PANTHER Gene Information

Gene Symbol(s):

Nep3

Organism:

Drosophila melanogaster

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Gene Name:

Neprilysin-3

Gene ID:

FBgn0031081

Protein ID:

Q9W5Y0

Persistent Id:

PTN000199909

Alternate Ids:

386764786(GI)	FBtr0070000(Ensembl_TRS)
NM_001258846(refSeq)	3.4.24.11 {ECO:0000250\|UniProtKB:Q8T062}(EC)
FBgn0031081(FlyBase)	33005(GeneID)
Nep3{ECO:0000303\|PubMed:24395329,ECO:0000312\|FlyBase:FBgn0031081}(Symbol)	FBpp0300207(Ensembl_PRO)
AE014298(EMBL)	NEP3(Synonym)
Q8SWS1(AltAccession)	NEP3_DROME(UniProtKB-ID)
FBgn0031081(Ensembl)	AAM12295(EMBL-CDS)
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PANTHER Classification

PANTHER Family:	ZINC METALLOPROTEASE FAMILY M13 NEPRILYSIN-RELATED (PTHR11733)
PANTHER Subfamily:	FI17812P1-RELATED (PTHR11733:SF167)
PANTHER GO-slim Molecular Function:	metalloendopeptidase activity
PANTHER GO-slim Biological Process:	protein processing
PANTHER GO-slim Cellular Component:	plasma membrane
PANTHER protein class:	metalloprotease

Pathway Categories:

Endothelin signaling pathway

Endothelin-coverting enzyme 1, 2, and 3

GENE ONTOLOGY DATABASE ANNOTATIONS

Click to Expand...

GO MF Complete:	metalloendopeptidase activity, metallopeptidase activity
GO BP Complete:	proteolysis, protein processing, peptide hormone processing
GO CC Complete:	membrane, plasma membrane

REACTOME DATABASE ANNOTATIONS Click to Expand...

Reactome Pathways:

Muscle contraction, Physiological factors, Immune System, Peptide hormone metabolism, Metabolism of proteins, Innate Immune System, Neutrophil degranulation, Metabolism of Angiotensinogen to Angiotensins, Cardiac conduction

Orthologs

ID	Organism	Type
HUMAN\|HGNC=3147\|UniProtKB=O95672	Homo sapiens	O
PANTR\|Ensembl=ENSPTRG00000013037.4\|UniProtKB=A0A2I3RJ55	Pan troglodytes	O
GORGO\|Ensembl=ENSGGOG00000005626.3\|UniProtKB=G3QYP2	Gorilla gorilla gorilla	O
MACMU\|Ensembl=ENSMMUG00000016873.4\|UniProtKB=H9H3W2	Macaca mulatta	O
MOUSE\|MGI=MGI=1343461\|UniProtKB=Q9JMI0	Mus musculus	O
RAT\|RGD=61806\|UniProtKB=Q9JHL3	Rattus norvegicus	O
BOVIN\|Ensembl=ENSBTAG00000021050.6\|UniProtKB=E1BJE2	Bos taurus	O
PIG\|Ensembl=ENSSSCG00000016285.4\|UniProtKB=F1SMT6	Sus scrofa	O
HORSE\|Ensembl=ENSECAG00000013336.3\|UniProtKB=F6ZP22	Equus caballus	O
FELCA\|Ensembl=ENSFCAG00000005677.6\|UniProtKB=M3W4H8	Felis catus	O
CANLF\|Ensembl=ENSCAFG00845025379.1\|UniProtKB=A0A8I3PQ33	Canis lupus familiaris	O
MONDO\|Ensembl=ENSMODG00000002624.4\|UniProtKB=F7FUF8	Monodelphis domestica	O
ORNAN\|Ensembl=ENSOANG00000001689.2\|UniProtKB=F7F7T8	Ornithorhynchus anatinus	O
CHICK\|Ensembl=ENSGALG00010017702.1\|UniProtKB=A0A8V0Z458	Gallus gallus	O
ANOCA\|Ensembl=ENSACAG00000011262.4\|UniProtKB=L7MTM2	Anolis carolinensis	O
XENLA\|Gene=ecel1.S\|UniProtKB=A0A1L8G3T7	Xenopus laevis	O
XENLA\|Gene=ecel1.L\|UniProtKB=A0A8J0TXF4	Xenopus laevis	O
XENTR\|Xenbase=XB-GENE-989944\|UniProtKB=A0A6I8RZA9	Xenopus tropicalis	O
ORYLA\|Ensembl=ENSORLG00000009595.2\|UniProtKB=H2M0U9	Oryzias latipes	O
DANRE\|Gene=LOC100332538\|UniProtKB=A0A8M9P7I8	Danio rerio	O
LEPOC\|Ensembl=ENSLOCG00000008900.1\|UniProtKB=W5MR37	lepisosteus oculatus	O
BRAFL\|Gene=LOC118403895\|UniProtKB=A0A9J7KG83	Branchiostoma floridae	O
BRAFL\|Gene=LOC118426696\|UniProtKB=A0A9J7M0I2	Branchiostoma floridae	O
BRAFL\|Gene=LOC118431155\|UniProtKB=A0A9J7NCJ3	Branchiostoma floridae	O
HUMAN\|HGNC=7154\|UniProtKB=P08473	Homo sapiens	O
PANTR\|Ensembl=ENSPTRG00000015550.6\|UniProtKB=K7CJF2	Pan troglodytes	O
GORGO\|Ensembl=ENSGGOG00000013260.3\|UniProtKB=G3SA97	Gorilla gorilla gorilla	O
MACMU\|Ensembl=ENSMMUG00000006662.4\|UniProtKB=F7H3Y6	Macaca mulatta	O
MOUSE\|MGI=MGI=97004\|UniProtKB=Q61391	Mus musculus	O
RAT\|RGD=3098\|UniProtKB=P07861	Rattus norvegicus	O
BOVIN\|Ensembl=ENSBTAG00000002075.5\|UniProtKB=E1BPL8	Bos taurus	O
PIG\|Ensembl=ENSSSCG00000011723.6\|UniProtKB=A0A8W4FP09	Sus scrofa	O
HORSE\|Ensembl=ENSECAG00000009138.4\|UniProtKB=F7B8E7	Equus caballus	O
FELCA\|Ensembl=ENSFCAG00000004615.6\|UniProtKB=A0A337SXF4	Felis catus	O
CANLF\|Ensembl=ENSCAFG00845020957.1\|UniProtKB=F5C3N2	Canis lupus familiaris	O
MONDO\|Ensembl=ENSMODG00000015805.4\|UniProtKB=F7FEB8	Monodelphis domestica	O
ORNAN\|Ensembl=ENSOANG00000009510.3\|UniProtKB=F6UPD1	Ornithorhynchus anatinus	O
CHICK\|Ensembl=ENSGALG00010001385.1\|UniProtKB=A0A8V0XAX6	Gallus gallus	O
ANOCA\|Ensembl=ENSACAG00000003903.4\|UniProtKB=A0A803U1T5	Anolis carolinensis	O
XENLA\|Gene=mme.L\|UniProtKB=A0A8J1KSV4	Xenopus laevis	O
XENTR\|Xenbase=XB-GENE-1011098\|UniProtKB=A0A6I8PTH1	Xenopus tropicalis	O
ORYLA\|Ensembl=ENSORLG00000005790.2\|UniProtKB=A0A3B3HI63	Oryzias latipes	O
LEPOC\|Ensembl=ENSLOCG00000002202.1\|UniProtKB=W5M2J5	lepisosteus oculatus	O
CIOIN\|Ensembl=ENSCING00000017942.1\|UniProtKB=H2XQ28	Ciona intestinalis	O
HUMAN\|HGNC=6308\|UniProtKB=P23276	Homo sapiens	O
PANTR\|Ensembl=ENSPTRG00000048557.1\|UniProtKB=H2R252	Pan troglodytes	O
GORGO\|Ensembl=ENSGGOG00000007998.3\|UniProtKB=G3QY99	Gorilla gorilla gorilla	O
MACMU\|Ensembl=ENSMMUG00000006571.4\|UniProtKB=F7HPX7	Macaca mulatta	O
MOUSE\|MGI=MGI=1346053\|UniProtKB=Q9EQF2	Mus musculus	O
RAT\|RGD=1565470\|UniProtKB=F1M761	Rattus norvegicus	O
BOVIN\|Ensembl=ENSBTAG00000014533.5\|UniProtKB=F1N2Q4	Bos taurus	O
PIG\|Ensembl=ENSSSCG00000016472.6\|UniProtKB=F1SRT7	Sus scrofa	O
HORSE\|Ensembl=ENSECAG00000010525.4\|UniProtKB=F7DG04	Equus caballus	O
FELCA\|Ensembl=ENSFCAG00000014937.5\|UniProtKB=M3WLM7	Felis catus	O
CANLF\|Ensembl=ENSCAFG00845018021.1\|UniProtKB=A0A8I3NZA2	Canis lupus familiaris	O
MONDO\|Ensembl=ENSMODG00000001067.4\|UniProtKB=F6YQX4	Monodelphis domestica	O
ORNAN\|Ensembl=ENSOANG00000040328.1\|UniProtKB=A0A6I8P7G0	Ornithorhynchus anatinus	O
CHICK\|Ensembl=ENSGALG00010021710.1\|UniProtKB=A0A8V0ZJU5	Gallus gallus	O
ANOCA\|Ensembl=ENSACAG00000000613.4\|UniProtKB=H9G401	Anolis carolinensis	O
ORYLA\|Ensembl=ENSORLG00000012141.2\|UniProtKB=H2M9K2	Oryzias latipes	O
DANRE\|ZFIN=ZDB-GENE-110411-118\|UniProtKB=F8W3A9	Danio rerio	O
LEPOC\|Ensembl=ENSLOCG00000008440.1\|UniProtKB=W5MPF6	lepisosteus oculatus	O
HUMAN\|HGNC=3146\|UniProtKB=P42892	Homo sapiens	LDO
PANTR\|Ensembl=ENSPTRG00000000298.7\|UniProtKB=K7BJM3	Pan troglodytes	LDO
GORGO\|Ensembl=ENSGGOG00000012085.3\|UniProtKB=G3R8T0	Gorilla gorilla gorilla	LDO
MACMU\|Ensembl=ENSMMUG00000010942.4\|UniProtKB=H9FQW5	Macaca mulatta	LDO
MOUSE\|MGI=MGI=1101357\|UniProtKB=Q4PZA2	Mus musculus	LDO
RAT\|RGD=620293\|UniProtKB=P42893	Rattus norvegicus	LDO
BOVIN\|Ensembl=ENSBTAG00000002977\|UniProtKB=P42891	Bos taurus	LDO
PIG\|Ensembl=ENSSSCG00000003513.5\|UniProtKB=A0A5G2RMY7	Sus scrofa	LDO
HORSE\|Ensembl=ENSECAG00000015812.4\|UniProtKB=A0A9L0TPB8	Equus caballus	LDO
FELCA\|Ensembl=ENSFCAG00000014530.6\|UniProtKB=M3WKV5	Felis catus	LDO
CANLF\|Ensembl=ENSCAFG00845001686.1\|UniProtKB=A0A8I3MHF9	Canis lupus familiaris	LDO
MONDO\|Ensembl=ENSMODG00000016000.4\|UniProtKB=F7EYY6	Monodelphis domestica	LDO
ORNAN\|Ensembl=ENSOANG00000014757.3\|UniProtKB=F7EHA3	Ornithorhynchus anatinus	LDO
CHICK\|Ensembl=ENSGALG00010021126.1\|UniProtKB=A0A8V0ZHS1	Gallus gallus	LDO
ANOCA\|Ensembl=ENSACAG00000005393.4\|UniProtKB=H9GA87	Anolis carolinensis	LDO
XENLA\|Gene=ece1.S\|UniProtKB=A0A8J1LAP2	Xenopus laevis	LDO
XENLA\|Gene=ece1.L\|UniProtKB=A0A8J1L456	Xenopus laevis	LDO
XENTR\|Ensembl=ENSXETG00000044790\|UniProtKB=A0A803JU36	Xenopus tropicalis	LDO
ORYLA\|Ensembl=ENSORLG00000017044.2\|UniProtKB=H2MRF3	Oryzias latipes	LDO
DANRE\|ZFIN=ZDB-GENE-061110-100\|UniProtKB=A0JMP1	Danio rerio	LDO
LEPOC\|Ensembl=ENSLOCG00000003479.1\|UniProtKB=W5M719	lepisosteus oculatus	LDO
CIOIN\|Ensembl=ENSCING00000007886.3\|UniProtKB=F6TGF6	Ciona intestinalis	O
CIOIN\|Ensembl=ENSCING00000005710.3\|UniProtKB=F6U2S1	Ciona intestinalis	LDO
BRAFL\|Gene=LOC118405049\|UniProtKB=A0A9J7HLG4	Branchiostoma floridae	O
BRAFL\|Gene=LOC118405047\|UniProtKB=A0A9J7HIW7	Branchiostoma floridae	O
BRAFL\|Gene=LOC118430801\|UniProtKB=A0A9J7MAC0	Branchiostoma floridae	LDO
STRPU\|EnsemblGenome=LOC580325\|UniProtKB=A0A7M7NXK5	Strongylocentrotus purpuratus	O
STRPU\|EnsemblGenome=LOC755783\|UniProtKB=A0A7M7NY20	Strongylocentrotus purpuratus	O
STRPU\|EnsemblGenome=LOC578052\|UniProtKB=A0A7M7MXI0	Strongylocentrotus purpuratus	O
STRPU\|EnsemblGenome=LOC580975\|UniProtKB=A0A7M7SZB7	Strongylocentrotus purpuratus	O
STRPU\|EnsemblGenome=LOC583486\|UniProtKB=A0A7M7N0E0	Strongylocentrotus purpuratus	O
STRPU\|EnsemblGenome=LOC594281\|UniProtKB=A0A7M7HMZ7	Strongylocentrotus purpuratus	LDO
CAEEL\|WormBase=WBGene00017393\|UniProtKB=Q09946	Caenorhabditis elegans	O
CAEBR\|Gene_ORFName=CBG02411\|UniProtKB=A8WUD7	Caenorhabditis briggsae	O
CAEEL\|WormBase=WBGene00017842\|UniProtKB=A0A5S9MNU9	Caenorhabditis elegans	LDO
CAEBR\|WormBase=WBGene00039561\|UniProtKB=A8XY73	Caenorhabditis briggsae	LDO
PRIPA\|EnsemblGenome=WBGene00279259\|UniProtKB=A0A2A6CM30	Pristionchus pacificus	O
PRIPA\|EnsemblGenome=WBGene00104229\|UniProtKB=A0A2A6CVL4	Pristionchus pacificus	LDO
ANOGA\|EnsemblGenome=AGAP007796\|UniProtKB=A0A1S4GX10	Anopheles gambiae	LDO
TRICA\|EnsemblGenome=TC015284\|UniProtKB=D2A4X8	Tribolium castaneum	O
TRICA\|EnsemblGenome=TC015285\|UniProtKB=D2A4X7	Tribolium castaneum	O
TRICA\|EnsemblGenome=TC015207\|UniProtKB=D2A597	Tribolium castaneum	LDO
DAPPU\|EnsemblGenome=DAPPUDRAFT_300917\|UniProtKB=E9HFF5	Daphnia pulex	LDO
IXOSC\|EnsemblGenome=ISCW014756\|UniProtKB=B7QM96	Ixodes scapularis	LDO
HELRO\|EnsemblGenome=HelroG110566\|UniProtKB=T1EF32	helobdella robusta	LDO
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g229362\|UniProtKB=A7S4D9	Nematostella vectensis	LDO
TRIAD\|EnsemblGenome=TriadG37639\|UniProtKB=B3RTH7	Trichoplax adhaerens	O
TRIAD\|EnsemblGenome=TriadG63323\|UniProtKB=B3RZU7	Trichoplax adhaerens	LDO
EMENI\|EnsemblGenome=ANIA_03091\|UniProtKB=C8VIN1	Emericella nidulans	LDO
ASPFU\|EnsemblGenome=AFUA_3G12420\|UniProtKB=Q4WYB2	Neosartorya fumigata	LDO
SCLS1\|EnsemblGenome=SS1G_05697\|UniProtKB=A7EK51	Sclerotinia sclerotiorum	LDO
PHANO\|EnsemblGenome=SNOG_15353\|UniProtKB=Q0TYS9	Phaeosphaeria nodorum	LDO
CRYNJ\|EnsemblGenome=CNB04230\|UniProtKB=Q5KLS5	Cryptococcus neoformans	LDO
USTMA\|EnsemblGenome=UMAG_02693\|UniProtKB=A0A0D1C704	Ustilago maydis	LDO
THAPS\|EnsemblGenome=THAPSDRAFT_269863\|UniProtKB=B8LCF9	Thalassiosira pseudonana	LDO
PHYRM\|Gene=H3GEF2_PHYRM\|UniProtKB=H3GEF2	Phytophthora ramorum	O
PHYRM\|Gene=H3HBZ9_PHYRM\|UniProtKB=H3HBZ9	Phytophthora ramorum	O
PHYRM\|Gene=H3H7F1_PHYRM\|UniProtKB=H3H7F1	Phytophthora ramorum	LDO
KLENI\|Gene_ORFName=KFL_000670270\|UniProtKB=A0A1Y1HUV6	Klebsormidium nitens	LDO
METAC\|EnsemblGenome=MA_2001\|UniProtKB=Q8TPB2	Methanosarcina acetivorans	LDO
MYCTU\|Gene_OrderedLocusName=Rv0198c\|UniProtKB=I6X8R2	Mycobacterium tuberculosis	LDO
STRR6\|EnsemblGenome=spr1491\|UniProtKB=Q8DNW9	Streptococcus pneumoniae	LDO
BACTN\|EnsemblGenome=BT_3811\|UniProtKB=Q8A156	Bacteroides thetaiotaomicron	LDO
SHEON\|Gene_OrderedLocusName=SO_0429\|UniProtKB=Q8EJN4	Shewanella oneidensis	LDO
SHEON\|Gene_OrderedLocusName=SO_3844\|UniProtKB=Q8EAQ3	Shewanella oneidensis	LDO
RHOBA\|EnsemblGenome=RB9029\|UniProtKB=Q7UM68	Rhodopirellula baltica	LDO
SHEON\|Gene_OrderedLocusName=SO_0491\|UniProtKB=Q8EJH4	Shewanella oneidensis	O
XANCP\|EnsemblGenome=XCC3671\|UniProtKB=Q8P4N6	Xanthomonas campestris	O
XANCP\|EnsemblGenome=XCC2710\|UniProtKB=Q8P7A3	Xanthomonas campestris	LDO
XANCP\|EnsemblGenome=XCC2035\|UniProtKB=Q8P931	Xanthomonas campestris	O
XANCP\|EnsemblGenome=XCC2575\|UniProtKB=Q8P7N6	Xanthomonas campestris	O
XANCP\|EnsemblGenome=XCC2574\|UniProtKB=Q8P7N7	Xanthomonas campestris	O