The mission of the PANTHER knowledgebase is to support biomedical and other research by providing
comprehensive information about the evolution of protein-coding gene families, particularly
protein phylogeny, function and genetic variation impacting that function. Learn more

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Current Release: PANTHER 19.0 | 15,683 family phylogenetic trees | 144 species | News
Whole genome function views

PANTHER Gene Information

Gene Symbol(s):

C1S

Organism:

Bos taurus

View Gene in Tree

Tree

Gene Name:

Complement C1s

Gene ID:

ENSBTAG00000004840.5

Protein ID:

A0A3Q1M7Q5

Persistent Id:

PTN008611221

Alternate Ids:

ENSBTAG00000004840(Ensembl)	A0A3Q1M7Q5(Synonym)
ENSBTAT00000086353(Ensembl_TRS)	ENSBTAP00000066104(Ensembl_PRO)
A0A3Q1M7Q5_BOVIN(UniProtKB-ID)
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PANTHER Classification

PANTHER Family:	COMPLEMENT COMPONENT 1, S SUBCOMPONENT-RELATED (PTHR24255)
PANTHER Subfamily:	COMPLEMENT C1S SUBCOMPONENT (PTHR24255:SF18)
PANTHER GO-slim Molecular Function:	serine-type endopeptidase activity
PANTHER GO-slim Biological Process:
PANTHER GO-slim Cellular Component:	extracellular space
PANTHER protein class:	serine protease

Pathway Categories:

No pathway information available

GENE ONTOLOGY DATABASE ANNOTATIONS

Click to Expand...

GO MF Complete:	identical protein binding, calcium ion binding, serine-type endopeptidase activity
GO BP Complete:	complement activation, classical pathway, proteolysis
GO CC Complete:	extracellular space

REACTOME DATABASE ANNOTATIONS Click to Expand...

Reactome Pathways:

Complement cascade, Initial triggering of complement, Immune System, Regulation of Complement cascade, Classical antibody-mediated complement activation, Innate Immune System, Creation of C4 and C2 activators

Orthologs

ID	Organism	Type
HUMAN\|HGNC=1247\|UniProtKB=P09871	Homo sapiens	LDO
PANTR\|Ensembl=ENSPTRG00000004605.7\|UniProtKB=K7AR52	Pan troglodytes	LDO
GORGO\|Ensembl=ENSGGOG00000001455.3\|UniProtKB=G3QGI0	Gorilla gorilla gorilla	LDO
MACMU\|Ensembl=ENSMMUG00000012786.4\|UniProtKB=F7EI47	Macaca mulatta	LDO
MOUSE\|MGI=MGI=1355312\|UniProtKB=Q8CG14	Mus musculus	O
MOUSE\|MGI=MGI=3644269\|UniProtKB=Q8CFG8	Mus musculus	LDO
RAT\|RGD=619983\|UniProtKB=Q6P6T1	Rattus norvegicus	LDO
PIG\|Ensembl=ENSSSCG00000055651.1\|UniProtKB=A0A8W4FL59	Sus scrofa	LDO
PIG\|Gene=C1S_PIG\|UniProtKB=Q69DK8	Sus scrofa	LDO
HORSE\|Ensembl=ENSECAG00000009519.4\|UniProtKB=A0A9L0SXE9	Equus caballus	LDO
FELCA\|Ensembl=ENSFCAG00000000175.5\|UniProtKB=A0A5F5XHF5	Felis catus	LDO
CANLF\|Ensembl=ENSCAFG00845025415.1\|UniProtKB=A0A8I3PUL5	Canis lupus familiaris	LDO
MONDO\|Ensembl=ENSMODG00000018167.4\|UniProtKB=F7CCG9	Monodelphis domestica	LDO
ORNAN\|Ensembl=ENSOANG00000008659.3\|UniProtKB=A0A6I8NGP7	Ornithorhynchus anatinus	LDO
CHICK\|Ensembl=ENSGALG00010023603.1\|UniProtKB=A0A8V0ZX35	Gallus gallus	LDO
ANOCA\|Ensembl=ENSACAG00000024727.2\|UniProtKB=H9GVD6	Anolis carolinensis	O
ANOCA\|Ensembl=ENSACAG00000007857.4\|UniProtKB=L7MZR9	Anolis carolinensis	LDO
XENLA\|Gene=c1s.L\|UniProtKB=A0JMR1	Xenopus laevis	LDO
XENTR\|Xenbase=XB-GENE-995410\|UniProtKB=A0A803KFI9	Xenopus tropicalis	LDO
DANRE\|ZFIN=ZDB-GENE-110421-4\|UniProtKB=X1WH68	Danio rerio	O
LEPOC\|Ensembl=ENSLOCG00000009432.1\|UniProtKB=W5MT02	lepisosteus oculatus	O
CIOIN\|Ensembl=ENSCING00000002726.3\|UniProtKB=F6TQ36	Ciona intestinalis	O
CIOIN\|Ensembl=ENSCING00000002747.3\|UniProtKB=F7AGV3	Ciona intestinalis	O
BRAFL\|Gene=LOC118430323\|UniProtKB=A0A9J7MBI6	Branchiostoma floridae	O
STRPU\|EnsemblGenome=GeneID_585663\|UniProtKB=A0A7M7P290	Strongylocentrotus purpuratus	O
ANOGA\|EnsemblGenome=AGAP029047\|UniProtKB=A0A1Y9IGS6	Anopheles gambiae	O
TRICA\|EnsemblGenome=TC003136\|UniProtKB=D6WF18	Tribolium castaneum	O
IXOSC\|EnsemblGenome=ISCW007056\|UniProtKB=B7PTI3	Ixodes scapularis	O
IXOSC\|EnsemblGenome=ISCW007148\|UniProtKB=B7PVI9	Ixodes scapularis	O
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g215748\|UniProtKB=A7SQB2	Nematostella vectensis	O
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g223268\|UniProtKB=A7T766	Nematostella vectensis	O
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g138799\|UniProtKB=A7SZ55	Nematostella vectensis	O