PANTHER Gene Information

Gene Symbol(s):

SESN1

Organism:

Canis lupus familiaris

View Gene in Tree

Tree

Gene Name:

Sestrin 1

Gene ID:

ENSCAFG00845009981.1

Protein ID:

A0A8I3RXG2

Persistent Id:

PTN008996925

Alternate Ids:

ENSCAFG00845009981(Ensembl)	ENSCAFT00845017595(Ensembl_TRS)
A0A8I3RXG2_CANLF(UniProtKB-ID)	A0A8I3RXG2(Synonym)
ENSCAFP00845013699(Ensembl_PRO)
Show All

PANTHER Classification

PANTHER Family:	P53 REGULATED PA26 NUCLEAR PROTEIN SESTRIN (PTHR12474)
PANTHER Subfamily:	SESTRIN-1 (PTHR12474:SF3)
PANTHER GO-slim Molecular Function:	oxidoreductase activity, acting on peroxide as acceptor amino acid binding
PANTHER GO-slim Biological Process:	positive regulation of macroautophagy negative regulation of TORC1 signaling cellular response to oxygen-containing compound cellular response to amino acid starvation cellular response to organonitrogen compound
PANTHER GO-slim Cellular Component:
PANTHER protein class:	peroxidase

Pathway Categories:

No pathway information available

GENE ONTOLOGY DATABASE ANNOTATIONS

Click to Expand...

GO MF Complete:	L-leucine binding, oxidoreductase activity, acting on peroxide as acceptor
GO BP Complete:	positive regulation of macroautophagy, regulation of response to reactive oxygen species, negative regulation of TORC1 signaling, cellular response to L-leucine, cellular response to leucine starvation
GO CC Complete:	nucleus, cytoplasm

REACTOME DATABASE ANNOTATIONS Click to Expand...

Reactome Pathways:

Gene expression (Transcription), Generic Transcription Pathway, TP53 Regulates Metabolic Genes, Cellular response to chemical stress, KEAP1-NFE2L2 pathway, Transcriptional Regulation by TP53, Cellular responses to stimuli, RNA Polymerase II Transcription, Cellular response to starvation, Amino acids regulate mTORC1, Cellular responses to stress

Orthologs

ID	Organism	Type
HUMAN\|HGNC=21595\|UniProtKB=Q9Y6P5	Homo sapiens	LDO
PANTR\|Ensembl=ENSPTRG00000018479.5\|UniProtKB=K7B8T7	Pan troglodytes	LDO
GORGO\|Ensembl=ENSGGOG00000008196.3\|UniProtKB=G3RU39	Gorilla gorilla gorilla	LDO
MACMU\|Ensembl=ENSMMUG00000018232.4\|UniProtKB=F7D7D8	Macaca mulatta	LDO
MOUSE\|MGI=MGI=2155278\|UniProtKB=P58006	Mus musculus	LDO
RAT\|RGD=1307517\|UniProtKB=A0A8I6AEX8	Rattus norvegicus	LDO
BOVIN\|Ensembl=ENSBTAG00000003015.6\|UniProtKB=A6QQS4	Bos taurus	LDO
PIG\|Ensembl=ENSSSCG00000004390.5\|UniProtKB=F1RT20	Sus scrofa	LDO
HORSE\|Ensembl=ENSECAG00000001101.4\|UniProtKB=F6TVU6	Equus caballus	LDO
FELCA\|Ensembl=ENSFCAG00000031995.4\|UniProtKB=M3X2C6	Felis catus	LDO
MONDO\|Ensembl=ENSMODG00000017990.4\|UniProtKB=F7B8G7	Monodelphis domestica	LDO
ORNAN\|Ensembl=ENSOANG00000015028.4\|UniProtKB=F6W2I5	Ornithorhynchus anatinus	LDO
CHICK\|Ensembl=ENSGALG00010014244.1\|UniProtKB=A0A8V0YH04	Gallus gallus	LDO
ANOCA\|Ensembl=ENSACAG00000006083.4\|UniProtKB=G1KF20	Anolis carolinensis	LDO
XENLA\|Gene=sesn1.L\|UniProtKB=A0A8J1KL11	Xenopus laevis	O
XENLA\|Gene=sesn1\|UniProtKB=P58003	Xenopus laevis	LDO
XENLA\|Gene=sesn1.S\|UniProtKB=A0A1L8G2X6	Xenopus laevis	LDO
XENTR\|Xenbase=XB-GENE-491636\|UniProtKB=B3DLB2	Xenopus tropicalis	LDO
ORYLA\|Ensembl=ENSORLG00000013484.2\|UniProtKB=A0A3B3I4R8	Oryzias latipes	LDO
DANRE\|Gene=sesn1\|UniProtKB=A0A8M2B7J7	Danio rerio	LDO
LEPOC\|Ensembl=ENSLOCG00000016607.1\|UniProtKB=W5NIQ5	lepisosteus oculatus	LDO
CIOIN\|Ensembl=ENSCING00000007668.3\|UniProtKB=F6T7E5	Ciona intestinalis	O
BRAFL\|Gene=LOC118423082\|UniProtKB=A0A9J7LQS3	Branchiostoma floridae	O
STRPU\|EnsemblGenome=LOC584902\|UniProtKB=A0A7M7PFI8	Strongylocentrotus purpuratus	O
CAEEL\|WormBase=WBGene00022279\|UniProtKB=Q9N4D6	Caenorhabditis elegans	O
CAEBR\|Gene_ORFName=CBG03915\|UniProtKB=A8WVR0	Caenorhabditis briggsae	O
PRIPA\|EnsemblGenome=WBGene00117377\|UniProtKB=A0A2A6BL70	Pristionchus pacificus	O
DROME\|FlyBase=FBgn0034897\|UniProtKB=Q9W1K5	Drosophila melanogaster	O
ANOGA\|EnsemblGenome=AGAP007169\|UniProtKB=Q7PTB1	Anopheles gambiae	O
TRICA\|EnsemblGenome=TC003553\|UniProtKB=D6WHQ5	Tribolium castaneum	O
DAPPU\|EnsemblGenome=DAPPUDRAFT_200622\|UniProtKB=E9H5P4	Daphnia pulex	O
IXOSC\|EnsemblGenome=ISCW002773\|UniProtKB=B7P7V9	Ixodes scapularis	O
HELRO\|EnsemblGenome=HelroG117076\|UniProtKB=T1EGK0	helobdella robusta	O
HELRO\|EnsemblGenome=HelroG185938\|UniProtKB=T1FNG7	helobdella robusta	O
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g188161\|UniProtKB=A7SCG7	Nematostella vectensis	O
TRIAD\|EnsemblGenome=TriadG25289\|UniProtKB=B3RYA9	Trichoplax adhaerens	O
MONBE\|EnsemblGenome=MONBRDRAFT_1017\|UniProtKB=A9UW02	Monosiga brevicollis	O
DICDI\|dictyBase=DDB_G0279427\|UniProtKB=Q54WU6	Dictyostelium discoideum	O
DICPU\|EnsemblGenome=DICPUDRAFT_98918\|UniProtKB=F0ZUS8	Dictyostelium purpureum	O
LEIMA\|EnsemblGenome=LMJF_18_0650\|UniProtKB=Q4QDX6	Leishmania major	O
TRYB2\|Gene_ORFName=Tb10.05.0190\|UniProtKB=Q388Q1	Trypanosoma brucei	O
PARTE\|EnsemblGenome=GSPATT00006213001\|UniProtKB=A0C4J8	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00023191001\|UniProtKB=A0E401	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00009541001\|UniProtKB=A0CR11	Paramecium tetraurelia	O
PHYRM\|Gene=H3GGE2_PHYRM\|UniProtKB=H3GGE2	Phytophthora ramorum	O