PANTHER Gene Information

Gene Symbol(s):

mcm-6

Organism:

Caenorhabditis elegans

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Gene Name:

DNA replication licensing factor mcm-6

Gene ID:

WBGene00003158

Protein ID:

P34647

Persistent Id:

PTN000180135

Alternate Ids:

176385(GeneID)	CE38018(WormBase_PRO)
ZK632.1a(WormBase_TRS)	WBGene00003158(WormBase)
MCM6(Synonym)	mcm-6(Symbol)
CAI46590(EMBL-CDS)	Z29095(EMBL)
311819934(GI)	WBGene00003158(Ensembl)
NP_001023012(refSeq)	3.6.4.12 {ECO:0000250\|UniProtKB:P97311}(EC)
MCM6_CAEEL(UniProtKB-ID)	Q5FC84(AltAccession)
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PANTHER Classification

PANTHER Family:	DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER (PTHR11630)
PANTHER Subfamily:	DNA REPLICATION LICENSING FACTOR MCM6 (PTHR11630:SF43)
PANTHER GO-slim Molecular Function:	single-stranded DNA binding 3'-5' DNA helicase activity single-stranded DNA helicase activity
PANTHER GO-slim Biological Process:	DNA unwinding involved in DNA replication mitotic DNA replication double-strand break repair via break-induced replication
PANTHER GO-slim Cellular Component:	MCM complex nucleus
PANTHER protein class:	DNA metabolism protein

Pathway Categories:

No pathway information available

GENE ONTOLOGY DATABASE ANNOTATIONS

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GO MF Complete:	ATP hydrolysis activity, DNA binding, ATP binding, DNA helicase activity, protein binding, helicase activity, single-stranded 3'-5' DNA helicase activity, single-stranded DNA binding, hydrolase activity
GO BP Complete:	DNA replication initiation, mitotic DNA replication, double-strand break repair via break-induced replication, DNA replication, DNA duplex unwinding, DNA unwinding involved in DNA replication, cell cycle
GO CC Complete:	nucleus, MCM complex

REACTOME DATABASE ANNOTATIONS Click to Expand...

Reactome Pathways:

Assembly of the pre-replicative complex, DNA Replication, Cell Cycle, S Phase, Mitotic G1 phase and G1/S transition, Orc1 removal from chromatin, Switching of origins to a post-replicative state, Cell Cycle, Mitotic, DNA Replication Pre-Initiation, Synthesis of DNA, G1/S Transition, Activation of the pre-replicative complex

Orthologs

ID	Organism	Type
XENLA\|Gene=mmcm6\|UniProtKB=Q5FWY4	Xenopus laevis	O
XENTR\|Xenbase=XB-GENE-5870537\|UniProtKB=Q28CM3	Xenopus tropicalis	O
DANRE\|ZFIN=ZDB-GENE-050913-141\|UniProtKB=Q4V9J1	Danio rerio	O
LEPOC\|Ensembl=ENSLOCG00000013289.1\|UniProtKB=W5N6W3	lepisosteus oculatus	O
HUMAN\|HGNC=6949\|UniProtKB=Q14566	Homo sapiens	LDO
PANTR\|Ensembl=ENSPTRG00000012498.2\|UniProtKB=K7BMV9	Pan troglodytes	LDO
GORGO\|Ensembl=ENSGGOG00000010911.3\|UniProtKB=A0A2I2ZI12	Gorilla gorilla gorilla	LDO
MACMU\|Ensembl=ENSMMUG00000017486.4\|UniProtKB=F6VC72	Macaca mulatta	LDO
MOUSE\|MGI=MGI=1298227\|UniProtKB=P97311	Mus musculus	LDO
BOVIN\|Gene=MCM6\|UniProtKB=Q2KIZ8	Bos taurus	O
BOVIN\|Ensembl=ENSBTAG00000015172.6\|UniProtKB=E1BH89	Bos taurus	LDO
PIG\|Ensembl=ENSSSCG00000035564.3\|UniProtKB=M3TYJ4	Sus scrofa	LDO
HORSE\|Ensembl=ENSECAG00000008840.4\|UniProtKB=F6YYN8	Equus caballus	LDO
FELCA\|Ensembl=ENSFCAG00000013595.6\|UniProtKB=M3WJ49	Felis catus	LDO
CANLF\|Ensembl=ENSCAFG00845009951.1\|UniProtKB=A0A8I3N2T8	Canis lupus familiaris	LDO
MONDO\|Ensembl=ENSMODG00000000989.3\|UniProtKB=F7ES17	Monodelphis domestica	LDO
ORNAN\|Ensembl=ENSOANG00000007988.3\|UniProtKB=F7F503	Ornithorhynchus anatinus	LDO
CHICK\|Ensembl=ENSGALG00010019843.1\|UniProtKB=A0A8V0ZC95	Gallus gallus	LDO
ANOCA\|Ensembl=ENSACAG00000001072.4\|UniProtKB=A0A803TZ54	Anolis carolinensis	LDO
XENLA\|Gene=mcm6.L\|UniProtKB=A0A8J0TRM8	Xenopus laevis	O
XENLA\|Gene=zmcm6-a\|UniProtKB=Q498J7	Xenopus laevis	O
XENLA\|Gene=zmcm6-b\|UniProtKB=Q7ZY18	Xenopus laevis	LDO
XENTR\|Xenbase=XB-GENE-962678\|UniProtKB=Q6P1V8	Xenopus tropicalis	LDO
ORYLA\|Ensembl=ENSORLG00000011329.2\|UniProtKB=H2M6U6	Oryzias latipes	LDO
DANRE\|ZFIN=ZDB-GENE-030909-6\|UniProtKB=A3KMS0	Danio rerio	LDO
LEPOC\|Ensembl=ENSLOCG00000000872.1\|UniProtKB=W5LXW8	lepisosteus oculatus	LDO
CIOIN\|Ensembl=ENSCING00000006371.3\|UniProtKB=F6RKM9	Ciona intestinalis	LDO
BRAFL\|Gene=LOC118403146\|UniProtKB=A0A9J7KFC3	Branchiostoma floridae	LDO
STRPU\|EnsemblGenome=LOC577868\|UniProtKB=A0A7M7MXD3	Strongylocentrotus purpuratus	LDO
STRPU\|EnsemblGenome=LOC115918006\|UniProtKB=A0A7M7SZH7	Strongylocentrotus purpuratus	LDO
CAEBR\|WormBase=WBGene00031483\|UniProtKB=Q61J08	Caenorhabditis briggsae	LDO
PRIPA\|EnsemblGenome=WBGene00108067\|UniProtKB=A0A8R1YL31	Pristionchus pacificus	O
PRIPA\|EnsemblGenome=WBGene00108066\|UniProtKB=A0A2A6CZ35	Pristionchus pacificus	LDO
DROME\|FlyBase=FBgn0025815\|UniProtKB=Q9V461	Drosophila melanogaster	LDO
ANOGA\|EnsemblGenome=AGAP010219\|UniProtKB=Q7Q0Q1	Anopheles gambiae	LDO
TRICA\|EnsemblGenome=TC011200\|UniProtKB=D6X3S8	Tribolium castaneum	LDO
DAPPU\|EnsemblGenome=DAPPUDRAFT_307300\|UniProtKB=E9H176	Daphnia pulex	LDO
IXOSC\|EnsemblGenome=ISCW019158\|UniProtKB=B7PKH2	Ixodes scapularis	LDO
HELRO\|EnsemblGenome=HelroG185013\|UniProtKB=T1FMA0	helobdella robusta	LDO
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g192492\|UniProtKB=A7SQR1	Nematostella vectensis	LDO
TRIAD\|EnsemblGenome=TriadG31010\|UniProtKB=B3S8M6	Trichoplax adhaerens	LDO
MONBE\|EnsemblGenome=MONBRDRAFT_25214\|UniProtKB=A9UYR3	Monosiga brevicollis	LDO
YEAST\|SGD=S000003169\|UniProtKB=P53091	Saccharomyces cerevisiae	LDO
EREGS\|EnsemblGenome=AGOS_AFR546W\|UniProtKB=Q752M8	Eremothecium gossypii	LDO
CANAL\|CGD=CAL0000192979\|UniProtKB=A0A1D8PS48	Candida albicans	LDO
YARLI\|EnsemblGenome=YALI0_B16544g\|UniProtKB=Q6CED4	Yarrowia lipolytica	LDO
EMENI\|EnsemblGenome=ANIA_00228\|UniProtKB=Q5BGV2	Emericella nidulans	LDO
ASPFU\|EnsemblGenome=AFUA_5G10890\|UniProtKB=Q4WV57	Neosartorya fumigata	LDO
NEUCR\|EnsemblGenome=NCU05194\|UniProtKB=Q7S9D8	Neurospora crassa	LDO
SCLS1\|EnsemblGenome=SS1G_13854\|UniProtKB=A7F8C3	Sclerotinia sclerotiorum	LDO
PHANO\|EnsemblGenome=SNOG_14041\|UniProtKB=Q0U2J2	Phaeosphaeria nodorum	LDO
SCHPO\|PomBase=SPBC211.04c\|UniProtKB=P49731	Schizosaccharomyces pombe	LDO
SCHJY\|EnsemblGenome=SJAG_00857\|UniProtKB=B6JWT2	Schizosaccharomyces japonicus	LDO
CRYNJ\|EnsemblGenome=CNB04510\|UniProtKB=Q5KLP9	Cryptococcus neoformans	LDO
USTMA\|EnsemblGenome=UMAG_00366\|UniProtKB=A0A0D1E7U1	Ustilago maydis	LDO
PUCGT\|EnsemblGenome=PGTG_04267\|UniProtKB=E3K2Z1	Puccinia graminis	LDO
BATDJ\|Gene_ORFName=BATDEDRAFT_20137\|UniProtKB=F4P6S8	Batrachochytrium dendrobatidis	LDO
ENTH1\|EnsemblGenome=CL6EHI_118870\|UniProtKB=C4LYN5	Entamoeba histolytica	LDO
DICDI\|dictyBase=DDB_G0272760\|UniProtKB=Q86B14	Dictyostelium discoideum	LDO
DICPU\|EnsemblGenome=DICPUDRAFT_98424\|UniProtKB=F0ZQA5	Dictyostelium purpureum	O
DICPU\|EnsemblGenome=DICPUDRAFT_156483\|UniProtKB=F0ZWP5	Dictyostelium purpureum	LDO
LEIMA\|EnsemblGenome=LMJF_28_2385\|UniProtKB=Q4Q826	Leishmania major	LDO
TRYB2\|Gene_ORFName=Tb11.01.3510\|UniProtKB=Q383B6	Trypanosoma brucei	LDO
GIAIC\|Gene_ORFName=GL50803_0017390\|UniProtKB=A0A644F0W7	Giardia intestinalis	LDO
TRIV3\|Gene_ORFName=TVAG_198280\|UniProtKB=A2DDL4	Trichomonas vaginalis	LDO
PLAF7\|EnsemblGenome=PF3D7_1355100\|UniProtKB=Q8IDF0	Plasmodium falciparum	LDO
PARTE\|EnsemblGenome=GSPATT00027500001\|UniProtKB=A0EIN0	Paramecium tetraurelia	LDO
PARTE\|EnsemblGenome=GSPATT00018686001\|UniProtKB=A0DN64	Paramecium tetraurelia	O
THAPS\|EnsemblGenome=THAPSDRAFT_26545\|UniProtKB=B8BT64	Thalassiosira pseudonana	LDO
PHYRM\|Gene=H3G6I6_PHYRM\|UniProtKB=H3G6I6	Phytophthora ramorum	LDO
CHLRE\|EnsemblGenome=CHLRE_03g178650v5\|UniProtKB=A0A2K3DXM2	Chlamydomonas reinhardtii	LDO
AMBTC\|EnsemblGenome=AMTR_s00068p00194270\|UniProtKB=U5DIX5	Amborella trichopoda	LDO
ZOSMR\|Gene_ORFName=ZOSMA_177G00240\|UniProtKB=A0A0K9PRU7	Zostera marina	LDO
MUSAM\|EnsemblGenome=Ma06_g15460\|UniProtKB=A0A804JGJ7	Musa acuminata subsp. malaccensis	LDO
SETIT\|EnsemblGenome=SETIT_021224mg\|UniProtKB=K3Z3V6	Setaria italica	LDO
SORBI\|EnsemblGenome=SORBI_3009G087000\|UniProtKB=C5YV76	Sorghum bicolor	LDO
MAIZE\|EnsemblGenome=Zm00001eb350340\|UniProtKB=Q5I285	Zea mays	O
MAIZE\|EnsemblGenome=Zm00001eb284360\|UniProtKB=A0A804Q0H7	Zea mays	LDO
ORYSJ\|EnsemblGenome=Os05g0235800\|UniProtKB=Q6F353	Oryza sativa	LDO
BRADI\|EnsemblGenome=BRADI_2g31580v3\|UniProtKB=I1HKQ4	Brachypodium distachyon	LDO
HORVV\|EnsemblGenome=HORVU.MOREX.r3.1HG0031730\|UniProtKB=M0UEL1	Hordeum vulgare subsp. vulgare	LDO
WHEAT\|EnsemblGenome=TraesCS1B02G146200\|UniProtKB=A0A3B5YVL5	Triticum aestivum	LDO
WHEAT\|EnsemblGenome=TraesCS1A02G129400\|UniProtKB=A0A3B5XXA7	Triticum aestivum	LDO
WHEAT\|EnsemblGenome=TraesCS1D02G125300\|UniProtKB=A0A3B5ZSV7	Triticum aestivum	LDO
NELNU\|Gene_ORFName=HUJ06_026907\|UniProtKB=A0A1U8A3C6	Nelumbo nucifera	LDO
SPIOL\|Gene=LOC110786684\|UniProtKB=A0A9R0JUE6	Spinacia oleracea	LDO
HELAN\|EnsemblGenome=HanXRQr2_Chr07g0290281\|UniProtKB=A0A251UA83	Helianthus annuus	LDO
LACSA\|Gene_ORFName=LSAT_V11C900496200\|UniProtKB=A0A9R1UFP2	Lactuca sativa	LDO
ERYGU\|Gene_ORFName=MIMGU_mgv1a0015571mg\|UniProtKB=A0A022RTI8	Erythranthe guttata	LDO
CAPAN\|EnsemblGenome=T459_09334\|UniProtKB=A0A2G2ZZ33	Capsicum annuum	O
CAPAN\|EnsemblGenome=T459_05973\|UniProtKB=A0A2G3A9H6	Capsicum annuum	LDO
SOLTU\|EnsemblGenome=PGSC0003DMG400013633\|UniProtKB=M1B2A8	Solanum tuberosum	LDO
SOLLC\|EnsemblGenome=Solyc02g082180.3\|UniProtKB=A0A3Q7F5V9	Solanum lycopersicum	LDO
TOBAC\|Gene=LOC107805416\|UniProtKB=A0A1S4B7U0	Nicotiana tabacum	LDO
TOBAC\|Gene=LOC107799111\|UniProtKB=A0A1S4AM34	Nicotiana tabacum	LDO
VITVI\|Gene_ORFName=VIT_00s0184g00040\|UniProtKB=F6HJI1	Vitis vinifera	LDO
EUCGR\|EnsemblGenome=EUGRSUZ_D00002\|UniProtKB=A0A059CAZ6	Eucalyptus grandis	LDO
BRANA\|Gene_ORFName=GSBRNA2T00084867001\|UniProtKB=A0A078FKG8	Brassica napus	O
BRACM\|EnsemblGenome=Bra039520\|UniProtKB=M4FEJ9	Brassica campestris	O
BRANA\|Gene_ORFName=DARMORV10_A06P47040.1\|UniProtKB=A0A078IDW9	Brassica napus	LDO
BRACM\|EnsemblGenome=Bra033756\|UniProtKB=M4EY65	Brassica campestris	LDO
ARATH\|TAIR=locus=504954997\|UniProtKB=F4KAB8	Arabidopsis thaliana	LDO
GOSHI\|Gene=LOC107908531\|UniProtKB=A0A1U8JLQ2	Gossypium hirsutum	LDO
GOSHI\|Gene=LOC107938485\|UniProtKB=A0A1U8MNF7	Gossypium hirsutum	O
THECC\|EnsemblGenome=TCM_005965\|UniProtKB=A0A061DVS5	Theobroma cacao	LDO
POPTR\|Gene_ORFName=POPTR_001G074000\|UniProtKB=A0A3N7FRW7	Populus trichocarpa	LDO
MANES\|EnsemblGenome=MANES_16G060200\|UniProtKB=A0A2C9U983	Manihot esculenta	LDO
RICCO\|Gene_ORFName=RCOM_0133060\|UniProtKB=B9T7E5	Ricinus communis	LDO
SOYBN\|EnsemblGenome=GLYMA_09G047300\|UniProtKB=I1L122	Glycine max	O
SOYBN\|EnsemblGenome=GLYMA_15G154900\|UniProtKB=A0A0R0GCD2	Glycine max	LDO
MEDTR\|EnsemblGenome=MTR_2g437540\|UniProtKB=A0A072V682	Medicago truncatula	O
MEDTR\|EnsemblGenome=MTR_8g090000\|UniProtKB=A0A072TUF1	Medicago truncatula	LDO
JUGRE\|EnsemblGenome=Jr03_16850\|UniProtKB=A0A2I4EYK9	Juglans regia	LDO
CUCSA\|EnsemblGenome=Csa_6G538780\|UniProtKB=A0A0A0KL50	Cucumis sativus	LDO
PRUPE\|EnsemblGenome=PRUPE_4G121000\|UniProtKB=A0A251PJF9	Prunus persica	LDO
SELML\|EnsemblGenome=SELMODRAFT_438068\|UniProtKB=D8QT69	Selaginella moellendorffii	LDO
SELML\|EnsemblGenome=SELMODRAFT_406458\|UniProtKB=D8R2F2	Selaginella moellendorffii	LDO
PHYPA\|EnsemblGenome=Pp3c23_390\|UniProtKB=A0A2K1IHP1	Physcomitrella patens	LDO
MARPO\|EnsemblGenome=MARPO_0119s0016\|UniProtKB=A0A2R6WAC1	Marchantia polymorpha	LDO
KLENI\|Gene_ORFName=KFL_000290270\|UniProtKB=A0A1Y1HS40	Klebsormidium nitens	LDO
NITMS\|EnsemblGenome=Nmar_0242\|UniProtKB=A9A310	Nitrosopumilus maritimus	O
KORCO\|EnsemblGenome=Kcr_1352\|UniProtKB=B1L6L9	Korarchaeum cryptofilum	O
SACS2\|EnsemblGenome=SSO0774\|UniProtKB=Q9UXG1	Sulfolobus solfataricus	O
PYRAE\|EnsemblGenome=PAE0901\|UniProtKB=Q8ZY88	Pyrobaculum aerophilum	O
METAC\|EnsemblGenome=MA_3829\|UniProtKB=Q8TJF6	Methanosarcina acetivorans	O
METAC\|EnsemblGenome=MA_0681\|UniProtKB=Q8TSW4	Methanosarcina acetivorans	O
METJA\|EnsemblGenome=MJ_ECL13\|UniProtKB=Q60275	Methanocaldococcus jannaschii	O
METJA\|EnsemblGenome=MJ_1489\|UniProtKB=Q58884	Methanocaldococcus jannaschii	O
METJA\|EnsemblGenome=MJ_0363\|UniProtKB=Q57809	Methanocaldococcus jannaschii	O
METJA\|EnsemblGenome=MJ_0961\|UniProtKB=Q58371	Methanocaldococcus jannaschii	O
HALSA\|EnsemblGenome=VNG_2181G\|UniProtKB=Q9HNA5	Halobacterium salinarum	O
THEKO\|EnsemblGenome=TK1361\|UniProtKB=Q5JGW1	Thermococcus kodakaraensis	O
THEKO\|EnsemblGenome=TK0096\|UniProtKB=Q5JEJ0	Thermococcus kodakaraensis	O
THEKO\|EnsemblGenome=TK1620\|UniProtKB=Q5JIT1	Thermococcus kodakaraensis	O