PANTHER Gene Information

Gene Symbol(s):

SH3BP1

Organism:

Homo sapiens

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Gene Name:

SH3 domain-binding protein 1

Gene ID:

HGNC:10824

Protein ID:

Q9Y3L3

Enhancers:

View enhancers for HUMAN|HGNC=10824|UniProtKB=Q9Y3L3

Genetic Variant Annotation:

Annoq

Persistent Id:

PTN002493843

Alternate Ids:

3BP1_HUMAN(UniProtKB-ID)	ENSG00000100092(Ensembl)
BAC85842(EMBL-CDS)	Q96HQ5(AltAccession)
576865119(GI)	Z83844(EMBL)
HGNC:10824(HGNC)	617368(MIM)
SH3BP1{ECO:0000312\|HGNC:HGNC:10824}(Symbol)	23616(GeneID)
3BP1(Synonym)
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PANTHER Classification

PANTHER Family:	3BP-1 RELATED RHOGAP (PTHR14130)
PANTHER Subfamily:	BARGIN-RELATED (PTHR14130:SF12)
PANTHER GO-slim Molecular Function:	GTPase activator activity
PANTHER GO-slim Biological Process:	regulation of small GTPase mediated signal transduction regulation of actin cytoskeleton organization positive regulation of GTPase activity
PANTHER GO-slim Cellular Component:	cytosol
PANTHER protein class:	GTPase-activating protein

Pathway Categories:

No pathway information available

GENE ONTOLOGY DATABASE ANNOTATIONS

Click to Expand...

GO MF Complete:	protein binding, GTPase activator activity, SH3 domain binding, semaphorin receptor binding
GO BP Complete:	regulation of Rac protein signal transduction, actin filament organization, filopodium assembly, positive regulation of GTPase activity, regulation of blood vessel endothelial cell migration, phagocytosis, engulfment, regulation of actin filament depolymerization, regulation of actin cytoskeleton organization, negative regulation of small GTPase mediated signal transduction, ruffle assembly, regulation of small GTPase mediated signal transduction, establishment of epithelial cell apical/basal polarity, cell junction assembly, cell migration, semaphorin-plexin signaling pathway
GO CC Complete:	nucleus, adherens junction, bicellular tight junction, cell leading edge, cytosol, phagocytic cup, intracellular anatomical structure, exocyst, lamellipodium

REACTOME DATABASE ANNOTATIONS Click to Expand...

Reactome Pathways:

RHO GTPase cycle, Signal Transduction, RAC1 GTPase cycle, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, Signaling by Rho GTPases

Orthologs

ID	Organism	Type
PANTR\|Ensembl=ENSPTRG00000014340.7\|UniProtKB=H2R2A0	Pan troglodytes	LDO
GORGO\|Ensembl=ENSGGOG00000011833.3\|UniProtKB=G3R852	Gorilla gorilla gorilla	LDO
MACMU\|Ensembl=ENSMMUG00000003854.4\|UniProtKB=F7HAB0	Macaca mulatta	LDO
MOUSE\|MGI=MGI=104603\|UniProtKB=P55194	Mus musculus	LDO
RAT\|RGD=1306275\|UniProtKB=D3ZFJ3	Rattus norvegicus	LDO
BOVIN\|Ensembl=ENSBTAG00000030257.4\|UniProtKB=E1BL56	Bos taurus	LDO
PIG\|Ensembl=ENSSSCG00000028531.4\|UniProtKB=A0A8W4FNZ4	Sus scrofa	LDO
HORSE\|Ensembl=ENSECAG00000007864.4\|UniProtKB=F6T530	Equus caballus	LDO
FELCA\|Ensembl=ENSFCAG00000018984.5\|UniProtKB=M3WPG5	Felis catus	LDO
CANLF\|Ensembl=ENSCAFG00845005964.1\|UniProtKB=A0A8I3NCX7	Canis lupus familiaris	LDO
ORNAN\|Ensembl=ENSOANG00000011219.4\|UniProtKB=A0A6I8PFN8	Ornithorhynchus anatinus	LDO
CHICK\|Ensembl=ENSGALG00010014026.1\|UniProtKB=A0A8V0YMG6	Gallus gallus	LDO
ANOCA\|Ensembl=ENSACAG00000015666.4\|UniProtKB=G1KRF9	Anolis carolinensis	LDO
XENLA\|Gene=sh3bp1.L\|UniProtKB=A0A1L8GP19	Xenopus laevis	O
XENLA\|Gene=sh3bp1.S\|UniProtKB=A0A8J1KLI5	Xenopus laevis	LDO
XENTR\|Ensembl=ENSXETG00000032660\|UniProtKB=A0A6I8SWA3	Xenopus tropicalis	LDO
ORYLA\|Ensembl=ENSORLG00000029676.1\|UniProtKB=A0A3B3IA92	Oryzias latipes	LDO
DANRE\|ZFIN=ZDB-GENE-121128-2\|UniProtKB=E7FFF8	Danio rerio	LDO
LEPOC\|Ensembl=ENSLOCG00000011670.1\|UniProtKB=W5N133	lepisosteus oculatus	LDO
BRAFL\|Gene=LOC118428373\|UniProtKB=A0A9J7M5C5	Branchiostoma floridae	O
STRPU\|EnsemblGenome=LOC592564\|UniProtKB=A0A7M7NQT0	Strongylocentrotus purpuratus	O
CAEEL\|WormBase=WBGene00021324\|UniProtKB=A0A2K5AU23	Caenorhabditis elegans	O
CAEBR\|WormBase=WBGene00035078\|UniProtKB=A8XKD4	Caenorhabditis briggsae	O
PRIPA\|EnsemblGenome=WBGene00110064\|UniProtKB=A0A2A6D253	Pristionchus pacificus	O
DROME\|FlyBase=FBgn0038747\|UniProtKB=Q9VDS5	Drosophila melanogaster	O
ANOGA\|EnsemblGenome=AGAP009727\|UniProtKB=A0A1S4H2S3	Anopheles gambiae	O
TRICA\|EnsemblGenome=TC003222\|UniProtKB=D6WE39	Tribolium castaneum	O
IXOSC\|EnsemblGenome=ISCW003282\|UniProtKB=B7PAK9	Ixodes scapularis	O
HELRO\|EnsemblGenome=HelroG164475\|UniProtKB=T1EVH0	helobdella robusta	O
HELRO\|EnsemblGenome=HelroG190227\|UniProtKB=T1FRS7	helobdella robusta	O
MONBE\|EnsemblGenome=MONBRDRAFT_26508\|UniProtKB=A9V2K3	Monosiga brevicollis	O
USTMA\|EnsemblGenome=UMAG_01161\|UniProtKB=A0A0D1E6N8	Ustilago maydis	O
BATDJ\|Gene_ORFName=BATDEDRAFT_25160\|UniProtKB=F4P2Y4	Batrachochytrium dendrobatidis	O
DICDI\|dictyBase=DDB_G0283955\|UniProtKB=Q54QB9	Dictyostelium discoideum	O