PANTHER Gene Information

Gene Symbol(s):

Mbtps1

Organism:

Rattus norvegicus

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Gene Name:

Membrane-bound transcription factor site-1 protease

Gene ID:

70935

Protein ID:

Q9WTZ3

Persistent Id:

PTN000083297

Alternate Ids:

G3V7Z2(AltAccession)	MBTP1_RAT(UniProtKB-ID)
Ski1{ECO:0000303\|PubMed:9990022}(Synonym)	XP_006255785(refSeq)
ENSRNOP00000020838(Ensembl_PRO)	89842(GeneID)
3.4.21.112 {ECO:0000269\|PubMed:9990022}(EC)	70935(RGD)
EDL92670(EMBL-CDS)	564396081(GI)
ENSRNOT00000020838(Ensembl_TRS)	CH473972(EMBL)
ENSRNOG00000015173(Ensembl)	Mbtps1(Symbol)
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PANTHER Classification

PANTHER Family:	PEPTIDASE S8 (PTHR43806)
PANTHER Subfamily:	MEMBRANE-BOUND TRANSCRIPTION FACTOR SITE-1 PROTEASE (PTHR43806:SF7)
PANTHER GO-slim Molecular Function:	serine-type endopeptidase activity
PANTHER GO-slim Biological Process:
PANTHER GO-slim Cellular Component:	Golgi apparatus
PANTHER protein class:	serine protease

Pathway Categories:

No pathway information available

GENE ONTOLOGY DATABASE ANNOTATIONS

Click to Expand...

GO MF Complete:	serine-type endopeptidase activity
GO BP Complete:	lysosome organization, mitotic G2 DNA damage checkpoint signaling, membrane protein intracellular domain proteolysis, proteolysis, lipid metabolic process, cholesterol metabolic process, protein processing, protein maturation, regulation of vesicle-mediated transport
GO CC Complete:	endoplasmic reticulum membrane, membrane, Golgi membrane, Golgi apparatus, Golgi stack

REACTOME DATABASE ANNOTATIONS Click to Expand...

Reactome Pathways:

Unfolded Protein Response (UPR), Cellular responses to stress, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs), Regulation of cholesterol biosynthesis by SREBP (SREBF), Cellular responses to stimuli, Metabolism of proteins, ATF6B (ATF6-beta) activates chaperones, Post-translational protein modification, Metabolism, CREB3 factors activate genes, Metabolism of lipids, Post-translational protein phosphorylation, Metabolism of steroids, ATF6 (ATF6-alpha) activates chaperones

Orthologs

ID	Organism	Type
HUMAN\|HGNC=15456\|UniProtKB=Q14703	Homo sapiens	LDO
PANTR\|Ensembl=ENSPTRG00000008408.6\|UniProtKB=H2QBL9	Pan troglodytes	LDO
GORGO\|Ensembl=ENSGGOG00000010784.3\|UniProtKB=G3R5F2	Gorilla gorilla gorilla	LDO
MACMU\|Ensembl=ENSMMUG00000020053.4\|UniProtKB=F7G9K2	Macaca mulatta	LDO
MOUSE\|MGI=MGI=1927235\|UniProtKB=Q9WTZ2	Mus musculus	LDO
BOVIN\|Ensembl=ENSBTAG00000010170.6\|UniProtKB=Q08E55	Bos taurus	LDO
PIG\|Ensembl=ENSSSCG00000002682.5\|UniProtKB=A0A286ZZH4	Sus scrofa	LDO
HORSE\|Ensembl=ENSECAG00000010283.3\|UniProtKB=F7DG36	Equus caballus	LDO
FELCA\|Ensembl=ENSFCAG00000011554.6\|UniProtKB=M3WFB1	Felis catus	LDO
CANLF\|Ensembl=ENSCAFG00845016031.1\|UniProtKB=A0A8I3P735	Canis lupus familiaris	LDO
MONDO\|Ensembl=ENSMODG00000004990.3\|UniProtKB=A0A5F8H5T2	Monodelphis domestica	LDO
ORNAN\|Ensembl=ENSOANG00000005148.4\|UniProtKB=F6VKY7	Ornithorhynchus anatinus	LDO
CHICK\|Ensembl=ENSGALG00010024733.1\|UniProtKB=A0A8V1A1S2	Gallus gallus	LDO
ANOCA\|Ensembl=ENSACAG00000012864.4\|UniProtKB=G1KN46	Anolis carolinensis	LDO
XENLA\|Gene=mbtps1.L\|UniProtKB=A0A1L8GKG1	Xenopus laevis	LDO
XENTR\|Xenbase=XB-GENE-1016860\|UniProtKB=A0A6I8QWB9	Xenopus tropicalis	LDO
ORYLA\|Ensembl=ENSORLG00000012869.2\|UniProtKB=H2MC43	Oryzias latipes	LDO
DANRE\|ZFIN=ZDB-GENE-030131-4909\|UniProtKB=Q1LWH3	Danio rerio	LDO
LEPOC\|Ensembl=ENSLOCG00000006637.1\|UniProtKB=W5MI11	lepisosteus oculatus	LDO
CIOIN\|Ensembl=ENSCING00000017937.1\|UniProtKB=H2XTU1	Ciona intestinalis	LDO
BRAFL\|Gene=LOC118417031\|UniProtKB=A0A9J7MTF1	Branchiostoma floridae	LDO
STRPU\|EnsemblGenome=LOC100890867\|UniProtKB=A0A7M7N5Y5	Strongylocentrotus purpuratus	LDO
PRIPA\|EnsemblGenome=WBGene00304990\|UniProtKB=A0A8R1Z651	Pristionchus pacificus	LDO
DROME\|FlyBase=FBgn0037105\|UniProtKB=Q9VP10	Drosophila melanogaster	LDO
ANOGA\|EnsemblGenome=AGAP012203\|UniProtKB=A0A1S4H8N6	Anopheles gambiae	LDO
TRICA\|EnsemblGenome=TC002816\|UniProtKB=A0A139WLB7	Tribolium castaneum	LDO
DAPPU\|EnsemblGenome=DAPPUDRAFT_310948\|UniProtKB=E9FW48	Daphnia pulex	LDO
HELRO\|EnsemblGenome=HelroG194246\|UniProtKB=T1FVU8	helobdella robusta	LDO
TRIAD\|EnsemblGenome=TriadG19704\|UniProtKB=B3RJ26	Trichoplax adhaerens	LDO
MONBE\|EnsemblGenome=MONBRDRAFT_27758\|UniProtKB=A9V683	Monosiga brevicollis	LDO
DICDI\|dictyBase=DDB_G0282397\|UniProtKB=Q54SL5	Dictyostelium discoideum	LDO
DICPU\|EnsemblGenome=DICPUDRAFT_42435\|UniProtKB=F1A214	Dictyostelium purpureum	LDO
PHYRM\|Gene=H3HCV8_PHYRM\|UniProtKB=H3HCV8	Phytophthora ramorum	LDO
CHLRE\|EnsemblGenome=CHLRE_14g628800v5\|UniProtKB=A0A2K3CYH5	Chlamydomonas reinhardtii	LDO
AMBTC\|EnsemblGenome=AMTR_s00109p00040520\|UniProtKB=W1NV76	Amborella trichopoda	LDO
ZOSMR\|Gene_ORFName=ZOSMA_11G00780\|UniProtKB=A0A0K9Q3L7	Zostera marina	LDO
MUSAM\|EnsemblGenome=Ma06_g07410\|UniProtKB=A0A804JDN2	Musa acuminata subsp. malaccensis	LDO
SETIT\|EnsemblGenome=SETIT_005756mg\|UniProtKB=K3XUZ9	Setaria italica	LDO
SORBI\|EnsemblGenome=SORBI_3010G051200\|UniProtKB=C5Z4U7	Sorghum bicolor	LDO
MAIZE\|EnsemblGenome=Zm00001eb375700\|UniProtKB=A0A804QZX5	Zea mays	LDO
BRADI\|EnsemblGenome=BRADI_1g48447v3\|UniProtKB=I1H0R2	Brachypodium distachyon	LDO
HORVV\|EnsemblGenome=HORVU.MOREX.r3.7HG0655200\|UniProtKB=A0A8I6Z7D2	Hordeum vulgare subsp. vulgare	LDO
WHEAT\|EnsemblGenome=TraesCS7B02G022900\|UniProtKB=A0A3B6S9A8	Triticum aestivum	O
WHEAT\|EnsemblGenome=TraesCS7A02G124000\|UniProtKB=A0A3B6RDQ8	Triticum aestivum	O
WHEAT\|EnsemblGenome=TraesCS7D02G121900\|UniProtKB=A0A3B6TA38	Triticum aestivum	LDO
NELNU\|Gene=LOC104592191\|UniProtKB=A0A1U7ZMG0	Nelumbo nucifera	O
NELNU\|Gene=LOC104595191\|UniProtKB=A0A1U7ZQC8	Nelumbo nucifera	LDO
SPIOL\|Gene=LOC110775696\|UniProtKB=A0A9R0HUB4	Spinacia oleracea	LDO
HELAN\|EnsemblGenome=HanXRQr2_Chr10g0464521\|UniProtKB=A0A251TQ57	Helianthus annuus	LDO
LACSA\|Gene_ORFName=LSAT_V11C800426870\|UniProtKB=A0A9R1UQX7	Lactuca sativa	O
LACSA\|Gene_ORFName=LSAT_V11C500265470\|UniProtKB=A0A9R1XFB1	Lactuca sativa	LDO
ERYGU\|Gene_ORFName=MIMGU_mgv1a000706mg\|UniProtKB=A0A022QM66	Erythranthe guttata	LDO
CAPAN\|EnsemblGenome=T459_25714\|UniProtKB=A0A2G2YLJ9	Capsicum annuum	LDO
SOLTU\|EnsemblGenome=PGSC0003DMG400017594\|UniProtKB=M1BHI1	Solanum tuberosum	LDO
TOBAC\|Gene=LOC107799117\|UniProtKB=A0A1S4AM39	Nicotiana tabacum	LDO
CAPAN\|EnsemblGenome=T459_22754\|UniProtKB=A0A1U8E5Z1	Capsicum annuum	O
SOLLC\|EnsemblGenome=Solyc09g007300.2\|UniProtKB=A0A3Q7HW94	Solanum lycopersicum	O
TOBAC\|Gene=LOC107828026\|UniProtKB=A0A1S4DC21	Nicotiana tabacum	O
VITVI\|EnsemblGenome=Vitvi11g00331\|UniProtKB=F6HH18	Vitis vinifera	LDO
EUCGR\|EnsemblGenome=EUGRSUZ_C03820\|UniProtKB=A0A059CW93	Eucalyptus grandis	LDO
BRACM\|EnsemblGenome=Bra006513\|UniProtKB=M4CQM4	Brassica campestris	LDO
ARATH\|TAIR=locus=2183224\|UniProtKB=Q0WUG6	Arabidopsis thaliana	LDO
GOSHI\|Gene=LOC107958761\|UniProtKB=A0A1U8PG25	Gossypium hirsutum	O
GOSHI\|Gene=LOC107907212\|UniProtKB=A0A1U8JI69	Gossypium hirsutum	O
GOSHI\|Gene=LOC107939494\|UniProtKB=A0A1U8MNB2	Gossypium hirsutum	O
GOSHI\|Gene=LOC107932897\|UniProtKB=A0A1U8M134	Gossypium hirsutum	LDO
THECC\|EnsemblGenome=TCM_037871\|UniProtKB=A0A061GMN3	Theobroma cacao	LDO
CITSI\|Gene_ORFName=CISIN_1g0401331mg\|UniProtKB=A0A067EDA1	Citrus sinensis	LDO
POPTR\|EnsemblGenome=POPTR_018G081400v3\|UniProtKB=B9ILM9	Populus trichocarpa	LDO
MANES\|EnsemblGenome=MANES_16G115100\|UniProtKB=A0A2C9UB11	Manihot esculenta	LDO
RICCO\|Gene_ORFName=RCOM_1052690\|UniProtKB=B9RKQ2	Ricinus communis	LDO
SOYBN\|EnsemblGenome=GLYMA_07G085500\|UniProtKB=I1KIQ2	Glycine max	LDO
SOYBN\|EnsemblGenome=GLYMA_09G191400\|UniProtKB=I1L4I9	Glycine max	O
MEDTR\|EnsemblGenome=MTR_6g087520\|UniProtKB=G7KP16	Medicago truncatula	LDO
JUGRE\|EnsemblGenome=Jr01_28430\|UniProtKB=A0A2I4DEK8	Juglans regia	LDO
JUGRE\|EnsemblGenome=Jr01_28410\|UniProtKB=A0A2I4DEK9	Juglans regia	LDO
JUGRE\|EnsemblGenome=Jr01_28420\|UniProtKB=A0A2I4DEL6	Juglans regia	LDO
CUCSA\|EnsemblGenome=Csa_1G250160\|UniProtKB=A0A0A0LTP5	Cucumis sativus	LDO
PRUPE\|EnsemblGenome=PRUPE_7G232300\|UniProtKB=M5W7F1	Prunus persica	LDO
SELML\|EnsemblGenome=SELMODRAFT_85837\|UniProtKB=D8R6D7	Selaginella moellendorffii	O
SELML\|EnsemblGenome=SELMODRAFT_50575\|UniProtKB=D8S4L7	Selaginella moellendorffii	LDO
PHYPA\|EnsemblGenome=Pp3c3_30280\|UniProtKB=A0A2K1KWL4	Physcomitrella patens	LDO
MARPO\|EnsemblGenome=MARPO_0155s0018\|UniProtKB=A0A2R6W4H1	Marchantia polymorpha	LDO
KLENI\|Gene_ORFName=KFL_002850060\|UniProtKB=A0A1Y1I8T3	Klebsormidium nitens	LDO
NITMS\|EnsemblGenome=Nmar_1545\|UniProtKB=A9A4Y7	Nitrosopumilus maritimus	O
HALSA\|EnsemblGenome=VNG_1951G\|UniProtKB=Q9HNT7	Halobacterium salinarum	O
HALSA\|EnsemblGenome=VNG_2573G\|UniProtKB=Q9HMF2	Halobacterium salinarum	O
THEKO\|EnsemblGenome=TK0076\|UniProtKB=Q5JEH9	Thermococcus kodakaraensis	O
CHLAA\|EnsemblGenome=Caur_1909\|UniProtKB=A9WDW5	Chloroflexus aurantiacus	O
CHLAA\|EnsemblGenome=Caur_2635\|UniProtKB=A9WIW4	Chloroflexus aurantiacus	O
STRCO\|Gene_OrderedLocusName=SCO1824\|UniProtKB=Q9RJ44	Streptomyces coelicolor	O
STRCO\|Gene_OrderedLocusName=SCO2637\|UniProtKB=Q9L1Z8	Streptomyces coelicolor	O
CLOBH\|Gene_OrderedLocusName=CBO2322\|UniProtKB=A5I492	Clostridium botulinum	O
STRR6\|EnsemblGenome=spr1771\|UniProtKB=Q8DNF3	Streptococcus pneumoniae	O
STRR6\|EnsemblGenome=spr0561\|UniProtKB=Q8DQP7	Streptococcus pneumoniae	O
STAA8\|EnsemblGenome=SAOUHSC_01949\|UniProtKB=Q2FXB6	Staphylococcus aureus	O
BACSU\|EnsemblGenome=BSU_17260\|UniProtKB=O31788	Bacillus subtilis	O
BACSU\|EnsemblGenome=BSU_38090\|UniProtKB=P29141	Bacillus subtilis	O
BACCR\|EnsemblGenome=BC_4869\|UniProtKB=Q816G4	Bacillus cereus	O
BACCR\|EnsemblGenome=BC_4351\|UniProtKB=Q818B5	Bacillus cereus	O
BACCR\|EnsemblGenome=BC_3412\|UniProtKB=Q81AY5	Bacillus cereus	O
BACCR\|EnsemblGenome=BC_2316\|UniProtKB=Q81DP0	Bacillus cereus	O
DEIRA\|EnsemblGenome=DR_B0069\|UniProtKB=Q9RZQ1	Deinococcus radiodurans	O
DEIRA\|EnsemblGenome=DR_A0283\|UniProtKB=Q9RYM8	Deinococcus radiodurans	O
DEIRA\|EnsemblGenome=DR_1536\|UniProtKB=Q9RU58	Deinococcus radiodurans	O
DEIRA\|EnsemblGenome=DR_1937\|UniProtKB=Q9RT31	Deinococcus radiodurans	O
GLOVI\|Gene=Q7NKC4_GLOVI\|UniProtKB=Q7NKC4	Gloeobacter violaceus	O
SYNY3\|Gene=Q55477_SYNY3\|UniProtKB=Q55477	Synechocystis	O
RHOBA\|EnsemblGenome=RB9765\|UniProtKB=Q7UL36	Rhodopirellula baltica	O
RHOBA\|EnsemblGenome=RB13186\|UniProtKB=Q7UHI0	Rhodopirellula baltica	O
FUSNN\|EnsemblGenome=FN2100\|UniProtKB=Q8RHD7	Fusobacterium nucleatum	O
GEOSL\|EnsemblGenome=GSU2075\|UniProtKB=Q74BG6	Geobacter sulfurreducens	O
BRADU\|Gene=papA\|UniProtKB=Q89SV6	Bradyrhizobium diazoefficiens	O
BRADU\|Gene=Q89QT0_BRADU\|UniProtKB=Q89QT0	Bradyrhizobium diazoefficiens	O
SHEON\|Gene_OrderedLocusName=SO_3800\|UniProtKB=Q8EAU2	Shewanella oneidensis	O
SHEON\|Gene_OrderedLocusName=SO_0187\|UniProtKB=Q8EKA8	Shewanella oneidensis	O
XANCP\|EnsemblGenome=XCC0659\|UniProtKB=Q8PCQ4	Xanthomonas campestris	O
XANCP\|EnsemblGenome=XCC0854\|UniProtKB=Q8PC81	Xanthomonas campestris	O
XANCP\|EnsemblGenome=XCC0851\|UniProtKB=P23314	Xanthomonas campestris	O
XANCP\|EnsemblGenome=XCC1298\|UniProtKB=Q8PB28	Xanthomonas campestris	O
XANCP\|EnsemblGenome=XCC0852\|UniProtKB=Q8PC83	Xanthomonas campestris	O