PANTHER Gene Information   
Gene Symbol(s): Traf6
Organism: Drosophila melanogaster
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Gene Name: GH01161p
Gene ID: FBgn0265464
Protein ID: Q9W3I9
Persistent Id: PTN000015137
Alternate Ids:
FBgn0265464(FlyBase) 7290897(GI)
Q9W3I9_DROME(UniProtKB-ID) 31746(GeneID)
FBgn0265464(Ensembl) NM_078525(refSeq)
AY047501(EMBL) AAK77233(EMBL-CDS)
FBtr0071188(Ensembl_TRS) Q9W3I9(Synonym)
FBpp0071136(Ensembl_PRO)
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PANTHER Classification
PANTHER Family: TNF RECEPTOR ASSOCIATED FACTOR (PTHR10131)
PANTHER Subfamily: TNF RECEPTOR-ASSOCIATED FACTOR 6 (PTHR10131:SF152)  
PANTHER GO-slim Molecular Function: ubiquitin protein ligase activity
PANTHER GO-slim Biological Process: positive regulation of NF-kappaB transcription factor activity
regulation of canonical NF-kappaB signal transduction
lipopolysaccharide-mediated signaling pathway
innate immune response
PANTHER GO-slim Cellular Component: plasma membrane signaling receptor complex
PANTHER protein class: scaffold/adaptor protein
Pathway Categories: p53 pathway
   TNF receptor-associated factor
Toll receptor signaling pathway
   tumor necrosis factor (TNF) receptor-associated factor 6
p38 MAPK pathway
   tumor necrosis factor receptor associated factor 6
Apoptosis signaling pathway
   TNF receptor-associated factor 2
GENE ONTOLOGY DATABASE ANNOTATIONS      Click to Expand...
GO MF Complete: ubiquitin-protein transferase activity, zinc ion binding, ubiquitin protein ligase activity, protein binding, tumor necrosis factor receptor superfamily binding, signaling adaptor activity, metal ion binding, tumor necrosis factor receptor binding
GO BP Complete: dorsal closure, positive regulation of peptidoglycan recognition protein signaling pathway, protein polyubiquitination, positive regulation of tumor necrosis factor-mediated signaling pathway, positive regulation of programmed cell death, positive regulation of canonical NF-kappaB signal transduction, regulation of canonical NF-kappaB signal transduction, positive regulation of Toll signaling pathway, negative regulation of Notch signaling pathway, positive regulation of autophagy, tumor necrosis factor-mediated signaling pathway, innate immune response, positive regulation of JNK cascade, lipopolysaccharide-mediated signaling pathway, protein K63-linked ubiquitination, protein ubiquitination, regulation of defense response to virus
GO CC Complete: cytoplasm, plasma membrane signaling receptor complex
REACTOME DATABASE ANNOTATIONS   Click to Expand...
Reactome Pathways: Toll Like Receptor TLR6:TLR2 Cascade, IRAK1 recruits IKK complex, Toll Like Receptor 10 (TLR10) Cascade, Toll Like Receptor 3 (TLR3) Cascade, Interleukin-1 family signaling, Deubiquitination, MyD88-independent TLR4 cascade , Toll Like Receptor 7/8 (TLR7/8) Cascade, Ovarian tumor domain proteases, Signaling by Interleukins, Interleukin-1 signaling, Post-translational protein modification, MAP kinase activation, IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation, IRAK2 mediated activation of TAK1 complex, Innate Immune System, TAK1-dependent IKK and NF-kappa-B activation , IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation, TRIF(TICAM1)-mediated TLR4 signaling , Toll Like Receptor 5 (TLR5) Cascade, Toll Like Receptor 9 (TLR9) Cascade, Interleukin-17 signaling, MyD88:MAL(TIRAP) cascade initiated on plasma membrane, Toll Like Receptor TLR1:TLR2 Cascade, Immune System, Metabolism of proteins, activated TAK1 mediates p38 MAPK activation, Ub-specific processing proteases, Cytokine Signaling in Immune system, TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation, JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1, MyD88 cascade initiated on plasma membrane, MyD88 dependent cascade initiated on endosome, Toll Like Receptor 4 (TLR4) Cascade, Toll-like Receptor Cascades, TRAF6-mediated induction of TAK1 complex within TLR4 complex, Toll Like Receptor 2 (TLR2) Cascade

Orthologs