PANTHER Gene Information

Gene Symbol(s):

BnaC09g14390D

Organism:

Brassica napus

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Tree

Gene Name:

Splicing factor U2af large subunit

Gene ID:

DARMORV10_C09P21120.1

Protein ID:

A0A078HRZ0

Persistent Id:

PTN007736557

Alternate Ids:

CDY40481(EMBL-CDS)	A0A078HRZ0(Synonym)
HG994373(EMBL)	A0A078HRZ0_BRANA(UniProtKB-ID)
674892288(GI)
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PANTHER Classification

PANTHER Family:	RNA-BINDING PROTEIN (PTHR23139)
PANTHER Subfamily:	SPLICING FACTOR U2AF LARGE SUBUNIT (PTHR23139:SF120)
PANTHER GO-slim Molecular Function:	pre-mRNA binding single-stranded RNA binding
PANTHER GO-slim Biological Process:	spliceosomal complex assembly
PANTHER GO-slim Cellular Component:	U2-type prespliceosome nuclear speck
PANTHER protein class:

Pathway Categories:

No pathway information available

GENE ONTOLOGY DATABASE ANNOTATIONS

Click to Expand...

GO MF Complete:	RNA binding, pre-mRNA 3'-splice site binding, poly-pyrimidine tract binding
GO BP Complete:	RNA splicing, mRNA processing, spliceosomal complex assembly
GO CC Complete:	commitment complex, nucleus, U2AF complex, nuclear speck, U2-type prespliceosome

REACTOME DATABASE ANNOTATIONS Click to Expand...

Reactome Pathways:

Orthologs

ID	Organism	Type
HUMAN\|HGNC=23156\|UniProtKB=P26368	Homo sapiens	O
PANTR\|Ensembl=ENSPTRG00000011523.5\|UniProtKB=K6ZG02	Pan troglodytes	O
MACMU\|Ensembl=ENSMMUG00000004810.4\|UniProtKB=F6RZR0	Macaca mulatta	O
MOUSE\|MGI=MGI=98886\|UniProtKB=P26369	Mus musculus	O
RAT\|RGD=1310690\|UniProtKB=A0A8I6A9Y1	Rattus norvegicus	O
RAT\|RGD=1310690\|UniProtKB=A0A8I6A9Y1	Rattus norvegicus	O
BOVIN\|Ensembl=ENSBTAG00000002830.6\|UniProtKB=Q24JZ8	Bos taurus	O
PIG\|Ensembl=ENSSSCG00000034815.3\|UniProtKB=A0A481APG3	Sus scrofa	O
HORSE\|Ensembl=ENSECAG00000010110.4\|UniProtKB=A0A9L0S799	Equus caballus	O
CANLF\|Ensembl=ENSCAFG00845000480.1\|UniProtKB=A0A8I3RP62	Canis lupus familiaris	O
ORNAN\|Ensembl=ENSOANG00000040411.1\|UniProtKB=A0A6I8PMQ0	Ornithorhynchus anatinus	O
ANOCA\|Ensembl=ENSACAG00000015489.3\|UniProtKB=H9GMF2	Anolis carolinensis	O
XENLA\|Gene=u2af2.S\|UniProtKB=A0A1L8FGS2	Xenopus laevis	O
XENLA\|Gene=LOC108696656\|UniProtKB=A0A1L8FMU9	Xenopus laevis	O
XENTR\|Xenbase=XB-GENE-494184\|UniProtKB=Q6NVN9	Xenopus tropicalis	O
ORYLA\|Ensembl=ENSORLG00000011545.2\|UniProtKB=H2M7K7	Oryzias latipes	O
DANRE\|ZFIN=ZDB-GENE-050706-131\|UniProtKB=E7F8Y4	Danio rerio	O
DANRE\|ZFIN=ZDB-GENE-040426-1881\|UniProtKB=A0A0R4IMP0	Danio rerio	O
LEPOC\|Ensembl=ENSLOCG00000010843.1\|UniProtKB=W5MY30	lepisosteus oculatus	O
LEPOC\|Ensembl=ENSLOCG00000008050.1\|UniProtKB=W5MN22	lepisosteus oculatus	O
CIOIN\|Ensembl=ENSCING00000003455.3\|UniProtKB=F6UAX7	Ciona intestinalis	O
BRAFL\|Gene=LOC118429074\|UniProtKB=A0A9J7M6W8	Branchiostoma floridae	O
STRPU\|EnsemblGenome=LOC588126\|UniProtKB=A0A7M7HKD8	Strongylocentrotus purpuratus	O
CAEEL\|WormBase=WBGene00006697\|UniProtKB=P90978	Caenorhabditis elegans	O
CAEBR\|WormBase=WBGene00035480\|UniProtKB=P90727	Caenorhabditis briggsae	O
PRIPA\|EnsemblGenome=WBGene00114928\|UniProtKB=A0A2A6CQR2	Pristionchus pacificus	O
DROME\|FlyBase=FBgn0034834\|UniProtKB=Q9W1T4	Drosophila melanogaster	O
DROME\|FlyBase=FBgn0005411\|UniProtKB=Q24562	Drosophila melanogaster	O
ANOGA\|EnsemblGenome=AGAP002908\|UniProtKB=Q7QD20	Anopheles gambiae	O
TRICA\|EnsemblGenome=TC005736\|UniProtKB=D6WWI5	Tribolium castaneum	O
DAPPU\|EnsemblGenome=DAPPUDRAFT_232197\|UniProtKB=E9FS33	Daphnia pulex	O
IXOSC\|EnsemblGenome=ISCW002946\|UniProtKB=B7PCK4	Ixodes scapularis	O
HELRO\|EnsemblGenome=HelroG186326\|UniProtKB=T1FNY6	helobdella robusta	O
HELRO\|EnsemblGenome=HelroG185543\|UniProtKB=T1FMY6	helobdella robusta	O
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g228171\|UniProtKB=A7RJT7	Nematostella vectensis	O
TRIAD\|EnsemblGenome=TriadG21652\|UniProtKB=B3RQ51	Trichoplax adhaerens	O
MONBE\|EnsemblGenome=MONBRDRAFT_1352\|UniProtKB=A9UNN4	Monosiga brevicollis	O
YEAST\|SGD=S000001557\|UniProtKB=P36084	Saccharomyces cerevisiae	O
EREGS\|EnsemblGenome=AGOS_ADR130W\|UniProtKB=Q759Z3	Eremothecium gossypii	O
CANAL\|CGD=CAL0000187516\|UniProtKB=A0A1D8PGR8	Candida albicans	O
YARLI\|EnsemblGenome=YALI0_E09889g\|UniProtKB=Q6C6F8	Yarrowia lipolytica	O
EMENI\|EnsemblGenome=ANIA_06681\|UniProtKB=C8V1L6	Emericella nidulans	O
ASPFU\|EnsemblGenome=AFUA_7G05310\|UniProtKB=Q4WGK1	Neosartorya fumigata	O
NEUCR\|EnsemblGenome=NCU00231\|UniProtKB=Q7RZY0	Neurospora crassa	O
NEUCR\|EnsemblGenome=NCU03039\|UniProtKB=Q7SDG9	Neurospora crassa	O
SCLS1\|EnsemblGenome=SS1G_02977\|UniProtKB=A7ECD8	Sclerotinia sclerotiorum	O
PHANO\|EnsemblGenome=SNOG_04461\|UniProtKB=Q0UUV3	Phaeosphaeria nodorum	O
SCHPO\|PomBase=SPBC146.07\|UniProtKB=P36629	Schizosaccharomyces pombe	O
SCHJY\|EnsemblGenome=SJAG_03995\|UniProtKB=B6K5L9	Schizosaccharomyces japonicus	O
CRYNJ\|EnsemblGenome=CNF01250\|UniProtKB=Q5KFM4	Cryptococcus neoformans	O
USTMA\|EnsemblGenome=UMAG_05363\|UniProtKB=A0A0D1CHB4	Ustilago maydis	O
PUCGT\|EnsemblGenome=PGTG_22302\|UniProtKB=H6QU19	Puccinia graminis	O
BATDJ\|Gene_ORFName=BATDEDRAFT_21058\|UniProtKB=F4PE51	Batrachochytrium dendrobatidis	O
ENTH1\|EnsemblGenome=CL6EHI_098300\|UniProtKB=C4LXB3	Entamoeba histolytica	O
DICDI\|dictyBase=DDB_G0286395\|UniProtKB=Q54LV5	Dictyostelium discoideum	O
DICPU\|EnsemblGenome=DICPUDRAFT_56283\|UniProtKB=F0ZQL5	Dictyostelium purpureum	O
LEIMA\|EnsemblGenome=LMJF_03_0520\|UniProtKB=E9ACJ7	Leishmania major	O
TRYB2\|Gene_ORFName=Tb10.70.3950\|UniProtKB=Q38BP9	Trypanosoma brucei	O
TRIV3\|Gene_ORFName=TVAG_453940\|UniProtKB=A2DPX0	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_062480\|UniProtKB=A2DLL0	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_417030\|UniProtKB=A2ESG1	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_056670\|UniProtKB=A2ECM6	Trichomonas vaginalis	O
PLAF7\|Gene_ORFName=PF3D7_1326300\|UniProtKB=A0A5K1K940	Plasmodium falciparum	O
PLAF7\|EnsemblGenome=PF3D7_0716000\|UniProtKB=Q8IBU0	Plasmodium falciparum	O
PLAF7\|EnsemblGenome=PF3D7_1468800\|UniProtKB=Q8IKE9	Plasmodium falciparum	O
PARTE\|EnsemblGenome=GSPATT00011065001\|UniProtKB=A0CXB6	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00020344001\|UniProtKB=A0DUF5	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00039350001\|UniProtKB=A0DA33	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00021019001\|UniProtKB=A0DWG0	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00023584001\|UniProtKB=A0E540	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00022927001\|UniProtKB=A0E387	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00006257001\|UniProtKB=A0C4P1	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00024974001\|UniProtKB=A0EAC5	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00007366001\|UniProtKB=A0CGK9	Paramecium tetraurelia	O
THAPS\|EnsemblGenome=THAPSDRAFT_263000\|UniProtKB=B8C4E7	Thalassiosira pseudonana	O
PHYRM\|Gene=H3GVM8_PHYRM\|UniProtKB=H3GVM8	Phytophthora ramorum	O
PHYRM\|Gene=H3GDY4_PHYRM\|UniProtKB=H3GDY4	Phytophthora ramorum	O
PHYRM\|Gene=H3GIY2_PHYRM\|UniProtKB=H3GIY2	Phytophthora ramorum	O
CHLRE\|EnsemblGenome=CHLRE_13g607850v5\|UniProtKB=A0A2K3D1J8	Chlamydomonas reinhardtii	O
CHLRE\|EnsemblGenome=CHLRE_02g093975v5\|UniProtKB=A0A2K3E1C6	Chlamydomonas reinhardtii	O
CHLRE\|EnsemblGenome=CHLRE_12g499750v5\|UniProtKB=A0A2K3D3A9	Chlamydomonas reinhardtii	O
CHLRE\|EnsemblGenome=CHLRE_12g549100v5\|UniProtKB=A0A2K3D6A2	Chlamydomonas reinhardtii	O
CHLRE\|EnsemblGenome=CHLRE_16g695450v5\|UniProtKB=A0A2K3CSA5	Chlamydomonas reinhardtii	O
CHLRE\|EnsemblGenome=CHLRE_07g352650v5\|UniProtKB=A0A2K3DLE6	Chlamydomonas reinhardtii	O
CHLRE\|EnsemblGenome=CHLRE_09g391949v5\|UniProtKB=A0A2K3DE86	Chlamydomonas reinhardtii	O
AMBTC\|EnsemblGenome=AMTR_s00059p00102910\|UniProtKB=U5D811	Amborella trichopoda	O
ZOSMR\|Gene_ORFName=ZOSMA_53G00640\|UniProtKB=A0A0K9NZ62	Zostera marina	O
ZOSMR\|Gene_ORFName=ZOSMA_92G00890\|UniProtKB=A0A0K9NIZ6	Zostera marina	O
MUSAM\|EnsemblGenome=Ma04_g17070\|UniProtKB=A0A804IQN2	Musa acuminata subsp. malaccensis	O
MUSAM\|EnsemblGenome=Ma01_g02190\|UniProtKB=A0A804HPD9	Musa acuminata subsp. malaccensis	O
MUSAM\|EnsemblGenome=Ma04_g11000\|UniProtKB=A0A804INE8	Musa acuminata subsp. malaccensis	O
SETIT\|EnsemblGenome=SETIT_026205mg\|UniProtKB=K3ZI03	Setaria italica	O
SORBI\|EnsemblGenome=SORBI_3005G216300\|UniProtKB=C5Y7Z5	Sorghum bicolor	O
MAIZE\|EnsemblGenome=Zm00001eb165060\|UniProtKB=B4FD21	Zea mays	O
ORYSJ\|Gene_OrderedLocusName=LOC_Os11g45590\|UniProtKB=Q2QZL4	Oryza sativa	O
BRADI\|EnsemblGenome=BRADI_4g09940v3\|UniProtKB=A0A0Q3HFT0	Brachypodium distachyon	O
HORVV\|EnsemblGenome=HORVU.MOREX.r3.4HG0359330\|UniProtKB=M0ULV7	Hordeum vulgare subsp. vulgare	O
WHEAT\|EnsemblGenome=TraesCS4A02G171800\|UniProtKB=A0A3B6HWF0	Triticum aestivum	O
WHEAT\|EnsemblGenome=TraesKAR4B01G0238210\|UniProtKB=Q2QKB4	Triticum aestivum	O
WHEAT\|EnsemblGenome=TraesCS4D02G143400\|UniProtKB=A0A3B6JGZ6	Triticum aestivum	O
WHEAT\|EnsemblGenome=TraesCSU02G068100\|UniProtKB=A0A3B6U4Q9	Triticum aestivum	O
SETIT\|EnsemblGenome=SETIT_026142mg\|UniProtKB=K3ZHU0	Setaria italica	O
SORBI\|EnsemblGenome=SORBI_3005G216800\|UniProtKB=A0A1B6PTY1	Sorghum bicolor	O
SORBI\|EnsemblGenome=SORBI_3005G195800\|UniProtKB=A0A1B6PTJ4	Sorghum bicolor	O
MAIZE\|EnsemblGenome=Zm00001eb115220\|UniProtKB=B4FR45	Zea mays	O
MAIZE\|EnsemblGenome=Zm00001eb166260\|UniProtKB=C0P852	Zea mays	O
ORYSJ\|EnsemblGenome=Os11g0636900\|UniProtKB=Q2R0Q1	Oryza sativa	O
BRADI\|EnsemblGenome=BRADI_4g38060v3\|UniProtKB=I1ISV7	Brachypodium distachyon	O
HORVV\|EnsemblGenome=HORVU.MOREX.r3.5HG0506290\|UniProtKB=A0A8I7BF83	Hordeum vulgare subsp. vulgare	O
WHEAT\|EnsemblGenome=TraesCS5B02G368400\|UniProtKB=A0A3B6LR46	Triticum aestivum	O
WHEAT\|EnsemblGenome=TraesCLE_scaffold_004645_01G000700\|UniProtKB=Q2QKB3	Triticum aestivum	O
WHEAT\|EnsemblGenome=TraesCS5D02G375600\|UniProtKB=A0A3B6MVS8	Triticum aestivum	O
WHEAT\|EnsemblGenome=TraesCS5B02G358000\|UniProtKB=A0A3B6LQT0	Triticum aestivum	O
WHEAT\|EnsemblGenome=TraesCS5A02G366000\|UniProtKB=A0A3B6KL48	Triticum aestivum	O
BRADI\|EnsemblGenome=BRADI_4g12260v3\|UniProtKB=I1IK06	Brachypodium distachyon	O
HORVV\|EnsemblGenome=HORVU.MOREX.r3.4HG0369460\|UniProtKB=A0A8I6XPC6	Hordeum vulgare subsp. vulgare	O
WHEAT\|EnsemblGenome=TraesCS4D02G150000\|UniProtKB=A0A3B6JHB8	Triticum aestivum	O
WHEAT\|EnsemblGenome=TraesCS4B02G145600\|UniProtKB=A0A3B6IPY1	Triticum aestivum	O
WHEAT\|EnsemblGenome=TraesCS4A02G165000\|UniProtKB=A0A3B6HUP7	Triticum aestivum	O
NELNU\|Gene=LOC104588172\|UniProtKB=A0A1U7YXQ6	Nelumbo nucifera	O
NELNU\|Gene=LOC104595741\|UniProtKB=A0A1U7ZNK7	Nelumbo nucifera	O
SPIOL\|Gene=LOC110800178\|UniProtKB=A0A9R0K7A2	Spinacia oleracea	O
SPIOL\|Gene=LOC110789395\|UniProtKB=A0A9R0JWK0	Spinacia oleracea	O
SPIOL\|Gene=LOC110791632\|UniProtKB=A0A9R0IMW8	Spinacia oleracea	O
HELAN\|EnsemblGenome=HanXRQr2_Chr09g0394001\|UniProtKB=A0A251TWT6	Helianthus annuus	O
HELAN\|EnsemblGenome=HanXRQr2_Chr11g0470941\|UniProtKB=A0A251T768	Helianthus annuus	O
HELAN\|EnsemblGenome=HanXRQr2_Chr09g0394021\|UniProtKB=A0A251TWT0	Helianthus annuus	O
LACSA\|Gene_ORFName=LSAT_V11C400216150\|UniProtKB=A0A9R1VYM8	Lactuca sativa	O
ERYGU\|Gene_ORFName=MIMGU_mgv1a003650mg\|UniProtKB=A0A022PUP0	Erythranthe guttata	O
ERYGU\|Gene_ORFName=MIMGU_mgv1a003557mg\|UniProtKB=A0A022QBN1	Erythranthe guttata	O
CAPAN\|EnsemblGenome=T459_06300\|UniProtKB=A0A2G3AAC4	Capsicum annuum	O
SOLTU\|EnsemblGenome=PGSC0003DMG400012685\|UniProtKB=M1AYI6	Solanum tuberosum	O
SOLLC\|EnsemblGenome=Solyc02g085570.3\|UniProtKB=A0A3Q7F9T8	Solanum lycopersicum	O
TOBAC\|Gene=LOC107828366\|UniProtKB=A0A1S4DCH5	Nicotiana tabacum	O
TOBAC\|Gene=LOC107829384\|UniProtKB=A0A1S4DFV3	Nicotiana tabacum	O
SOLLC\|EnsemblGenome=Solyc02g062920.3\|UniProtKB=A0A3Q7EYR9	Solanum lycopersicum	O
TOBAC\|Gene=LOC107774338\|UniProtKB=A0A1S3YB35	Nicotiana tabacum	O
TOBAC\|Gene=LOC107790528\|UniProtKB=A0A1S3ZUA6	Nicotiana tabacum	O
VITVI\|Gene_ORFName=VIT_00s0561g00030\|UniProtKB=F6HWU3	Vitis vinifera	O
VITVI\|EnsemblGenome=Vitvi04g01257\|UniProtKB=F6GWY2	Vitis vinifera	O
EUCGR\|EnsemblGenome=EUGRSUZ_I02460\|UniProtKB=A0A059ASW9	Eucalyptus grandis	O
BRACM\|EnsemblGenome=Bra027119\|UniProtKB=M4EEA7	Brassica campestris	O
ARATH\|TAIR=locus=2206001\|UniProtKB=Q8L716	Arabidopsis thaliana	O
GOSHI\|Gene=LOC107945661\|UniProtKB=A0A1U8NB92	Gossypium hirsutum	O
THECC\|EnsemblGenome=TCM_000427\|UniProtKB=A0A061DGE4	Theobroma cacao	O
GOSHI\|Gene=LOC107904274\|UniProtKB=A0A1U8J6V0	Gossypium hirsutum	O
GOSHI\|Gene=LOC107957409\|UniProtKB=A0A1U8PB40	Gossypium hirsutum	O
GOSHI\|Gene=LOC107904217\|UniProtKB=A0A1U8J6P0	Gossypium hirsutum	O
THECC\|EnsemblGenome=TCM_043260\|UniProtKB=A0A061FNW9	Theobroma cacao	O
CITSI\|Gene_ORFName=CISIN_1g009052mg\|UniProtKB=A0A067GW09	Citrus sinensis	O
POPTR\|Gene_ORFName=POPTR_005G125500\|UniProtKB=A0A3N7GEW6	Populus trichocarpa	O
POPTR\|EnsemblGenome=POPTR_011G050400v3\|UniProtKB=A0A2K1YFQ9	Populus trichocarpa	O
POPTR\|EnsemblGenome=POPTR_004G040900v3\|UniProtKB=B9H2X3	Populus trichocarpa	O
POPTR\|Gene_ORFName=POPTR_007G028500\|UniProtKB=A0A3N7F662	Populus trichocarpa	O
MANES\|EnsemblGenome=MANES_04G048700\|UniProtKB=A0A2C9VZR3	Manihot esculenta	O
MANES\|EnsemblGenome=MANES_13G137500\|UniProtKB=A0A2C9URM6	Manihot esculenta	O
RICCO\|Gene_ORFName=RCOM_0553420\|UniProtKB=B9SGJ4	Ricinus communis	O
SOYBN\|EnsemblGenome=GLYMA_04G255700\|UniProtKB=I1JZD4	Glycine max	O
SOYBN\|EnsemblGenome=GLYMA_06G324000\|UniProtKB=K7KYQ4	Glycine max	O
MEDTR\|EnsemblGenome=MTR_4g031680\|UniProtKB=G7JM14	Medicago truncatula	O
MEDTR\|EnsemblGenome=MTR_3g005670\|UniProtKB=A0A072UTX0	Medicago truncatula	O
JUGRE\|EnsemblGenome=Jr12_01990\|UniProtKB=A0A2I4FCN4	Juglans regia	O
JUGRE\|EnsemblGenome=Jr12_02000\|UniProtKB=A0A2I4FCN6	Juglans regia	O
CUCSA\|EnsemblGenome=Csa_6G022350\|UniProtKB=A0A0A0K920	Cucumis sativus	O
PRUPE\|EnsemblGenome=PRUPE_7G151700\|UniProtKB=M5W6T7	Prunus persica	O
SELML\|EnsemblGenome=SELMODRAFT_235524\|UniProtKB=D8SYH5	Selaginella moellendorffii	O
SELML\|EnsemblGenome=SELMODRAFT_24180\|UniProtKB=D8SYH4	Selaginella moellendorffii	O
SELML\|EnsemblGenome=SELMODRAFT_13030\|UniProtKB=D8S917	Selaginella moellendorffii	O
SELML\|EnsemblGenome=SELMODRAFT_153568\|UniProtKB=D8S916	Selaginella moellendorffii	O
SELML\|EnsemblGenome=SELMODRAFT_161898\|UniProtKB=D8T825	Selaginella moellendorffii	O
SELML\|EnsemblGenome=SELMODRAFT_160385\|UniProtKB=D8T2C4	Selaginella moellendorffii	O
PHYPA\|EnsemblGenome=Pp3c10_9710\|UniProtKB=A0A2K1JYF7	Physcomitrella patens	O
PHYPA\|EnsemblGenome=Pp3c6_9210\|UniProtKB=A0A7I4E322	Physcomitrella patens	O
PHYPA\|EnsemblGenome=Pp3c14_9430\|UniProtKB=A0A2K1JH19	Physcomitrella patens	O
PHYPA\|EnsemblGenome=Pp3c25_5610\|UniProtKB=A0A2K1IDY1	Physcomitrella patens	O
MARPO\|EnsemblGenome=MARPO_0054s0061\|UniProtKB=A0A2R6WVR7	Marchantia polymorpha	O
MARPO\|EnsemblGenome=MARPO_0038s0053\|UniProtKB=A0A2R6X3N5	Marchantia polymorpha	O
KLENI\|Gene_ORFName=KFL_000540160\|UniProtKB=A0A0U9HTV2	Klebsormidium nitens	O