PANTHER Gene Information

Gene Symbol(s):

PSEN2

Organism:

Bos taurus

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Tree

Gene Name:

Presenilin-2

Gene ID:

ENSBTAG00000013197

Protein ID:

Q9XT96

Persistent Id:

PTN007426068

Alternate Ids:

PSN2_BOVIN(UniProtKB-ID)	Q2KI10(AltAccession)
3.4.23.-(EC)	XP_010811415(refSeq)
ENSBTAG00000013197(Ensembl)	741953830(GI)
AF038937(EMBL)	AAI12812(EMBL-CDS)
PSEN2(Symbol)	ENSBTAT00000072821(Ensembl_TRS)
ENSBTAP00000017565(Ensembl_PRO)	PSN2(Synonym)
282010(GeneID)
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PANTHER Classification

PANTHER Family:	PRESENILIN (PTHR10202)
PANTHER Subfamily:	PRESENILIN-2 (PTHR10202:SF24)
PANTHER GO-slim Molecular Function:	aspartic-type endopeptidase activity
PANTHER GO-slim Biological Process:	membrane protein ectodomain proteolysis peptide metabolic process Notch signaling pathway protein processing calcium ion homeostasis
PANTHER GO-slim Cellular Component:	catalytic complex plasma membrane protein complex
PANTHER protein class:	aspartic protease

Pathway Categories:

Notch signaling pathway

Presenilin enhancer 2

Alzheimer disease-presenilin pathway

Presenilin

Alzheimer disease-amyloid secretase pathway

Presenilin

Alzheimer disease-presenilin pathway

Presenilin N-terminal fragment

Alzheimer disease-amyloid secretase pathway

Presenilin C-terminal fragment

Alzheimer disease-amyloid secretase pathway

Presenilin N-terminal fragment

Alzheimer disease-presenilin pathway

Presenilin C-terminal fragment

GENE ONTOLOGY DATABASE ANNOTATIONS

Click to Expand...

GO MF Complete:	aspartic endopeptidase activity, intramembrane cleaving
GO BP Complete:	Notch signaling pathway, calcium ion homeostasis, membrane protein ectodomain proteolysis, mitochondrion-endoplasmic reticulum membrane tethering, protein processing, intracellular signal transduction, regulation of calcium import into the mitochondrion, amyloid-beta formation
GO CC Complete:	endoplasmic reticulum membrane, nuclear inner membrane, centrosome, gamma-secretase complex, Golgi membrane, kinetochore

REACTOME DATABASE ANNOTATIONS Click to Expand...

Reactome Pathways:

Axon guidance, EPH-ephrin mediated repulsion of cells, NRIF signals cell death from the nucleus, Signaling by Receptor Tyrosine Kinases, Regulated proteolysis of p75NTR, Cell death signalling via NRAGE, NRIF and NADE, Signal Transduction, Death Receptor Signaling, Developmental Biology, p75 NTR receptor-mediated signalling, Signaling by ERBB4, Nervous system development, Nuclear signaling by ERBB4, EPH-Ephrin signaling

Orthologs

ID	Organism	Type
HUMAN\|HGNC=9509\|UniProtKB=P49810	Homo sapiens	LDO
PANTR\|Ensembl=ENSPTRG00000002052.7\|UniProtKB=A0A2I3SHN4	Pan troglodytes	LDO
GORGO\|Ensembl=ENSGGOG00000003332.3\|UniProtKB=G3SCU1	Gorilla gorilla gorilla	LDO
MACMU\|Ensembl=ENSMMUG00000018525.4\|UniProtKB=F7A2D1	Macaca mulatta	LDO
MOUSE\|MGI=MGI=109284\|UniProtKB=Q61144	Mus musculus	LDO
RAT\|RGD=621060\|UniProtKB=O88777	Rattus norvegicus	LDO
PIG\|Ensembl=ENSSSCG00005010874\|UniProtKB=Q0MS45	Sus scrofa	LDO
HORSE\|Ensembl=ENSECAG00000008285.4\|UniProtKB=F6WAW1	Equus caballus	LDO
FELCA\|Ensembl=ENSFCAG00000008781.5\|UniProtKB=A0A337SFA1	Felis catus	LDO
CANLF\|Ensembl=ENSCAFG00845008023.1\|UniProtKB=A0A8I3N5I6	Canis lupus familiaris	LDO
MONDO\|Ensembl=ENSMODG00000006114.4\|UniProtKB=A0A5F8GDB4	Monodelphis domestica	LDO
ORNAN\|Ensembl=ENSOANG00000010238.4\|UniProtKB=F7AD40	Ornithorhynchus anatinus	LDO
CHICK\|Gene=PSEN2\|UniProtKB=Q90X07	Gallus gallus	O
CHICK\|Ensembl=ENSGALG00010018045.1\|UniProtKB=A0A8V0Z5X8	Gallus gallus	LDO
ANOCA\|Ensembl=ENSACAG00000006455.4\|UniProtKB=G1KFF8	Anolis carolinensis	LDO
XENLA\|Gene=psen2\|UniProtKB=O12977	Xenopus laevis	LDO
XENLA\|Gene=psen2.L\|UniProtKB=A0A1L8G7M0	Xenopus laevis	O
XENLA\|Gene=psen2.S\|UniProtKB=A0A8J0VE80	Xenopus laevis	LDO
XENTR\|Xenbase=XB-GENE-854877\|UniProtKB=F7C949	Xenopus tropicalis	LDO
ORYLA\|Ensembl=ENSORLG00000020169.2\|UniProtKB=H2N0U7	Oryzias latipes	LDO
DANRE\|ZFIN=ZDB-GENE-000330-9\|UniProtKB=Q90ZE4	Danio rerio	LDO
LEPOC\|Ensembl=ENSLOCG00000015948.1\|UniProtKB=W5NG78	lepisosteus oculatus	LDO
CIOIN\|Ensembl=ENSCING00000002361.3\|UniProtKB=F6RA92	Ciona intestinalis	LDO
BRAFL\|Gene=LOC118418980\|UniProtKB=A0A9J7MWD5	Branchiostoma floridae	LDO
STRPU\|EnsemblGenome=LOC578066\|UniProtKB=A0A7M7T5N2	Strongylocentrotus purpuratus	LDO
CAEEL\|WormBase=WBGene00004958\|UniProtKB=Q01608	Caenorhabditis elegans	O
CAEBR\|WormBase=WBGene00032967\|UniProtKB=G2J6Q7	Caenorhabditis briggsae	O
PRIPA\|EnsemblGenome=WBGene00278263\|UniProtKB=A0A2A6BII2	Pristionchus pacificus	O
PRIPA\|EnsemblGenome=WBGene00115594\|UniProtKB=A0A2A6BL51	Pristionchus pacificus	O
CAEEL\|WormBase=WBGene00001985\|UniProtKB=O02100	Caenorhabditis elegans	O
CAEBR\|WormBase=WBGene00033101\|UniProtKB=A8XEJ8	Caenorhabditis briggsae	O
CAEEL\|WormBase=WBGene00004769\|UniProtKB=P52166	Caenorhabditis elegans	LDO
CAEBR\|WormBase=WBGene00029955\|UniProtKB=A8X5S7	Caenorhabditis briggsae	LDO
PRIPA\|EnsemblGenome=WBGene00276783\|UniProtKB=A0A454XXP0	Pristionchus pacificus	LDO
DROME\|FlyBase=FBgn0284421\|UniProtKB=O02194	Drosophila melanogaster	LDO
ANOGA\|EnsemblGenome=AGAP002957\|UniProtKB=Q7PR98	Anopheles gambiae	LDO
TRICA\|EnsemblGenome=TC010178\|UniProtKB=D6WT91	Tribolium castaneum	LDO
DAPPU\|EnsemblGenome=DAPPUDRAFT_205191\|UniProtKB=E9FSB0	Daphnia pulex	LDO
IXOSC\|EnsemblGenome=ISCW003378\|UniProtKB=B7P928	Ixodes scapularis	O
IXOSC\|EnsemblGenome=ISCW022390\|UniProtKB=B7QGI2	Ixodes scapularis	O
IXOSC\|EnsemblGenome=ISCW020583\|UniProtKB=B7Q2V0	Ixodes scapularis	LDO
HELRO\|EnsemblGenome=HelroG87358\|UniProtKB=T1G6P3	helobdella robusta	O
HELRO\|EnsemblGenome=HelroG114139\|UniProtKB=T1EFZ6	helobdella robusta	LDO
TRIAD\|EnsemblGenome=TriadG57183\|UniProtKB=B3S0V5	Trichoplax adhaerens	LDO
MONBE\|EnsemblGenome=MONBRDRAFT_29512\|UniProtKB=A9VBA9	Monosiga brevicollis	LDO
ENTH1\|EnsemblGenome=CL6EHI_188280\|UniProtKB=C4M1A2	Entamoeba histolytica	LDO
DICDI\|dictyBase=DDB_G0291352\|UniProtKB=Q54ET2	Dictyostelium discoideum	O
DICPU\|EnsemblGenome=DICPUDRAFT_87693\|UniProtKB=F0ZJS7	Dictyostelium purpureum	O
DICDI\|dictyBase=DDB_G0292310\|UniProtKB=Q54DE8	Dictyostelium discoideum	LDO
DICPU\|EnsemblGenome=DICPUDRAFT_51947\|UniProtKB=F1A6B3	Dictyostelium purpureum	LDO
LEIMA\|EnsemblGenome=LMJF_15_1530\|UniProtKB=Q4QF26	Leishmania major	LDO
TRYB2\|Gene_ORFName=Tb09.160.3510\|UniProtKB=Q38F54	Trypanosoma brucei	LDO
TRIV3\|Gene_ORFName=TVAG_026700\|UniProtKB=A2DZ73	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_428310\|UniProtKB=A2G9L8	Trichomonas vaginalis	LDO
TRIV3\|Gene_ORFName=TVAG_412920\|UniProtKB=A2F6H8	Trichomonas vaginalis	O
THAPS\|EnsemblGenome=THAPSDRAFT_261548\|UniProtKB=B8BVL0	Thalassiosira pseudonana	O
THAPS\|EnsemblGenome=THAPSDRAFT_268976\|UniProtKB=B8C3Y7	Thalassiosira pseudonana	LDO
PHYRM\|Gene=H3GSQ0_PHYRM\|UniProtKB=H3GSQ0	Phytophthora ramorum	O
PHYRM\|Gene=H3GE34_PHYRM\|UniProtKB=H3GE34	Phytophthora ramorum	LDO
CHLRE\|EnsemblGenome=CHLRE_02g078858v5\|UniProtKB=A0A2K3E0E4	Chlamydomonas reinhardtii	LDO
AMBTC\|EnsemblGenome=AMTR_s00119p00061920\|UniProtKB=W1NQ31	Amborella trichopoda	O
ZOSMR\|Gene_ORFName=ZOSMA_74G00250\|UniProtKB=A0A0K9NPJ2	Zostera marina	O
MUSAM\|EnsemblGenome=Ma05_g07460\|UniProtKB=A0A804J1Y4	Musa acuminata subsp. malaccensis	O
SETIT\|EnsemblGenome=SETIT_001249mg\|UniProtKB=K3XH78	Setaria italica	O
SORBI\|EnsemblGenome=SORBI_3003G130500\|UniProtKB=C5XH90	Sorghum bicolor	O
MAIZE\|EnsemblGenome=Zm00001eb128860\|UniProtKB=A0A804N249	Zea mays	O
MAIZE\|EnsemblGenome=Zm00001eb332720\|UniProtKB=B6TCG9	Zea mays	O
ORYSJ\|EnsemblGenome=Os01g0276400\|UniProtKB=A0A0P0V1R2	Oryza sativa	O
BRADI\|EnsemblGenome=BRADI_2g10480v3\|UniProtKB=A0A0Q3ITY7	Brachypodium distachyon	O
HORVV\|EnsemblGenome=HORVU.MOREX.r3.3HG0257130\|UniProtKB=F2CQD9	Hordeum vulgare subsp. vulgare	O
WHEAT\|EnsemblGenome=TraesCS3A02G189100\|UniProtKB=A0A3B6EFK6	Triticum aestivum	O
WHEAT\|EnsemblGenome=TraesCS3B02G218100\|UniProtKB=A0A3B6FLQ8	Triticum aestivum	O
WHEAT\|EnsemblGenome=TraesCS3D02G192400\|UniProtKB=A0A3B6GUU3	Triticum aestivum	O
NELNU\|Gene_ORFName=HUJ06_030740\|UniProtKB=A0A1U7ZEC8	Nelumbo nucifera	O
SPIOL\|Gene=LOC110795153\|UniProtKB=A0A9R0IX21	Spinacia oleracea	O
HELAN\|EnsemblGenome=HanXRQr2_Chr06g0259241\|UniProtKB=A0A251UI93	Helianthus annuus	O
LACSA\|Gene_ORFName=LSAT_V11C800422800\|UniProtKB=A0A9R1UPM9	Lactuca sativa	O
ERYGU\|Gene_ORFName=MIMGU_mgv1a006808mg\|UniProtKB=A0A022R9S5	Erythranthe guttata	O
SOLTU\|EnsemblGenome=PGSC0003DMG400028205\|UniProtKB=M1CQE1	Solanum tuberosum	O
SOLLC\|EnsemblGenome=Solyc10g081230.2\|UniProtKB=A0A3Q7IL79	Solanum lycopersicum	O
TOBAC\|Gene=LOC107765978\|UniProtKB=A0A1S3XK05	Nicotiana tabacum	O
TOBAC\|Gene=LOC107802357\|UniProtKB=A0A1S4AXB7	Nicotiana tabacum	O
VITVI\|EnsemblGenome=Vitvi08g00072\|UniProtKB=F6HMV3	Vitis vinifera	O
EUCGR\|EnsemblGenome=EUGRSUZ_K01546\|UniProtKB=A0A059A286	Eucalyptus grandis	O
BRACM\|EnsemblGenome=Bra018606\|UniProtKB=M4DQ15	Brassica campestris	O
ARATH\|TAIR=locus=2025640\|UniProtKB=O64668	Arabidopsis thaliana	O
GOSHI\|Gene=LOC107890049\|UniProtKB=A0A1U8I1H6	Gossypium hirsutum	O
GOSHI\|Gene=LOC107948937\|UniProtKB=A0A1U8NMF4	Gossypium hirsutum	O
THECC\|EnsemblGenome=TCM_025793\|UniProtKB=A0A061F038	Theobroma cacao	O
CITSI\|Gene_ORFName=CISIN_1g013051mg\|UniProtKB=A0A067E5X1	Citrus sinensis	O
POPTR\|EnsemblGenome=POPTR_013G067700v3\|UniProtKB=A0A2K1Y252	Populus trichocarpa	O
MANES\|EnsemblGenome=MANES_08G150800\|UniProtKB=A0A2C9VGG5	Manihot esculenta	O
MANES\|EnsemblGenome=MANES_09G135600\|UniProtKB=A0A2C9VC94	Manihot esculenta	O
RICCO\|Gene_ORFName=RCOM_0845230\|UniProtKB=B9SY83	Ricinus communis	O
SOYBN\|EnsemblGenome=GLYMA_19G119800\|UniProtKB=I1N8G3	Glycine max	O
SOYBN\|EnsemblGenome=GLYMA_03G006300\|UniProtKB=I1JK51	Glycine max	O
MEDTR\|EnsemblGenome=MTR_7g087200\|UniProtKB=G7L2M4	Medicago truncatula	O
JUGRE\|EnsemblGenome=Jr03_20120\|UniProtKB=A0A2I4GFG6	Juglans regia	O
CUCSA\|EnsemblGenome=Csa_4G417500\|UniProtKB=A0A0A0L3E5	Cucumis sativus	O
PRUPE\|EnsemblGenome=PRUPE_5G048300\|UniProtKB=M5WAI2	Prunus persica	O
AMBTC\|EnsemblGenome=AMTR_s00154p00031240\|UniProtKB=W1PC62	Amborella trichopoda	LDO
ZOSMR\|Gene_ORFName=ZOSMA_50G00620\|UniProtKB=A0A0K9P098	Zostera marina	LDO
MUSAM\|EnsemblGenome=Ma04_g29950\|UniProtKB=A0A804IVI3	Musa acuminata subsp. malaccensis	LDO
SETIT\|EnsemblGenome=SETIT_035617mg\|UniProtKB=K4A9R1	Setaria italica	LDO
SORBI\|EnsemblGenome=SORBI_3001G171500\|UniProtKB=A0A1B6QJF6	Sorghum bicolor	LDO
MAIZE\|EnsemblGenome=Zm00001eb219250\|UniProtKB=A0A1D6GLV1	Zea mays	LDO
ORYSJ\|EnsemblGenome=Os03g0603800\|UniProtKB=C7J054	Oryza sativa	LDO
BRADI\|EnsemblGenome=BRADI_1g14960v3\|UniProtKB=A0A0Q3RMS2	Brachypodium distachyon	LDO
HORVV\|EnsemblGenome=HORVU.MOREX.r3.4HG0342160\|UniProtKB=F2EGF7	Hordeum vulgare subsp. vulgare	LDO
WHEAT\|EnsemblGenome=TraesCS4D02G075300\|UniProtKB=A0A3B6JDQ4	Triticum aestivum	O
WHEAT\|EnsemblGenome=TraesCS4A02G238100\|UniProtKB=A0A3B6HYQ3	Triticum aestivum	LDO
WHEAT\|EnsemblGenome=TraesCS4B02G076800\|UniProtKB=A0A3B6IKZ6	Triticum aestivum	LDO
NELNU\|Gene_ORFName=HUJ06_005686\|UniProtKB=A0A1U8A559	Nelumbo nucifera	LDO
SPIOL\|Gene=LOC110795635\|UniProtKB=A0A9R0K3L9	Spinacia oleracea	LDO
HELAN\|EnsemblGenome=HanXRQr2_Chr09g0408231\|UniProtKB=A0A251U0K1	Helianthus annuus	LDO
LACSA\|Gene_ORFName=LSAT_V11C400200950\|UniProtKB=A0A9R1VSY6	Lactuca sativa	LDO
ERYGU\|Gene_ORFName=MIMGU_mgv1a026313mg\|UniProtKB=A0A022RMU2	Erythranthe guttata	LDO
CAPAN\|EnsemblGenome=T459_10444\|UniProtKB=A0A2G3A286	Capsicum annuum	O
CAPAN\|EnsemblGenome=T459_10442\|UniProtKB=A0A2G3A294	Capsicum annuum	LDO
SOLTU\|EnsemblGenome=PGSC0003DMG400024636\|UniProtKB=M1CAI2	Solanum tuberosum	LDO
SOLLC\|EnsemblGenome=Solyc03g115075.1\|UniProtKB=A0A3Q7FSU6	Solanum lycopersicum	LDO
TOBAC\|Gene=LOC107823683\|UniProtKB=A0A1S4CXH8	Nicotiana tabacum	O
TOBAC\|Gene=LOC107790304\|UniProtKB=A0A1S3ZTL3	Nicotiana tabacum	LDO
VITVI\|EnsemblGenome=Vitvi17g00712\|UniProtKB=F6GSZ0	Vitis vinifera	LDO
BRANA\|Gene_ORFName=DARMORV10_C04P20920.1\|UniProtKB=A0A078JFQ8	Brassica napus	O
BRANA\|Gene_ORFName=DARMORV10_A05P15530.1\|UniProtKB=A0A078J4P4	Brassica napus	LDO
BRACM\|EnsemblGenome=Bra018354\|UniProtKB=M4DPB3	Brassica campestris	LDO
ARATH\|TAIR=locus=2052080\|UniProtKB=Q9SIK7	Arabidopsis thaliana	LDO
GOSHI\|Gene=LOC107941447\|UniProtKB=A0A1U8MY34	Gossypium hirsutum	O
GOSHI\|Gene=LOC107953480\|UniProtKB=A0A1U8P253	Gossypium hirsutum	LDO
THECC\|EnsemblGenome=TCM_014267\|UniProtKB=A0A061FYV6	Theobroma cacao	LDO
CITSI\|Gene_ORFName=CISIN_1g013935mg\|UniProtKB=A0A067FHZ3	Citrus sinensis	LDO
MANES\|EnsemblGenome=MANES_06G084500\|UniProtKB=A0A2C9VP23	Manihot esculenta	LDO
RICCO\|Gene_ORFName=RCOM_1469710\|UniProtKB=B9RLN5	Ricinus communis	LDO
SOYBN\|EnsemblGenome=GLYMA_05G020800\|UniProtKB=I1JZI3	Glycine max	O
SOYBN\|EnsemblGenome=GLYMA_17G078500\|UniProtKB=I1MT67	Glycine max	LDO
MEDTR\|EnsemblGenome=MTR_4g109550\|UniProtKB=A0A072UQB9	Medicago truncatula	LDO
JUGRE\|EnsemblGenome=Jr02_07000\|UniProtKB=A0A2I4EZP0	Juglans regia	LDO
CUCSA\|EnsemblGenome=Csa_1G039210\|UniProtKB=A0A0A0LQ93	Cucumis sativus	LDO
PRUPE\|EnsemblGenome=PRUPE_5G205400\|UniProtKB=M5W9E2	Prunus persica	LDO
SELML\|EnsemblGenome=SELMODRAFT_55385\|UniProtKB=D8RGP0	Selaginella moellendorffii	LDO
PHYPA\|EnsemblGenome=Pp3c3_30410\|UniProtKB=A9S846	Physcomitrella patens	LDO
MARPO\|EnsemblGenome=MARPO_0001s0218\|UniProtKB=A0A2R6XVP7	Marchantia polymorpha	LDO
KLENI\|Gene_ORFName=KFL_003960070\|UniProtKB=A0A1Y1IH42	Klebsormidium nitens	LDO