	O
HORSE\|Ensembl=ENSECAG00000004152.4\|UniProtKB=F7AWD8	Equus caballus	O
FELCA\|Ensembl=ENSFCAG00000025086.4\|UniProtKB=M3XC12	Felis catus	O
CANLF\|Ensembl=ENSCAFG00845016860.1\|UniProtKB=A0A8I3NY77	Canis lupus familiaris	O
MONDO\|Ensembl=ENSMODG00000021299.4\|UniProtKB=F7G3T7	Monodelphis domestica	O
ORNAN\|Ensembl=ENSOANG00000050467.1\|UniProtKB=A0A6I8NWB7	Ornithorhynchus anatinus	O
CHICK\|Ensembl=ENSGALG00010018123\|UniProtKB=E1BY77	Gallus gallus	O
ANOCA\|Ensembl=ENSACAG00000004318.4\|UniProtKB=G1KCT7	Anolis carolinensis	O
ORYLA\|Ensembl=ENSORLG00000005687.2\|UniProtKB=A0A3B3I0J6	Oryzias latipes	O
DANRE\|ZFIN=ZDB-GENE-080724-7\|UniProtKB=F1QFS9	Danio rerio	O
LEPOC\|Ensembl=ENSLOCG00000001321.1\|UniProtKB=W5LZG4	lepisosteus oculatus	O
HUMAN\|HGNC=12628\|UniProtKB=P45974	Homo sapiens	LDO
PANTR\|Ensembl=ENSPTRG00000004594.6\|UniProtKB=K7B7B4	Pan troglodytes	LDO
GORGO\|Ensembl=ENSGGOG00000002615.3\|UniProtKB=G3QJI4	Gorilla gorilla gorilla	LDO
MACMU\|Ensembl=ENSMMUG00000005192.3\|UniProtKB=F7CT78	Macaca mulatta	LDO
MOUSE\|MGI=MGI=1347343\|UniProtKB=P56399	Mus musculus	LDO
RAT\|RGD=1308438\|UniProtKB=D3ZVQ0	Rattus norvegicus	LDO
BOVIN\|Ensembl=ENSBTAG00000019780.6\|UniProtKB=F1N3P2	Bos taurus	LDO
PIG\|Ensembl=ENSSSCG00000000684.5\|UniProtKB=A0A5G2QPU0	Sus scrofa	LDO
HORSE\|Ensembl=ENSECAG00000014532.4\|UniProtKB=A0A9L0TL35	Equus caballus	LDO
FELCA\|Ensembl=ENSFCAG00000004276.6\|UniProtKB=M3W1X0	Felis catus	LDO
CANLF\|Ensembl=ENSCAFG00845027217.1\|UniProtKB=A0A8I3PWW2	Canis lupus familiaris	LDO
MONDO\|Ensembl=ENSMODG00000018148.3\|UniProtKB=F7CWU5	Monodelphis domestica	LDO
ORNAN\|Ensembl=ENSOANG00000040189.1\|UniProtKB=A0A6I8PAZ6	Ornithorhynchus anatinus	LDO
CHICK\|Ensembl=ENSGALG00010023380.1\|UniProtKB=A0A8V0ZUX9	Gallus gallus	LDO
ANOCA\|Ensembl=ENSACAG00000005682.4\|UniProtKB=H9GAJ7	Anolis carolinensis	LDO
ORYLA\|Ensembl=ENSORLG00000012752.2\|UniProtKB=H2MBP9	Oryzias latipes	LDO
DANRE\|ZFIN=ZDB-GENE-040426-2584\|UniProtKB=Q1MT86	Danio rerio	LDO
LEPOC\|Ensembl=ENSLOCG00000007807.1\|UniProtKB=W5MM90	lepisosteus oculatus	LDO
CIOIN\|Ensembl=ENSCING00000006975.3\|UniProtKB=F6SBG8	Ciona intestinalis	LDO
CAEEL\|EnsemblGenome=WBGene00020839\|UniProtKB=A0A8D9I6U5	Caenorhabditis elegans	LDO
CAEBR\|Gene_ORFName=CBG20283\|UniProtKB=A8XXG5	Caenorhabditis briggsae	LDO
ANOGA\|EnsemblGenome=AGAP012248\|UniProtKB=Q7Q039	Anopheles gambiae	LDO
TRICA\|EnsemblGenome=TC003401\|UniProtKB=D6WG65	Tribolium castaneum	LDO
DAPPU\|EnsemblGenome=DAPPUDRAFT_215987\|UniProtKB=E9H6T7	Daphnia pulex	LDO
HELRO\|EnsemblGenome=HelroG105332\|UniProtKB=T1EDT8	helobdella robusta	LDO
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g78936\|UniProtKB=A7REZ3	Nematostella vectensis	LDO
TRIAD\|EnsemblGenome=TriadG50430\|UniProtKB=B3S034	Trichoplax adhaerens	LDO
MONBE\|EnsemblGenome=MONBRDRAFT_27958\|UniProtKB=A9V6I6	Monosiga brevicollis	LDO
YEAST\|SGD=S000000262\|UniProtKB=P38237	Saccharomyces cerevisiae	LDO
EREGS\|EnsemblGenome=AGOS_AGR023C\|UniProtKB=Q750D2	Eremothecium gossypii	LDO
YARLI\|EnsemblGenome=YALI0_B17072g\|UniProtKB=Q6CEB0	Yarrowia lipolytica	LDO
EMENI\|EnsemblGenome=ANIA_07422\|UniProtKB=Q5AWA8	Emericella nidulans	LDO
ASPFU\|EnsemblGenome=AFUA_2G06330\|UniProtKB=Q4WH81	Neosartorya fumigata	LDO
NEUCR\|EnsemblGenome=NCU05777\|UniProtKB=Q7S5R6	Neurospora crassa	LDO
SCLS1\|Gene_ORFName=SS1G_10528\|UniProtKB=A7EYW2	Sclerotinia sclerotiorum	LDO
PHANO\|EnsemblGenome=SNOG_02884\|UniProtKB=Q0UZD0	Phaeosphaeria nodorum	LDO
SCHPO\|PomBase=SPBC6B1.06c\|UniProtKB=Q11119	Schizosaccharomyces pombe	LDO
SCHJY\|EnsemblGenome=SJAG_00644\|UniProtKB=B6JW74	Schizosaccharomyces japonicus	LDO
CRYNJ\|EnsemblGenome=CNF02660\|UniProtKB=Q5KF83	Cryptococcus neoformans	LDO
USTMA\|EnsemblGenome=UMAG_00298\|UniProtKB=A0A0D1EBZ2	Ustilago maydis	LDO
PUCGT\|EnsemblGenome=PGTG_16962\|UniProtKB=E3L3H5	Puccinia graminis	LDO
BATDJ\|Gene_ORFName=BATDEDRAFT_16102\|UniProtKB=F4NXU7	Batrachochytrium dendrobatidis	LDO
DICDI\|dictyBase=DDB_G0291239\|UniProtKB=P54201	Dictyostelium discoideum	LDO
DICPU\|EnsemblGenome=DICPUDRAFT_57131\|UniProtKB=F0ZUI0	Dictyostelium purpureum	LDO
TRIV3\|Gene_ORFName=TVAG_204420\|UniProtKB=A2FJ36	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_219230\|UniProtKB=A2FKQ5	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_450920\|UniProtKB=A2EYP5	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_056730\|UniProtKB=A2ECN2	Trichomonas vaginalis	LDO
PHYRM\|Gene=H3GM71_PHYRM\|UniProtKB=H3GM71	Phytophthora ramorum	LDO
CHLRE\|EnsemblGenome=CHLRE_02g080350v5\|UniProtKB=A0A2K3E0J5	Chlamydomonas reinhardtii	LDO