PANTHER Gene Information

Gene Symbol(s):

LDHA

Organism:

Bos taurus

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Tree

Gene Name:

L-lactate dehydrogenase A chain

Gene ID:

ENSBTAG00000008683

Protein ID:

P19858

Persistent Id:

PTN000166344

Alternate Ids:

XP_005226796(refSeq)	BAA14171(EMBL-CDS)
CHEMBL2102(ChEMBL)	ENSBTAP00000047729(Ensembl_PRO)
217588(GI)	1.1.1.27 {ECO:0000250\|UniProtKB:P00338}(EC)
LDHA_BOVIN(UniProtKB-ID)	LDH-A(Synonym)
LDHA(Symbol)	ENSBTAG00000008683(Ensembl)
ENSBTAT00000056276(Ensembl_TRS)	A6H7E0(AltAccession)
281274(GeneID)	D90143(EMBL)
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PANTHER Classification

PANTHER Family:	L-2-HYDROXYCARBOXYLATE DEHYDROGENASE (NAD(P)(+)) (PTHR43128)
PANTHER Subfamily:	L-LACTATE DEHYDROGENASE A CHAIN (PTHR43128:SF10)
PANTHER GO-slim Molecular Function:	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
PANTHER GO-slim Biological Process:	monocarboxylic acid metabolic process organic hydroxy compound metabolic process
PANTHER GO-slim Cellular Component:
PANTHER protein class:	dehydrogenase

Pathway Categories:

No pathway information available

GENE ONTOLOGY DATABASE ANNOTATIONS

Click to Expand...

GO MF Complete:	L-lactate dehydrogenase activity
GO BP Complete:	lactate metabolic process, carboxylic acid metabolic process, pyruvate metabolic process
GO CC Complete:	cytoplasm, mitochondrion

REACTOME DATABASE ANNOTATIONS Click to Expand...

Reactome Pathways:

The citric acid (TCA) cycle and respiratory electron transport, Pyruvate metabolism and Citric Acid (TCA) cycle, Pyruvate metabolism, Metabolism

Orthologs

ID	Organism	Type
PANTR\|Ensembl=ENSPTRG00000050437.1\|UniProtKB=A0A2I3T1N6	Pan troglodytes	O
GORGO\|Ensembl=ENSGGOG00000015254.3\|UniProtKB=A0A2I2ZXA0	Gorilla gorilla gorilla	O
PANTR\|Ensembl=ENSPTRG00000050528.1\|UniProtKB=A0A2I3RVL6	Pan troglodytes	O
GORGO\|Ensembl=ENSGGOG00000042433.1\|UniProtKB=G3RPH6	Gorilla gorilla gorilla	O
HUMAN\|HGNC=6535\|UniProtKB=P00338	Homo sapiens	LDO
PANTR\|Ensembl=ENSPTRG00000043159.1\|UniProtKB=A0A2I3TIB4	Pan troglodytes	O
PANTR\|Ensembl=ENSPTRG00000047792.1\|UniProtKB=A0A2I3RJT2	Pan troglodytes	O
PANTR\|Ensembl=ENSPTRG00000003421\|UniProtKB=Q5R1W9	Pan troglodytes	LDO
GORGO\|Ensembl=ENSGGOG00000043118.1\|UniProtKB=A0A2I2ZB50	Gorilla gorilla gorilla	O
GORGO\|Ensembl=ENSGGOG00000010350.3\|UniProtKB=G3RGX1	Gorilla gorilla gorilla	LDO
MACMU\|Ensembl=ENSMMUG00000021460.4\|UniProtKB=F7E6F6	Macaca mulatta	O
MACMU\|Ensembl=ENSMMUG00000031024.3\|UniProtKB=F6R1N2	Macaca mulatta	LDO
MOUSE\|MGI=MGI=96759\|UniProtKB=P06151	Mus musculus	LDO
RAT\|RGD=15003548\|UniProtKB=A0A8I6ASS6	Rattus norvegicus	O
RAT\|RGD=2996\|UniProtKB=P04642	Rattus norvegicus	LDO
HORSE\|Ensembl=ENSECAG00000020669.4\|UniProtKB=A0A9L0S7B8	Equus caballus	LDO
FELCA\|Ensembl=ENSFCAG00000015735.6\|UniProtKB=A0A337S8L1	Felis catus	LDO
CANLF\|Ensembl=ENSCAFG00845029892.1\|UniProtKB=A0A8I3Q8U0	Canis lupus familiaris	O
CANLF\|Ensembl=ENSCAFG00845003702.1\|UniProtKB=A0A8I3MMN3	Canis lupus familiaris	LDO
CANLF\|Ensembl=ENSCAFG00845015232.1\|UniProtKB=A0A8I3S1C9	Canis lupus familiaris	O
CANLF\|Ensembl=ENSCAFG00845027826.1\|UniProtKB=A0A8I3S6H4	Canis lupus familiaris	LDO
MONDO\|Ensembl=ENSMODG00000019596.3\|UniProtKB=A0A5S8BEX8	Monodelphis domestica	O
MONDO\|Ensembl=ENSMODG00000006509.3\|UniProtKB=F7EJX3	Monodelphis domestica	O
MONDO\|Ensembl=ENSMODG00000016773.3\|UniProtKB=F7GGA7	Monodelphis domestica	O
MONDO\|Ensembl=ENSMODG00000040672.1\|UniProtKB=A0A5F8GE81	Monodelphis domestica	O
MONDO\|Ensembl=ENSMODG00000023086.2\|UniProtKB=F7BNV4	Monodelphis domestica	O
MONDO\|Ensembl=ENSMODG00000006522\|UniProtKB=Q9XT87	Monodelphis domestica	LDO
ORNAN\|Ensembl=ENSOANG00000008367.4\|UniProtKB=F7BRJ4	Ornithorhynchus anatinus	O
ORNAN\|Ensembl=ENSOANG00000048733.1\|UniProtKB=A0A6I8PC18	Ornithorhynchus anatinus	LDO
CHICK\|Gene=LDHA\|UniProtKB=P00340	Gallus gallus	LDO
CHICK\|Ensembl=ENSGALG00010024472.1\|UniProtKB=E1BTT8	Gallus gallus	LDO
ANOCA\|Ensembl=ENSACAG00000000061.4\|UniProtKB=G1K888	Anolis carolinensis	LDO
XENLA\|Gene=ldha.L\|UniProtKB=Q9W7M7	Xenopus laevis	O
XENLA\|Gene=ldha.S\|UniProtKB=Q9W5Z7	Xenopus laevis	LDO
XENTR\|Xenbase=XB-GENE-480608\|UniProtKB=Q6P7L5	Xenopus tropicalis	LDO
ORYLA\|Ensembl=ENSORLG00000003767.2\|UniProtKB=A0A3B3I1R7	Oryzias latipes	LDO
DANRE\|ZFIN=ZDB-GENE-991026-5\|UniProtKB=Q9PVK5	Danio rerio	LDO
LEPOC\|Ensembl=ENSLOCG00000000737.1\|UniProtKB=W5LXG1	lepisosteus oculatus	LDO
CIOIN\|Ensembl=ENSCING00000003426.3\|UniProtKB=F6XLK3	Ciona intestinalis	O
STRPU\|EnsemblGenome=LOC115917976\|UniProtKB=A0A7M7NZ80	Strongylocentrotus purpuratus	O
STRPU\|EnsemblGenome=LOC586683\|UniProtKB=A0A7M7P3V3	Strongylocentrotus purpuratus	O
CAEEL\|WormBase=WBGene00002262\|UniProtKB=Q27888	Caenorhabditis elegans	O
CAEBR\|Gene_ORFName=CBG03136\|UniProtKB=A8WSQ2	Caenorhabditis briggsae	O
PRIPA\|EnsemblGenome=WBGene00304582\|UniProtKB=A0A8R1Z903	Pristionchus pacificus	O
DROME\|FlyBase=FBgn0033856\|UniProtKB=A1Z9F8	Drosophila melanogaster	O
DROME\|FlyBase=FBgn0001258\|UniProtKB=Q95028	Drosophila melanogaster	O
ANOGA\|EnsemblGenome=AGAP004880\|UniProtKB=Q7Q981	Anopheles gambiae	O
TRICA\|EnsemblGenome=TC003922\|UniProtKB=D6WHN0	Tribolium castaneum	O
DAPPU\|EnsemblGenome=DAPPUDRAFT_61140\|UniProtKB=E9HCE3	Daphnia pulex	O
DAPPU\|EnsemblGenome=DAPPUDRAFT_230172\|UniProtKB=E9FTK7	Daphnia pulex	O
HELRO\|EnsemblGenome=HelroG156879\|UniProtKB=T1EM25	helobdella robusta	O
HELRO\|EnsemblGenome=HelroG166102\|UniProtKB=T1EXR7	helobdella robusta	O
HELRO\|EnsemblGenome=HelroG115469\|UniProtKB=T1EG84	helobdella robusta	O
MONBE\|EnsemblGenome=MONBRDRAFT_32392\|UniProtKB=A9UZ89	Monosiga brevicollis	O
AMBTC\|EnsemblGenome=AMTR_s00007p00083810\|UniProtKB=W1P5V6	Amborella trichopoda	O
ZOSMR\|Gene_ORFName=ZOSMA_85G00700\|UniProtKB=A0A0K9NLK7	Zostera marina	O
ZOSMR\|Gene_ORFName=ZOSMA_26G01440\|UniProtKB=A0A0K9PEA0	Zostera marina	O
ZOSMR\|Gene_ORFName=ZOSMA_85G00680\|UniProtKB=A0A0K9NL55	Zostera marina	O
MUSAM\|EnsemblGenome=Ma01_g13550\|UniProtKB=A0A804HTP8	Musa acuminata subsp. malaccensis	O
MUSAM\|EnsemblGenome=Ma07_g06750\|UniProtKB=A0A804JSZ9	Musa acuminata subsp. malaccensis	O
MUSAM\|EnsemblGenome=Ma07_g06760\|UniProtKB=A0A804JT00	Musa acuminata subsp. malaccensis	O
SETIT\|EnsemblGenome=SETIT_019533mg\|UniProtKB=K3YZ26	Setaria italica	O
SORBI\|EnsemblGenome=SORBI_3004G004500\|UniProtKB=C5XRJ7	Sorghum bicolor	O
MAIZE\|EnsemblGenome=Zm00001eb229440\|UniProtKB=A0A804U7B0	Zea mays	O
SETIT\|EnsemblGenome=SETIT_017639mg\|UniProtKB=K3YTP3	Setaria italica	O
SORBI\|EnsemblGenome=SORBI_3004G004400\|UniProtKB=C5XRJ6	Sorghum bicolor	O
MAIZE\|Gene=LDH_MAIZE\|UniProtKB=P29038	Zea mays	O
MAIZE\|EnsemblGenome=Zm00001eb229430\|UniProtKB=B6T856	Zea mays	O
ORYSJ\|EnsemblGenome=Os06g0104900\|UniProtKB=Q9LWZ6	Oryza sativa	O
ORYSJ\|EnsemblGenome=Os02g0105400\|UniProtKB=Q0E4Q5	Oryza sativa	O
BRADI\|EnsemblGenome=BRADI_3g15560v3\|UniProtKB=I1I144	Brachypodium distachyon	O
HORVV\|EnsemblGenome=HORVU.MOREX.r3.2HG0107000\|UniProtKB=A0A8I6WQS5	Hordeum vulgare subsp. vulgare	O
WHEAT\|EnsemblGenome=TraesCS7B02G317500\|UniProtKB=A0A3B6SK62	Triticum aestivum	O
WHEAT\|EnsemblGenome=TraesCS7B02G317900\|UniProtKB=A0A3B6SHI3	Triticum aestivum	O
WHEAT\|EnsemblGenome=TraesCS2B02G091400\|UniProtKB=A0A3B6BZD0	Triticum aestivum	O
WHEAT\|EnsemblGenome=TraesCS7A02G417800\|UniProtKB=A0A3B6RP30	Triticum aestivum	O
WHEAT\|EnsemblGenome=TraesCS7D02G410800\|UniProtKB=A0A3B6TVM4	Triticum aestivum	O
WHEAT\|EnsemblGenome=TraesCS2D02G075200\|UniProtKB=A0A3B6D9F6	Triticum aestivum	O
WHEAT\|EnsemblGenome=TraesCS7A02G417400\|UniProtKB=A0A3B6RNX9	Triticum aestivum	O
WHEAT\|EnsemblGenome=TraesCS6B02G029700\|UniProtKB=A0A3B6PDH3	Triticum aestivum	O
WHEAT\|EnsemblGenome=TraesCS2A02G076600\|UniProtKB=A0A3B6ASL4	Triticum aestivum	O
HORVV\|EnsemblGenome=HORVU.MOREX.r3.6HG0552610\|UniProtKB=A0A8I7BB49	Hordeum vulgare subsp. vulgare	O
WHEAT\|EnsemblGenome=TraesCS6B02G116700\|UniProtKB=A0A3B6PIW3	Triticum aestivum	O
WHEAT\|EnsemblGenome=TraesCS6D02G078300\|UniProtKB=A0A3B6QD94	Triticum aestivum	O
WHEAT\|EnsemblGenome=TraesCS6A02G085300\|UniProtKB=A0A3B6NJD4	Triticum aestivum	O
NELNU\|Gene_ORFName=HUJ06_017754\|UniProtKB=A0A1U8AAA6	Nelumbo nucifera	O
NELNU\|Gene=LOC104598555\|UniProtKB=A0A1U7ZYQ4	Nelumbo nucifera	O
SPIOL\|Gene=LOC110792497\|UniProtKB=A0A9R0IP55	Spinacia oleracea	O
HELAN\|Gene_ORFName=HanXRQr2_Chr02g0073481\|UniProtKB=A0A9K3JNW6	Helianthus annuus	O
HELAN\|EnsemblGenome=HanXRQr2_Chr13g0578121\|UniProtKB=A0A251SQ98	Helianthus annuus	O
LACSA\|Gene_ORFName=LSAT_V11C600299770\|UniProtKB=A0A9R1X7M9	Lactuca sativa	O
HELAN\|Gene_ORFName=HanXRQr2_Chr17g0800981\|UniProtKB=A0A9K3GU27	Helianthus annuus	O
HELAN\|Gene_ORFName=HanXRQr2_Chr17g0801001\|UniProtKB=A0A9K3GUH5	Helianthus annuus	O
HELAN\|EnsemblGenome=HanXRQr2_Chr06g0238801\|UniProtKB=A0A251UEK1	Helianthus annuus	O
LACSA\|Gene_ORFName=LSAT_V11C300101670\|UniProtKB=A0A9R1W2L3	Lactuca sativa	O
ERYGU\|Gene_ORFName=MIMGU_mgv1a009187mg\|UniProtKB=A0A022QZV6	Erythranthe guttata	O
CAPAN\|EnsemblGenome=T459_03876\|UniProtKB=A0A2G3AP36	Capsicum annuum	O
SOLTU\|EnsemblGenome=PGSC0003DMG400012478\|UniProtKB=M1AXH9	Solanum tuberosum	O
SOLLC\|EnsemblGenome=Solyc08g007420.3\|UniProtKB=A0A3Q7HKP3	Solanum lycopersicum	O
TOBAC\|Gene=LOC107806030\|UniProtKB=A0A077D9R7	Nicotiana tabacum	O
CAPAN\|EnsemblGenome=T459_00568\|UniProtKB=A0A2G3AEL6	Capsicum annuum	O
SOLTU\|EnsemblGenome=PGSC0003DMG400004800\|UniProtKB=M1A0Y3	Solanum tuberosum	O
SOLLC\|EnsemblGenome=Solyc08g078850.3\|UniProtKB=Q96569	Solanum lycopersicum	O
TOBAC\|Gene=LOC107780728\|UniProtKB=A0A1S3YWT9	Nicotiana tabacum	O
TOBAC\|Gene=LOC107803141\|UniProtKB=A0A1S4AZZ0	Nicotiana tabacum	O
VITVI\|EnsemblGenome=Vitvi15g00715\|UniProtKB=F6I382	Vitis vinifera	O
VITVI\|EnsemblGenome=Vitvi02g00533\|UniProtKB=D7TN36	Vitis vinifera	O
EUCGR\|EnsemblGenome=EUGRSUZ_D02046\|UniProtKB=A0A059CH86	Eucalyptus grandis	O
EUCGR\|EnsemblGenome=EUGRSUZ_E00444\|UniProtKB=A0A059C263	Eucalyptus grandis	O
BRANA\|Gene_ORFName=DARMORV10_C01P25250.1\|UniProtKB=A0A078HD00	Brassica napus	O
BRANA\|Gene_ORFName=DARMORV10_A01P20100.1\|UniProtKB=A0A078I074	Brassica napus	O
BRACM\|EnsemblGenome=Bra026240\|UniProtKB=A0A3P5Z6C3	Brassica campestris	O
BRANA\|Gene_ORFName=GSBRNA2T00031281001\|UniProtKB=A0A078F8I0	Brassica napus	O
BRACM\|EnsemblGenome=Bra012671\|UniProtKB=A0A398AAN2	Brassica campestris	O
ARATH\|TAIR=locus=2130764\|UniProtKB=O23569	Arabidopsis thaliana	O
GOSHI\|Gene=LOC107940833\|UniProtKB=A0A1U8MW28	Gossypium hirsutum	O
GOSHI\|Gene=LOC107946940\|UniProtKB=A0A1U8NGK4	Gossypium hirsutum	O
GOSHI\|Gene=LOC107942082\|UniProtKB=A0A1U8N066	Gossypium hirsutum	O
THECC\|EnsemblGenome=TCM_015995\|UniProtKB=A0A061GBE3	Theobroma cacao	O
CITSI\|Gene_ORFName=CISIN_1g018760mg\|UniProtKB=A0A067F5R0	Citrus sinensis	O
POPTR\|EnsemblGenome=POPTR_003G111200v3\|UniProtKB=U5GJ57	Populus trichocarpa	O
POPTR\|EnsemblGenome=POPTR_001G122400v3\|UniProtKB=U5GU43	Populus trichocarpa	O
MANES\|EnsemblGenome=MANES_02G038200\|UniProtKB=A0A2C9WAN2	Manihot esculenta	O
MANES\|EnsemblGenome=MANES_01G079100\|UniProtKB=A0A2C9WIP3	Manihot esculenta	O
RICCO\|Gene_ORFName=RCOM_0540800\|UniProtKB=B9SIT4	Ricinus communis	O
RICCO\|Gene_ORFName=RCOM_0540790\|UniProtKB=B9SIT3	Ricinus communis	O
SOYBN\|EnsemblGenome=GLYMA_17G140600\|UniProtKB=I1MUZ7	Glycine max	O
SOYBN\|EnsemblGenome=GLYMA_05G058100\|UniProtKB=A0A0R0JRB0	Glycine max	O
MEDTR\|EnsemblGenome=MTR_4g101130\|UniProtKB=G7JIY5	Medicago truncatula	O
SOYBN\|EnsemblGenome=GLYMA_01G210400\|UniProtKB=I1J9W9	Glycine max	O
MEDTR\|EnsemblGenome=MTR_5g012390\|UniProtKB=G7JW16	Medicago truncatula	O
JUGRE\|EnsemblGenome=Jr02_20010\|UniProtKB=A0A2I4GWV6	Juglans regia	O
JUGRE\|Gene=LOC109013131\|UniProtKB=A0A6P9ER86	Juglans regia	O
CUCSA\|EnsemblGenome=Csa_5G161920\|UniProtKB=A0A0A0KKU9	Cucumis sativus	O
PRUPE\|EnsemblGenome=PRUPE_5G072700\|UniProtKB=M5X008	Prunus persica	O
PRUPE\|EnsemblGenome=PRUPE_1G339800\|UniProtKB=M5Y9S9	Prunus persica	O
SELML\|EnsemblGenome=SELMODRAFT_236713\|UniProtKB=D8TCK2	Selaginella moellendorffii	O
SELML\|EnsemblGenome=SELMODRAFT_92401\|UniProtKB=D8RFP2	Selaginella moellendorffii	O
SELML\|EnsemblGenome=SELMODRAFT_405919\|UniProtKB=D8R035	Selaginella moellendorffii	O
SELML\|EnsemblGenome=SELMODRAFT_447483\|UniProtKB=D8SZU9	Selaginella moellendorffii	O
PHYPA\|EnsemblGenome=Pp3c21_11360\|UniProtKB=A9TI55	Physcomitrella patens	O
PHYPA\|EnsemblGenome=Pp3c18_10120\|UniProtKB=A0A2K1J0K3	Physcomitrella patens	O
PHYPA\|EnsemblGenome=Pp3c22_12920\|UniProtKB=A0A2K1INA9	Physcomitrella patens	O
MARPO\|EnsemblGenome=MARPO_0049s0082\|UniProtKB=A0A2R6WY69	Marchantia polymorpha	O
KLENI\|Gene_ORFName=KFL_001690070\|UniProtKB=A0A1Y1I3E4	Klebsormidium nitens	O