PANTHER Gene Information

Gene Symbol(s):

Iml1

Organism:

Drosophila melanogaster

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Gene Name:

GATOR complex protein Iml1

Gene ID:

FBgn0035227

Protein ID:

Q9W0E3

Persistent Id:

PTN000323690

Alternate Ids:

AAN11485(EMBL-CDS)	23092784(GI)
AY075414(EMBL)	IML1_DROME(UniProtKB-ID)
DEPDC5{ECO:0000303\|PubMed:23723238}(Synonym)	E8NH72(AltAccession)
FBgn0035227(Ensembl)	Iml1{ECO:0000303\|PubMed:25512509,ECO:0000312\|FlyBase:FBgn0035227}(Symbol)
38176(GeneID)	FBgn0035227(FlyBase)
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PANTHER Classification

PANTHER Family:	DEP DOMAIN CONTAINING PROTEIN 5 (PTHR13179)
PANTHER Subfamily:	GATOR COMPLEX PROTEIN DEPDC5 (PTHR13179:SF8)
PANTHER GO-slim Molecular Function:	GTPase activator activity
PANTHER GO-slim Biological Process:	negative regulation of TORC1 signaling positive regulation of autophagy
PANTHER GO-slim Cellular Component:	Seh1-associated complex
PANTHER protein class:	GTPase-activating protein

Pathway Categories:

No pathway information available

GENE ONTOLOGY DATABASE ANNOTATIONS

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GO MF Complete:	GTPase activator activity
GO BP Complete:	positive regulation of autophagy, germarium-derived cystoblast division, negative regulation of TORC1 signaling, cellular response to amino acid starvation, germline cell cycle switching, mitotic to meiotic cell cycle, negative regulation of cell size, negative regulation of TOR signaling
GO CC Complete:	Seh1-associated complex, GATOR1 complex, lysosomal membrane, lysosome

REACTOME DATABASE ANNOTATIONS Click to Expand...

Reactome Pathways:

Orthologs

ID	Organism	Type
HUMAN\|HGNC=18423\|UniProtKB=O75140	Homo sapiens	LDO
PANTR\|Ensembl=ENSPTRG00000047761.1\|UniProtKB=A0A2I3RM83	Pan troglodytes	O
PANTR\|Ensembl=ENSPTRG00000014279.6\|UniProtKB=A0A2I3SXB8	Pan troglodytes	LDO
GORGO\|Ensembl=ENSGGOG00000039473.1\|UniProtKB=A0A2I2YUC1	Gorilla gorilla gorilla	LDO
MACMU\|Ensembl=ENSMMUG00000021727.4\|UniProtKB=A0A1D5QIJ7	Macaca mulatta	LDO
MOUSE\|MGI=MGI=2141101\|UniProtKB=P61460	Mus musculus	LDO
RAT\|RGD=1311535\|UniProtKB=A0A8I5YBC5	Rattus norvegicus	LDO
BOVIN\|Ensembl=ENSBTAG00000001295.6\|UniProtKB=F1MN63	Bos taurus	LDO
PIG\|Ensembl=ENSSSCG00005035059.1\|UniProtKB=A0A8D0ZFE4	Sus scrofa	LDO
HORSE\|Ensembl=ENSECAG00000014746.4\|UniProtKB=A0A9L0TN96	Equus caballus	LDO
FELCA\|Ensembl=ENSFCAG00000001328.6\|UniProtKB=A0A337RYK9	Felis catus	LDO
CANLF\|Ensembl=ENSCAFG00845025431.1\|UniProtKB=A0A8I3PSK5	Canis lupus familiaris	LDO
MONDO\|Ensembl=ENSMODG00000009845.4\|UniProtKB=F6WAK9	Monodelphis domestica	LDO
ORNAN\|Ensembl=ENSOANG00000011371.3\|UniProtKB=A0A6I8PB40	Ornithorhynchus anatinus	LDO
CHICK\|Ensembl=ENSGALG00010026673.1\|UniProtKB=A0A8V1A160	Gallus gallus	LDO
XENLA\|Gene=LOC108707109\|UniProtKB=A0A1L8HQ99	Xenopus laevis	O
XENLA\|Gene=LOC108716023\|UniProtKB=A0A1L8I0B3	Xenopus laevis	LDO
DANRE\|Gene=depdc5\|UniProtKB=A0A8M9QKY4	Danio rerio	LDO
BRAFL\|Gene=LOC118426624\|UniProtKB=A0A9J7M2P2	Branchiostoma floridae	LDO
STRPU\|EnsemblGenome=LOC115926467\|UniProtKB=A0A7M7P8N3	Strongylocentrotus purpuratus	O
STRPU\|EnsemblGenome=LOC594618\|UniProtKB=A0A7M7PB16	Strongylocentrotus purpuratus	O
STRPU\|EnsemblGenome=LOC589283\|UniProtKB=A0A7M7P768	Strongylocentrotus purpuratus	LDO
STRPU\|EnsemblGenome=LOC591890\|UniProtKB=A0A7M7P7B3	Strongylocentrotus purpuratus	O
CAEEL\|WormBase=WBGene00011604\|UniProtKB=G5EBK0	Caenorhabditis elegans	LDO
ANOGA\|EnsemblGenome=AGAP007010\|UniProtKB=A0A499FW22	Anopheles gambiae	LDO
TRICA\|EnsemblGenome=TC012042\|UniProtKB=D6X293	Tribolium castaneum	LDO
DAPPU\|EnsemblGenome=DAPPUDRAFT_327275\|UniProtKB=E9HA94	Daphnia pulex	LDO
TRIAD\|EnsemblGenome=TriadG58356\|UniProtKB=B3S1V9	Trichoplax adhaerens	LDO
MONBE\|EnsemblGenome=MONBRDRAFT_31201\|UniProtKB=A9USC5	Monosiga brevicollis	LDO
YEAST\|SGD=S000003899\|UniProtKB=P47170	Saccharomyces cerevisiae	LDO
EREGS\|EnsemblGenome=AGOS_ABL079C\|UniProtKB=Q75DV2	Eremothecium gossypii	LDO
CANAL\|Gene_OrderedLocusName=CAALFM_C102610WA\|UniProtKB=Q5AIA4	Candida albicans	LDO
YARLI\|EnsemblGenome=YALI0_D01067g\|UniProtKB=Q6CAP3	Yarrowia lipolytica	LDO
EMENI\|EnsemblGenome=ANIA_07506\|UniProtKB=Q5AW24	Emericella nidulans	LDO
ASPFU\|EnsemblGenome=AFUA_2G05390\|UniProtKB=Q4WHH4	Neosartorya fumigata	LDO
NEUCR\|EnsemblGenome=NCU07710\|UniProtKB=Q7S9J6	Neurospora crassa	LDO
SCLS1\|EnsemblGenome=SS1G_08244\|UniProtKB=A7ESD9	Sclerotinia sclerotiorum	LDO
PHANO\|EnsemblGenome=SNOG_08690\|UniProtKB=Q0UHS4	Phaeosphaeria nodorum	LDO
SCHPO\|PomBase=SPBC26H8.04c\|UniProtKB=O74788	Schizosaccharomyces pombe	LDO
SCHJY\|EnsemblGenome=SJAG_00824\|UniProtKB=B6JWP6	Schizosaccharomyces japonicus	LDO
CRYNJ\|EnsemblGenome=CNC00940\|UniProtKB=P0CO32	Cryptococcus neoformans	LDO
USTMA\|EnsemblGenome=UMAG_01612\|UniProtKB=Q4PE51	Ustilago maydis	LDO
PUCGT\|EnsemblGenome=PGTG_02216\|UniProtKB=E3JXI0	Puccinia graminis	LDO
BATDJ\|Gene_ORFName=BATDEDRAFT_26032\|UniProtKB=F4P6D1	Batrachochytrium dendrobatidis	LDO
DICDI\|dictyBase=DDB_G0279099\|UniProtKB=Q54XA2	Dictyostelium discoideum	LDO
DICPU\|EnsemblGenome=DICPUDRAFT_52722\|UniProtKB=F0Z9Q8	Dictyostelium purpureum	LDO
LEIMA\|EnsemblGenome=LMJF_07_0920\|UniProtKB=Q4QIJ5	Leishmania major	LDO
TRYB2\|Gene_ORFName=Tb927.8.830\|UniProtKB=Q57YE8	Trypanosoma brucei	LDO
PARTE\|EnsemblGenome=GSPATT00016100001\|UniProtKB=A0DDZ1	Paramecium tetraurelia	LDO
PHYRM\|Gene=H3GUZ7_PHYRM\|UniProtKB=H3GUZ7	Phytophthora ramorum	LDO
PHYRM\|Gene=H3GHT8_PHYRM\|UniProtKB=H3GHT8	Phytophthora ramorum	O