PANTHER Gene Information

Gene Symbol(s):

PKN1

Organism:

Bos taurus

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Gene Name:

Serine_threonine-protein kinase N1

Gene ID:

ENSBTAG00000017037

Protein ID:

A1A4I4

Persistent Id:

PTN000683964

Alternate Ids:

509080(GeneID)	NP_001073715(refSeq)
Protein kinase PKN-alpha(Synonym)	ENSBTAP00000074304(Ensembl_PRO)
ENSBTAT00000070272(Ensembl_TRS)	PKN1(Symbol)
AAI26540(EMBL-CDS)	BC126539(EMBL)
119223892(GI)	ENSBTAG00000017037(Ensembl)
PKN1_BOVIN(UniProtKB-ID)	2.7.11.13 {ECO:0000250\|UniProtKB:Q16512}(EC)
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PANTHER Classification

PANTHER Family:	SERINE/THREONINE-PROTEIN KINASE (PTHR24356)
PANTHER Subfamily:	SERINE_THREONINE-PROTEIN KINASE N1 (PTHR24356:SF246)
PANTHER GO-slim Molecular Function:	protein serine/threonine kinase activity
PANTHER GO-slim Biological Process:	peptidyl-serine phosphorylation intracellular signal transduction
PANTHER GO-slim Cellular Component:
PANTHER protein class:	non-receptor serine/threonine protein kinase

Pathway Categories:

Alzheimer disease-amyloid secretase pathway

Protein kinase C

Muscarinic acetylcholine receptor 1 and 3 signaling pathway

Protein kinase C

GENE ONTOLOGY DATABASE ANNOTATIONS

Click to Expand...

GO MF Complete:	diacylglycerol-dependent, calcium-independent serine/threonine kinase activity, ATP binding, histone deacetylase binding, nuclear androgen receptor binding, histone binding, nuclear receptor coactivator activity, small GTPase binding, chromatin binding, protein serine/threonine kinase activity, calcium,diacylglycerol-dependent serine/threonine kinase activity, histone H3T11 kinase activity, protein serine kinase activity
GO BP Complete:	chromatin remodeling, signal transduction, positive regulation of DNA-templated transcription, regulation of cell motility, protein phosphorylation, post-translational protein modification, epithelial cell migration, intracellular signal transduction, regulation of transcription by RNA polymerase II
GO CC Complete:	nucleus, endosome, cytoplasm, cleavage furrow, midbody

REACTOME DATABASE ANNOTATIONS Click to Expand...

Reactome Pathways:

RHO GTPase cycle, Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, RAC1 GTPase cycle, RHO GTPases activate PKNs, RHOC GTPase cycle, Signal Transduction, RHO GTPase Effectors, RHOA GTPase cycle, Signaling by Rho GTPases

Orthologs

ID	Organism	Type
HUMAN\|HGNC=9405\|UniProtKB=Q16512	Homo sapiens	LDO
PANTR\|Ensembl=ENSPTRG00000010591.7\|UniProtKB=H2R6B7	Pan troglodytes	LDO
GORGO\|Ensembl=ENSGGOG00000015787.3\|UniProtKB=A0A2I2Y7S7	Gorilla gorilla gorilla	LDO
MACMU\|Ensembl=ENSMMUG00000005727.4\|UniProtKB=A0A1D5R8U8	Macaca mulatta	LDO
MOUSE\|MGI=MGI=108022\|UniProtKB=P70268	Mus musculus	LDO
RAT\|RGD=69308\|UniProtKB=Q63433	Rattus norvegicus	LDO
PIG\|Ensembl=ENSSSCG00000013779.5\|UniProtKB=F1SCG1	Sus scrofa	LDO
HORSE\|Ensembl=ENSECAG00000038257.3\|UniProtKB=A0A3Q2IB27	Equus caballus	LDO
FELCA\|Ensembl=ENSFCAG00000013492.6\|UniProtKB=A0A2I2UA97	Felis catus	LDO
CANLF\|Ensembl=ENSCAFG00845022295.1\|UniProtKB=A0A8I3PJ31	Canis lupus familiaris	LDO
MONDO\|Ensembl=ENSMODG00000002524.5\|UniProtKB=F7B8S9	Monodelphis domestica	LDO
ORNAN\|Ensembl=ENSOANG00000007494.3\|UniProtKB=A0A6I8NAQ7	Ornithorhynchus anatinus	LDO
ANOCA\|Ensembl=ENSACAG00000016849.4\|UniProtKB=G1KTB7	Anolis carolinensis	LDO
XENLA\|Gene=LOC121398989\|UniProtKB=A0A8J1M0Y9	Xenopus laevis	O
XENLA\|Gene=LOC121400595\|UniProtKB=A0A8J1MDY2	Xenopus laevis	O
XENLA\|Gene=LOC108696953\|UniProtKB=A0A8J1LAE8	Xenopus laevis	O
XENTR\|Gene=LOC116412457\|UniProtKB=A0A8J1JXE1	Xenopus tropicalis	O
XENTR\|Gene=LOC100487273\|UniProtKB=A0A8J1JW53	Xenopus tropicalis	O
XENTR\|Ensembl=ENSXETG00000049094\|UniProtKB=A0A803JLH0	Xenopus tropicalis	O
XENTR\|Ensembl=ENSXETG00000006293\|UniProtKB=F7A5K6	Xenopus tropicalis	O
XENLA\|Gene=LOC108700343\|UniProtKB=A0A8J0THS4	Xenopus laevis	O
XENLA\|Gene=LOC108705938\|UniProtKB=A0A8J1LK66	Xenopus laevis	O
XENLA\|Gene=LOC121397585\|UniProtKB=A0A8J1LLK8	Xenopus laevis	O
XENLA\|Gene=LOC108718670\|UniProtKB=A0A8J1KWJ3	Xenopus laevis	O
XENLA\|Gene=LOC121397262\|UniProtKB=A0A8J1LKD4	Xenopus laevis	O
XENLA\|Gene=LOC108700411\|UniProtKB=A0A8J1LLP7	Xenopus laevis	O
XENTR\|Gene=LOC116408603\|UniProtKB=A0A8J1J2L8	Xenopus tropicalis	O
XENTR\|Gene=LOC116412317\|UniProtKB=A0A8J1K0M7	Xenopus tropicalis	O
XENTR\|Gene=LOC116406699\|UniProtKB=A0A8J1INQ8	Xenopus tropicalis	O
XENTR\|Gene=LOC116408267\|UniProtKB=A0A8J1J1P5	Xenopus tropicalis	O
XENTR\|Gene=LOC116407824\|UniProtKB=A0A8J1IVV3	Xenopus tropicalis	O
XENTR\|Gene=LOC116408602\|UniProtKB=A0A8J1J610	Xenopus tropicalis	O
XENTR\|Gene=LOC105948304\|UniProtKB=A0A8J1IPY7	Xenopus tropicalis	O
XENTR\|Gene=LOC116407820\|UniProtKB=A0A8J1IVU8	Xenopus tropicalis	O
XENTR\|Gene=LOC116411623\|UniProtKB=A0A8J1JU85	Xenopus tropicalis	O
XENTR\|Gene=LOC116408269\|UniProtKB=A0A8J1IZB3	Xenopus tropicalis	O
XENLA\|Gene=LOC108715043\|UniProtKB=A0A8J1N2R5	Xenopus laevis	LDO
XENTR\|Gene=LOC100495168\|UniProtKB=A0A8J1K060	Xenopus tropicalis	LDO
XENTR\|Gene=LOC116412465\|UniProtKB=A0A8J1JXH7	Xenopus tropicalis	O
XENLA\|Gene=LOC121398797\|UniProtKB=A0A8J1LZ92	Xenopus laevis	O
XENLA\|Gene=LOC108706000\|UniProtKB=A0A8J1LX15	Xenopus laevis	O
XENLA\|Gene=LOC121398807\|UniProtKB=A0A8J1LZA0	Xenopus laevis	O
XENLA\|Gene=LOC121398798\|UniProtKB=A0A8J1LYC3	Xenopus laevis	O
XENTR\|Gene=LOC116407843\|UniProtKB=A0A8J1IVY2	Xenopus tropicalis	O
XENTR\|Gene=LOC108645367\|UniProtKB=A0A8J1JK11	Xenopus tropicalis	O
XENTR\|Gene=LOC101733833\|UniProtKB=A0A8J1IY09	Xenopus tropicalis	O
XENLA\|Gene=LOC121394138\|UniProtKB=A0A8J1KRX8	Xenopus laevis	O
XENTR\|Gene=LOC116408357\|UniProtKB=A0A8J1J1U8	Xenopus tropicalis	O
ORYLA\|Ensembl=ENSORLG00000016312.2\|UniProtKB=A0A3B3IFI0	Oryzias latipes	LDO
ORYLA\|Ensembl=ENSORLG00000000385.2\|UniProtKB=A0A3B3IEQ9	Oryzias latipes	O
DANRE\|ZFIN=ZDB-GENE-070424-87\|UniProtKB=A4QNX9	Danio rerio	O
DANRE\|Gene=pkn1a\|UniProtKB=A0A8M2B6W9	Danio rerio	LDO
LEPOC\|Ensembl=ENSLOCG00000006607.1\|UniProtKB=W5MHX4	lepisosteus oculatus	LDO
CIOIN\|Ensembl=ENSCING00000009071.3\|UniProtKB=F6QIR4	Ciona intestinalis	LDO
BRAFL\|Gene=LOC118420649\|UniProtKB=A0A9J7LI73	Branchiostoma floridae	LDO
STRPU\|EnsemblGenome=LOC582022\|UniProtKB=A0A7M7PM13	Strongylocentrotus purpuratus	LDO
CAEEL\|WormBase=WBGene00016980\|UniProtKB=G4S4W1	Caenorhabditis elegans	O
CAEBR\|Gene_ORFName=CBG19698\|UniProtKB=A8XW82	Caenorhabditis briggsae	O
CAEEL\|WormBase=WBGene00009793\|UniProtKB=A0A4V0ILM7	Caenorhabditis elegans	LDO
CAEBR\|Gene_ORFName=CBG17230\|UniProtKB=A8XQI7	Caenorhabditis briggsae	LDO
DROME\|FlyBase=FBgn0020621\|UniProtKB=A1Z7T0	Drosophila melanogaster	LDO
ANOGA\|EnsemblGenome=AGAP007587\|UniProtKB=A0A1S4GVK5	Anopheles gambiae	LDO
TRICA\|EnsemblGenome=TC032431\|UniProtKB=A0A139WL43	Tribolium castaneum	LDO
DAPPU\|EnsemblGenome=DAPPUDRAFT_305605\|UniProtKB=E9FWM9	Daphnia pulex	LDO
DAPPU\|EnsemblGenome=DAPPUDRAFT_305606\|UniProtKB=E9FWN0	Daphnia pulex	LDO
IXOSC\|EnsemblGenome=ISCW011060\|UniProtKB=B7Q8L8	Ixodes scapularis	LDO
HELRO\|EnsemblGenome=HelroG89736\|UniProtKB=T1G7G9	helobdella robusta	LDO
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g98367\|UniProtKB=A7RYZ0	Nematostella vectensis	LDO
TRIAD\|EnsemblGenome=TriadG20881\|UniProtKB=B3RNW1	Trichoplax adhaerens	LDO
MONBE\|EnsemblGenome=MONBRDRAFT_31267\|UniProtKB=A9USR5	Monosiga brevicollis	O
MONBE\|EnsemblGenome=MONBRDRAFT_10752\|UniProtKB=A9V750	Monosiga brevicollis	O
MONBE\|EnsemblGenome=MONBRDRAFT_21555\|UniProtKB=A9V1T6	Monosiga brevicollis	O
MONBE\|EnsemblGenome=MONBRDRAFT_34036\|UniProtKB=A9V9H6	Monosiga brevicollis	O
MONBE\|EnsemblGenome=MONBRDRAFT_39232\|UniProtKB=A9VD19	Monosiga brevicollis	O
MONBE\|EnsemblGenome=MONBRDRAFT_20766\|UniProtKB=A9UXQ2	Monosiga brevicollis	O
YEAST\|SGD=S000000201\|UniProtKB=P24583	Saccharomyces cerevisiae	O
EREGS\|EnsemblGenome=AGOS_ACR191C\|UniProtKB=Q75BT0	Eremothecium gossypii	O
CANAL\|CGD=CAL0000201435\|UniProtKB=Q5ANK2	Candida albicans	O
YARLI\|EnsemblGenome=YALI0_F09746g\|UniProtKB=Q6C292	Yarrowia lipolytica	O
EMENI\|EnsemblGenome=ANIA_00106\|UniProtKB=C8VQM0	Emericella nidulans	O
NEUCR\|EnsemblGenome=NCU06544\|UniProtKB=P87253	Neurospora crassa	O
PHANO\|EnsemblGenome=SNOG_07073\|UniProtKB=Q0UME1	Phaeosphaeria nodorum	O
SCHPO\|PomBase=SPAC17G8.14c\|UniProtKB=P36582	Schizosaccharomyces pombe	O
SCHPO\|PomBase=SPBC12D12.04c\|UniProtKB=P36583	Schizosaccharomyces pombe	O
CRYNJ\|EnsemblGenome=CNE01630\|UniProtKB=Q5KH12	Cryptococcus neoformans	O
CRYNJ\|EnsemblGenome=CNC03300\|UniProtKB=Q5KKE3	Cryptococcus neoformans	O
USTMA\|EnsemblGenome=UMAG_15023\|UniProtKB=A0A0D1DRE2	Ustilago maydis	O
PUCGT\|EnsemblGenome=PGTG_12641\|UniProtKB=E3KRH5	Puccinia graminis	O
BATDJ\|Gene_ORFName=BATDEDRAFT_15370\|UniProtKB=F4NTP5	Batrachochytrium dendrobatidis	O
BATDJ\|Gene_ORFName=BATDEDRAFT_19449\|UniProtKB=F4P170	Batrachochytrium dendrobatidis	O
ENTH1\|EnsemblGenome=CL6EHI_125820\|UniProtKB=C4LVW8	Entamoeba histolytica	O
ENTH1\|EnsemblGenome=CL6EHI_097620\|UniProtKB=C4M933	Entamoeba histolytica	O
ENTH1\|EnsemblGenome=CL6EHI_188930\|UniProtKB=C4M2W0	Entamoeba histolytica	O
ENTH1\|EnsemblGenome=CL6EHI_044470\|UniProtKB=B1N2G7	Entamoeba histolytica	O
ENTH1\|EnsemblGenome=CL6EHI_042150\|UniProtKB=C4M4G9	Entamoeba histolytica	O
ENTH1\|EnsemblGenome=CL6EHI_053040\|UniProtKB=C4M3C2	Entamoeba histolytica	O
ENTH1\|Gene_ORFName=EHI_138540\|UniProtKB=A0A8U0WPI4	Entamoeba histolytica	O
DICDI\|dictyBase=DDB_G0288795\|UniProtKB=Q54IF2	Dictyostelium discoideum	O
DICPU\|EnsemblGenome=DICPUDRAFT_149347\|UniProtKB=F0ZDG7	Dictyostelium purpureum	O
DICDI\|dictyBase=DDB_G0268620\|UniProtKB=P54644	Dictyostelium discoideum	O
DICPU\|EnsemblGenome=DICPUDRAFT_152431\|UniProtKB=F0ZLC3	Dictyostelium purpureum	O
DICPU\|EnsemblGenome=DICPUDRAFT_38849\|UniProtKB=F0ZVB0	Dictyostelium purpureum	O
LEIMA\|EnsemblGenome=LMJF_30_0800\|UniProtKB=Q4Q7M5	Leishmania major	O
TRYB2\|Gene_ORFName=Tb11.01.2290\|UniProtKB=Q383M7	Trypanosoma brucei	O
TRYB2\|Gene_ORFName=Tb927.3.2690\|UniProtKB=Q582Y1	Trypanosoma brucei	O
GIAIC\|EnsemblGenome=GL50803_11364\|UniProtKB=E2RTY0	Giardia intestinalis	O
TRIV3\|Gene_ORFName=TVAG_195270\|UniProtKB=A2FLX7	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_324020\|UniProtKB=A2F4A4	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_430560\|UniProtKB=A2E382	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_316050\|UniProtKB=A2FAW3	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_447920\|UniProtKB=A2DS63	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_047250\|UniProtKB=A2FHJ2	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_267830\|UniProtKB=A2DLD2	Trichomonas vaginalis	O
SACS2\|EnsemblGenome=SSO3207\|UniProtKB=Q97U18	Sulfolobus solfataricus	O