PANTHER Gene Information

Gene Symbol(s):

ISG15

Organism:

Bos taurus

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Tree

Gene Name:

Ubiquitin-like protein ISG15

Gene ID:

ENSBTAG00000014707

Protein ID:

O02741

Persistent Id:

PTN000071957

Alternate Ids:

NP_776791(refSeq)	UCRP(Synonym)
ISG15_BOVIN(UniProtKB-ID)	Q3T0N6(AltAccession)
ENSBTAP00000019573(Ensembl_PRO)	281871(GeneID)
74354945(GI)	U96014(EMBL)
ISG15(Symbol)	AAD56716(EMBL-CDS)
ENSBTAT00000019573(Ensembl_TRS)	ENSBTAG00000014707(Ensembl)
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PANTHER Classification

PANTHER Family:	UBIQUITIN (PTHR10666)
PANTHER Subfamily:	UBIQUITIN-LIKE PROTEIN ISG15 (PTHR10666:SF267)
PANTHER GO-slim Molecular Function:	ubiquitin protein ligase binding
PANTHER GO-slim Biological Process:	modification-dependent protein catabolic process protein ubiquitination
PANTHER GO-slim Cellular Component:	nucleus cytoplasm
PANTHER protein class:

Pathway Categories:

No pathway information available

GENE ONTOLOGY DATABASE ANNOTATIONS

Click to Expand...

GO MF Complete:	ubiquitin protein ligase binding, integrin binding, protein tag activity
GO BP Complete:	positive regulation of protein oligomerization, ISG15-protein conjugation, response to type I interferon, negative regulation of type I interferon-mediated signaling pathway, defense response to bacterium, positive regulation of erythrocyte differentiation, regulation of type II interferon production, integrin-mediated signaling pathway, protein localization to mitochondrion, positive regulation of interferon-beta production, positive regulation of type II interferon production, defense response to virus, negative regulation of protein ubiquitination, positive regulation of interleukin-10 production, modification-dependent protein catabolic process, negative regulation of viral genome replication, positive regulation of bone mineralization
GO CC Complete:	nucleus, cytoplasm, extracellular region

REACTOME DATABASE ANNOTATIONS Click to Expand...

Reactome Pathways:

Interferon Signaling, Cytokine Signaling in Immune system, Negative regulators of DDX58/IFIH1 signaling, Immune System, Innate Immune System, Antiviral mechanism by IFN-stimulated genes, DNA Repair, DNA Damage Bypass, Termination of translesion DNA synthesis, DDX58/IFIH1-mediated induction of interferon-alpha/beta, Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template, ISG15 antiviral mechanism, PKR-mediated signaling

Orthologs

ID	Organism	Type
HUMAN\|HGNC=4053\|UniProtKB=P05161	Homo sapiens	LDO
PANTR\|Ensembl=ENSPTRG00000039924.2\|UniProtKB=H2RH79	Pan troglodytes	LDO
PANTR\|Ensembl=ENSPTRG00000023135.3\|UniProtKB=H2R4D4	Pan troglodytes	LDO
GORGO\|Ensembl=ENSGGOG00000014967.3\|UniProtKB=G3RG63	Gorilla gorilla gorilla	LDO
MACMU\|Ensembl=ENSMMUG00000050757.1\|UniProtKB=A0A1D5QQL5	Macaca mulatta	LDO
MOUSE\|MGI=MGI=1855694\|UniProtKB=Q64339	Mus musculus	LDO
RAT\|RGD=1310312\|UniProtKB=D4A3X3	Rattus norvegicus	LDO
PIG\|Ensembl=ENSSSCG00005010676.1\|UniProtKB=A0A287AB58	Sus scrofa	LDO
HORSE\|Ensembl=ENSECAG00000059003.1\|UniProtKB=A0A9L0QZV7	Equus caballus	LDO
FELCA\|Ensembl=ENSFCAG00000032098.3\|UniProtKB=A0A2I2UUQ0	Felis catus	LDO
CANLF\|Ensembl=ENSCAFG00845020316.1\|UniProtKB=A0A8I3P342	Canis lupus familiaris	LDO
MONDO\|Ensembl=ENSMODG00000022596.3\|UniProtKB=H9H875	Monodelphis domestica	LDO
ORNAN\|Ensembl=ENSOANG00000036592.1\|UniProtKB=A0A6I8NFQ8	Ornithorhynchus anatinus	LDO
ANOCA\|Ensembl=ENSACAG00000010190.3\|UniProtKB=H9GQN0	Anolis carolinensis	O
ORYLA\|Ensembl=ENSORLG00000001204.2\|UniProtKB=H2L6N3	Oryzias latipes	O
STRPU\|EnsemblGenome=LOC115922115\|UniProtKB=A0A7M7NFU7	Strongylocentrotus purpuratus	O
STRPU\|EnsemblGenome=LOC105437947\|UniProtKB=A0A7M7HCP4	Strongylocentrotus purpuratus	O
CAEEL\|WormBase=WBGene00015853\|UniProtKB=P91055	Caenorhabditis elegans	O
CAEEL\|WormBase=WBGene00015842\|UniProtKB=P91057	Caenorhabditis elegans	O
CAEEL\|WormBase=WBGene00015852\|UniProtKB=P91053	Caenorhabditis elegans	O
CAEEL\|WormBase=WBGene00018659\|UniProtKB=O44821	Caenorhabditis elegans	O
IXOSC\|EnsemblGenome=ISCW020697\|UniProtKB=Q4PM08	Ixodes scapularis	O
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g231164\|UniProtKB=A7SYF9	Nematostella vectensis	O
SCLS1\|Gene_ORFName=SS1G_11945\|UniProtKB=A7F3U9	Sclerotinia sclerotiorum	O
PUCGT\|EnsemblGenome=PGTG_08310\|UniProtKB=E3KDZ2	Puccinia graminis	O
BATDJ\|Gene_ORFName=BATDEDRAFT_7706\|UniProtKB=F4NSL7	Batrachochytrium dendrobatidis	O
DICDI\|dictyBase=DDB_G0281703\|UniProtKB=Q54TK0	Dictyostelium discoideum	O
DICDI\|dictyBase=DDB_G0282441\|UniProtKB=Q54SI8	Dictyostelium discoideum	O
DICDI\|dictyBase=DDB_G0286927\|UniProtKB=Q54L35	Dictyostelium discoideum	O
DICPU\|EnsemblGenome=DICPUDRAFT_76703\|UniProtKB=F0ZED6	Dictyostelium purpureum	O
DICPU\|EnsemblGenome=DICPUDRAFT_151658\|UniProtKB=F0ZJF1	Dictyostelium purpureum	O
TRIV3\|Gene_ORFName=TVAG_113620\|UniProtKB=A2DNL5	Trichomonas vaginalis	O
PARTE\|EnsemblGenome=GSPATT00018051001\|UniProtKB=A0DL17	Paramecium tetraurelia	O
PHYRM\|Gene=H3G5H7_PHYRM\|UniProtKB=H3G5H7	Phytophthora ramorum	O
PHYRM\|Gene=H3G682_PHYRM\|UniProtKB=H3G682	Phytophthora ramorum	O
CHLRE\|EnsemblGenome=CHLRE_08g382689v5\|UniProtKB=A0A2K3DI57	Chlamydomonas reinhardtii	O
CHLRE\|EnsemblGenome=CHLRE_06g273600v5\|UniProtKB=A8HVK4	Chlamydomonas reinhardtii	O
CHLRE\|EnsemblGenome=CHLRE_08g382700v5\|UniProtKB=A0A2K3DI59	Chlamydomonas reinhardtii	O
SELML\|EnsemblGenome=SELMODRAFT_173723\|UniProtKB=D8RS28	Selaginella moellendorffii	O
PHYPA\|EnsemblGenome=Pp3c25_6580\|UniProtKB=A0A7I4EXY7	Physcomitrella patens	O
SELML\|EnsemblGenome=SELMODRAFT_227280\|UniProtKB=D8QSE0	Selaginella moellendorffii	O
PHYPA\|EnsemblGenome=Pp3c12_18200\|UniProtKB=A9S3Y6	Physcomitrella patens	O
SELML\|EnsemblGenome=SELMODRAFT_228943\|UniProtKB=D8RZG9	Selaginella moellendorffii	O
PHYPA\|EnsemblGenome=Pp3c19_8830\|UniProtKB=A9T6V8	Physcomitrella patens	O
MUSAM\|EnsemblGenome=Ma11_g24570\|UniProtKB=A0A804LBJ6	Musa acuminata subsp. malaccensis	O
NELNU\|Gene=LOC104593164\|UniProtKB=A0A1U7ZEF2	Nelumbo nucifera	O
SPIOL\|Gene=LOC110799459\|UniProtKB=A0A9R0K7F4	Spinacia oleracea	O
CAPAN\|EnsemblGenome=T459_21046\|UniProtKB=A0A1U8HLZ5	Capsicum annuum	O
TOBAC\|Gene=LOC107788853\|UniProtKB=A0A1S3ZNF7	Nicotiana tabacum	O
BRANA\|Gene_ORFName=GSBRNA2T00042174001\|UniProtKB=A0A078GXA3	Brassica napus	O
GOSHI\|Gene=LOC107936781\|UniProtKB=A0A1U8MDV4	Gossypium hirsutum	O
THECC\|EnsemblGenome=TCM_001647\|UniProtKB=A0A061DJK8	Theobroma cacao	O
POPTR\|EnsemblGenome=POPTR_017G135600v3\|UniProtKB=U5FK53	Populus trichocarpa	O
SELML\|EnsemblGenome=SELMODRAFT_162680\|UniProtKB=D8TBD2	Selaginella moellendorffii	O
PHYPA\|EnsemblGenome=Pp3c16_16170\|UniProtKB=A0A2K1J8U2	Physcomitrella patens	O
PHYPA\|EnsemblGenome=Pp3c22_21900\|UniProtKB=A9SPC5	Physcomitrella patens	O
PHYPA\|EnsemblGenome=Pp3c18_2470\|UniProtKB=A0A2K1IZS0	Physcomitrella patens	O
PHYPA\|EnsemblGenome=Pp3c4_19000\|UniProtKB=A9RJI9	Physcomitrella patens	O
MARPO\|EnsemblGenome=MARPO_0056s0116\|UniProtKB=A0A2R6WUY7	Marchantia polymorpha	O
MARPO\|EnsemblGenome=MARPO_0003s0284\|UniProtKB=A0A2R6XTN4	Marchantia polymorpha	O
SPIOL\|Gene=LOC110791259\|UniProtKB=A0A9R0ILR8	Spinacia oleracea	O
CAPAN\|EnsemblGenome=T459_31412\|UniProtKB=A0A1U8F749	Capsicum annuum	O
SELML\|EnsemblGenome=SELMODRAFT_162003\|UniProtKB=D8S9W3	Selaginella moellendorffii	O
PHYPA\|EnsemblGenome=Pp3c10_25270\|UniProtKB=A0A2K1KW14	Physcomitrella patens	O
MARPO\|EnsemblGenome=MARPO_0009s0154\|UniProtKB=A0A2R6XLS5	Marchantia polymorpha	O
SELML\|EnsemblGenome=SELMODRAFT_138728\|UniProtKB=D8TBP0	Selaginella moellendorffii	O
PHYPA\|EnsemblGenome=Pp3c12_5760\|UniProtKB=A0A2K1JPM8	Physcomitrella patens	O
MARPO\|EnsemblGenome=MARPO_0094s0010\|UniProtKB=A0A2R6WG48	Marchantia polymorpha	O
SELML\|EnsemblGenome=SELMODRAFT_270468\|UniProtKB=D8R1K6	Selaginella moellendorffii	O
PHYPA\|EnsemblGenome=Pp3c8_14230\|UniProtKB=A9T8M3	Physcomitrella patens	O
MARPO\|EnsemblGenome=MARPO_0024s0072\|UniProtKB=A0A2R6XBP8	Marchantia polymorpha	O
AMBTC\|EnsemblGenome=AMTR_s00009p00161810\|UniProtKB=W1NI89	Amborella trichopoda	O
ZOSMR\|Gene_ORFName=ZOSMA_139G00110\|UniProtKB=A0A0K9PXZ6	Zostera marina	O
MUSAM\|EnsemblGenome=Ma11_g16830\|UniProtKB=A0A804L8N5	Musa acuminata subsp. malaccensis	O
MUSAM\|EnsemblGenome=Ma05_g00870\|UniProtKB=M0TVP4	Musa acuminata subsp. malaccensis	O
SETIT\|EnsemblGenome=SETIT_032257mg\|UniProtKB=K4A070	Setaria italica	O
SETIT\|EnsemblGenome=SETIT_012354mg\|UniProtKB=K3YDP8	Setaria italica	O
SORBI\|EnsemblGenome=SORBI_3005G099100\|UniProtKB=A0A1B6PRB3	Sorghum bicolor	O
MAIZE\|EnsemblGenome=Zm00001eb169170\|UniProtKB=A0A804NLA8	Zea mays	O
SORBI\|EnsemblGenome=SORBI_3001G036600\|UniProtKB=A0A1Z5S465	Sorghum bicolor	O
SORBI\|EnsemblGenome=SORBI_3004G050100\|UniProtKB=A0A194YMW6	Sorghum bicolor	O
MAIZE\|EnsemblGenome=Zm00001eb282450\|UniProtKB=B6SIL9	Zea mays	O
ORYSJ\|EnsemblGenome=Os07g0492200\|UniProtKB=Q6ZHK0	Oryza sativa	O
ORYSJ\|EnsemblGenome=Os07g0489500\|UniProtKB=A0A0P0X6U8	Oryza sativa	O
BRADI\|EnsemblGenome=BRADI_1g32447v3\|UniProtKB=A0A0Q3L1C9	Brachypodium distachyon	O
BRADI\|EnsemblGenome=BRADI_4g10335v3\|UniProtKB=A0A2K2CLT5	Brachypodium distachyon	O
BRADI\|EnsemblGenome=BRADI_1g32460v3\|UniProtKB=I1GW31	Brachypodium distachyon	O
HORVV\|EnsemblGenome=HORVU.MOREX.r3.7HG0736110\|UniProtKB=A0A287TNE7	Hordeum vulgare subsp. vulgare	O
WHEAT\|EnsemblGenome=TraesCS6B02G012500\|UniProtKB=A0A3B6PEF0	Triticum aestivum	O
WHEAT\|EnsemblGenome=TraesCS7A02G465600\|UniProtKB=A0A3B6RQD3	Triticum aestivum	O
WHEAT\|EnsemblGenome=TraesCS7A02G105400\|UniProtKB=A0A3B6R947	Triticum aestivum	O
WHEAT\|EnsemblGenome=TraesCS1B02G171700\|UniProtKB=A0A3B5YWL9	Triticum aestivum	O
WHEAT\|EnsemblGenome=TraesCS5A02G551700\|UniProtKB=A0A3B6KUY2	Triticum aestivum	O
WHEAT\|EnsemblGenome=TraesCS2A02G408500\|UniProtKB=A0A3B6B3W7	Triticum aestivum	O
WHEAT\|EnsemblGenome=TraesCSU02G125900\|UniProtKB=A0A3B6UB79	Triticum aestivum	O
WHEAT\|EnsemblGenome=TraesCSU02G213900\|UniProtKB=A0A3B6UCB3	Triticum aestivum	O
WHEAT\|EnsemblGenome=TraesCSU02G035100\|UniProtKB=A0A3B6UA95	Triticum aestivum	O
WHEAT\|EnsemblGenome=TraesCS1A02G166000\|UniProtKB=A0A1D6DKE6	Triticum aestivum	O
NELNU\|Gene=LOC104602828\|UniProtKB=A0A1U8AQK3	Nelumbo nucifera	O
NELNU\|Gene=LOC104607002\|UniProtKB=A0A1U8AS62	Nelumbo nucifera	O
SPIOL\|Gene=LOC110805591\|UniProtKB=A0A0K9RKZ3	Spinacia oleracea	O
HELAN\|Gene_ORFName=HanXRQr2_Chr00c011g0832801\|UniProtKB=A0A251SIE4	Helianthus annuus	O
HELAN\|EnsemblGenome=HanXRQr2_Chr01g0038491\|UniProtKB=A0A251VS55	Helianthus annuus	O
HELAN\|Gene_ORFName=HanXRQr2_Chr01g0038461\|UniProtKB=A0A9K3JYQ4	Helianthus annuus	O
HELAN\|Gene_ORFName=HanXRQr2_Chr11g0499141\|UniProtKB=A0A9K3N0N0	Helianthus annuus	O
HELAN\|EnsemblGenome=HanXRQr2_Chr15g0704051\|UniProtKB=A0A251V0G9	Helianthus annuus	O
ERYGU\|Gene_ORFName=MIMGU_mgv1a015483mg\|UniProtKB=A0A022S3M2	Erythranthe guttata	O
CAPAN\|EnsemblGenome=T459_16647\|UniProtKB=A0A2G2Z9N8	Capsicum annuum	O
CAPAN\|EnsemblGenome=T459_22618\|UniProtKB=A0A2G2YQ06	Capsicum annuum	O
SOLTU\|EnsemblGenome=PGSC0003DMG400021634\|UniProtKB=M1BYD8	Solanum tuberosum	O
SOLTU\|EnsemblGenome=PGSC0003DMG400004686\|UniProtKB=O04829	Solanum tuberosum	O
SOLLC\|EnsemblGenome=Solyc06g053210.3\|UniProtKB=A0A3Q7HP50	Solanum lycopersicum	O
SOLLC\|EnsemblGenome=Solyc12g098940.2\|UniProtKB=A0A3Q7JDE8	Solanum lycopersicum	O
TOBAC\|Gene=LOC107780076\|UniProtKB=A0A1S3YUW6	Nicotiana tabacum	O
VITVI\|EnsemblGenome=Vitvi19g01668\|UniProtKB=D7T0Y4	Vitis vinifera	O
EUCGR\|EnsemblGenome=EUGRSUZ_K020232\|UniProtKB=A0A059A2C9	Eucalyptus grandis	O
BRANA\|Gene_ORFName=DARMORV10_A07P12750.1\|UniProtKB=A0A078IMG4	Brassica napus	O
BRANA\|Gene_ORFName=DARMORV10_C07P19140.1\|UniProtKB=A0A078G216	Brassica napus	O
ARATH\|TAIR=locus=2014435\|UniProtKB=Q9SYF4	Arabidopsis thaliana	O
ARATH\|TAIR=locus=6532564744\|UniProtKB=Q9SYF1	Arabidopsis thaliana	O
BRANA\|Gene_ORFName=DARMORV10_A04P06830.1\|UniProtKB=A0A078GCW5	Brassica napus	O
BRACM\|EnsemblGenome=Bra033420\|UniProtKB=A0A3P6CMI1	Brassica campestris	O
BRANA\|Gene_ORFName=GSBRNA2T00033184001\|UniProtKB=A0A078GMF0	Brassica napus	O
ARATH\|TAIR=locus=2184762\|UniProtKB=Q9FY81	Arabidopsis thaliana	O
ARATH\|TAIR=locus=2827139\|UniProtKB=Q3E7K8	Arabidopsis thaliana	O
ARATH\|TAIR=locus=2074909\|UniProtKB=Q39256	Arabidopsis thaliana	O
ARATH\|TAIR=locus=2014440\|UniProtKB=Q9SYE9	Arabidopsis thaliana	O
ARATH\|TAIR=locus=505006295\|UniProtKB=Q8RUC6	Arabidopsis thaliana	O
GOSHI\|Gene=LOC107922157\|UniProtKB=A0A1U8KYN5	Gossypium hirsutum	O
THECC\|EnsemblGenome=TCM_010413\|UniProtKB=A0A061E838	Theobroma cacao	O
CITSI\|Gene_ORFName=CISIN_1g040824mg\|UniProtKB=A0A067ENM1	Citrus sinensis	O
POPTR\|EnsemblGenome=POPTR_006G129600v3\|UniProtKB=A0A2K2A1F9	Populus trichocarpa	O
MANES\|EnsemblGenome=MANES_05G011000\|UniProtKB=A0A2C9VSB5	Manihot esculenta	O
RICCO\|Gene_ORFName=RCOM_1574840\|UniProtKB=B9RI09	Ricinus communis	O
SOYBN\|EnsemblGenome=GLYMA_18G152700\|UniProtKB=K7MSB5	Glycine max	O
SOYBN\|EnsemblGenome=GLYMA_10G051100\|UniProtKB=I1L8T7	Glycine max	O
MEDTR\|EnsemblGenome=MTR_8g479250\|UniProtKB=A0A072TSU9	Medicago truncatula	O
MEDTR\|EnsemblGenome=MTR_4g088485\|UniProtKB=A0A072UMU4	Medicago truncatula	O
JUGRE\|EnsemblGenome=Jr02_23620\|UniProtKB=A0A2I4DUR6	Juglans regia	O
CUCSA\|EnsemblGenome=Csa_2G348875\|UniProtKB=A0A0A0LQL6	Cucumis sativus	O
PRUPE\|EnsemblGenome=PRUPE_2G185300\|UniProtKB=A0A251QHQ5	Prunus persica	O
PRUPE\|EnsemblGenome=PRUPE_4G203900\|UniProtKB=A0A251PPY0	Prunus persica	O
SELML\|EnsemblGenome=SELMODRAFT_101548\|UniProtKB=D8RT32	Selaginella moellendorffii	O
SELML\|EnsemblGenome=SELMODRAFT_19615\|UniProtKB=D8S8X4	Selaginella moellendorffii	O
PHYPA\|EnsemblGenome=Pp3c10_20350\|UniProtKB=A0A2K1JZS5	Physcomitrella patens	O
PHYPA\|EnsemblGenome=Pp3c1_41960\|UniProtKB=A0A2K1LBV0	Physcomitrella patens	O
PHYPA\|EnsemblGenome=Pp3c7_23750\|UniProtKB=A0A2K1KCS7	Physcomitrella patens	O
PHYPA\|EnsemblGenome=Pp3c4_11430\|UniProtKB=A9TGV0	Physcomitrella patens	O
MARPO\|EnsemblGenome=MARPO_0003s0257\|UniProtKB=A0A2R6WRG2	Marchantia polymorpha	O
KLENI\|Gene_ORFName=KFL_003480100\|UniProtKB=A0A1Y1IF26	Klebsormidium nitens	O