PANTHER Gene Information   
Gene Symbol(s): Ripk3
Organism: Rattus norvegicus
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Gene Name: Receptor-interacting serine_threonine-protein kinase 3
Gene ID: 628899
Protein ID: Q9Z2P5
Persistent Id: PTN000585196
Alternate Ids:
EDM14286(EMBL-CDS) NM_139342(refSeq)
Ripk3{ECO:0000312|RGD:628899}(Symbol) AABR06083269(EMBL)
628899(RGD) RIP-3 {ECO:0000250|UniProtKB:Q9QZL0}(Synonym)
14161748(GI) 246240(GeneID)
B0BMV6(AltAccession) RIPK3_RAT(UniProtKB-ID)
2.7.11.1(EC)
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PANTHER Classification
PANTHER Family: SERINE-THREONINE PROTEIN KINASE (PTHR23257)
PANTHER Subfamily: RECEPTOR-INTERACTING SERINE_THREONINE-PROTEIN KINASE 3 (PTHR23257:SF974)  
PANTHER GO-slim Molecular Function: protein kinase activity
PANTHER GO-slim Biological Process: signal transduction
PANTHER GO-slim Cellular Component: cytoplasm
PANTHER protein class: non-receptor serine/threonine protein kinase
Pathway Categories: No pathway information available
GENE ONTOLOGY DATABASE ANNOTATIONS      Click to Expand...
GO MF Complete: protein-containing complex binding, ribosomal protein S6 kinase activity, DNA-dependent protein kinase activity, ATP binding, histone H2AT120 kinase activity, AMP-activated protein kinase activity, histone H3S57 kinase activity, histone H4S1 kinase activity, histone H3S28 kinase activity, histone H3T45 kinase activity, histone H2AXS139 kinase activity, protein serine kinase activity, identical protein binding, histone H3S10 kinase activity, histone H2BS14 kinase activity, histone H2AS1 kinase activity, protein kinase activity, eukaryotic translation initiation factor 2alpha kinase activity, protein serine/threonine kinase activity, 3-phosphoinositide-dependent protein kinase activity, histone H2AS121 kinase activity, histone H3T3 kinase activity, histone H2BS36 kinase activity, Rho-dependent protein serine/threonine kinase activity, histone H3T11 kinase activity, histone H3T6 kinase activity
GO BP Complete: spleen development, lymph node development, positive regulation of NF-kappaB transcription factor activity, positive regulation of necroptotic process, T cell homeostasis, thymus development, regulation of type II interferon production, chromatin remodeling, programmed necrotic cell death, necroptotic process, apoptotic process, regulation of reactive oxygen species metabolic process, activation of protein kinase activity, defense response to virus, execution phase of necroptosis, regulation of CD8-positive, alpha-beta cytotoxic T cell extravasation, cellular response to hydrogen peroxide, necroptotic signaling pathway, regulation of adaptive immune response, positive regulation of intrinsic apoptotic signaling pathway, positive regulation of transferase activity, positive regulation of reactive oxygen species metabolic process, signal transduction, T cell differentiation in thymus, regulation of activated T cell proliferation, non-canonical NF-kappaB signal transduction, regulation of apoptotic process, amyloid fibril formation, reactive oxygen species metabolic process, positive regulation of oxidoreductase activity, positive regulation of ligase activity, regulation of T cell mediated cytotoxicity, regulation of activation-induced cell death of T cells
GO CC Complete: nucleus, cytoplasm, cytosol, protein-containing complex
REACTOME DATABASE ANNOTATIONS   Click to Expand...
Reactome Pathways: Toll Like Receptor 4 (TLR4) Cascade, MyD88-independent TLR4 cascade , Regulation of necroptotic cell death, Regulated Necrosis, TRP channels, RIPK1-mediated regulated necrosis, Immune System, Ion channel transport, Programmed Cell Death, Toll-like Receptor Cascades, Innate Immune System, IKK complex recruitment mediated by RIP1, Stimuli-sensing channels, Transport of small molecules, TRIF-mediated programmed cell death, TRIF(TICAM1)-mediated TLR4 signaling

Orthologs