PANTHER Gene Information   
Gene Symbol(s): HUWE1
Organism: Drosophila melanogaster
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Gene Name: HECT-type E3 ubiquitin transferase
Gene ID: FBgn0030674
Protein ID: X2JF73
Persistent Id: PTN002258122
Alternate Ids:
32510(GeneID) FBgn0030674(FlyBase)
X2JF73_DROME(UniProtKB-ID) NP_001285288(refSeq)
FBpp0309265(Ensembl_PRO) FBtr0340304(Ensembl_TRS)
X2JF73(Synonym) AHN59758(EMBL-CDS)
FBgn0030674(Ensembl) AE014298(EMBL)
665391560(GI)
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PANTHER Classification
PANTHER Family: HECT DOMAIN UBIQUITIN-PROTEIN LIGASE (PTHR11254)
PANTHER Subfamily: E3 UBIQUITIN-PROTEIN LIGASE HUWE1 (PTHR11254:SF67)  
PANTHER GO-slim Molecular Function: ubiquitin protein ligase activity
PANTHER GO-slim Biological Process: ubiquitin-dependent protein catabolic process
protein polyubiquitination
PANTHER GO-slim Cellular Component: cytoplasm
PANTHER protein class: ubiquitin-protein ligase
Pathway Categories: Ubiquitin proteasome pathway
   Ubiquitin protein ligase E3

GO MF Complete: ubiquitin-protein transferase activity, ubiquitin protein ligase activity
GO BP Complete: negative regulation of canonical Wnt signaling pathway, regulation of axonogenesis, negative regulation of tumor necrosis factor-mediated signaling pathway, salivary gland development, negative regulation of programmed cell death, negative regulation of JNK cascade, ubiquitin-dependent protein catabolic process, protein ubiquitination
GO CC Complete: nucleus, cytoplasm
Reactome Pathways: Class I MHC mediated antigen processing & presentation, Antigen processing: Ubiquitination & Proteasome degradation, Immune System, Adaptive Immune System, Innate Immune System, Neutrophil degranulation