PANTHER Gene Information

Gene Symbol(s):

TK1

Organism:

Bos taurus

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Tree

Gene Name:

Thymidine kinase, cytosolic

Gene ID:

TK1

Protein ID:

A5D7R8

Persistent Id:

PTN007507200

Alternate Ids:

A7E3S3(AltAccession)	KITH_BOVIN(UniProtKB-ID)
2.7.1.21 {ECO:0000250\|UniProtKB:P04183}(EC)	NM_001097572(refSeq)
TK1(Symbol)	504652(GeneID)
AAI40659(EMBL-CDS)	182705238(GI)
KITH(Synonym)	BC140658(EMBL)
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PANTHER Classification

PANTHER Family:	THYMIDINE KINASE (PTHR11441)
PANTHER Subfamily:	THYMIDINE KINASE, CYTOSOLIC (PTHR11441:SF0)
PANTHER GO-slim Molecular Function:	kinase activity
PANTHER GO-slim Biological Process:	nucleoside metabolic process pyrimidine-containing compound metabolic process
PANTHER GO-slim Cellular Component:
PANTHER protein class:	nucleotide kinase

Pathway Categories:

Salvage pyrimidine deoxyribonucleotides

Thymidine kinase

Salvage pyrimidine deoxyribonucleotides

Deoxyuridine kinase

GENE ONTOLOGY DATABASE ANNOTATIONS

Click to Expand...

GO MF Complete:	ATP binding, zinc ion binding, identical protein binding, thymidine kinase activity
GO BP Complete:	protein homotetramerization, DNA synthesis involved in mitotic DNA replication, thymidine biosynthetic process, DNA biosynthetic process, deoxyribonucleoside monophosphate biosynthetic process, thymidine metabolic process
GO CC Complete:	nucleus, cytoplasm

REACTOME DATABASE ANNOTATIONS Click to Expand...

Reactome Pathways:

Orthologs

ID	Organism	Type
HUMAN\|HGNC=11830\|UniProtKB=P04183	Homo sapiens	LDO
PANTR\|Ensembl=ENSPTRG00000009704.6\|UniProtKB=H2QDZ3	Pan troglodytes	LDO
GORGO\|Ensembl=ENSGGOG00000039135.1\|UniProtKB=A0A2I2ZSB8	Gorilla gorilla gorilla	LDO
MACMU\|Ensembl=ENSMMUG00000021867.4\|UniProtKB=F6V4Y1	Macaca mulatta	LDO
MOUSE\|MGI=MGI=98763\|UniProtKB=P04184	Mus musculus	LDO
RAT\|RGD=15005275\|UniProtKB=A0A8I6GCC5	Rattus norvegicus	LDO
PIG\|Ensembl=ENSSSCG00000037120.3\|UniProtKB=A0A286ZID2	Sus scrofa	LDO
HORSE\|Ensembl=ENSECAG00000016173.4\|UniProtKB=A0A9L0THV3	Equus caballus	LDO
FELCA\|Ensembl=ENSFCAG00000013007.5\|UniProtKB=A0A5F5XUV9	Felis catus	LDO
CANLF\|Ensembl=ENSCAFG00845014848.1\|UniProtKB=A0A8I3S154	Canis lupus familiaris	LDO
MONDO\|Ensembl=ENSMODG00000003840.3\|UniProtKB=F7EBQ4	Monodelphis domestica	O
MONDO\|Ensembl=ENSMODG00000001854.3\|UniProtKB=F6SP09	Monodelphis domestica	LDO
ORNAN\|Ensembl=ENSOANG00000004467.2\|UniProtKB=F7DNI7	Ornithorhynchus anatinus	LDO
CHICK\|Ensembl=ENSGALG00010029331.1\|UniProtKB=A0A8V1AJL1	Gallus gallus	LDO
CHICK\|Gene=TK1\|UniProtKB=P04047	Gallus gallus	LDO
ANOCA\|Ensembl=ENSACAG00000016730.4\|UniProtKB=G1KT08	Anolis carolinensis	LDO
XENLA\|Gene=tk1.L\|UniProtKB=A0A1L8ETR7	Xenopus laevis	LDO
XENTR\|Xenbase=XB-GENE-978544\|UniProtKB=Q5I0A2	Xenopus tropicalis	LDO
ORYLA\|Ensembl=ENSORLG00000012303.2\|UniProtKB=H2MA53	Oryzias latipes	LDO
DANRE\|ZFIN=ZDB-GENE-030131-5801\|UniProtKB=Q803Y1	Danio rerio	LDO
LEPOC\|Ensembl=ENSLOCG00000012676.1\|UniProtKB=W5N4P0	lepisosteus oculatus	LDO
CIOIN\|Ensembl=ENSCING00000021067.1\|UniProtKB=H2XT70	Ciona intestinalis	LDO
BRAFL\|Gene=LOC118428771\|UniProtKB=A0A9J7M514	Branchiostoma floridae	LDO
STRPU\|EnsemblGenome=LOC579588\|UniProtKB=A0A7M7NR15	Strongylocentrotus purpuratus	LDO
CAEEL\|WormBase=WBGene00006568\|UniProtKB=G5EEZ5	Caenorhabditis elegans	LDO
CAEBR\|WormBase=WBGene00027082\|UniProtKB=A8WXG7	Caenorhabditis briggsae	LDO
DAPPU\|EnsemblGenome=DAPPUDRAFT_200671\|UniProtKB=E9H5G7	Daphnia pulex	LDO
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g2938\|UniProtKB=A7T5J2	Nematostella vectensis	O
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g243527\|UniProtKB=A7S8B0	Nematostella vectensis	LDO
TRIAD\|EnsemblGenome=TriadG31584\|UniProtKB=B3S9A1	Trichoplax adhaerens	LDO
ENTH1\|Gene_ORFName=EHI_177540\|UniProtKB=A0A8U0WPR2	Entamoeba histolytica	LDO
DICDI\|dictyBase=DDB_G0289179\|UniProtKB=Q27564	Dictyostelium discoideum	LDO
DICPU\|EnsemblGenome=DICPUDRAFT_49097\|UniProtKB=F0ZSA2	Dictyostelium purpureum	LDO
LEIMA\|EnsemblGenome=LMJF_21_1210\|UniProtKB=Q4QC75	Leishmania major	LDO
TRYB2\|Gene_ORFName=Tb10.70.7270\|UniProtKB=Q38CF2	Trypanosoma brucei	LDO
GIAIC\|EnsemblGenome=GL50803_8364\|UniProtKB=A8BRU1	Giardia intestinalis	LDO
TRIV3\|Gene_ORFName=TVAG_344830\|UniProtKB=A2F0T1	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_083490\|UniProtKB=A2DM76	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_050740\|UniProtKB=A2EEN4	Trichomonas vaginalis	LDO
PARTE\|EnsemblGenome=GSPATT00034995001\|UniProtKB=A0C3Z8	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00028201001\|UniProtKB=A0BF49	Paramecium tetraurelia	LDO
PARTE\|EnsemblGenome=GSPATT00036470001\|UniProtKB=A0CA73	Paramecium tetraurelia	LDO
PARTE\|EnsemblGenome=GSPATT00037708001\|UniProtKB=A0CEQ2	Paramecium tetraurelia	O
PHYRM\|Gene=H3GE58_PHYRM\|UniProtKB=H3GE58	Phytophthora ramorum	LDO
CHLRE\|EnsemblGenome=CHLRE_03g192600v5\|UniProtKB=A0A2K3DYD9	Chlamydomonas reinhardtii	LDO
AMBTC\|EnsemblGenome=AMTR_s00088p00176970\|UniProtKB=W1NRM6	Amborella trichopoda	LDO
ZOSMR\|Gene_ORFName=ZOSMA_258G00220\|UniProtKB=A0A0K9PFT1	Zostera marina	LDO
MUSAM\|EnsemblGenome=Ma07_g27330\|UniProtKB=A0A804K0H1	Musa acuminata subsp. malaccensis	O
MUSAM\|EnsemblGenome=Ma03_g31060\|UniProtKB=A0A804IIA4	Musa acuminata subsp. malaccensis	LDO
SETIT\|EnsemblGenome=SETIT_036941mg\|UniProtKB=K4ADI4	Setaria italica	LDO
SORBI\|EnsemblGenome=SORBI_3001G324400\|UniProtKB=C5WVG5	Sorghum bicolor	LDO
MAIZE\|EnsemblGenome=Zm00001eb021070\|UniProtKB=B0R217	Zea mays	LDO
ORYSJ\|Gene_OrderedLocusName=LOC_Os03g02200\|UniProtKB=O81263	Oryza sativa	LDO
BRADI\|EnsemblGenome=BRADI_1g60190v3\|UniProtKB=I1H4P3	Brachypodium distachyon	LDO
HORVV\|EnsemblGenome=HORVU.MOREX.r3.1HG0083980\|UniProtKB=A0A8I6WU22	Hordeum vulgare subsp. vulgare	LDO
WHEAT\|EnsemblGenome=TraesCS1D02G383300\|UniProtKB=A0A3B6A0P8	Triticum aestivum	O
WHEAT\|EnsemblGenome=TraesCS1A02G375900\|UniProtKB=A0A3B5Y6P4	Triticum aestivum	O
WHEAT\|EnsemblGenome=TraesCS1B02G396300\|UniProtKB=A0A3B5Z3K9	Triticum aestivum	LDO
MUSAM\|EnsemblGenome=Ma08_g31660\|UniProtKB=A0A804KD02	Musa acuminata subsp. malaccensis	O
NELNU\|Gene_ORFName=HUJ06_021526\|UniProtKB=A0A1U7ZW18	Nelumbo nucifera	O
NELNU\|Gene_ORFName=HUJ06_021746\|UniProtKB=A0A1U8AQM9	Nelumbo nucifera	LDO
SPIOL\|Gene=LOC110803839\|UniProtKB=A0A9R0JEN9	Spinacia oleracea	O
HELAN\|EnsemblGenome=HanXRQr2_Chr01g0044031\|UniProtKB=A0A251VSR0	Helianthus annuus	O
HELAN\|EnsemblGenome=HanXRQr2_Chr11g0473231\|UniProtKB=A0A251T7W3	Helianthus annuus	O
LACSA\|Gene_ORFName=LSAT_V11C700380050\|UniProtKB=A0A9R1UYN1	Lactuca sativa	O
ERYGU\|Gene_ORFName=MIMGU_mgv1a014023mg\|UniProtKB=A0A022RRQ2	Erythranthe guttata	O
CAPAN\|EnsemblGenome=T459_24025\|UniProtKB=A0A1U8F762	Capsicum annuum	O
SOLTU\|EnsemblGenome=PGSC0003DMG401028822\|UniProtKB=M1CT94	Solanum tuberosum	O
TOBAC\|Gene=LOC107804836\|UniProtKB=A0A1S4B5Y3	Nicotiana tabacum	O
TOBAC\|Gene=LOC107762488\|UniProtKB=A0A1S3X950	Nicotiana tabacum	O
SOLTU\|EnsemblGenome=PGSC0003DMG402007356\|UniProtKB=M1ABG0	Solanum tuberosum	O
SOLLC\|EnsemblGenome=Solyc11g065760.2\|UniProtKB=Q71F77	Solanum lycopersicum	O
TOBAC\|Gene=LOC107789082\|UniProtKB=A0A1S3ZQ02	Nicotiana tabacum	O
TOBAC\|Gene=LOC107769449\|UniProtKB=A0A1S3XW97	Nicotiana tabacum	O
VITVI\|EnsemblGenome=Vitvi12g00657\|UniProtKB=F6HHL3	Vitis vinifera	O
EUCGR\|EnsemblGenome=EUGRSUZ_A01057\|UniProtKB=A0A059DDZ2	Eucalyptus grandis	O
BRANA\|Gene_ORFName=DARMORV10_C03P43060.1\|UniProtKB=A0A078F3L9	Brassica napus	O
BRACM\|EnsemblGenome=Bra001266\|UniProtKB=M4CAN7	Brassica campestris	O
BRANA\|Gene_ORFName=GSBRNA2T00093326001\|UniProtKB=A0A078IKK0	Brassica napus	O
BRANA\|Gene_ORFName=GSBRNA2T00018525001\|UniProtKB=A0A078G6P1	Brassica napus	O
BRACM\|EnsemblGenome=Bra040030\|UniProtKB=M4FG06	Brassica campestris	O
BRANA\|Gene_ORFName=GSBRNA2T00053305001\|UniProtKB=A0A078JFE0	Brassica napus	O
BRANA\|Gene_ORFName=GSBRNA2T00059521001\|UniProtKB=A0A078HC48	Brassica napus	O
BRACM\|EnsemblGenome=Bra029680\|UniProtKB=M4ELL2	Brassica campestris	O
ARATH\|TAIR=locus=2077382\|UniProtKB=Q9S750	Arabidopsis thaliana	O
GOSHI\|Gene=LOC107922966\|UniProtKB=A0A1U8L1W3	Gossypium hirsutum	O
GOSHI\|Gene=LOC107912609\|UniProtKB=A0A1U8K1H0	Gossypium hirsutum	O
THECC\|EnsemblGenome=TCM_002307\|UniProtKB=A0A061DMW8	Theobroma cacao	O
CITSI\|Gene_ORFName=CISIN_1g026304mg\|UniProtKB=A0A067ETL2	Citrus sinensis	O
POPTR\|Gene_ORFName=POPTR_002G222300\|UniProtKB=A0A3N7EK81	Populus trichocarpa	O
MANES\|EnsemblGenome=MANES_13G064000\|UniProtKB=A0A2C9UQI8	Manihot esculenta	O
RICCO\|Gene_ORFName=RCOM_0732580\|UniProtKB=B9S3D2	Ricinus communis	O
RICCO\|Gene_ORFName=RCOM_1120040\|UniProtKB=B9T6J4	Ricinus communis	O
SOYBN\|EnsemblGenome=GLYMA_20G059200\|UniProtKB=I1NE76	Glycine max	O
SOYBN\|EnsemblGenome=GLYMA_13G025800\|UniProtKB=I1LXW1	Glycine max	O
MEDTR\|EnsemblGenome=MTR_3g083230\|UniProtKB=G7J9J2	Medicago truncatula	O
JUGRE\|EnsemblGenome=Jr01_33930\|UniProtKB=A0A2I4H190	Juglans regia	O
CUCSA\|EnsemblGenome=Csa_6G110310\|UniProtKB=A0A0A0KAS7	Cucumis sativus	O
PRUPE\|EnsemblGenome=PRUPE_3G202500\|UniProtKB=M5XD79	Prunus persica	O
SPIOL\|Gene=LOC110800020\|UniProtKB=A0A9R0J6U5	Spinacia oleracea	LDO
HELAN\|EnsemblGenome=HanXRQr2_Chr11g0500161\|UniProtKB=A0A251U2K0	Helianthus annuus	LDO
LACSA\|Gene_ORFName=LSAT_V11C100050180\|UniProtKB=A0A9R1XUF3	Lactuca sativa	LDO
CAPAN\|EnsemblGenome=T459_17508\|UniProtKB=A0A2G2ZBS5	Capsicum annuum	O
CAPAN\|EnsemblGenome=T459_18318\|UniProtKB=A0A2G2ZE39	Capsicum annuum	O
CAPAN\|EnsemblGenome=T459_29054\|UniProtKB=A0A1U8EY32	Capsicum annuum	LDO
SOLTU\|EnsemblGenome=PGSC0003DMG400013288\|UniProtKB=M1B0X6	Solanum tuberosum	LDO
SOLLC\|EnsemblGenome=Solyc11g012480.2\|UniProtKB=A0A3Q7JJP6	Solanum lycopersicum	LDO
TOBAC\|Gene=LOC107820953\|UniProtKB=A0A1S4CP26	Nicotiana tabacum	LDO
TOBAC\|Gene=LOC107807865\|UniProtKB=A0A1S4BG24	Nicotiana tabacum	LDO
EUCGR\|EnsemblGenome=EUGRSUZ_D01432\|UniProtKB=A0A059CGN5	Eucalyptus grandis	LDO
BRANA\|EnsemblGenome=GSBRNA2T00066031001\|UniProtKB=A0A078JMM5	Brassica napus	LDO
BRACM\|EnsemblGenome=Bra013014\|UniProtKB=M4D954	Brassica campestris	LDO
ARATH\|TAIR=locus=2178297\|UniProtKB=F4KBF5	Arabidopsis thaliana	LDO
GOSHI\|Gene=LOC107963718\|UniProtKB=A0A1U8PZE2	Gossypium hirsutum	O
GOSHI\|Gene=LOC107960161\|UniProtKB=A0A1U8PL72	Gossypium hirsutum	LDO
THECC\|EnsemblGenome=TCM_030387\|UniProtKB=A0A061GGB4	Theobroma cacao	LDO
CITSI\|Gene_ORFName=CISIN_1g023563mg\|UniProtKB=A0A067GT29	Citrus sinensis	LDO
POPTR\|EnsemblGenome=POPTR_006G015800v3\|UniProtKB=U5G8W1	Populus trichocarpa	O
POPTR\|Gene_ORFName=POPTR_016G009951\|UniProtKB=A0A3N7H1C3	Populus trichocarpa	LDO
MANES\|EnsemblGenome=MANES_01G168200\|UniProtKB=A0A2C9WMX9	Manihot esculenta	O
MANES\|EnsemblGenome=MANES_02G127400\|UniProtKB=A0A2C9WDC0	Manihot esculenta	LDO
SOYBN\|EnsemblGenome=GLYMA_15G116000\|UniProtKB=I1MFP9	Glycine max	LDO
SOYBN\|EnsemblGenome=GLYMA_09G011500\|UniProtKB=I1L011	Glycine max	O
JUGRE\|EnsemblGenome=Jr03_12580\|UniProtKB=A0A2I4F9R8	Juglans regia	LDO
CUCSA\|EnsemblGenome=Csa_1G181480\|UniProtKB=A0A0A0LYL4	Cucumis sativus	LDO
PRUPE\|EnsemblGenome=PRUPE_4G007900\|UniProtKB=A0A251PDW9	Prunus persica	LDO
SELML\|EnsemblGenome=SELMODRAFT_412008\|UniProtKB=D8RJR7	Selaginella moellendorffii	LDO
SELML\|EnsemblGenome=SELMODRAFT_403348\|UniProtKB=D8QTW0	Selaginella moellendorffii	LDO
PHYPA\|EnsemblGenome=Pp3c20_20920\|UniProtKB=A9S0Y8	Physcomitrella patens	O
PHYPA\|EnsemblGenome=Pp3c10_21120\|UniProtKB=A0A2K1JZX6	Physcomitrella patens	LDO
MARPO\|EnsemblGenome=MARPO_0007s0053\|UniProtKB=A0A2R6XNA9	Marchantia polymorpha	LDO
KLENI\|Gene_ORFName=KFL_000660130\|UniProtKB=A0A1Y1HUR1	Klebsormidium nitens	LDO
PYRAE\|EnsemblGenome=PAE2453\|UniProtKB=Q8ZV53	Pyrobaculum aerophilum	LDO
HALSA\|EnsemblGenome=VNG_1515G\|UniProtKB=Q9HPQ9	Halobacterium salinarum	LDO
THEKO\|EnsemblGenome=TK1318\|UniProtKB=Q5JGT7	Thermococcus kodakaraensis	LDO
CHLAA\|EnsemblGenome=Caur_2309\|UniProtKB=A9WGI6	Chloroflexus aurantiacus	LDO
STRCO\|Gene_OrderedLocusName=SCO5845\|UniProtKB=O50519	Streptomyces coelicolor	LDO
MYCGE\|EnsemblGenome=MG_034\|UniProtKB=P47280	mycoplasma genitalium	LDO
CLOBH\|Gene_OrderedLocusName=CBO0136\|UniProtKB=A5HY32	Clostridium botulinum	LDO
STRR6\|EnsemblGenome=spr0922\|UniProtKB=Q8DPZ6	Streptococcus pneumoniae	LDO
STAA8\|EnsemblGenome=SAOUHSC_02360\|UniProtKB=Q2FWD9	Staphylococcus aureus	LDO
LISMO\|EnsemblGenome=CAD00622\|UniProtKB=Q8Y4A7	Listeria monocytogenes	LDO
BACSU\|EnsemblGenome=BSU_37060\|UniProtKB=Q03221	Bacillus subtilis	LDO
BACCR\|EnsemblGenome=BC_5330\|UniProtKB=Q814U0	Bacillus cereus	LDO
THEMA\|EnsemblGenome=TM_0401\|UniProtKB=Q9WYN2	Thermotoga maritima	LDO
DEIRA\|EnsemblGenome=DR_1984\|UniProtKB=Q9RSY5	Deinococcus radiodurans	LDO
BACTN\|EnsemblGenome=BT_2275\|UniProtKB=Q8A5G4	Bacteroides thetaiotaomicron	LDO
RHOBA\|EnsemblGenome=RB8399\|UniProtKB=Q7UFR1	Rhodopirellula baltica	LDO
DICTD\|EnsemblGenome=Dtur_0803\|UniProtKB=B8E001	Dictyoglomus turgidum	LDO
COXBU\|EnsemblGenome=CBU_2069\|UniProtKB=Q83A42	Coxiella burnetii	LDO
HAEIN\|EnsemblGenome=HI_0529\|UniProtKB=P44309	Haemophilus influenzae	LDO
SHEON\|Gene_OrderedLocusName=SO_3140\|UniProtKB=Q8ECK0	Shewanella oneidensis	LDO
VIBCH\|EnsemblGenome=VC_1167\|UniProtKB=Q9KST9	Vibrio cholerae	LDO
XANCP\|EnsemblGenome=XCC4143\|UniProtKB=Q8P3C8	Xanthomonas campestris	LDO
SALTY\|EnsemblGenome=STM1750\|UniProtKB=Q7CQF3	Salmonella typhimurium	LDO
YERPE\|EnsemblGenome=YP_1975\|UniProtKB=Q8ZEJ1	Yersinia pestis	LDO
ECOLI\|EnsemblGenome=BAA36118\|UniProtKB=P23331	Escherichia coli	LDO