PANTHER Gene Information   
Gene Symbol(s): IRAK2
Organism: Bos taurus
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Gene Name: Interleukin-1 receptor-associated kinase-like 2
Gene ID: ENSBTAG00000006193
Protein ID: Q0P5I2
Persistent Id: PTN007801773
Alternate Ids:
ENSBTAT00000008135(Ensembl_TRS) BC120001(EMBL)
NM_001075696(refSeq) IRAK2(Synonym)
515034(GeneID) ENSBTAP00000008135(Ensembl_PRO)
ENSBTAG00000006193(Ensembl) AAI20002(EMBL-CDS)
IRAK2_BOVIN(UniProtKB-ID) 115496712(GI)
IRAK2(Symbol)
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PANTHER Classification
PANTHER Family: INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASE (PTHR24419)
PANTHER Subfamily: INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASE-LIKE 2 (PTHR24419:SF2)  
PANTHER GO-slim Molecular Function: protein serine/threonine kinase activity
histone modifying activity
PANTHER GO-slim Biological Process: response to interleukin-1
cellular response to lipopolysaccharide
positive regulation of NF-kappaB transcription factor activity
mitotic cell cycle
intracellular signal transduction
cytokine-mediated signaling pathway
PANTHER GO-slim Cellular Component: plasma membrane
nucleus
cytoplasm
PANTHER protein class: non-receptor serine/threonine protein kinase
Pathway Categories: No pathway information available
GO MF Complete: ATP binding, protein homodimerization activity, signaling adaptor activity, protein heterodimerization activity, protein kinase activity
GO BP Complete: Toll signaling pathway, toll-like receptor 4 signaling pathway, positive regulation of canonical NF-kappaB signal transduction, lipopolysaccharide-mediated signaling pathway, regulation of cytokine-mediated signaling pathway, interleukin-1-mediated signaling pathway, canonical NF-kappaB signal transduction, intracellular signal transduction
GO CC Complete: nucleus, cytoplasm, plasma membrane
Reactome Pathways: Cytokine Signaling in Immune system, Interleukin-1 family signaling, Signaling by Interleukins, Toll Like Receptor 7/8 (TLR7/8) Cascade, Toll Like Receptor TLR6:TLR2 Cascade, Toll Like Receptor 2 (TLR2) Cascade, Toll Like Receptor 10 (TLR10) Cascade, Toll Like Receptor 3 (TLR3) Cascade, TRAF6-mediated induction of TAK1 complex within TLR4 complex, MyD88-independent TLR4 cascade , Innate Immune System, Interleukin-1 signaling, MyD88 cascade initiated on plasma membrane, MyD88 dependent cascade initiated on endosome, JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1, TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation, activated TAK1 mediates p38 MAPK activation, Interleukin-17 signaling, Toll Like Receptor 5 (TLR5) Cascade, IRAK2 mediated activation of TAK1 complex, TRIF(TICAM1)-mediated TLR4 signaling , MyD88:MAL(TIRAP) cascade initiated on plasma membrane, Toll Like Receptor TLR1:TLR2 Cascade, Immune System, Toll-like Receptor Cascades, Toll Like Receptor 9 (TLR9) Cascade, Toll Like Receptor 4 (TLR4) Cascade, IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation, MAP kinase activation