PANTHER Gene Information

Gene Symbol(s):

UBE2L3

Organism:

Bos taurus

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Gene Name:

Ubiquitin-conjugating enzyme E2 L3

Gene ID:

ENSBTAG00000013038

Protein ID:

Q3MHP1

Persistent Id:

PTN001938126

Alternate Ids:

75947622(GI)	ENSBTAG00000013038(Ensembl)
767894(GeneID)	ENSBTAP00000017332(Ensembl_PRO)
NM_001078094(refSeq)	2.3.2.23(EC)
UB2L3_BOVIN(UniProtKB-ID)	Q1JPH3(AltAccession)
BC105164(EMBL)	ENSBTAT00000017332(Ensembl_TRS)
UB2L3(Synonym)	UBE2L3(Symbol)
AAI05165(EMBL-CDS)
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PANTHER Classification

PANTHER Family:	UBIQUITIN-CONJUGATING ENZYME E2 (PTHR24068)
PANTHER Subfamily:	UBIQUITIN-CONJUGATING ENZYME E2 L3 (PTHR24068:SF67)
PANTHER GO-slim Molecular Function:	ubiquitin conjugating enzyme activity ubiquitin protein ligase binding
PANTHER GO-slim Biological Process:	ubiquitin-dependent protein catabolic process protein K11-linked ubiquitination
PANTHER GO-slim Cellular Component:	nucleus ubiquitin ligase complex
PANTHER protein class:	ubiquitin-protein ligase

Pathway Categories:

Parkinson disease

ubiquitin-conjugating enzyme E2L3

Ubiquitin proteasome pathway

Ubiquitin-conjugating enzyme E2

GENE ONTOLOGY DATABASE ANNOTATIONS

Click to Expand...

GO MF Complete:	ubiquitin-protein transferase activity, ATP binding, ubiquitin conjugating enzyme activity, transcription coactivator activity
GO BP Complete:	cell population proliferation, cellular response to steroid hormone stimulus, protein K11-linked ubiquitination, positive regulation of DNA-templated transcription, protein polyubiquitination, cellular response to glucocorticoid stimulus, cell cycle phase transition, regulation of DNA-templated transcription, ubiquitin-dependent protein catabolic process, protein ubiquitination
GO CC Complete:	nucleus, cytoplasm

REACTOME DATABASE ANNOTATIONS Click to Expand...

Reactome Pathways:

Regulated Necrosis, Adaptive Immune System, Post-translational protein modification, Metabolism of proteins, Regulation of TNFR1 signaling, E3 ubiquitin ligases ubiquitinate target proteins, Immune System, TNF signaling, Signal Transduction, RIPK1-mediated regulated necrosis, Programmed Cell Death, Antigen processing: Ubiquitination & Proteasome degradation, Death Receptor Signaling, Class I MHC mediated antigen processing & presentation, Synthesis of active ubiquitin: roles of E1 and E2 enzymes, Regulation of necroptotic cell death, Protein ubiquitination

Orthologs

ID	Organism	Type
HUMAN\|HGNC=13477\|UniProtKB=A0A1B0GUS4	Homo sapiens	O
PANTR\|Ensembl=ENSPTRG00000050842.1\|UniProtKB=A0A2J8MLR7	Pan troglodytes	O
GORGO\|Ensembl=ENSGGOG00000006857.3\|UniProtKB=A0A2I2Z459	Gorilla gorilla gorilla	O
MACMU\|Ensembl=ENSMMUG00000008940.3\|UniProtKB=F7EVY1	Macaca mulatta	O
PANTR\|Ensembl=ENSPTRG00000043458.1\|UniProtKB=A0A2I3RRD2	Pan troglodytes	O
GORGO\|Ensembl=ENSGGOG00000042391.1\|UniProtKB=A0A2I2ZVM1	Gorilla gorilla gorilla	O
HUMAN\|HGNC=12488\|UniProtKB=P68036	Homo sapiens	LDO
PANTR\|Ensembl=ENSPTRG00000005754.5\|UniProtKB=H2Q7D5	Pan troglodytes	O
PANTR\|Ensembl=ENSPTRG00000014114.6\|UniProtKB=K7C140	Pan troglodytes	LDO
MACMU\|Ensembl=ENSMMUG00000061397.1\|UniProtKB=F6S052	Macaca mulatta	O
MACMU\|Ensembl=ENSMMUG00000045056.2\|UniProtKB=A0A1D5QFY2	Macaca mulatta	O
MACMU\|Ensembl=ENSMMUG00000018994.4\|UniProtKB=A0A1D5R4N3	Macaca mulatta	LDO
MOUSE\|MGI=MGI=109240\|UniProtKB=P68037	Mus musculus	LDO
RAT\|RGD=1308361\|UniProtKB=D3Z8W5	Rattus norvegicus	LDO
PIG\|Ensembl=ENSSSCG00000033372.2\|UniProtKB=A0A286ZPA7	Sus scrofa	O
PIG\|Ensembl=ENSSSCG00000037143.3\|UniProtKB=B8Y648	Sus scrofa	LDO
HORSE\|Ensembl=ENSECAG00000051124.1\|UniProtKB=A0A3Q2HSD4	Equus caballus	LDO
FELCA\|Ensembl=ENSFCAG00000008008.5\|UniProtKB=A0A337SGQ0	Felis catus	LDO
CANLF\|Ensembl=ENSCAFG00845029035.1\|UniProtKB=A0A8I3SC03	Canis lupus familiaris	O
CANLF\|Ensembl=ENSCAFG00845006985.1\|UniProtKB=A0A8I3N4L9	Canis lupus familiaris	O
CANLF\|Ensembl=ENSCAFG00845018467.1\|UniProtKB=A0A8I3PBI6	Canis lupus familiaris	O
CANLF\|Ensembl=ENSCAFG00845025758.1\|UniProtKB=A0A8I3PW29	Canis lupus familiaris	LDO
MONDO\|Ensembl=ENSMODG00000017665.4\|UniProtKB=A0A5F8GNU3	Monodelphis domestica	LDO
ORNAN\|Ensembl=ENSOANG00000008005.2\|UniProtKB=A0A6I8N864	Ornithorhynchus anatinus	LDO
CHICK\|Ensembl=ENSGALG00010024321.1\|UniProtKB=A0A8V0ZX13	Gallus gallus	LDO
ANOCA\|Ensembl=ENSACAG00000007191.3\|UniProtKB=G1KG86	Anolis carolinensis	O
ANOCA\|Ensembl=ENSACAG00000043983.1\|UniProtKB=A0A803SS63	Anolis carolinensis	LDO
XENLA\|Gene=ube2l3.L\|UniProtKB=Q4QR35	Xenopus laevis	LDO
XENTR\|Ensembl=ENSXETG00000036095\|UniProtKB=A0A6I8RJD4	Xenopus tropicalis	LDO
ORYLA\|Ensembl=ENSORLG00000000771.2\|UniProtKB=H2L582	Oryzias latipes	O
ORYLA\|Ensembl=ENSORLG00000017349.2\|UniProtKB=H2MSF7	Oryzias latipes	LDO
DANRE\|ZFIN=ZDB-GENE-030131-2977\|UniProtKB=Q6IQK2	Danio rerio	O
DANRE\|ZFIN=ZDB-GENE-030131-662\|UniProtKB=A2BIR4	Danio rerio	LDO
LEPOC\|Ensembl=ENSLOCG00000002117.1\|UniProtKB=W5M253	lepisosteus oculatus	LDO
CIOIN\|Ensembl=ENSCING00000013961.2\|UniProtKB=F6RN78	Ciona intestinalis	LDO
BRAFL\|Gene=LOC118426622\|UniProtKB=A0A9J7N577	Branchiostoma floridae	LDO
CAEEL\|WormBase=WBGene00006713\|UniProtKB=Q21633	Caenorhabditis elegans	LDO
CAEBR\|WormBase=WBGene00036426\|UniProtKB=A8XPD5	Caenorhabditis briggsae	LDO
PRIPA\|EnsemblGenome=WBGene00104954\|UniProtKB=A0A454Y0I1	Pristionchus pacificus	LDO
DROME\|FlyBase=FBgn0017456\|UniProtKB=P52487	Drosophila melanogaster	O
DROME\|FlyBase=FBgn0035584\|UniProtKB=Q9VZ73	Drosophila melanogaster	O
DROME\|FlyBase=FBgn0026316\|UniProtKB=Q7K738	Drosophila melanogaster	LDO
ANOGA\|EnsemblGenome=AGAP001056\|UniProtKB=Q7QDD7	Anopheles gambiae	LDO
TRICA\|EnsemblGenome=TC015328\|UniProtKB=D2A4Q0	Tribolium castaneum	LDO
DAPPU\|EnsemblGenome=DAPPUDRAFT_56112\|UniProtKB=E9GYI0	Daphnia pulex	LDO
HELRO\|EnsemblGenome=HelroG186164\|UniProtKB=T1FNR2	helobdella robusta	LDO
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g235862\|UniProtKB=A7SRR4	Nematostella vectensis	LDO
TRIAD\|EnsemblGenome=TriadG19187\|UniProtKB=B3RJL4	Trichoplax adhaerens	LDO
MONBE\|EnsemblGenome=MONBRDRAFT_3366\|UniProtKB=A9UT34	Monosiga brevicollis	O
MONBE\|EnsemblGenome=MONBRDRAFT_3345\|UniProtKB=A9UQH7	Monosiga brevicollis	LDO
BATDJ\|Gene_ORFName=BATDEDRAFT_9165\|UniProtKB=F4NU25	Batrachochytrium dendrobatidis	LDO
ENTH1\|EnsemblGenome=CL6EHI_070750\|UniProtKB=C4M5T2	Entamoeba histolytica	O
DICDI\|dictyBase=DDB_G0284865\|UniProtKB=Q94490	Dictyostelium discoideum	O
DICPU\|EnsemblGenome=DICPUDRAFT_48481\|UniProtKB=F0ZPB2	Dictyostelium purpureum	O
DICDI\|dictyBase=DDB_G0290547\|UniProtKB=Q54FX4	Dictyostelium discoideum	O
LEIMA\|EnsemblGenome=LMJF_35_1300\|UniProtKB=Q9GNC1	Leishmania major	O
TRYB2\|Gene_ORFName=Tb927.5.1000\|UniProtKB=Q57W45	Trypanosoma brucei	O
GIAIC\|Gene_ORFName=GL50803_0015252\|UniProtKB=A0A644F7I8	Giardia intestinalis	O
TRIV3\|Gene_ORFName=TVAG_191220\|UniProtKB=A2EFK5	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_043860\|UniProtKB=A2E0E6	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_153580\|UniProtKB=A2EPR3	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_467860\|UniProtKB=A2E0M6	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_257610\|UniProtKB=A2F4E2	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_076890\|UniProtKB=A2D9T6	Trichomonas vaginalis	O
PLAF7\|EnsemblGenome=PF3D7_1203900\|UniProtKB=Q8I607	Plasmodium falciparum	O
PARTE\|EnsemblGenome=GSPATT00013520001\|UniProtKB=A0D4V6	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00004931001\|UniProtKB=A0BJ41	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00000658001\|UniProtKB=A0BUC8	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00039052001\|UniProtKB=A0CVS4	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00038076001\|UniProtKB=A0CFR8	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00007512001\|UniProtKB=A0CH05	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00006096001\|UniProtKB=A0C0C6	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00002619001\|UniProtKB=A0DQA2	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00012058001\|UniProtKB=A0D0D9	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00003257001\|UniProtKB=A0DZ21	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00031081001\|UniProtKB=A0BQN5	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00013765001\|UniProtKB=A0D5L8	Paramecium tetraurelia	O
THAPS\|EnsemblGenome=THAPSDRAFT_22432\|UniProtKB=B8C0C0	Thalassiosira pseudonana	O
PHYRM\|Gene=H3G8P2_PHYRM\|UniProtKB=H3G8P2	Phytophthora ramorum	O
PHYRM\|Gene=H3HAQ5_PHYRM\|UniProtKB=H3HAQ5	Phytophthora ramorum	O
CHLRE\|EnsemblGenome=CHLRE_16g693700v5\|UniProtKB=A8JBJ3	Chlamydomonas reinhardtii	O
AMBTC\|EnsemblGenome=AMTR_s00089p00096280\|UniProtKB=W1P1R2	Amborella trichopoda	O
ZOSMR\|Gene_ORFName=ZOSMA_53G00060\|UniProtKB=A0A0K9NWT1	Zostera marina	O
MUSAM\|EnsemblGenome=Ma01_g09760\|UniProtKB=A0A804HS88	Musa acuminata subsp. malaccensis	O
MUSAM\|EnsemblGenome=Ma09_g28520\|UniProtKB=A0A804KPP2	Musa acuminata subsp. malaccensis	O
MUSAM\|EnsemblGenome=Ma09_g12320\|UniProtKB=A0A804KIS4	Musa acuminata subsp. malaccensis	O
MUSAM\|EnsemblGenome=Ma03_g11680\|UniProtKB=A0A804IB03	Musa acuminata subsp. malaccensis	O
MUSAM\|EnsemblGenome=Ma09_g28520\|UniProtKB=A0A804KPP2	Musa acuminata subsp. malaccensis	O
SETIT\|EnsemblGenome=SETIT_031414mg\|UniProtKB=K3ZXT2	Setaria italica	O
SORBI\|EnsemblGenome=SORBI_3002G155500\|UniProtKB=C5X897	Sorghum bicolor	O
MAIZE\|EnsemblGenome=Zm00001eb309020\|UniProtKB=B4FCQ9	Zea mays	O
SETIT\|EnsemblGenome=SETIT_019237mg\|UniProtKB=K3YY87	Setaria italica	O
MAIZE\|EnsemblGenome=Zm00001eb097550\|UniProtKB=B6U4K0	Zea mays	O
ORYSJ\|EnsemblGenome=Os09g0293400\|UniProtKB=Q69JN7	Oryza sativa	O
BRADI\|EnsemblGenome=BRADI_4g27430v3\|UniProtKB=I1IP59	Brachypodium distachyon	O
HORVV\|EnsemblGenome=HORVU.MOREX.r3.5HG0471520\|UniProtKB=A0A8I6XP97	Hordeum vulgare subsp. vulgare	O
WHEAT\|EnsemblGenome=TraesCS5D02G181400\|UniProtKB=A0A3B6MQQ7	Triticum aestivum	O
WHEAT\|EnsemblGenome=TraesCS5B02G174300\|UniProtKB=A0A3B6LL01	Triticum aestivum	O
WHEAT\|EnsemblGenome=TraesCS5A02G177100\|UniProtKB=A0A3B6KHB9	Triticum aestivum	O
NELNU\|Gene_ORFName=HUJ06_025412\|UniProtKB=A0A1U7Z3R7	Nelumbo nucifera	O
NELNU\|Gene=LOC104609421\|UniProtKB=A0A1U8B034	Nelumbo nucifera	O
PRUPE\|EnsemblGenome=PRUPE_1G008300\|UniProtKB=A0A251QRV4	Prunus persica	O
NELNU\|Gene=LOC104594343\|UniProtKB=A0A1U7ZWL5	Nelumbo nucifera	O
TOBAC\|Gene=LOC107788577\|UniProtKB=A0A1S3ZMY8	Nicotiana tabacum	O
EUCGR\|EnsemblGenome=EUGRSUZ_E04235\|UniProtKB=A0A059CB82	Eucalyptus grandis	O
THECC\|EnsemblGenome=TCM_034533\|UniProtKB=A0A061FFI9	Theobroma cacao	O
POPTR\|Gene_ORFName=POPTR_017G055300\|UniProtKB=A0A3N7G574	Populus trichocarpa	O
RICCO\|Gene_ORFName=RCOM_1019510\|UniProtKB=B9RWH5	Ricinus communis	O
PRUPE\|EnsemblGenome=PRUPE_4G150600\|UniProtKB=M5X5F5	Prunus persica	O
SELML\|EnsemblGenome=SELMODRAFT_187468\|UniProtKB=D8SFW4	Selaginella moellendorffii	O
MARPO\|EnsemblGenome=MARPO_0140s0024\|UniProtKB=A0A2R6W6L2	Marchantia polymorpha	O